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57-50-1

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Michael T Henzl et al.
Biochemistry, 46(1), 23-35 (2007-01-03)
Although rat beta-parvalbumin and chicken parvalbumin 3 (CPV3) are identical at 74 of 108 residues, rat beta exhibits perceptibly lower Ca2+ and Mg2+ affinities. At 25 degrees C, in Hepes-buffered saline, at pH 7.4, the overall deltadeltaG degrees ' values...
Fernanda C Costa et al.
Biochimica et biophysica acta, 1843(12), 2944-2956 (2014-09-11)
Ki-1/57 (HABP4) and CGI-55 (SERBP1) are regulatory proteins and paralogs with 40.7% amino acid sequence identity and 67.4% similarity. Functionally, they have been implicated in the regulation of gene expression on both the transcriptional and mRNA metabolism levels. A link...
Younis Baqi et al.
Journal of medicinal chemistry, 54(3), 817-830 (2011-01-07)
Evaluation and optimization of anthraquinone derivatives related to Reactive Blue 2 at P2X2 receptors yielded the first potent and selective P2X2 receptor antagonists. The compounds were tested for inhibition of ATP (10 μM) mediated currents in Xenopus oocytes expressing the...
Zhen-Yu Lu et al.
Journal of natural products, 71(4), 543-546 (2008-02-20)
In order to search for structurally novel and bioactive natural compounds from microorganisms, a halotolerant fungal strain, Penicillium citrinum B-57, which mainly produces citrinin derivatives, was isolated from sediments collected from the Jilantai salt field. From the ethyl acetate extract...
Jilong Yang et al.
Technology in cancer research & treatment, 9(2), 161-169 (2010-03-12)
The expression of apurinic/apyrimidinic exonuclease 1 (APEX1) in tumors has been linked with chemoresistance, radioresistance, and shorter patient survival times. We sought to gain insight into the role of APEX1 in human osteosarcoma by evaluation of gene copy number alterations...
Luigi Aurelio et al.
Bioorganic & medicinal chemistry, 16(3), 1319-1327 (2007-11-06)
Two series of 5-substituted 2-amino-4-(3-trifluoromethylphenyl)thiophenes were prepared and evaluated as allosteric enhancers at the A(1) adenosine receptor (A(1)AR). In the 3-benzoyl series, a 5-phenyl group was found to confer the greatest potency (9a: ED(50)=2.1 microM, AE score=18%). However, the analogue...
R G Abou el-Ela et al.
Journal of the Egyptian Society of Parasitology, 30(1), 51-58 (2000-04-29)
Four pediculicides were tested against head lice in-vitro. The LT50 for Licid ranged between 10.75 (at conc. 50%) to 25.08 (at conc. 1%). All lice died with conc. 100% within 5 minutes. With Malathion, the LT50 ranged between 4.23 to...
Mitsuhiko Ohta et al.
Oncology reports, 15(6), 1529-1532 (2006-05-11)
We previously reported some cancer testis antigens, especially for MAGE genes, to be expressed in a relatively high population of gastro-intestinal and breast cancers. TRAG-3 (Taxol resistant associated gene-3) may be another cancer testis antigen; however, its expression has still...
Marvin T Nieman
Biochemistry, 47(50), 13279-13286 (2008-12-05)
Thrombin activates protease-activated receptor 1 (PAR1) faster than protease-activated receptor 4 (PAR4) due to a hirudin-like sequence in the exodomain of PAR1 that binds thrombin's exosite I. However, recombinant exodomain studies indicate that PAR4 does have extended contacts with alpha-thrombin...
Taridaporn Bunyapaiboonsri et al.
Journal of natural products, 72(4), 756-759 (2009-03-07)
New spirocyclic and bicyclic hemiacetals, isariotins E (1) and F (2), together with TK-57-164A (3) were isolated from the entomopathogenic fungus Isaria tenuipes BCC 12625. The absolute configuration of 3 was addressed by application of the modified Mosher's method. Isariotin...
