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455830

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Glucose cryoprotectant affects glutathione-responsive antitumor drug release from polysaccharide nanoparticles.

Manuela Curcio et al.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 93, 281-292 (2015-04-29)

The aim of this work was to prepare polysaccharide-based nanoparticles (NPs) sensitive to glutathione (GSH), and to elucidate the effect of the concentration of glucose used as cryoprotectant during freeze-drying on the GSH-responsiveness. NPs were obtained via ionic interaction between

Induction of potent CD8 T cell cytotoxicity by specific targeting of antigen to cross-presenting dendritic cells in vivo via murine or human XCR1.

Evelyn Hartung et al.

Journal of immunology (Baltimore, Md. : 1950), 194(3), 1069-1079 (2014-12-19)

Current subunit vaccines are incapable of inducing Ag-specific CD8(+) T cell cytotoxicity needed for the defense of certain infections and for therapy of neoplastic diseases. In experimental vaccines, cytotoxic responses can be elicited by targeting of Ag into cross-presenting dendritic

Structure, expression profile and phylogenetic inference of chalcone isomerase-like genes from the narrow-leafed lupin (Lupinus angustifolius L.) genome.

Łucja Przysiecka et al.

Frontiers in plant science, 6, 268-268 (2015-05-09)

Lupins, like other legumes, have a unique biosynthesis scheme of 5-deoxy-type flavonoids and isoflavonoids. A key enzyme in this pathway is chalcone isomerase (CHI), a member of CHI-fold protein family, encompassing subfamilies of CHI1, CHI2, CHI-like (CHIL), and fatty acid-binding

Exome sequencing unravels unexpected differential diagnoses in individuals with the tentative diagnosis of Coffin-Siris and Nicolaides-Baraitser syndromes.

Nuria C Bramswig et al.

Human genetics, 134(6), 553-568 (2015-03-01)

Coffin-Siris syndrome (CSS) and Nicolaides-Baraitser syndrome (NCBRS) are rare intellectual disability/congenital malformation syndromes that represent distinct entities but show considerable clinical overlap. They are caused by mutations in genes encoding members of the BRG1- and BRM-associated factor (BAF) complex. However

Vaccine and oncogenic strains of gallid herpesvirus 2 contain specific subtype variations in the 5' region of the latency-associated transcript that evolve in vitro and in vivo.

Jennifer Labaille et al.

Archives of virology, 160(1), 161-171 (2014-10-10)

Gallid herpesvirus 2 (GaHV-2) is the alphaherpesvirus responsible for Marek's disease (MD), a T-cell lymphoma of chickens. The virulence of the GaHV-2 field strain is steadily increasing, but MD is still controlled by the CVI988/Rispens vaccine. We tried to determine

Effects of ammonium hexafluorosilicate concentration on dentin tubule occlusion and composition of the precipitate.

Toshiyuki Suge et al.

Dental materials : official publication of the Academy of Dental Materials, 26(1), 29-34 (2009-09-15)

Ammonium hexafluorosilicate [SiF: (NH(4))(2)SiF(6)] was prepared in order to overcome the tooth discoloration caused by diamine silver fluoride [AgF: (NH(3))(2)AgF] application. We employed a single concentration of SiF solution in our previous study; therefore, it is still unclear how the

Robust and selective nano cavities for protein separation: an interpenetrating polymer network modified hierarchically protein imprinted hydrogel.

Ali Nematollahzadeh et al.

Journal of chromatography. A, 1345, 154-163 (2014-05-03)

In the present work, we report a novel method for the reinforcement of hierarchically structured molecularly imprinted polymer (MIP) for the separation of human serum albumin (HSA) and immunoglobulin G (IgG) proteins under pressure driven flow conditions. The template proteins

A deletion at ADAMTS9-MAGI1 locus is associated with psoriatic arthritis risk.

Antonio Julià et al.

Annals of the rheumatic diseases, 74(10), 1875-1881 (2015-05-21)

Copy number variants (CNVs) have been associated with the risk to develop multiple autoimmune diseases. Our objective was to identify CNVs associated with the risk to develop psoriatic arthritis (PsA) using a genome-wide analysis approach. A total of 835 patients

New insights on the transcriptional regulation of CD69 gene through a potent enhancer located in the conserved non-coding sequence 2.

Teresa Laguna et al.

Molecular immunology, 66(2), 171-179 (2015-03-25)

The CD69 type II C-type lectin is one of the earliest indicators of leukocyte activation acting in lymphocyte migration and cytokine secretion. CD69 expression in hematopoietic lineage undergoes rapid changes depending on the cell-lineage, the activation state or the localization

Identification of a common risk haplotype for canine idiopathic epilepsy in the ADAM23 gene.

Lotta L E Koskinen et al.

BMC genomics, 16, 465-465 (2015-06-19)

Idiopathic epilepsy is a common neurological disease in human and domestic dogs but relatively few risk genes have been identified to date. The seizure characteristics, including focal and generalised seizures, are similar between the two species, with gene discovery facilitated

Structural characteristics of ScBx genes controlling the biosynthesis of hydroxamic acids in rye (Secale cereale L.).

