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Steven Carberry et al.
Biology, 2(4), 1438-1464 (2013-01-01)
In this article, we illustrate the application of difference in-gel electrophoresis for the proteomic analysis of dystrophic skeletal muscle. The mdx diaphragm was used as a tissue model of dystrophinopathy. Two-dimensional gel electrophoresis is a widely employed protein separation method
Jin-hua Tao et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 991, 1-8 (2015-04-23)
To explore the metabolic pathways and metabolites of luteoloside yielded by the isolated human intestinal bacteria from healthy human feces and characterize the β-d-glucosidase activity of the specific strain which catalyzed the breakdown of luteoloside, a preculture bacterial GAM broth
A O Shpakov et al.
Bulletin of experimental biology and medicine, 160(1), 40-44 (2015-11-26)
The peptides structurally corresponding in to cytoplasmic loops of G protein-coupled receptors (GPCR) are able to control functional activity of homologous receptors and the corresponding signaling pathways. Modification of these peptides with hydrophobic radicals enhances their biological activity due to
Sifei Han et al.
Pharmaceutical research, 32(5), 1830-1844 (2014-12-03)
Recent studies have demonstrated the potential for a triglyceride (TG) mimetic prodrug to promote the delivery of mycophenolic acid (MPA) to the lymphatic system. Here, the metabolic pathways that facilitate the lymphatic transport of the TG prodrug (1,3-dipalmitoyl-2-mycophenoloyl glycerol, 2-MPA-TG)
Elias Ranjbari et al.
Talanta, 139, 216-225 (2015-04-18)
An exact, rapid and efficient method for the extraction of rhodamine B (RB) and rhodamine 6G (RG) as well as their determination in three different matrices was developed using magnetic stirring assisted dispersive liquid-liquid microextraction (MSA-DLLME) and HPLC-Vis. 1-Octanol and
Joseph J LaConti et al.
BMC genomics, 16 Suppl 1, S1-S1 (2015-04-30)
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer deaths worldwide with less than a 6% 5-year survival rate. PDAC is associated with poor prognosis based on the late stage diagnosis of the disease. Current diagnostic tests lack
Xiao-Cui Qian et al.
Journal of pharmaceutical and biomedical analysis, 105, 64-73 (2014-12-30)
Rhizoma coptidis (R.C.), a widely used traditional Chinese medicine, has been used for centuries in the treatment of hypertension, inflammation, dysentery and liver diseases, etc. Wine-processing is a specialized technology by sautéing crude herbal medicine using Chinese rice wine. This
Tõiv Haljasorg et al.
Journal of agricultural and food chemistry, 62(23), 5259-5268 (2014-05-23)
A wide range of anthropogenic pollutants that possess serious environmental and health risks are known. One type of these harmful substances that have become a focus of interest during the past decade are perfluoroalkyl acids (PFAAs), which are extensively used
Hiroaki Tamaki et al.
PloS one, 10(6), e0131213-e0131213 (2015-06-23)
Sink/source relationships, regulating the mobilization of stored carbohydrates from the vegetative tissues to the grains, are of key importance for grain filling and grain yield. We used different inhibitors of plant hormone action to assess their effects on grain yield
Xanel Vecino et al.
Journal of agricultural and food chemistry, 63(32), 7143-7150 (2015-07-25)
A decontamination technique based on the utilization of a lipopeptide biosurfactant extracted from corn steep liquor has been developed to eliminate polycyclic aromatic hydrocarbons (PAHs) from sewage sludge. High concentrations of PAHs were used during experiments observing that 408.3 mg/kg
Valentina Trotta et al.
Drug development and industrial pharmacy, 40(9), 1233-1239 (2013-07-11)
Essential requirements for the efficacy of sunscreen agents are optimal UV absorption, high photostability and resistance against water removal. Aim of this study was to investigate the effect of encapsulation in lipid microparticles (LMs) on the overall performance of the
Xi-Wen Tong et al.
Scientific reports, 5, 12542-12542 (2015-07-28)
The migratory locust displays a reversible, density-dependent transition between the two phases of gregaria and solitaria. This phenomenon is a typical kind of behavior plasticity. Here, we report that COP9 signalosome complex subunit 7A (CSN7A) is involved in the regulation
Cristiane Effting et al.
Therapeutic drug monitoring, 37(1), 66-70 (2015-01-15)
Busulfan is an alkylating agent used for conditioning patients undergoing hematopoietic stem cell transplantation with a narrow therapeutic range and highly variable pharmacokinetics. High concentrations induce toxicity, especially hepatic veno-occlusive disease, also referred to as sinusoidal obstruction syndrome. This study
Anders Burild et al.
Scandinavian journal of clinical and laboratory investigation, 74(5), 418-423 (2014-04-23)
Serum 25-hydroxy-vitamin D is the established biomarker of vitamin D status although serum concentrations of vitamin D and 24,25-dihydroxyvitamin D may also be of interest to understand the in vivo kinetics of serum 25-hydroxyvitamin D. An LC-MS/MS method was developed
Daniel G Beach et al.
Analytical and bioanalytical chemistry, 407(28), 8397-8409 (2015-09-24)
The neurotoxin β-N-methylamino-L-alanine (BMAA) has been reported in cyanobacteria and shellfish, raising concerns about widespread human exposure. However, inconsistent results for BMAA analysis have led to controversy. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is the most appropriate method for analysis of
Ramprasad Kandavar et al.