Lars Ole Simonsen et al.
Blood cells, molecules & diseases, 47(4), 214-225 (2011-10-04)
The passive transport of calcium and cobalt and their interference were studied in human red cells using (45)Ca and (57)Co as tracers. In ATP-depleted cells, with the ATP concentration reduced to about 1μM, the progress curve for (45)Ca uptake at...
Toshiyuki Miura et al.
Journal of virology, 83(1), 140-149 (2008-10-31)
Human immunodeficiency virus type 1 (HIV-1)-infected persons who maintain plasma viral loads of <50 copies RNA/ml without treatment have been termed elite controllers (EC). Factors contributing to durable control of HIV in EC are unknown, but an HLA-dependent mechanism is...
Fadil Vardar et al.
The Turkish journal of pediatrics, 49(3), 270-273 (2007-11-10)
The aim of this study was to examine the presence of any association between mannose binding lectin (MBL) gene variants and bacterial meningitis. Codon 54 (B allele) and codon 57 (C allele) polymorphisms in exon 1 of the MBL gene...
Neta Pessah et al.
Journal of medicinal chemistry, 52(8), 2233-2242 (2009-03-20)
2,2,3,3-Tetramethylcyclopropanecarboxylic acid (TMCA, 4) is a cyclic analogue of the antiepileptic drug (AED) valproic acid (VPA) (1). alpha-F, alpha-Cl, alpha-Br, and alpha-methyl derivatives of 4 and their amides were synthesized and tested in rodent models for anticonvulsant potency and AED-induced...
Juozas A Zavadzkas et al.
American journal of physiology. Heart and circulatory physiology, 295(4), H1394-H1402 (2008-08-12)
The matrix metalloproteinases (MMPs) play a pivotal role in adverse left ventricular (LV) myocardial remodeling. The transmembrane protein extracellular MMP inducer (EMMPRIN) causes increased MMP expression in vitro, and elevated levels occur in patients with LV failure. However, the direct...
Huseyin Onay et al.
European journal of dermatology : EJD, 17(2), 146-148 (2007-03-06)
Mannose binding lectin (MBL) is a calcium dependent lectin that causes predisposition to infections and autoimmune diseases. This study aimed to examine the presence of any association between MBL2 gene variants and vitiligo. Codon 54 (allele B) and codon 57(allele...
S Yanagi et al.
Journal of the National Cancer Institute, 73(4), 887-894 (1984-10-01)
A probably promoter-specific decrease of L-type pyruvate kinase (L-PK) in Wistar rat liver is described. The possibility of utilizing the decrease in L-PK activity for screening of hepatic promoters is discussed. A significantly decreased level of activity of L-PK was...
H Kato et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 1(2), 121-128 (2002-07-09)
This study analyzes the effects and mechanisms of heme oxygenase-1 (HO-1)-mediated cytoprotection in rat livers exposed to cold preservation. In the first series, rats were pretreated with cobalt protoporphyrin (CoPP) or zinc protoporphyrin (ZnPP), HO-1 inducer and antagonist, respectively. Livers...
H Vierhapper et al.
Thyroid : official journal of the American Thyroid Association, 14(8), 580-583 (2004-08-24)
The possibility of germline mutations of the RET proto-oncogene (exons 10, 11, 13, 14, and 16) was investigated in 75 patients (57 men, 18 women) with a negative family history for medullary thyroid carcinoma (MTC), elevated (> 10 pg/mL) basal...
Robert Ullrich et al.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 24(10), 1600-1605 (2005-10-08)
The heme oxygenase-1 (HO-1) isoenzyme has recently been suggested to protect transplants from ischemia-reperfusion and immunologic injury. Inducibility of this enzyme is modulated by a (GT)n dinucleotide length polymorphism in the HO-1 gene promoter. Short (class S) repeats are associated...