Beata Bakera et al.

Journal of applied genetics, 56(3), 287-298 (2015-02-11)

Benzoxazinoids (BX) are major secondary metabolites of gramineous plants that play an important role in disease resistance and allelopathy. They also have many other unique properties including anti-bacterial and anti-fungal activity, and the ability to reduce alfa-amylase activity. The biosynthesis

Development of a highly sensitive method for the quantification of estrone and estradiol in serum by liquid chromatography tandem mass spectrometry without derivatization.

Tom Fiers et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 893-894, 57-62 (2012-03-21)

Measurement of estrone (E1) and estradiol (E2) values <1 pg/mL (3.7 pmol/L) is necessary for postmenopausal, pediatric and male serum samples. Until now this was rarely reached and only through derivatization which can present problems for estradiol. A very sensitive

Chemical Communications (Cambridge, England), 1641-1641 (1996)

Characterization of 14 novel deletions underlying Rubinstein-Taybi syndrome: an update of the CREBBP deletion repertoire.

Daniela Rusconi et al.

Human genetics, 134(6), 613-626 (2015-03-26)

Rubinstein-Taybi syndrome (RSTS) is a rare, clinically heterogeneous disorder characterized by cognitive impairment and several multiple congenital anomalies. The syndrome is caused by almost private point mutations in the CREBBP (~55% of cases) and EP300 (~8%) genes. The CREBBP mutational

Drug resistance of clinical varicella-zoster virus strains confirmed by recombinant thymidine kinase expression and by targeted resistance mutagenesis of a cloned wild-type isolate.

Anne-Kathrin Brunnemann et al.

Antimicrobial agents and chemotherapy, 59(5), 2726-2734 (2015-02-26)

In this study, approaches were developed to examine the phenotypes of nonviable clinical varicella-zoster virus (VZV) strains with amino acid substitutions in the thymidine kinase (TK) (open reading frame 36 [ORF36]) and/or DNA polymerase (Pol) (ORF28) suspected to cause resistance

Estrogen-induced chromatin decondensation and nuclear re-organization linked to regional epigenetic regulation in breast cancer.

Sehrish Rafique et al.

Genome biology, 16, 145-145 (2015-08-04)

Epigenetic changes are being increasingly recognized as a prominent feature of cancer. This occurs not only at individual genes, but also over larger chromosomal domains. To investigate this, we set out to identify large chromosomal domains of epigenetic dysregulation in

Absence of the uracil DNA glycosylase of murine gammaherpesvirus 68 impairs replication and delays the establishment of latency in vivo.

Nana Minkah et al.

Journal of virology, 89(6), 3366-3379 (2015-01-16)

Uracil DNA glycosylases (UNG) are highly conserved proteins that preserve DNA fidelity by catalyzing the removal of mutagenic uracils. All herpesviruses encode a viral UNG (vUNG), and yet the role of the vUNG in a pathogenic course of gammaherpesvirus infection

Physical Mapping and Refinement of the Painted Turtle Genome (Chrysemys picta) Inform Amniote Genome Evolution and Challenge Turtle-Bird Chromosomal Conservation.

Daleen Badenhorst et al.

Genome biology and evolution, 7(7), 2038-2050 (2015-06-26)

Comparative genomics continues illuminating amniote genome evolution, but for many lineages our understanding remains incomplete. Here, we refine the assembly (CPI 3.0.3 NCBI AHGY00000000.2) and develop a cytogenetic map of the painted turtle (Chrysemys picta-CPI) genome, the first in turtles

Afatinib induces apoptosis in NSCLC without EGFR mutation through Elk-1-mediated suppression of CIP2A.

Ting-Ting Chao et al.

Oncotarget, 6(4), 2164-2179 (2014-12-30)

Afatinib has anti-tumor effect in non-small cell lung carcinoma (NSCLC) with epidermal growth factor receptor (EGFR) mutation. We found afatinib can also induce apoptosis in NSCLC cells without EGFR mutation through CIP2A pathway. Four NSCLC cell lines (H358 H441 H460

Identification by array comparative genomic hybridization of a new amplicon on chromosome 17q highly recurrent in BRCA1 mutated triple negative breast cancer.

Sébastien Toffoli et al.

Breast cancer research : BCR, 16(6), 466-466 (2014-11-25)

Triple Negative Breast Cancers (TNBC) represent about 12% to 20% of all breast cancers (BC) and have a worse outcome compared to other BC subtypes. TNBC often show a deficiency in DNA double-strand break repair mechanisms. This is generally related

Arctigenin Protects against Lipopolysaccharide-Induced Pulmonary Oxidative Stress and Inflammation in a Mouse Model via Suppression of MAPK, HO-1, and iNOS Signaling.

Wen-zhou Zhang et al.

