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Matthew Carran et al.
The New Zealand medical journal, 125(1358), 52-63 (2012-08-07)
It is well known that the endocrine-disrupting chemical (EDC) dibutylphthalate (DBP) inhibits testosterone synthesis and can lead to feminisation in male laboratory animals. Moreover, it has long been speculated that human exposure would result in the similar effects, but this
Samuel Beck et al.
Nature communications, 5, 5490-5490 (2014-11-19)
Both transcriptional and epigenetic regulations are fundamental for the control of eukaryotic gene expression. Here we perform a compendium analysis of >200 large sequencing data sets to elucidate the regulatory logic of global gene expression programs in mouse embryonic stem
Susan L Makris et al.
Toxicology and applied pharmacology, 271(3), 336-348 (2010-09-21)
A case study was conducted, using dibutyl phthalate (DBP), to explore an approach to using toxicogenomic data in risk assessment. The toxicity and toxicogenomic data sets relative to DBP-related male reproductive developmental outcomes were considered conjointly to derive information about
Makoto Ema
Congenital anomalies, 42(4), 297-308 (2003-03-14)
Developmental toxicity following administration of dibutyl phthalate (DBP) and its major metabolite, monobutyl phthalate (MBuP), by gavage was determined in Wistar rats. DBP on days 0-8 of pregnancy induced an increase in the incidence of preimplantation loss at 1250 mg/kg
Simona Perga et al.
PloS one, 10(6), e0129291-e0129291 (2015-06-06)
Multiple sclerosis (MS) is a multifactorial autoimmune disease of the central nervous system with a heterogeneous and unpredictable course. To date there are no prognostic biomarkers even if they would be extremely useful for early patient intervention with personalized therapies.
Jeong Eun Song et al.
Journal of tissue engineering and regenerative medicine, 9(11), E98-107 (2013-03-06)
Demineralized bone particle (DBP), which is widely used as a biomaterial in the field of tissue engineering, contains various bioactive molecules, such as cytokines. For this reason, in this study we investigated the effects of injectable DBP gels on cell
Yimin Yao et al.
Journal of hypertension, 33(6), 1249-1260 (2015-03-13)
The effect of angiotensin II type I receptor (AT1R) inhibition on the pattern of reflex sympathetic nerve activity (SNA) to multiple target organs in the Lewis polycystic kidney (LPK) rat model of chronic kidney disease was determined. Mean arterial pressure
Vivian Wing-Yi Li et al.
The American journal of cardiology, 115(3), 348-353 (2014-12-09)
We assessed the left ventricular (LV) contractile reserve in young adults with repaired coarctation of the aorta and interrupted aortic arch by determination of LV force-frequency relation (FFR). Eighteen (7 men) patients aged 24.2 ± 5.4 years and 20 (9
Nobuya Inagaki et al.
Journal of diabetes investigation, 6(2), 210-218 (2015-03-25)
Canagliflozin is a sodium-glucose cotransporter 2 inhibitor under development for the treatment of type 2 diabetes. Our aim was to examine its efficacy and safety as monotherapy or in combination with commonly used oral antihyperglycemic drugs in Japanese patients with
Kyoko Kumagai et al.
Journal of hypertension, 33(2), 323-329 (2014-11-08)
Although central blood pressure (BP) is considered to be more closely associated with large arterial remodeling and cardiovascular outcomes than brachial BP, few studies have investigated these associations with changes in small arteries. As morphological changes in retinal vessels might
Viktor Švigelj et al.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 25(6), 383-390 (2015-09-17)
The arterial baroreflex depends on the integrity of the afferent limb, which can be quantified using the baroreceptor's sensitivity (BRS) during the Valsalva maneuver (VM). The aim of this study was to evaluate, using autonomic nervous system tests, the autonomic
Alpesh Mistry et al.
Molecular pharmaceutics, 12(8), 2755-2766 (2015-05-23)
The ability to deliver therapeutically relevant amounts of drugs directly from the nasal cavity to the central nervous system to treat neurological diseases is dependent on the availability of efficient drug delivery systems. Increased delivery and/or therapeutic effect has been
Myrna Medlej-Hashim et al.
Annals of human genetics, 79(6), 394-401 (2015-09-26)
Bioactive vitamin D is a steroid hormone transported in blood via the vitamin D binding protein (DBP). Our study aimed to investigate the vitamin D status in a young Lebanese population and study the association of hypovitaminosis with levels of
Matthew Lorber et al.
Environment international, 59, 469-477 (2013-08-21)
In a published controlled dosing experiment, a single individual consumed 5mg each of labeled di-n-butyl phthalate (DnBP) and diisobutyl phthalate (DiBP) on separate occasions and tracked metabolites in his blood and urine over 48h. Data from this study were used
Meili Zheng et al.
Medicine, 93(29), e262-e262 (2014-12-30)
Blood pressure (BP) changes with age. We conducted a cross-sectional study in rural Chinese adults to investigate: (1) what is the relationship between age, arterial stiffness, and BP in Chinese men and women; and (2) to what degree can the
Xiu-Juan Li et al.
Environmental toxicology and pharmacology, 36(2), 392-402 (2013-06-06)
Dibutyl-phthalate (DBP) is a ubiquitous environmental contaminant. However, its neurotoxic effects on neonatal, immature or mature brains remain unclear. Here, we aimed to investigate the neurotoxicity of perinatal exposure of DBP on rodent offspring animals. Pregnant rats received intragastric DBP
Thomas B Thornley et al.
