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Winnie W Y Tong et al.
The Journal of infectious diseases, 211(3), 405-415 (2014-08-21)
Most anal cancers are attributable to persistent human papillomavirus type 16 (HPV-16) infection. The anal cancer precursor, high-grade squamous intraepithelial lesion (HSIL), frequently regresses spontaneously. We hypothesized that T-cell responses are associated with HSIL regression. In men who have sex
Milu T Cherian et al.
Molecular pharmacology, 87(5), 878-889 (2015-03-13)
Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are xenobiotic sensors that enhance the detoxification and elimination of xenobiotics and endobiotics by modulating the expression of genes encoding drug-metabolizing enzymes and transporters. Elevated levels of drug-metabolizing enzymes and efflux
Can Lu et al.
Acta pharmacologica Sinica, 35(7), 929-936 (2014-06-10)
Receptor-interacting protein 3 (RIP3) is involved in tumor necrosis factor receptor signaling, and results in NF-κB-mediated prosurvival signaling and programmed cell death. The aim of this study was to determine whether overexpression of the RIP3 gene could sensitize human breast
Nina Ilić et al.
Vojnosanitetski pregled, 71(7), 651-659 (2014-08-12)
Mesenchymal stromal cells (MSCs) have been utilised in many clinical trials as an experimental treatment in numerous clinical settings. Bone marrow remains the traditional source tissue for MSCs but is relatively hard to access in large volumes. Alternatively, MSCs may
Matthew Di Rago et al.
Forensic science international, 243, 35-43 (2014-05-06)
The aim of this study was to develop an LC-MS/MS based screening technique that covers a broad range of acidic and neutral drugs and poisons by combining a small sample volume and efficient extraction technique with simple automated data processing.
Joaquin Zacarías-Cabeza et al.
Journal of immunology (Baltimore, Md. : 1950), 194(7), 3432-3443 (2015-03-04)
V(D)J recombination assembles Ag receptor genes during lymphocyte development. Enhancers at AR loci are known to control V(D)J recombination at associated alleles, in part by increasing chromatin accessibility of the locus, to allow the recombination machinery to gain access to
Omodele Ashiru et al.
Virology, 462-463, 135-148 (2014-06-28)
Nitazoxanide (NTZ) inhibits influenza, Japanese encephalitis, hepatitis B and hepatitis C virus replication but effects on the replication of other members of the Flaviviridae family has yet to be defined. The pestivirus bovine viral diarrhoea virus (BVDV) is a surrogate
Lu Zhang et al.
ACS nano, 9(10), 9912-9921 (2015-10-09)
The functionalized lipid shell of hybrid nanoparticles plays an important role for improving their biocompatibility and in vivo stability. Yet few efforts have been made to critically examine the shell structure of nanoparticles and its effect on cell-particle interaction. Here
Filipe M de Melo et al.
Immunology and cell biology, 93(1), 86-98 (2014-09-17)
Current therapies against malignant melanoma generally fail to increase survival in most patients, and immunotherapy is a promising approach as it could reduce the dosage of toxic therapeutic drugs. In the present study, we show that an immunotherapeutic approach based
Yi-Chun Liao et al.
Archives of toxicology, 89(11), 1971-1979 (2014-09-10)
Inorganic arsenite (iAs) is a human carcinogen. Numerous studies have shown that mutation-activated H-Ras is frequently observed in human urothelial carcinomas. The interaction between iAs, an environmental factor, and H-Ras, an oncogene, is not clear. In this study, we explored
Subburayan Karthikeyan et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 70, 274-282 (2015-03-18)
Previously, we reported that the prepared resveratrol (RSV) loaded gelatin nanoparticles (GNPs) possessed enhanced anticancer effect than free RSV in non-small cell lung carcinoma cells and Swiss albino mice. The present study aims to explore the relevant mechanism of cell
Yi-Fei Chen et al.
International journal of molecular medicine, 34(6), 1591-1598 (2014-10-17)
The difficulties faced in the effective treatment of ovarian cancer are multifactorial, but are mainly associated with relapse and drug resistance. Cancer stem-like cells have been reported to be an important contributor to these hindering factors. In this study, we
Bikramjit Ghosh et al.
Marine biotechnology (New York, N.Y.), 17(6), 841-853 (2015-09-28)
This study examined the feasibility of alginate microcapsules manufactured using a low-impact technology and reagents to protect orally delivered immunogens for use as immunoprophylactics for fish. Physical characteristics and protein release kinetics of the microcapsules were examined at different pH
Tristan P C van Doormaal et al.
The Journal of surgical research, 192(1), 200-205 (2014-06-04)
We aim to find a storage protocol for vessels that preserves their dimensional, histologic, and mechanical characteristics to facilitate reproducible anastomosis experiments and microsurgical training with constant quality. We compared stored rabbit aortas, harvested in a slaughterhouse, using five different
Ian L Gunsolus et al.
The Analyst, 139(12), 3174-3178 (2014-05-13)
A method to fluorescently stain the surfaces of both Gram-negative and Gram-positive bacterial cells compatible with super-resolution fluorescence microscopy is presented. This method utilizes a commercially-available fluorescent probe to label primary amines at the surface of the cell. We demonstrate
Ling Ding et al.