Inflammation, 38(4), 1406-1414 (2015-01-27)

Arctigenin, a bioactive component of Arctium lappa (Nubang), has anti-inflammatory activity. Here, we investigated the effects of arctigenin on lipopolysaccharide (LPS)-induced acute lung injury. Mice were divided into four groups: control, LPS, LPS + DMSO, and LPS + Arctigenin. Mice in the LPS + Arctigenin group

Two novel DXZ4-associated long noncoding RNAs show developmental changes in expression coincident with heterochromatin formation at the human (Homo sapiens) macrosatellite repeat.

Debbie M Figueroa et al.

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 23(4), 733-752 (2015-07-21)

On the male X and female active X chromosome (Xa), the macrosatellite repeat (MSR) DXZ4 is packaged into constitutive heterochromatin characterized by CpG methylation and histone H3 tri-methylated at lysine-9 (H3K9me3). In contrast, DXZ4 on the female inactive X chromosome

HDL from apoA1 transgenic mice expressing the 4WF isoform is resistant to oxidative loss of function.

Stela Z Berisha et al.

Journal of lipid research, 56(3), 653-664 (2015-01-07)

HDL functions are impaired by myeloperoxidase (MPO), which selectively targets and oxidizes human apoA1. We previously found that the 4WF isoform of human apoA1, in which the four tryptophan residues are substituted with phenylalanine, is resistant to MPO-mediated loss of

Amplification of the 3q chromosomal region as a specific marker in cervical cancer.

Thomas C Wright et al.

American journal of obstetrics and gynecology, 213(1), 51-51 (2015-02-11)

Chromosome 3q gain has been consistently observed in cervical intraepithelial neoplasia grades 2 and 3 (CIN 2,3) and squamous cell carcinomas of the cervix. There are a number of potential clinical uses of testing for 3q gain in liquid cytology

Human cytomegalovirus resistance to deoxyribosylindole nucleosides maps to a transversion mutation in the terminase subunit-encoding gene UL89.

Brian G Gentry et al.

Antimicrobial agents and chemotherapy, 59(1), 226-232 (2014-10-29)

Human cytomegalovirus (HCMV) infection can cause severe illnesses, including encephalopathy and mental retardation, in immunocompromised and immunologically immature patients. Current pharmacotherapies for treating systemic HCMV infections include ganciclovir, cidofovir, and foscarnet. However, long-term administration of these agents can result in

The nsp3 macrodomain promotes virulence in mice with coronavirus-induced encephalitis.

Anthony R Fehr et al.

Journal of virology, 89(3), 1523-1536 (2014-11-28)

All coronaviruses encode a macrodomain containing ADP-ribose-1"-phosphatase (ADRP) activity within the N terminus of nonstructural protein 3 (nsp3). Previous work showed that mouse hepatitis virus strain A59 (MHV-A59) with a mutated catalytic site (N1348A) replicated similarly to wild-type virus but

Role of the short telomeric repeat region in Marek's disease virus replication, genomic integration, and lymphomagenesis.

Annachiara Greco et al.

Journal of virology, 88(24), 14138-14147 (2014-10-03)

Marek's disease virus (MDV) is a cell-associated alphaherpesvirus that causes generalized polyneuritis and T-cell lymphomas in chickens. MDV is able to integrate its genome into host telomeres, but the mechanism of integration is poorly understood. The MDV genome harbors two

Nitrogen-doped TiO2 modified with NH4F for efficient photocatalytic degradation of formaldehyde under blue light-emitting diodes.

Yuexiang Li et al.

Journal of hazardous materials, 182(1-3), 90-96 (2010-06-29)

A nitrogen-doped TiO(2) (N-TiO(2)) photocatalyst was prepared by calcination of the hydrolysis precipitate of Ti(SO(4))(2) with aqueous ammonia. The prepared N-TiO(2) was treated with NH(4)F (F-N-TiO(2)) by an impregnation-calcination method. The photocatalyst (F-N-TiO(2)) was characterized by X-ray diffraction (XRD), Fourier

Post-synthesis, characterization and catalytic properties of fluorine-planted MWW-type titanosilicate.

Xiangqing Fang et al.

Physical chemistry chemical physics : PCCP, 15(14), 4930-4938 (2013-02-27)

F-Ti-MWW was post-synthesized by implanting fluorine species into a Ti-MWW framework through an acid treatment process in the presence of ammonium fluoride. The effects of NH4F addition amount, acid treatment temperature and precursor Ti content were investigated on the incorporation

Decrease in Corneal Damage due to Benzalkonium Chloride by the Addition of Mannitol into Timolol Maleate Eye Drops.

Noriaki Nagai et al.

Journal of oleo science, 64(7), 743-750 (2015-07-03)

We investigated the protective effects of mannitol on corneal damage caused by benzalkonium chloride (BAC), which is used as a preservative in commercially available timolol maleate eye drops, using rat debrided corneal epithelium and a human cornea epithelial cell line

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