Showing 1-30 of 79 resultados for "46706"
H M McIntosh
The Cochrane database of systematic reviews, (4)(4), CD000386-CD000386 (2001-11-01)
Amodiaquine and chloroquine give fast relief from malaria symptoms, particularly fever. When used alone in areas where there is some parasite resistance they do not completely clear parasites from the blood in all cases, and so not all patients are...
A R Aguemon et al.
Bulletin de la Societe de pathologie exotique (1990), 90(2), 117-119 (1997-01-01)
Intoxication by pyrimethamine is rare compare to these of patients who ingest a massive dose of amino-4-quinoleine. Clinic manifestations can be delayed and they are specially based on haematologic disorder as shown by literature data. Others organs can be concerned....
George W Mbogo et al.
The American journal of tropical medicine and hygiene, 91(1), 54-61 (2014-05-07)
Standard therapy for malaria in Uganda changed from chloroquine to chloroquine + sulfadoxine-pyrimethamine in 2000, and artemether-lumefantrine in 2004, although implementation of each change was slow. Plasmodium falciparum genetic polymorphisms are associated with alterations in drug sensitivity. We followed the...
Ayse Aksoy et al.
Pediatric neurology, 48(3), 236-239 (2013-02-20)
Acute disseminated encephalomyelitis is an acute demyelinating disorder of the central nervous system, which principally affects the brain and spinal cord. It usually follows a benign infection or vaccination in children. Although a number of infectious agents have been implicated...
Shuxian Liu et al.
Parasites & vectors, 13(1), 242-242 (2020-05-13)
Toxoplasma gondii is a zoonotic pathogen that causes toxoplasmosis and leads to serious public health problems in developing countries. However, current clinical therapeutic drugs have some disadvantages, such as serious side effects, a long course of treatment and the emergence...
John J Aponte et al.
Lancet (London, England), 374(9700), 1533-1542 (2009-09-22)
Intermittent preventive treatment (IPT) is a promising strategy for malaria control in infants. We undertook a pooled analysis of the safety and efficacy of IPT in infants (IPTi) with sulfadoxine-pyrimethamine in Africa. We pooled data from six double-blind, randomised, placebo-controlled...
Shuai Ding et al.
Scientific reports, 3, 1008-1008 (2013-01-10)
Can we predict the rise and spread of resistance to multi-drug therapy in a more predictable manner? We raise this question after analyzing over 500 Plasmodium vivax isolates collected from different, geographically isolated regions of China for sequence variation in...
Tomohisa Nakada et al.
Drug metabolism and pharmacokinetics, 29(3), 266-271 (2014-01-07)
Telaprevir-based triple therapy is a highly effective treatment for chronic hepatitis C. However, adverse reactions include reversible and dose-dependent elevation of serum creatinine levels. We speculated that this effect reflects inhibition of the renal organic cation transporters hOCT2, hMATE1, and...
H Bukirwa et al.
The Cochrane database of systematic reviews, (1)(1), CD004966-CD004966 (2006-01-27)
Artemisinin-based combination treatments are strongly advocated, but supplies are limited. Sulfadoxine combined with amodiaquine is an alternative non-artemisinin combination. To compare sulfadoxine-pyrimethamine plus amodiaquine (SP plus AQ) with sulfadoxine-pyrimethamine plus artesunate (SP plus AS) for treating uncomplicated Plasmodium falciparum malaria....
Feiko O ter Kuile et al.
JAMA, 297(23), 2603-2616 (2007-06-21)
In malaria-endemic regions, strategies to control malaria during pregnancy rely on case management of malaria illness and anemia, and preventive measures such as insecticide-treated nets and intermittent preventive therapy (IPT). To determine the effect of increasing resistance to sulfadoxine-pyrimethamine on...
Shane A Pawluk et al.
Clinical pharmacokinetics, 52(3), 153-167 (2013-01-05)
Malaria is one of the most common parasitic infections worldwide. Plasmodium falciparum is the most prevalent strain in Africa and also the most fatal. The disease especially affects children, with those under age 5 years accounting for approximately 86 %...
Jessica T Lin et al.
Tropical medicine & international health : TM & IH, 18(2), 175-178 (2012-12-04)
In the context of an Intermittent preventive treatment (IPTp) trial for pregnant women in Malawi, Plasmodium falciparum samples from 85 women at enrollment and 35 women at delivery were genotyped for mutations associated with sulfadoxine-pyrimethamine resistance. The prevalence of the...
R D Pearson et al.
Annals of internal medicine, 106(5), 714-718 (1987-05-01)
The widespread emergence of chloroquine-resistant Plasmodium falciparum led to the formulation of an effective, fixed combination of two antimalarial agents, pyrimethamine and the long-acting sulfonamide sulfadoxine, for prophylaxis and treatment. These drugs act at sequential steps to inhibit the formation...
R de Aguiar Cordeiro et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 32(4), 557-564 (2012-11-30)
The Cryptococcus neoformans species complex contains the most important agents of fungal meningoencephalitis. Therapeutic choices are limited and issues related to toxicity and resistance to antifungals have been described. The present study evaluated the inhibitory effect of the antifolate combinations...
Xiyuan Yao et al.
