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C B Pilon et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 14(12), 2874-2882 (2014-11-15)
Human CD4(+) CD25(+) FoxP3(+) regulatory T cells (Tregs) prevent allogeneic graft rejection by inhibiting T cell activation, as has been shown in mouse models. Recently, low-dose IL-2 administration was shown to specifically activate Tregs but not pathogenic conventional T cells
Clemens von Birgelen et al.
Lancet (London, England), 383(9915), 413-423 (2013-11-05)
Third-generation, permanent-polymer-based drug-eluting stents with novel, flexible designs might be more easily delivered than previous generations of stents in complex coronary lesions, but might be less longitudinally stable. We aimed to assess the safety and efficacy in all-comer patients of
H Artee Luchman et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(22), 5756-5767 (2014-10-16)
The EGFR and PI3K/mTORC1/2 pathways are frequently altered in glioblastoma (GBM), but pharmacologic targeting of EGFR and PI3K signaling has failed to demonstrate efficacy in clinical trials. Lack of relevant models has rendered it difficult to assess whether targeting these
S Miyagawa et al.
Oncogene, 34(8), 1035-1043 (2014-03-19)
Numerous studies support a role of phosphatase and tensin homolog deleted from chromosome 10 (Pten) as a tumor suppressor gene that controls epithelial cell homeostasis to prevent tumor formation. Mouse vaginal epithelium cyclically exhibits cell proliferation and differentiation in response
Lin Song et al.
Naunyn-Schmiedeberg's archives of pharmacology, 393(9), 1739-1752 (2020-01-05)
Autophagy, a lysosomal degradative pathway, is crucial for the pathogenesis of Alzheimer's disease (AD). Schizandrol A (SchA) shows multiple pharmacological effects. However, the potential effects and mechanisms of SchA on amyloid-β (Aβ)-induced autophagy remain unclear. In this study, differentiated SH-SY5Y
David R Jones et al.
The FEBS journal, 281(16), 3591-3608 (2014-06-19)
Glucose provides an essential nutrient source that supports glycolysis and the hexosamine biosynthesis pathway (HBP) to maintain tumour cell growth and survival. Here we investigated if short-term glucose deprivation specifically modulates the phosphatidylinositol 3-kinase/protein kinase B (PI3K/PKB) cell survival pathway.
Andrew X Zhu et al.
JAMA, 312(1), 57-67 (2014-07-25)
Aside from the multikinase inhibitor sorafenib, there are no effective systemic therapies for the treatment of advanced hepatocellular carcinoma. To assess the efficacy of everolimus in patients with advanced hepatocellular carcinoma for whom sorafenib treatment failed. EVOLVE-1 was a randomized
Genomics and Proteomics. Roadmap to the epitranscriptome.
Dan Dominissini
Science (New York, N.Y.), 346(6214), 1192-1192 (2014-12-06)
Tangli Xiao et al.
Molecular and cellular biochemistry, 394(1-2), 145-154 (2014-05-23)
The aim was to explore the effects of rapamycin on autophagy and injury of podocytes in streptozocin (STZ)-induced type 1 diabetic mice, and its role in delaying progression of diabetic nephropathy. In this study, male Balb/c mice were divided into
Matthew M Hsieh et al.
JAMA, 312(1), 48-56 (2014-07-25)
Myeloablative allogeneic hematopoietic stem cell transplantation (HSCT) is curative for children with severe sickle cell disease, but toxicity may be prohibitive for adults. Nonmyeloablative transplantation has been attempted with degrees of preparative regimen intensity, but graft rejection and graft-vs-host disease
Yuqing Hao et al.
Autophagy, 15(9), 1558-1571 (2019-03-02)
Chaperone-mediated autophagy (CMA) is a lysosomal degradation pathway of select soluble proteins. Nearly one-third of the soluble proteins are predicted to be recognized by this pathway, yet only a minor fraction of this proteome has been identified as CMA substrates
Invited commentary.
Sangeeta Bhorade
The Annals of thoracic surgery, 97(1), 274-275 (2014-01-05)
Chuan Wang et al.
Biochemical and biophysical research communications, 447(1), 57-63 (2014-04-02)
Rapamycin, a mammalian target of rapamycin (mTOR)-specific inhibitor, has the effect of anti-lipid deposition on non-alcoholic fatty liver disease (NAFLD), but the mechanisms with which rapamycin alleviates hepatic steatosis are not fully disclosed. CD36 is known to facilitate long-chain fatty
Angelo M Taveira-DaSilva et al.
Chest, 147(1), 180-187 (2014-08-29)
Combined simvastatin and sirolimus therapy reduces tuberous sclerosis complex 2-null lesions and alveolar destruction in a mouse model of lymphangioleiomyomatosis (LAM), suggesting that therapy with both drugs may benefit patients with LAM. To determine whether simvastatin changed the prevalence of
Baptiste Ronan et al.
Nature chemical biology, 10(12), 1013-1019 (2014-10-20)
Vps34 is a phosphoinositide 3-kinase (PI3K) class III isoform that has attracted major attention over the recent years because of its role in autophagy. Herein we describe the biological characterization of SAR405, which is a low-molecular-mass kinase inhibitor of Vps34
N Yuan et al.