The Journal of clinical investigation, 124(8), 3443-3454 (2014-07-02)
Macrophages characterized as M2 and M2-like regulate immune responses associated with immune suppression and healing; however, the relationship of this macrophage subset to CD169+ tissue-resident macrophages and their contribution to shaping alloimmune responses is unknown. Here we identified a population
T Fierens et al.
Environment international, 73, 117-127 (2014-08-13)
In this study, a semi-probabilistic modelling approach was applied for the estimation of the long-term human dietary exposure to phthalates--one of world's most used families of plasticisers. Four phthalate compounds were considered: diethyl phthalate (DEP), di-n-butyl phthalate (DnBP), benzylbutyl phthalate
Eun Sil Lee et al.
The Australian & New Zealand journal of obstetrics & gynaecology, 55(3), 262-267 (2015-06-06)
Blood transfusions may be associated with risks and the risk: benefit ratio is not always clear, even in the setting of haemorrhage. To describe the management practices and outcomes in women with profound anaemia who refused blood transfusion. Retrospective analysis
Arfat Idrees et al.
Acta poloniae pharmaceutica, 71(2), 287-295 (2014-10-03)
This study was aimed to determine effects of penetration enhancers and plasticizers on drug release from rationally designed formulations of flurbiprofen based transdermal drug delivery system. Matrix type transdermal patches were formulated with ethyl cellulose (EC) as a polymer by
Federico Catalano et al.
Small (Weinheim an der Bergstrasse, Germany), 11(24), 2919-2928 (2015-02-18)
The results of a systematic investigation of the role of serum proteins on the interaction of silica nanoparticles (NP) doped in their bulk with fluorescent molecules (IRIS Dots, 50 nm in size), with human mesenchymal stem cells (hMSCs) are reported.
Gang Ren et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(1), 62-64 (2012-06-28)
To study the chemical constituents of the roots of Dendropanax chevalieri. The constituents were isolated by column chromatography with silica gel, Sephadex LH-20 gel and RP-18. Their structures were elucidated by analysis of spectral data and physicochemical properties. Eight compounds
Peter Wohlfahrt et al.
Journal of hypertension, 33(2), 339-345 (2014-11-08)
There is no agreement on optimal blood pressure (BP) level during the acute phase of stroke, because studies on the relation between BP and stroke outcome have shown contradicting results. The aim of this study was to compare the relationship
Huamin Qiu et al.
Journal of pharmaceutical and biomedical analysis, 75, 123-129 (2012-12-19)
A microflow chemiluminescence (CL) sensor for determination of dibutyl phthalate (DBP) based on magnetic molecularly imprinted polymer (MMIP) as recognition element was fabricated. Briefly, a hydrophilic molecularly imprinted polymer layer was produced at the surface of Fe₃O₄@SiO₂ magnetic nanoparticles (MNPs)
Gaël Rouillé et al.
Physical chemistry chemical physics : PCCP, 17(45), 30404-30416 (2015-10-29)
Tetraphenyldibenzoperiflanthene (DBP) attracts interest as an organic electron donor for photovoltaic applications. In order to assist in the analysis of vibrational and optical spectra measured during the formation of thin films of DBP, we have studied the vibrational modes and
Benedict T Costello et al.
American journal of hypertension, 28(4), 480-486 (2014-09-07)
Central blood pressure (BP) can be estimated noninvasively by analyzing brachial artery waveforms. In this study, our aim was to assess the validity of a brachial cuff-based (suprasystolic) technique for estimating central BP (CBPestimated) by comparison with invasive aortic BP
Iván Prieto-Potin et al.
BMC musculoskeletal disorders, 16, 226-226 (2015-08-28)
Multinucleated giant cells have been noticed in diverse arthritic conditions since their first description in rheumatoid synovium. However, their role in the pathogenesis of osteoarthritis (OA) or rheumatoid arthritis (RA) still remains broadly unknown. We aimed to study the presence
Jun Wu et al.
Applied microbiology and biotechnology, 97(6), 2483-2491 (2012-06-26)
A dibutyl phthalate (DBP) transforming bacterium, strain M673, was isolated and identified as Acinetobacter sp. This strain could not grow on dialkyl phthalates, including dimethyl, diethyl, dipropyl, dibutyl, dipentyl, dihexyl, di(2-ethylhexyl), di-n-octyl, and dinonyl phthalate, but suspensions of cells could
Aina O Adeogun et al.
Marine environmental research, 108, 24-32 (2015-05-04)
The high global occurrence of phthalates in different environmental matrixes has resulted in the detection of their metabolites in human urine, blood, and breast milk, indicating a widespread human exposure. In addition, the notorious endocrine disrupting effects of phthalates have
Dion H Zappe et al.
Journal of hypertension, 33(2), 385-392 (2014-09-27)
Studies suggest that bedtime dosing of an angiotensin-converting enzyme (ACE)-inhibitor or angiotensin receptor blocker shows a more sustained and consistent 24-h antihypertensive profile, including greater night-time blood pressure (BP) reduction. We compared the antihypertensive effects of morning (a.m.) and evening
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