Scientific reports, 10(1), 15201-15201 (2020-09-18)
Cytotoxic drugs that are mechanistically distinct from current chemotherapies are attractive components of personalized combination regimens for combatting aggressive forms of cancer. To gain insight into the cellular mechanism of a potent platinum-acridine anticancer agent (compound 1), a correlation analysis...
Carolina B Moraes et al.
SLAS discovery : advancing life sciences R & D, 24(3), 346-361 (2019-02-21)
According to the World Health Organization, more than 1 billion people are at risk of or are affected by neglected tropical diseases. Examples of such diseases include trypanosomiasis, which causes sleeping sickness; leishmaniasis; and Chagas disease, all of which are...
Yu Pang et al.
Nature structural & molecular biology, 26(4), 289-296 (2019-03-27)
Ubiquitin or ubiquitin-like proteins can be covalently conjugated to multiple proteins that do not necessarily have binding interfaces. Here, we show that an evolutionary transition from covalent conjugation to non-covalent interaction has occurred in the ubiquitin-like autophagy-related 12 (ATG12) conjugation...
Ji Su Ma et al.
The Journal of experimental medicine, 211(10), 2013-2032 (2014-09-17)
Toxoplasma gondii infection results in co-option and subversion of host cellular signaling pathways. This process involves discharge of T. gondii effector molecules from parasite secretory organelles such as rhoptries and dense granules. We report that the T. gondii polymorphic dense...
Elamaran Meibalan et al.
Eukaryotic cell, 14(4), 371-384 (2015-02-11)
Malaria parasites replicating inside red blood cells (RBCs) export a large subset of proteins into the erythrocyte cytoplasm to facilitate parasite growth and survival. PTEX, the parasite-encoded translocon, mediates protein transport across the parasitophorous vacuolar membrane (PVM) in Plasmodium falciparum-infected...
Meera Venkatesan et al.
Trends in parasitology, 29(10), 497-504 (2013-08-21)
Mutations in the Plasmodium falciparum genes Pfdhfr and Pfdhps have rendered sulfadoxine-pyrimethamine (SP) ineffective for malaria treatment in most regions of the world. Yet, SP is efficacious as intermittent preventive therapy in pregnant women (IPTp) and infants (IPTi) and as...
Simeon Fogue Kouam et al.
Phytochemistry, 105, 52-59 (2014-07-21)
The stem bark of Polyalthia oliveri was screened for its chemical constituents using liquid chromatography high resolution mass spectrometry resulting in the isolation of three indolosesquiterpene alkaloids named 8α-polyveolinone (1), N-acetyl-8α-polyveolinone (2) and N-acetyl-polyveoline (3), together with three known compounds...
Nicholas J White et al.
Lancet (London, England), 383(9918), 723-735 (2013-08-21)
Although global morbidity and mortality have decreased substantially, malaria, a parasite infection of red blood cells, still kills roughly 2000 people per day, most of whom are children in Africa. Two factors largely account for these decreases; increased deployment of...
Severe toxoplasmosis in immunocompetent hosts: be aware of atypical strains.
Vincent Sobanski et al.
American journal of respiratory and critical care medicine, 187(10), 1143-1145 (2013-05-17)
Ukpo Grace Eigbibhalu et al.
Pakistan journal of pharmaceutical sciences, 26(1), 125-129 (2012-12-25)
The effects of oral administration of sulfadoxine - pyrimethamine (SP), artesunate (A) and sulfadoxine - pyrimethamine - artesunate (SPA) on blood chemistry and brain serotonin in rabbits were investigated. Forty rabbits were divided into four groups of ten animals each....
Mari Luntamo et al.
Tropical medicine & international health : TM & IH, 18(4), 386-397 (2013-02-26)
To examine the potential to reduce foetal and neonatal growth faltering through intermittent preventive treatment in pregnancy (IPTp) of malaria and reproductive tract infections with monthly sulphadoxine-pyrimethamine (SP), alone or with two doses of azithromycin. We enrolled 1320 women with...
Marya Plotkin et al.
The American journal of tropical medicine and hygiene, 91(2), 367-373 (2014-06-04)
Zanzibar has transitioned from malaria control to the pre-elimination phase, and the continued need for intermittent preventive treatment during pregnancy (IPTp) has been questioned. We conducted a prospective observational study to estimate placental malaria positivity rate among women who did...
Lubna Khatoon et al.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases, 17(5), 596-600 (2013-07-16)
Plasmodium vivax and Plasmodium falciparum are becoming resistant to drugs including antifolates, sulphonamides and chloroquine. This study was focused at sequence analysis of resistant genes of these parasites against sulphadoxine-pyrimethamine and chloroquine, from Bannu, Pakistan. Known mutations were detected at...
Pyrimethamine-sulfadiazine for treating Pneumocystis carinii pneumonia and toxoplasmosis in AIDS.
T M Gilman et al.
Clinical pharmacy, 8(2), 84-84 (1989-02-01)
H M McIntosh
The Cochrane database of systematic reviews, (2)(2), CD000386-CD000386 (2000-05-05)
Amodiaquine and chloroquine give fast relief from malaria symptoms, particularly fever. When used alone in areas where there is some parasite resistance they do not completely clear parasites from the blood in all cases, and so not all patients are...

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