Journal of clinical hypertension (Greenwich, Conn.), 17(1), 14-19 (2014-12-17)
Prehypertension is an important phenotype for cardiovascular risk and development of established hypertension. To better understand the early circulatory changes in this group, the authors studied 34 patients with prehypertension (blood pressure 120-139/80-89 mm Hg) using digital plethysmography for measurement
B Abi Salloum et al.
Endocrinology, 156(6), 2323-2337 (2015-03-13)
Gestational exposure to excess T leads to intrauterine growth restriction, low birth weight, and adult metabolic/reproductive disorders in female sheep. We hypothesized that as early mediators of such disruptions, gestational T disrupts steroidal and metabolic homeostasis in both the mother
Ji Liu et al.
Journal of proteomics, 126, 68-81 (2015-06-07)
Male sterility is a common phenomenon in flowering plants, and it has been successfully developed in several crops by taking advantage of heterosis. Cotton (Gossypium hirsutum L.) is an important economic crop, used mainly for the production of textile fiber.
Joao N Dos Santos Pereira et al.
The AAPS journal, 16(6), 1247-1258 (2014-08-27)
Variations in influx transport at the blood-brain barrier might affect the concentration of psychotropic drugs at their site of action and as a consequence might alter therapy response. Furthermore, influx transporters in organs such as the gut, liver and kidney
Paula Arbeláez et al.
Journal of chromatography. A, 1408, 15-21 (2015-07-23)
The occurrence of sweeteners in the environment has become a matter of concern due to the possibility of adverse effects on human health and wildlife species. One of the routes by which sweeteners enter the environment is through sewage sludge.
Marcello Locatelli et al.
Journal of chromatography. A, 1388, 79-86 (2015-02-24)
This paper reports the validation of a quantitative high performance liquid chromatography-photodiode array (HPLC-PDA) method for the simultaneous analysis, in mouse plasma, of eperisone hydrochloride and paracetamol by protein precipitation using zinc sulphate-methanol-acetonitrile. The analytes were resolved on a Gemini
Chun-Xia Zhao et al.
Biotechnology and bioengineering, 112(5), 957-964 (2014-11-27)
Antimicrobial peptides, as a new class of antibiotics, have generated tremendous interest as potential alternatives to classical antibiotics. However, the large-scale production of antimicrobial peptides remains a significant challenge. This paper reports a simple and low-cost chromatography-free platform technology for
Esther See et al.
International journal of pharmaceutics, 473(1-2), 528-535 (2014-08-01)
To facilitate the development of a liposomal formulation for cancer therapy, the physicochemical properties of asulacrine (ASL), an anticancer drug candidate, were characterized. Nano-liposomes were prepared by thin-film hydration in conjugation with active drug loading using ammonium sulphate and post-insertion
Peng Liu et al.
Chinese journal of natural medicines, 13(6), 471-480 (2015-06-16)
A method coupling ultra-performance liquid chromatography (UPLC) with quadrupole time-of-flight mass spectrometer (Qtof MS) using the electrospray ionization (ESI) source was developed for the identification of the major saponins from Panax notoginseng powder (PNP). Ten different PNP samples were analyzed
Tomeu Viver et al.
Systematic and applied microbiology, 38(4), 266-275 (2015-03-11)
The culturable fraction of aerobic, heterotrophic and extremely halophilic microbiota retrieved from sediment and brine samples of eight sampling sites in the Mediterranean, Canary Islands and Chile was studied by means of a tandem approach combining large-scale cultivation, MALDI-TOF MS
Sohail Mohammad et al.
Therapie, 70(4), 329-335 (2015-02-14)
A two way, randomized cross-over bioequivalence study was conducted to analyse the rate and extent of absorption of atorvastatin after a single dose of 80 mg atorvastatin as atorvastatin calcium tablets. The study was carried out using healthy male volunteers
Panfeng Yu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 959, 55-61 (2014-04-29)
This paper described a novel application of PEGylated magnetic carbon nanotubes as solid-phase extraction nanosorbents for the determination of puerarin in rat plasma by high performance liquid chromatography (HPLC). A solvothermal method was employed for the synthesis of monodisperse magnetites
Qiangwei Wang et al.
Aquatic toxicology (Amsterdam, Netherlands), 160, 163-171 (2015-02-01)
Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) is an organophosphate flame retardant that is detectable in the environment and biota, prompting concern over its risk to wildlife and human health. Our objective was to investigate whether long-term exposure to low concentrations of TDCPP can
Zhuoyang Fan et al.
PloS one, 10(4), e0120129-e0120129 (2015-04-02)
Genexol-PM, produced by Samyang Company (Korea) is an excellent preparation of paclitaxel (PTX) for clinical cancer treatment. However, it cannot resolve the issue of multidrug resistance (MDR)-a significant problem in the administration of PTX to cancer patients. To increase the
Miina Ruokolainen et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 65, 45-55 (2014-09-16)
The aim of this study was to investigate the feasibility of titanium dioxide (TiO2) photocatalysis for oxidation of anabolic steroids and for imitation of their phase I metabolism. The photocatalytic reaction products of five anabolic steroids were compared to their
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