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Osaama H Khan et al.
Neurosurgical focus, 37(4), E7-E7 (2014-12-04)
This paper describes a consecutive series of skull base meningiomas resected using an endoscopic endonasal approach through various corridors at a single institution over 7 years. The impact of case selection and experience, the presence of a cortical cuff between
Timothy C Chang et al.
Journal of visualized experiments : JoVE, (71)(71), e4409-e4409 (2013-01-29)
Probe-based confocal laser endomicroscopy (CLE) is an emerging optical imaging technology that enables real-time in vivo microscopy of mucosal surfaces during standard endoscopy. With applications currently in the respiratory and gastrointestinal tracts, CLE has also been explored in the urinary
Nadine Wittkopf et al.
PloS one, 10(3), e0118401-e0118401 (2015-03-24)
Gastrointestinal infections with EHEC and EPEC are responsible for outbreaks of diarrheal diseases and represent a global health problem. Innate first-line-defense mechanisms such as production of mucus and antimicrobial peptides by intestinal epithelial cells are of utmost importance for host
Misaki Nakajima et al.
The Journal of pharmacology and experimental therapeutics, 354(3), 440-447 (2015-07-04)
Tight junctions (TJs) are complex biochemical structures that seal the intercellular space and prevent the free movement of solutes across epithelial cell sheets. Modulating the TJ seal is a promising option for increasing the transdermal absorption of drugs. Within TJs
Shou-Ping Shih et al.
Marine drugs, 13(5), 3132-3153 (2015-05-27)
A marine polycyclic quinone-type metabolite, halenaquinone (HQ), was found to inhibit the proliferation of Molt 4, K562, MDA-MB-231 and DLD-1 cancer cell lines, with IC50 of 0.48, 0.18, 8.0 and 6.76 μg/mL, respectively. It exhibited the most potent activity against
Ofelia Maniti et al.
Journal of liposome research, 25(2), 122-130 (2014-09-16)
Conventional liposomes have a short life-time in blood, unless they are protected by a polymer envelope, most often polyethylene glycol. However, these stabilizing polymers frequently interfere with cellular uptake, impede liposome-membrane fusion and inhibit escape of liposome content from endosomes.
Agnieszka Krupa et al.
American journal of physiology. Lung cellular and molecular physiology, 307(6), L435-L448 (2014-08-03)
Previous observations made by our laboratory indicate that Bruton's tyrosine kinase (Btk) may play an important role in the pathophysiology of local inflammation in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). We have shown that there is cross talk
Dirk Rosentreter et al.
Shock (Augusta, Ga.), 44(1), 72-76 (2015-05-27)
Programmed necrosis (necroptosis), a newly discovered form of cell death, is mediated by receptor-interacting protein 1 (RIP1) and plays a pivotal role after myocardial, renal, and cerebral ischemia-reperfusion (I/R). The relevance of necroptosis in the postischemic liver remains, however, unclear.
Lea D Bennett et al.
Investigative ophthalmology & visual science, 55(7), 4063-4072 (2014-04-26)
Juvenile-onset autosomal dominant Stargardt-like macular dystrophy (STGD3) is caused by mutations in ELOVL4 (elongation of very long fatty acids-4), an elongase necessary for the biosynthesis of very long chain fatty acids (VLC-FAs ≥ C26). Photoreceptors are enriched with VLC polyunsaturated
Khushwant S Bhullar et al.
Food chemistry, 168, 595-605 (2014-08-31)
Partridgeberry (Vaccinium vitis-idaea) is a polyphenol-rich berry of the Ericaceous family, grown in Newfoundland and Labrador province of Canada. The aims of this study were to identify extraction solvents for the maximum recovery of polyphenols, to establish fractionation technique for
Howard C Masuoka et al.
Digestive diseases and sciences, 60(12), 3642-3646 (2015-07-22)
Hepatocyte apoptosis or necrosis from accumulation of bile salts may play an important role in the disease progression of primary sclerosing cholangitis (PSC). The aim of the current study was to measure serum markers of hepatocyte apoptosis (cytokeratin-18 fragments--K18) and
Masateru Hiyoshi et al.
Retrovirology, 12, 73-73 (2015-08-21)
Adult T-cell leukemia (ATL) is caused by human T-cell leukemia virus type 1 (HTLV-1) infection. However, there are no therapies to prevent ATL development in high-risk asymptomatic carriers. To develop a therapy targeting HTLV-1-infected cells that are known to express
Luca Flebus et al.
International journal of pharmaceutics, 492(1-2), 55-64 (2015-07-03)
Poly(2-dimethylamino)ethyl methacrylate (PDMAEMA) is an attractive polycation frequently proposed as a non-viral vector for gene therapy. As expected for other cationic carriers, intravenous administration of PDMAEMA can result in its ionic complexation with various negatively charged domains found within the
Cheng-Han Wu et al.
PloS one, 10(2), e0116068-e0116068 (2015-02-12)
Although still debated, limb regeneration in salamanders is thought to depend on the dedifferentiation of remnant tissue occurring early after amputation and generating the progenitor cells that initiate regeneration. This dedifferentiation has been demonstrated previously by showing the fragmentation of
Sonja Aits et al.
Autophagy, 11(8), 1408-1424 (2015-06-27)
Lysosomal membrane permeabilization (LMP) contributes to tissue involution, degenerative diseases, and cancer therapy. Its investigation has, however, been hindered by the lack of sensitive methods. Here, we characterize and validate the detection of galectin puncta at leaky lysosomes as a
Alexandr Sember et al.