Blood cancer journal, 5, e274-e274 (2015-01-24)
B-cell acute lymphoblastic leukemia (B-ALL) accounts for the most cancer incidences in children. We present here that autophagy is downregulated in pediatric B-ALL, suggesting a possible link between autophagy failure and pediatric B-ALL leukemogenesis. With a pediatric t(1;19) B-ALL xenograft
The mTOR inhibitor revolution rolls on.
Hope Northrup
The Lancet. Oncology, 15(13), 1418-1419 (2014-12-03)
Isidre Ferrer et al.
The Journal of pathology, 233(3), 247-257 (2014-03-08)
Most patients with tuberous sclerosis complex (TSC) develop cortical tubers that cause severe neurological disabilities. It has been suggested that defects in neuronal differentiation and/or migration underlie the appearance of tubers. However, the precise molecular alterations remain largely unknown. Here
YM155 reverses rapamycin resistance in renal cancer by decreasing survivin.
Koike H, Nitta T, Sekine Y, et al.
Journal of Cancer Research and Clinical Oncology, 140(10), 1705-1713 (2014)
Hyeon-Ju Kim et al.
Oncology reports, 33(2), 699-704 (2014-12-02)
Siegesbeckia glabrescens (SG) Makino (Compositae) has been used as a traditional medicine for the treatment of allergic and inflammatory diseases. In the present study, we report the effects and molecular mechanism of an ethanolic extract of SG on cell proliferation
X Song et al.
Cell death & disease, 5, e1281-e1281 (2014-06-06)
Peritoneal carcinomatosis (PC) is the most common secondary cancerous disease, and more effective novel regimens are needed. In this study, we identified a novel combination treatment for PC, chemotherapeutic agent mitomycin C in combination with mTOR (mammalian target of rapamycin)
Kim R Bridle et al.
Liver international : official journal of the International Association for the Study of the Liver, 35(4), 1451-1463 (2014-02-13)
Mammalian target of rapamycin and angiotensin-converting enzyme inhibition has been shown to have antifibrotic activity in models of liver fibrosis. The aim of our study was to determine the efficacy of rapamycin, everolimus, irbesartan and captopril, alone and in combination
A E Ramírez et al.
Biochimica et biophysica acta, 1842(9), 1495-1501 (2014-05-06)
The mammalian target of rapamycin (mTOR) is involved in the regulation of learning and memory. Recently, rapamycin has been shown to be neuroprotective in models for Alzheimer's disease in an autophagy-dependent manner. Here we show that rapamycin exerts neuroprotection via
Sachin Kotak et al.
The EMBO journal, 33(16), 1815-1830 (2014-07-06)
The positioning and the elongation of the mitotic spindle must be carefully regulated. In human cells, the evolutionary conserved proteins LGN/Gαi1-3 anchor the coiled-coil protein NuMA and dynein to the cell cortex during metaphase, thus ensuring proper spindle positioning. The
Patrícia C Lopes et al.
Metabolism: clinical and experimental, 63(5), 702-715 (2014-03-25)
Cyclosporine A (CsA) and sirolimus (SRL) are immunosuppressive agents (IA) associated with new onset diabetes after transplantation and dyslipidemia. We aim to evaluate the molecular effects of CsA (5mg/kg/day) and SRL (1mg/kg/day) treatment for 3 and 9weeks on lipid metabolism
Ilona Patursky-Polischuk et al.
PloS one, 9(10), e109410-e109410 (2014-10-23)
TOP mRNAs encode components of the translational apparatus, and repression of their translation comprises one mechanism, by which cells encountering amino acid deprivation downregulate the biosynthesis of the protein synthesis machinery. This mode of regulation involves TSC as knockout of
Zhili Deng et al.
Journal of molecular cell biology, 7(1), 62-72 (2015-01-23)
Hair follicles (HFs) undergo cycles of degeneration (catagen), rest (telogen), and regeneration (anagen) phases. Anagen begins when the hair follicle stem cells (HFSCs) obtain sufficient activation cues to overcome suppressive signals, mainly the BMP pathway, from their niche cells. Here
Junhui Xing et al.
PloS one, 9(12), e116165-e116165 (2014-12-30)
SIRT1 is central to the lifespan and vascular health, but undergoes degradation that contributes to several medical conditions, including diabetes. How SIRT1 turnover is regulated remains unclear. However, emerging evidence suggests that endothelial nitric oxide synthase (eNOS) positively regulates SIRT1
Caroline E von Allmen et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(28), 11673-11678 (2009-07-01)
Suppression by natural CD4(+)CD25(+) regulatory T cells (Tregs) is one mechanism by which tolerance is maintained. However, the way in which Tregs mediate suppression is not well understood. Here, we show that secreted phospholipase A2 (sPLA2)-IID is selectively produced by
Jinhee Kim et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 15(1), 81-90 (2009-01-02)
p27 localization and expression has prognostic and predictive value in cancer. Little is known regarding expression patterns of p27 in renal cell carcinoma (RCC) or how p27 participates in disease progression or response to therapy. RCC-derived cell lines, primary tumors
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