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Alamgir Rahman et al.
Phytopathology, 105(6), 748-757 (2015-03-05)
Sustainable integrated disease management for gray leaf spot of perennial ryegrass may involve use of plant defense elicitors with compatible traditional fungicides to reduce disease incidence and severity. Silicon (Si) has previously been identified as a potential inducer or modulator
Siripen Pesee et al.
Gerodontology, 32(2), 132-140 (2013-07-09)
This study investigated risk factors of denture stomatitis, and the levels of cytokines in the saliva of elderly Candida-related denture stomatitis participants compared with adult individuals. The occurrence of denture stomatitis in 128 patients with upper removable dentures was clinically
Dolores Bautista-España et al.
PloS one, 9(10), e109981-e109981 (2014-10-10)
In this study, we investigated the reverse transcriptase subunit of telomerase in the dimorphic fungus Ustilago maydis. This protein (Trt1) contains 1371 amino acids and all of the characteristic TERT motifs. Mutants created by disrupting trt1 had senescent traits, such
Rinrada Pattanayaiying et al.
International journal of food microbiology, 207, 77-82 (2015-05-23)
A combination of food grade compounds with edible films, used to inhibit foodborne pathogens associated with fresh or further processed muscle foods, is receiving considerable attention. In this study, pullulan films containing lauric arginate (LAE) and nisin Z (produced by
Guoli Guo et al.
Toxicology and applied pharmacology, 280(3), 475-483 (2014-08-26)
We previously reported the isolation of a novel Amaryllidaceae alkaloid, N-methylhemeanthidine chloride (NMHC), from Zephyranthes candida, which exhibits potent cytotoxicity in a spectrum of tumor cells. However, the mechanism of action remains unclear. Using multiple cell lines derived from human
Bei Liu et al.
Molecular neurobiology, 50(2), 327-338 (2014-01-28)
Efflux of monocaroxylates like lactate, pyruvate, and ketone bodies from astrocytes through monocarboxylate transporter 4 (MCT4) supplies the local neuron population with metabolic intermediates to meet energy requirements under conditions of increased demand. Disruption of this astroglial-neuron metabolic coupling pathway
Yanmin Hu et al.
Tuberculosis (Edinburgh, Scotland), 95(1), 31-36 (2014-12-08)
Effective global tuberculosis control is hindered by the need for prolonged chemotherapy which leads to poor patient compliance. Therefore novel drug targets that shorten the duration of chemotherapy and reduce disease relapse rates are highly desirable. We have previously shown
Serena Pagliarani et al.
Biochimica et biophysica acta, 1842(11), 2318-2328 (2014-08-06)
Glycogen storage disease type III is an autosomal recessive disease characterized by a deficiency in the glycogen debranching enzyme, encoded by AGL. Essential features of this disease are hepatomegaly, hypoglycemia, hyperlipidemia, and growth retardation. Progressive skeletal myopathy, neuropathy, and/or cardiomyopathy
Parjam S Zolfaghari et al.
American journal of physiology. Endocrinology and metabolism, 308(9), E713-E725 (2015-02-26)
Muscle dysfunction is a common feature of severe sepsis and multiorgan failure. Recent evidence implicates bioenergetic dysfunction and oxidative damage as important underlying pathophysiological mechanisms. Increased abundance of uncoupling protein-3 (UCP3) in sepsis suggests increased mitochondrial proton leak, which may
K-W Lee et al.
Molecular psychiatry, 20(12), 1546-1556 (2015-09-16)
Mood disorders and antidepressant therapy involve alterations of monoaminergic and glutamatergic transmission. The protein S100A10 (p11) was identified as a regulator of serotonin receptors, and it has been implicated in the etiology of depression and in mediating the antidepressant actions
Matthew D Greseth et al.
PLoS pathogens, 10(3), e1004021-e1004021 (2014-03-22)
The poxvirus life cycle, although physically autonomous from the host nucleus, is nevertheless dependent upon cellular functions. A requirement for de novo fatty acid biosynthesis was implied by our previous demonstration that cerulenin, a fatty acid synthase inhibitor, impaired vaccinia
Mustapha Aouida et al.
Journal of bioscience and bioengineering, 120(4), 364-371 (2015-04-25)
Targeted engineering of microbial genomes holds much promise for diverse biotechnological applications. Transcription activator-like effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeats/Cas9 systems are capable of efficiently editing microbial genomes, including that of Saccharomyces cerevisiae. Here, we demonstrate
Peter Gergics et al.
Molecular endocrinology (Baltimore, Md.), 29(4), 597-612 (2015-02-11)
Defects in the Lhx4, Lhx3, and Pitx2 genes can cause combined pituitary hormone deficiency and pituitary hypoplasia in both humans and mice. Not much is known about the mechanism underlying hypoplasia in these mutants beyond generally increased cell death and
Isabel Mirones et al.
Stem cells (Dayton, Ohio), 32(9), 2529-2538 (2014-05-09)
As the nervous system exerts direct and indirect effects on stem cells mobilization and catecholamines mobilize hematopoietic stem cells, we hypothesized that dopamine might induce mesenchymal progenitor cells (MPCs) mobilization. We show that dopamine induced in vitro MPCs migration through
Ayako Kohyama-Koganeya et al.
PloS one, 10(7), e0133083-e0133083 (2015-07-21)
Food intake and energy metabolism are tightly controlled to maintain stable energy homeostasis and healthy states. Thus, animals detect their stored energy levels, and based on this, they determine appropriate food intake and meal size. Drosophila melanogaster putative G protein-coupled
Seong Won Choi et al.
