Showing 1-30 of 161 resultados for "443808"
Cecilia Karlsson et al.
Endocrinology, 156(4), 1237-1241 (2014-12-31)
The individual weight loss response to obesity treatment is diverse. Here we test the hypothesis that the weight loss response to the CB1 receptor antagonist rimonabant is influenced by endogenous levels of receptor agonists. We show that baseline anandamide levels...
Justine Lanzini et al.
Biochimie, 118, 234-243 (2015-10-03)
Nude mice carry a spontaneous mutation affecting the gene Foxn1 mainly expressed in the epidermis. This gene is involved in several skin functions, especially in the proliferation and the differentiation of keratinocytes which are key cells of epithelial barrier. The...
Sarah K Abbott et al.
Lipids, 48(3), 307-318 (2013-01-29)
We have developed a protocol suitable for high-throughput lipidomic analysis of human brain samples. The traditional Folch extraction (using chloroform and glass-glass homogenization) was compared to a high-throughput method combining methyl-tert-butyl ether (MTBE) extraction with mechanical homogenization utilizing ceramic beads....
Liangpo Liu et al.
Journal of separation science, 38(2), 247-253 (2014-11-12)
In this study, a novel method for the analysis of perfluorinated compounds in whole blood has been developed and validated. The method was developed by using a conventional reversed-phase C18 column as a trapping column for the elimination of background...
C L Liguory et al.
Presse medicale (Paris, France : 1983), 17(33), 1683-1686 (1988-10-01)
Nine patients with gallstones were treated by injection of methyl-tert-butyl-ether (MTBE) into the gallbladder. Complete or incomplete dissolution was observed in 5 of the 9 patients. The 4 failures were due to 2 main factors: poor selection of the patients...
Damayanthi Devineni et al.
Clinical therapeutics, 37(3), 610-628 (2015-02-11)
Canagliflozin is a sodium-glucose cotransporter 2 inhibitor approved for the treatment of type 2 diabetes mellitus (T2DM). Because T2DM is often associated with renal or hepatic impairment, understanding the effects of these comorbid conditions on the pharmacokinetics of canagliflozin, and...
Enrico Gerace et al.
Forensic science international, 243, 68-73 (2014-05-23)
The distribution of mephedrone in the body fluids and tissues of a subject found dead after the concomitant intake of cocaine and mephedrone is reported. Mephedrone (4-methylmethcathinone) is a designer drug of the phenethylamine family that is able to cause...
Sylvain Merel et al.
Chemosphere, 127, 238-245 (2015-03-10)
N,N-diethyl-m-toluamide (DEET), the active component of many insect repellents, is among the most frequently detected compounds in aqueous environments with concentrations reported in the ng L(-1) to μg L(-1) range. However, DEET is often detected in blanks and reported concentrations...
I Zabaleta et al.
Journal of chromatography. A, 1387, 13-23 (2015-02-25)
An analytical method for the simultaneous determination in fish liver and muscle tissue and mussel samples of 14 perfluorinated compounds (PFCs), including three perfluoroalkylsulfonates (PFSAs), seven perfluorocarboxylic acids (PFCAs), three perfluorophosphonic acids (PFPAs) and perfluorooctanesulfonamide (PFOSA), and 10 potential precursors...
Ceinwen A Schreiner et al.
Regulatory toxicology and pharmacology : RTP, 70(2 Suppl), S29-S34 (2014-05-24)
Micronucleus and sister chromatid exchange (SCE) tests were performed for vapor condensate of baseline gasoline (BGVC), or gasoline with oxygenates, methyl tert-butyl ether (G/MTBE), ethyl tert butyl ether (G/ETBE), t-amyl methyl ether (G/TAME), diisopropyl ether (G/DIPE), t-butyl alcohol (TBA), or...
Relative solubility, stability, and absorptivity of lutein and β-carotene in organic solvents.
Craft NE and Soares JH.
Journal of Agricultural and Food Chemistry, 40(3), 431-434 (1992)
Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics.
Matyash V, et al.
Journal of Lipid Research, 49(5), 1137-1146 (2008)
Rikako Takahiro et al.
Biological & pharmaceutical bulletin, 38(1), 58-65 (2015-03-07)
The aim of this study was to characterize the kinetics of metabolite formation of the phosphodiesterase type-5 (PDE5) inhibitors sildenafil and tadalafil by CYP3A4, CYP3A5, and CYP3A7 isoforms. The formations of N-desmethyl sildenafil and desmethylene tadalafil were examined using CYP3A...
Chamila Nimalaratne et al.
Food chemistry, 194, 111-116 (2015-10-17)
The aromatic amino acids and carotenoids are the major contributors to the antioxidant properties of egg yolk. This study aimed to evaluate the effect of simulated retail storage and domestic cooking on the antioxidant activity as well as on the...
Giuseppe De Palma et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 17(4), 343-351 (2012-03-31)
This cross-sectional study was aimed at reconstructing the exposure to gasoline in 102 petrol station attendants by environmental and biological monitoring of benzene, toluene, ethylbenzene and xylene (BTEX) and biomonitoring of methyl tert-butyl ether (MTBE). Airborne BTEX were higher for...