Yimin Qian et al.
Journal of medicinal chemistry, 54(7), 2433-2446 (2011-03-19)
Diacylglycerol acyltransferase-1 (DGAT-1) is the enzyme that catalyzes the final and committed step of triglyceride formation, namely, the acylation of diacylglycerol with acyl coenzyme A. DGAT-1 deficient mice demonstrate resistance to weight gain on high fat diet, improved insulin sensitivity...
Y Gu et al.
The Journal of biological chemistry, 276(38), 35235-35238 (2001-08-03)
The intramembrane cleavage of beta-amyloid precursor protein by gamma-secretase is the final step in the generation of amyloid beta-protein. A 59- or 57-residue C-terminal fragment called CTFgamma is produced concomitantly. Putative CTFgamma generated in rat brain membrane preparations was purified...
Esther Sze Ping Tong et al.
Chemosphere, 80(1), 20-27 (2010-04-27)
The amphipod Melita longidactyla occurs in great abundance and serves important roles in the trophic transfer and nutrient recycling in marine systems along the Chinese coast. This study investigated the lethal dose (48h LC(50)), as well as sub-lethal effects of...
Jessica S Fortin et al.
Bioorganic & medicinal chemistry, 16(15), 7477-7488 (2008-06-27)
Recently, a subset of N-phenyl-N'-(2-chloroethyl)ureas (CEU) was found abrogating the nuclear translocation of thioredoxin-1 and arresting the cell cycle in G(0)/G(1) phase. Several derivatives were prepared to assess their effect on cell cycle progression and on the intracellular location of...
Edward A Hulten et al.
Cardiovascular diabetology, 16(1), 14-14 (2017-01-27)
To investigate the relationship among body mass index (BMI), cardiometabolic risk and coronary artery disease (CAD) among patients undergoing coronary computed tomography angiography (CTA). Retrospective cohort study of 1118 patients, who underwent coronary CTA at two centers from September 2004...
Deniz Dogru et al.
Pediatric pulmonology, 55(5), 1190-1198 (2020-03-03)
Mannose-binding lectin (MBL) is a complement protein involved in the innate immune system, and is associated with some chronic respiratory diseases including noncystic fibrosis (non-CF) bronchiectasis in adults. The aim of this study was to investigate the frequency of MBL2...
Enrique Sánchez-Lemus et al.
Neurochemical research, 31(4), 555-561 (2006-06-08)
In rat striatal slices labelled with [(3)H]-adenine and in the presence of 1 mM 3-isobutyl-1-methylxantine (IBMX), cyclic [(3)H]-AMP ([(3)H]-cAMP) accumulation induced by the dopamine D(1) receptor agonist SKF-81297 (1 microM; 177 +/- 13% of basal) was inhibited by the general...
Annamaria Ruzzo et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 24(12), 1883-1891 (2006-04-20)
To investigate whether polymorphisms with putative influence on fluorouracil/cisplatin activity are associated with clinical outcomes of patients with advanced gastric cancer (AGC). Peripheral blood samples from 175 prospectively enrolled AGC patients treated with fluorouracil/cisplatin palliative chemotherapy were used for genotyping...
Chun-Hua Wu et al.
Biotechnology letters, 29(8), 1179-1182 (2007-06-26)
Adventitious roots of Echinacea purpurea were cultured in airlift bioreactors (20 l, 500 l balloon-type, bubble bioreactors and 1,000 l drum-type bubble bioreactor) using Murashige and Skoog (MS) medium with 2 mg indole butyric acid l(-1) and 50 g sucrose...
Jeffrey L Ward et al.
Archives of biochemistry and biophysics, 411(1), 19-26 (2003-02-20)
Protein glycosylation is important for nucleoside transport, and this has been demonstrated for the human equilibrative nucleoside transporter-1 (hENT1). It is not known whether glycosylation affects the functions of hENT2 or where hENT2 is glycosylated. We address these questions using...
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