Nature communications, 5, 4989-4989 (2014-09-24)
There is urgent need for rapid, point-of-care diagnostic tools for tuberculosis (TB) and drug sensitivity. Current methods based on in vitro growth take weeks, while DNA amplification can neither differentiate live from dead organisms nor determine phenotypic drug resistance. Here
Malick Bill et al.
Food chemistry, 194, 938-943 (2015-10-17)
Thyme oil (TO) fumigation (96μll(-1)) to cv. Hass and Ryan avocados significantly reduced anthracnose incidence compared to prochloraz and the untreated control. Also, enhanced activities of β-1,3-glucanase, chitinase were noted in both cultivars. TO fumigation induced the expression of both
Prageeth Wijemanne et al.
PloS one, 9(11), e113230-e113230 (2014-11-20)
The present study tested whether exposure of enterotoxigenic Escherichia coli (ETEC) to glucose at different concentrations in the media results in increased bacterial adherence to host cells through increased heat-labile enterotoxin (LT) production, thereby suggesting the effects are physiological. Porcine-origin
I Röhe et al.
Poultry science, 93(8), 2060-2068 (2014-06-07)
Several studies illustrated that the structure of feed, i.e., the particle size, particle-size distribution, and the physical form of the diet, affects the avian gastrointestinal function and health leading to changes in productive performance. However, investigations concerning the effects of
Asya Smirnov et al.
Journal of immunological methods, 423, 60-69 (2015-05-15)
Recognition, binding, internalization, and elimination of pathogens and cell debris are important functions of professional as well as non-professional phagocytes. However, high-throughput methods for quantifying cell-associated particles and discriminating bound from internalized particles have been lacking. Here we describe a
Lin-Quan Ge et al.
Scientific reports, 5, 12194-12194 (2015-07-18)
The brown planthopper (BPH), Nilaparvata lugens, sugar transporter gene 6 (Nlst6) is a facilitative glucose/fructose transporter (often called a passive carrier) expressed in midgut that mediates sugar transport from the midgut lumen to hemolymph. The influence of down regulating expression
Clemence Girardet et al.
Endocrinology, 155(12), 4843-4855 (2014-09-12)
The stomach hormone ghrelin and hypothalamic melanocortin neurons belong to a gut-brain circuit controlling appetite and metabolic homeostasis. Mice lacking melanocortin-3 receptor (Mc3rKO) or growth hormone secretagogue receptor (GhsrKO) genes exhibit attenuated food anticipatory activity (FAA), a rise in locomotor
Girish Ramachandran et al.
PLoS neglected tropical diseases, 9(1), e3394-e3394 (2015-01-09)
Invasive non-typhoidal Salmonella (iNTS) are an important cause of septicemia in children under the age of five years in sub-Saharan Africa. A novel genotype of Salmonella enterica subsp. enterica serovar Typhimurium (multi-locus sequence type [ST] 313) circulating in this geographic
Accidental hypoglycaemia caused by an arterial flush drug error.
M Thirugnanam et al.
Anaesthesia, 69(5), 524-525 (2014-04-18)
Axel Rydevik et al.
Drug testing and analysis, 7(7), 626-633 (2014-09-12)
A new model is presented that can be used to screen for bioactivation of drugs. The evaluation of toxicity is an important step in the development of new drugs. One way to detect possible toxic metabolites is to use trapping
Robin Altman et al.
Biochimica et biophysica acta, 1854(12), 1860-1870 (2015-09-17)
Alzheimer's disease is characterized by the presence of extracellular plaques comprised of amyloid beta (Aβ) peptides. Soluble oligomers of the Aβ peptide underlie a cascade of neuronal loss and dysfunction associated with Alzheimer's disease. Single particle analyses of Aβ oligomers
M M Bertolini et al.
Molecular oral microbiology, 30(4), 307-322 (2015-03-11)
Candida albicans and streptococci of the mitis group form communities in multiple oral sites, where moisture and nutrient availability can change spatially or temporally. This study evaluated structural and virulence characteristics of Candida-streptococcal biofilms formed on moist or semidry mucosal
Zhang Yida et al.
BioMed research international, 2015, 602313-602313 (2015-12-22)
N-Acetylneuraminic acid (Neu5Ac) is a biomarker of cardiometabolic diseases. In the present study, we tested the hypothesis that dietary Neu5Ac may improve cardiometabolic indices. A high fat diet (HFD) + Neu5Ac (50 or 400 mg/kg BW/day) was fed to rats and
N R Maddela et al.
Bulletin of environmental contamination and toxicology, 95(3), 385-394 (2015-07-29)
The competence of two fungal isolates for degrading petroleum hydrocarbons was evaluated. The filamentous fungi were isolated from a crude oil-contaminated soil in northeastern Ecuador, and were 99 %-100 % similar in 18S rDNA sequence to the genus Geomyces. Their
Ryuki Miyauchi et al.
Phytochemistry, 116, 87-93 (2015-04-14)
Nectrisine, an iminosugar with a heterocyclic nitrogen-containing 5-membered ring, acts as a glycosidase inhibitor. Thelonectria discophora SANK 18292, a fungus, was identified as a nectrisine producer from its microbial library in our screening for nectrisine producing microorganisms. Biosynthesis of nectrisine
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