BMC evolutionary biology, 15, 251-251 (2015-11-18)
Loaches of the family Nemacheilidae are one of the most speciose elements of Palearctic freshwater ichthyofauna and have undergone rapid ecological adaptations and colonizations. Their cytotaxonomy is largely unexplored; with the impact of cytogenetical changes on this evolutionary diversification still
Won Jai Lee et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 23(3), 435-442 (2015-04-08)
Endothelial-to-mesenchymal transition is a phenotypic conversion characterized by down-regulation of vascular endothelial markers and the acquisition of a mesenchymal phenotype. We hypothesized that keloid fibroblasts are of endothelial origin and that endothelial-to-mesenchymal transition substantially contributes to collagen accumulation during the
Samantha Herretes et al.
Investigative ophthalmology & visual science, 56(4), 2348-2357 (2015-02-07)
The primary objective of the present study was to identify the kinetics and origin of ocular infiltrating T cells in a preclinical model of graft-versus-host disease (GVHD) that induces eye tissue damage. Graft-versus-host disease was induced using an major histocompatibility
Di Gao et al.
ACS applied materials & interfaces, 7(24), 13524-13537 (2015-05-29)
Ultrasound as an external stimulus for enhanced gene transfection represents a safe, noninvasive, cost-effective delivery strategy for gene therapy. Herein, we have developed an ultrasound-triggered phase-transition cationic nanodroplet based on a novel perfluorinated amphiphilic poly(amino acid), which could simultaneously load
Mizuha Sakashita et al.
Bioorganic & medicinal chemistry, 22(19), 5212-5219 (2014-08-27)
Highly efficient drug carriers targeting hepatocyte is needed for treatment for liver diseases such as liver cirrhosis and virus infections. Galactose or N-acetylgalactosamine is known to be recognized and incorporated into the cells through asialoglycoprotein receptor (ASGPR) that is exclusively
Darshan Sapkota et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(39), E4086-E4095 (2014-09-18)
Previously, we have shown that Onecut1 (Oc1) and Onecut2 (Oc2) are expressed in retinal progenitor cells, developing retinal ganglion cells (RGCs), and horizontal cells (HCs). However, in Oc1-null mice, we only observed an 80% reduction in HCs, but no defects
Marcela Valdés-Tovar et al.
Chronobiology international, 32(2), 164-177 (2014-09-24)
The light-dark cycle is an environmental factor that influences immune physiology, and so, variations of the photoperiod length result in altered immune responsivity. Macrophage physiology comprises a spectrum of functions that goes from host defense to immune down-regulation, in addition
Bei-Bei Cao et al.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 10(1), 162-178 (2015-02-05)
We previously have shown that cerebellar fastigial nucleus (FN) modulates immune function, but pathways or mechanisms underlying this immunomodulation require clarification. Herein, an anterograde and retrograde tracing of nerve tracts between the cerebellar FN and hypothalamus/thalamus was performed in rats.
Sailesh Palikhe et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 113(3), 276-281 (2014-07-20)
Platelets are actively involved in immune inflammatory processes that release inflammatory mediators. Platelet activation has been reported in various inflammatory diseases; however, few studies have described platelet involvement in chronic urticaria (CU). To investigate platelet-activation markers, namely P2Y12 receptor and
Fang Su et al.
Stem cell research & therapy, 6, 22-22 (2015-04-19)
The objective of the present study was to evaluate the capacity of a tissue-engineered complex of human osteoprotegerin (hOPG)-transfected periodontal ligament stem cells (PDLSCs) seeding on beta-tricalcium phosphate (β-TCP) to regenerate alveolar bone defects in New Zealand rabbits. PDLSCs were
Li Wang et al.
Experimental eye research, 127, 117-123 (2014-07-27)
Choroidal neovascularization (CNV) occurs as a result of age-related macular degeneration (AMD) and causes severe vision loss among elderly patients. High expression of tissue factor (TF) was found in the retinas of AMD patients. In this study, we used anti-TF
Yohei Harada et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(10), 1466-1473 (2015-07-16)
The present study investigated intra-articular injection of bone-marrow-derived mesenchymal stem cells (MSCs) combined with articulated joint distraction as treatment for osteochondral defects. Large osteochondral defects were created in the weight-bearing area of the medial femoral condyle in rabbit knees. Four
Joanna K Polko et al.
Plant physiology, 169(1), 194-208 (2015-06-05)
Upward leaf movement (hyponastic growth) is frequently observed in response to changing environmental conditions and can be induced by the phytohormone ethylene. Hyponasty results from differential growth (i.e. enhanced cell elongation at the proximal abaxial side of the petiole relative
Xintao Huang et al.
Experimental and therapeutic medicine, 10(3), 921-926 (2015-12-02)
The aim of this study was to investigate the expression levels of microRNA-208 (miR-208) and sex-determining region Y-box 6 (SOX6) in patients with progressive cardiac hypertrophy. A total of 50 patients with essential hypertension accompanied by left ventricular hypertrophy, and
Shanhu Hu et al.
Molecular cancer therapeutics, 14(11), 2576-2585 (2015-08-26)
Chromosomal instability (CIN) is a hallmark of solid tumor biology and is implicated in carcinogenesis. Preferentially eliminating malignant cells by targeting CIN and aneuploidy is an attractive antineoplastic strategy. We previously reported that CDK2 antagonism causes lung cancer cells to
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