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Mio Okada et al.
Journal of breath research, 8(4), 046004-046004 (2014-11-02)
Transplantation of insulin (INS)-secreting cells differentiated in vitro from stem cells promises a safer and easier treatment of severe diabetes mellitus. A volatile bioactive compound, hydrogen sulfide (H2S), promotes cell differentiation; human tooth-pulp stem cells undergo hepatic differentiation. The aim
Piera Versura et al.
Blood transfusion = Trasfusione del sangue, 12 Suppl 1, s44-s50 (2013-10-15)
Cord blood serum (CBS)-based eye drops are successfully used in corneal epithelial wound healing and are prepared to supply a known amount of epidermal growth factor (EGF). Product standardisation includes expensive EGF dosage in all cord blood (CB) units. The
Dongwook Lee et al.
Fish physiology and biochemistry, 41(6), 1569-1576 (2015-08-05)
This study was conducted to identify embryonic stem cell (ESC) activities of a long-term cultured embryonic cell line previously derived from blastula-stage Oryzias dancena embryos. Five sub-cell lines were established from the embryonic cell line via clonal expansion of single
Sarbani Mohan et al.
Molecular immunology, 62(1), 249-264 (2014-07-22)
Streptococcus pneumoniae is a Gram-positive bacterium, causing acute sinusitis, otitis media, and severe diseases such as pneumonia, bacteraemia, meningitis and sepsis. Here we identify elongation factor Tu (Tuf) as a new Factor H binding protein of S. pneumoniae. The surface
Jason M Tonne et al.
Diabetologia, 58(2), 313-323 (2014-10-24)
Achieving a better understanding of beta cell regeneration after immunological destruction is crucial for the development of immunotherapy approaches for type 1 diabetes. In previous type 1 diabetes models, sustained immune activation eliminates regenerating beta cells, thus limiting the study
Saidan Ding et al.
The international journal of biochemistry & cell biology, 55, 252-263 (2014-09-16)
We previously demonstrated that dopamine (DA) overload may be a key mechanism behind development of minimal hepatic encephalopathy (MHE) in rats. It has been shown that low-grade cerebral oedema and oxidative stress play important roles in the pathogenesis of MHE.
Ross M Tanis et al.
Biochimica et biophysica acta, 1853(1), 213-221 (2014-12-03)
While the 3T3-L1 adipocyte model is routinely used for the study of obesity and diabetes, the mitochondrial respiratory profile in normal versus high glucose has not been examined in detail. We matured adipocytes in normal (5mM) or high (30 mM)
M Sumit et al.
Integrative biology : quantitative biosciences from nano to macro, 7(11), 1378-1386 (2015-09-17)
Many biological processes are rhythmic and proper timing is increasingly appreciated as being critical for development and maintenance of physiological functions. To understand how temporal modulation of an input signal influences downstream responses, we employ microfluidic pulsatile stimulation of a
Woong Jin Bae et al.
Journal of Korean medical science, 30(9), 1313-1320 (2015-09-05)
Diabetes is related with a number of cystopathic complications. However, there have been no studies about the influence of alcohol consumption in the bladder of type 2 diabetes. Thus, we investigated the effect of moderate alcohol intake in the bladder
D R Scott et al.
Alimentary pharmacology & therapeutics, 42(11-12), 1315-1326 (2015-10-02)
The gastric H(+) ,K(+) -ATPase is the preferred target for acid suppression. Until recently, the only drugs that effectively inhibited this ATPase were the proton pump inhibitors (PPIs). PPIs are acid-activated prodrugs that require acid protection. Once acid-activated, PPIs bind
Irene de Bruijn et al.
BMC genomics, 16, 991-991 (2015-11-26)
Lysobacter species are Gram-negative bacteria widely distributed in soil, plant and freshwater habitats. Lysobacter owes its name to the lytic effects on other microorganisms. To better understand their ecology and interactions with other (micro)organisms, five Lysobacter strains representing the four
Andreina Ricci et al.
Journal of mass spectrometry : JMS, 50(1), 228-234 (2015-01-21)
Understanding on a molecular level the acid-catalysed decomposition of the sugar monomers from hemicellulose and cellulose (e.g. glucose, xylose), the main constituent of lignocellulosic biomass is very important to increase selectivity and reaction yields in solution, key steps for the development
Riccardo D'Elia et al.
BMC genomics, 10, 492-492 (2009-10-27)
Trichuris muris in the mouse is an invaluable model for infection of man with the gastrointestinal nematode Trichuris trichiura. Three T. muris isolates have been studied, the Edinburgh (E), the Japan (J) and the Sobreda (S) isolates. The S isolate
Regulation of glucose homeostasis using radiogenetics and magnetogenetics in mice.
Ingo B Leibiger et al.
Nature medicine, 21(1), 14-16 (2015-01-09)
Nadya Shusharina et al.
International journal of radiation oncology, biology, physics, 89(1), 137-144 (2014-04-15)
To investigate the spatial correlation between high uptake regions of 2-deoxy-2-[(18)F]-fluoro-D-glucose positron emission tomography ((18)F-FDG PET) before and after therapy in recurrent lung cancer. We enrolled 106 patients with inoperable lung cancer into a prospective study whose primary objectives were
Ke Wang et al.