Removal of methyl tert-butyl ether (MTBE) with Nafion.
Lien HL and Zhang WX
Journal of Hazardous Materials, 144(1), 194-199 (2007)
Susan M Christner et al.
Journal of pharmaceutical and biomedical analysis, 100, 199-204 (2014-08-30)
Epothilones are relatively new tubulin-poison anticancer drugs. Iso-fludelone (KOS-1803) is a synthetic third generation epothilone drug discovered at Memorial Sloan Kettering Cancer Center, and currently in phase I clinical trials. We report an LC-MS/MS assay for the sensitive, accurate and...
Yuru Wang et al.
Environmental science & technology, 48(24), 14534-14542 (2014-11-26)
A sulfate radical-based advanced oxidation process (SR-AOP) has received increasing application interest for the removal of water/wastewater contaminants. However, limited knowledge is available on its side effects. This study investigated the side effects in terms of the production of total...
Laura J Owen et al.
Annals of clinical biochemistry, 50(Pt 5), 489-491 (2013-07-31)
Supported liquid extraction (SLE) techniques are relatively new compared to other sample preparation approaches such as solid phase extraction (SPE), liquid-liquid extraction (LLE) and protein precipitation (PPE). We investigated the use of SLE as an alternative to SPE for the...
Jérôme Cotton et al.
Journal of agricultural and food chemistry, 62(46), 11335-11345 (2014-10-31)
Analytical methods for food control are mainly focused on restricted lists of well-known contaminants. This paper shows that liquid chromatography-high-resolution mass spectrometry (LC/ESI-HRMS) associated with the data mining tools developed for metabolomics can address this issue by enabling (i) targeted...
A Hokkanen et al.
Biomicrofluidics, 9(5), 054109-054109 (2015-10-01)
We have developed a microfluidics based sampling system for tissue analytics. The proof-of-concept of the sampling system was demonstrated by extracting lipid samples from tissue biopsies. The sample collection system consists of a disposable silicon based multiport microneedle integrated with...
Julie A Ray et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 970, 102-107 (2014-09-24)
Accurate measurement of aldosterone is important for the standardized testing of primary hyperaldosteronism. Commercial immunoassays show substantial between-method variations resulting in significant clinical consequences. We developed a specific two dimensional (2D)-LC-MS/MS method for measuring aldosterone in human serum and plasma...
Topical dissolution treatment of cholesterol gallstones with methyl tert-butyl ether.
J L Thistle
Seminars in liver disease, 10(3), 187-190 (1990-08-01)
Miroslav Ryska
European journal of mass spectrometry (Chichester, England), 21(3), 423-432 (2015-08-27)
Adsorption effects in the chromatographic system and/or ion source may play a very important role in the ionization processes of liquid chromatography/mass spectrometry. They have been illustrated and considered as matrix effects extensively. These effects cannot be simply removed by...
J-F Li et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 33(10), 1725-1732 (2014-05-09)
Hepatic steatosis affects disease progression in patients with chronic hepatitis C virus (HCV) infection. We investigated the plasma sphingolipid profile in patients with chronic hepatitis C (CHC) and whether there was an association between HCV-related steatosis and plasma sphingolipids. We...
Scott Phillips et al.
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 4(2), 115-126 (2008-06-24)
This paper reviews the published information assessing the kinetics and potential for adverse health effects related to exposure to the fuel oxygenate, methyl tert-butyl ether (MTBE). Data were obtained from previously published reports, using human data where possible. If human...
J Scott Boone et al.
Journal of chromatography. A, 1345, 68-77 (2014-05-06)
A trace analytical method was developed for the determination of seventeen specific perfluorinated chemicals (PFCs) in environmental and drinking waters. The objectives were to optimize an isotope-dilution method to increase the precision and accuracy of the analysis of the PFCs...
Walid M Ebeid et al.
Journal of chromatographic science, 53(7), 1178-1184 (2015-01-13)
A sensitive UPLC-MS/MS method was developed and validated for simultaneous estimation of aliskiren hemifumarate (ALS), amlodipine besylate (AML) and hydrochlorothiazide (HCZ) in spiked human plasma using valsartan as an internal standard (IS). Liquid-liquid extraction was used for purification and pre-concentration...
Bernhard Sandig et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(44), 15835-15842 (2015-10-24)
Mesoporous monolithic hybrid cellulose-2.5-acetate (CA)/polymer supports were prepared under solvent-induced phase separation conditions using cellulose-2.5-acetate microbeads 8-14 μm in diameter, 1,1,1-tris(hydroxymethyl)propane and 4,4'-methylenebis(phenylisocyanate) as monomers as well as THF and n-heptane as porogenic solvents. 4-(Dimethylamino)pyridine and dibutyltin dilaurate (DBTDL), respectively, were...
Nan Yang et al.
Molecules (Basel, Switzerland), 20(3), 4319-4336 (2015-03-11)
A high-throughput, sensitive and specific LC-ESI-MS/MS method was established for the quantitative determination of GP205, a potent inhibitor of hepatitis C virus NS3/4A protease, in rat. The analyte was isolated from 25 μL plasma sample by 96-well LLE. Good linearity...

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