Cancer letters, 356(2 Pt B), 828-836 (2014-12-03)
Although SAHA is approved for the treatment of cutaneous T-cell lymphoma by the U.S. Food and Drug Administration, clinical trials using SAHA as a monotherapy or in combination with other chemotherapeutic agents in solid tumors have not met with success
Shafiul Haque et al.
PloS one, 9(7), e102696-e102696 (2014-07-18)
Betulin (lup-20(29)-ene-3β, 28-diol) is a naturally occurring triterpene, which is found in substantial amounts from the outer bark of birch trees. A library of 51 structurally diverse semisynthetic betulin derivatives was screened against five bacterial strains, Enterobacter aerogenes, Escherichia coli
Kazimierz Studzian et al.
Investigational new drugs, 33(5), 1032-1039 (2015-08-14)
In this study, we compared the cellular uptake, intracellular localization and cytotoxicity of two groups of anthracycline derivatives in cultured H9c2(2-1) rat cardiomyoblasts. The first group consisted of doxorubicin (DOX) and two of its derivatives containing a formamidino group (-N = CH-N<)
Cheska Gillespie et al.
Combinatorial chemistry & high throughput screening, 16(8), 636-643 (2013-05-30)
Storage of pharmaceutical discovery compounds dissolved in dimethylsulfoxide (DMSO) is commonplace within industry. Often, the DMSO stock solution is added to an aqueous system (e.g. in bioassay or kinetic solubility testing)- since most test compounds are hydrophobic, precipitation could occur.
Pang-ning Teng et al.
Gynecologic oncology, 136(3), 554-561 (2015-01-07)
Significant reductions in gynecologic (GYN) cancer mortality and morbidity require treatments that prevent and reverse resistance to chemotherapy and radiation. The objective of this study was to determine if pharmacologic inhibition of key DNA damage response kinases in GYN cancers
Qing Wang et al.
Molecular vision, 17, 647-657 (2011-03-16)
To clarify the role of bone morphogenetic proteins (BMP-2,-4,-5) in sclera remodeling during myopia induction and their effect on sclera fibroblasts in cell culture. Reverse transcription and polymerase chain reaction (RT-PCR) as well as immunofluorescence were used to detect the
Judith Müller et al.
Nature communications, 5, 5712-5712 (2014-12-17)
Increased expression of the Microphthalmia-associated transcription factor (MITF) contributes to melanoma progression and resistance to BRAF pathway inhibition. Here we show that the lack of MITF is associated with more severe resistance to a range of inhibitors, while its presence
Ignacio M Larrayoz et al.
Investigative ophthalmology & visual science, 55(11), 7553-7561 (2014-11-02)
To understand the differential responses to doxycycline between Caucasian and Hispanic patients observed in a previous clinical trial. Primary cultures were established using pterygia excised from male Caucasian (n = 3) and Hispanic (n = 6) patients. The response of
Saeid Yazdi-Ravandi et al.
Pharmacology, biochemistry, and behavior, 126, 1-6 (2014-09-03)
Previous studies have shown that there are functional interactions among the lateral hypothalamus (LH), ventral tegmental area (VTA) and the nucleus accumbens (NAc), implicating pain modulation in the central nervous system. It has been shown that the LH-VTA orexinergic projecting
Li Xing et al.
ChemMedChem, 10(4), 715-726 (2015-03-11)
Anisole and fluoroanisoles display distinct conformational preferences, as evident from a survey of their crystal structures. In addition to altering the free ligand conformation, various degrees of fluorination have a strong impact on physicochemical and pharmacokinetic properties. Analysis of anisole
Tengyuan Liu et al.
Journal of neuroinflammation, 11, 107-107 (2014-06-15)
Neuroinflammation mediated by activation of microglia and interruption of the blood-brain barrier (BBB) is an important factor that contributes to neuron death and infarct area diffusion in ischemia reperfusion injury. Finding novel molecules to regulate neuroinflammation is of significant clinical
Qian Feng et al.
Journal of digestive diseases, 15(2), 85-95 (2013-11-14)
To determine the pathogenesis of gastrointestinal vascular malformation (GIVM) and the mechanism of thalidomide in treating GIVM by evaluating the expression of angiopoietin 2 (Ang2), Notch1, delta-like ligand 4 (Dll4) and hypoxia inducible factor 1α (Hif-1α). Data of 10 patients
Michalina Oplatowska-Stachowiak et al.
Journal of agricultural and food chemistry, 63(43), 9441-9451 (2015-10-10)
There are more than 300 potential mycotoxins that can contaminate food and feed and cause adverse effects in humans and animals. The data on the co-occurrence of mycotoxins in novel animal feed materials, such as distiller's dried grain with solubles
Juan I Bravo et al.
STAR protocols, 2(2), 100406-100406 (2021-04-16)
Researchers need in vitro models that mirror the biology of organisms. Primary fibroblasts play essential roles in wound healing and are present in many tissues. They are widely used in studies of cell cycle control, reprogramming, and aging. Though extraction
Samantha J Stoll et al.
The Journal of surgical research, 156(1), 39-44 (2009-06-26)
Effective therapies for the subset of follicular thyroid cancer (FTC) patients with aggressive, metastatic disease are lacking. Therefore, we sought to determine the effects of proteosome inhibition, an emerging class of chemotherapeutic agents, on metastatic FTC cells. Human metastatic FTC
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