PloS one, 9(5), e96894-e96894 (2014-05-14)
Diabetes exacerbates abnormal vascular smooth muscle cell (VSMC) accumulation in response to arterial wall injury. Vinpocetine has been shown to improve vascular remolding; however, little is known about the direct effects of vinpocetine on vascular complications mediated by diabetes. The
Marilyn G Wiebe et al.
Applied microbiology and biotechnology, 99(22), 9439-9447 (2015-08-13)
An open reading frame CC1225 from the Caulobacter crescentus CB15 genome sequence belongs to the Gfo/Idh/MocA protein family and has 47 % amino acid sequence identity with the glucose-fructose oxidoreductase from Zymomonas mobilis (Zm GFOR). We expressed the ORF CC1225
Roosmarijn Tm van Hooijdonk et al.
Annals of intensive care, 4(1), 8-8 (2014-03-07)
OptiScanner devices, continuous glucose monitoring devices that perform automated blood draws via a central venous catheter and create plasma through centrifugation, measure plasma glucose levels through mid-infrared spectroscopy at the bedside. The objective of this study was to determine accuracy
Nancy T Liu et al.
Journal of food protection, 78(1), 121-127 (2015-01-13)
Biofilm-forming bacteria resident to food processing facilities are a food safety concern due to the potential of biofilms to harbor foodborne bacterial pathogens. When cultured together, Ralstonia insidiosa, a strong biofilm former frequently isolated from produce processing environments, has been
Natasha R Ryz et al.
American journal of physiology. Gastrointestinal and liver physiology, 309(9), G730-G742 (2015-09-05)
Vitamin D deficiency affects more that 1 billion people worldwide. Although thought to increase risk of bacterial infections, the importance of vitamin D on host defense against intestinal bacterial pathogens is currently unclear since injection of the active form of
Dimitrios Moustakas et al.
PloS one, 10(4), e0123310-e0123310 (2015-04-17)
The stimulant effect of energy drinks is primarily attributed to the caffeine they contain. Many energy drinks also contain other ingredients that might enhance the tonic effects of these caffeinated beverages. One of these additives is guarana. Guarana is a
J Gui et al.
Placenta, 36(4), 410-418 (2015-02-17)
Gestational diabetes (GDM) is associated with long-term cardiovascular and metabolic diseases in offspring. However, the mechanisms are not well understood. We explored whether fetal exposure to a diabetic environment is associated with fetal endothelial progenitor cell dysfunction, and whether vitamin
N V Batista et al.
Clinical and experimental immunology, 178(3), 416-427 (2014-08-13)
The prevalence of food allergy is rising in the western world. Allergen restriction is the chosen treatment in this condition, but continuous ingestion of the antigen has shown positive results in clinical trials. In a previous study, we have shown
Yi-Chun Chen et al.
Diabetologia, 57(10), 2066-2075 (2014-07-06)
EGF and gastrin co-administration reverses type 1 diabetes in rodent models. However, the failure of this to translate into a clinical treatment suggests that EGF-mediated tissue repair is a complicated process and warrants further investigation. Thus, we aimed to determine
Jiayin Wu et al.
Molecular immunology, 64(2), 235-243 (2015-01-01)
Innate immunity is considered to be critical in the pathogenesis of fungal keratitis. Pattern recognition receptors (PRRs) recognize conserved microbial structures called pathogen-associated molecular patterns (PAMPS), thereby initiating the innate immunity. Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD)-like receptors
Lu Sun et al.
Journal of immunology (Baltimore, Md. : 1950), 195(10), 4922-4932 (2015-10-04)
TRPMLs (or mucolipins) constitute a family of endosomal cation channels with homology to the transient receptor potential superfamily. In mammals, the TRPML family includes three members: TRPML1-3. Although TRPML1 and TRPML3 have been well characterized, the cellular function of TRPML2
Jennifer Oberle et al.
Fungal biology, 119(11), 1100-1114 (2015-10-16)
Twenty distinct fungal isolates were analysed using three methods of sample preparation for FTIR spectroscopy and FTIR-ATR microspectroscopy to test for differences in surface chemical composition between living and dried fungal samples, as well as differences between surface chemistry and
Yueqiang Liu et al.
Journal of pharmacological sciences, 126(2), 107-114 (2014-09-19)
Safflower yellow (SY) has been widely used in Chinese medicine for the treatment of ischemic cardiocerebrovascular disease. Recent studies have indicated that SY has a reverse effect on vascular remodeling (VR). However, its detailed mechanisms require further study to provide
Yong-Sheng Cheng et al.
PLoS genetics, 11(10), e1005561-e1005561 (2015-10-07)
In mammals, the liver plays a central role in maintaining carbohydrate and lipid homeostasis by acting both as a major source and a major sink of glucose and lipids. In particular, when dietary carbohydrates are in excess, the liver converts
K V Derkach et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 47(12), 916-924 (2015-03-10)
The functions of hypothalamic-pituitary-thyroid axis are attenuated in type 1 diabetes mellitus due to insulin deficiency. The use of intranasally administered insulin is of considerable interest for treatment of diabetes and cognitive disorders, but its effect on the thyroid system
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