Showing 1-30 of 329 resultados for "694975"
Shicheng Su et al.
Nature communications, 6, 8523-8523 (2015-10-06)
Macrophages play a pivotal role in tissue fibrogenesis, which underlies the pathogenesis of many end-stage chronic inflammatory diseases. MicroRNAs are key regulators of immune cell functions, but their roles in macrophage's fibrogenesis have not been characterized. Here we show that...
Paula Costales et al.
The Journal of biological chemistry, 290(24), 14852-14865 (2015-04-29)
Low density lipoprotein receptor-related protein (LRP1) mediates the internalization of aggregated LDL (AgLDL), which in turn increases the expression of LRP1 in human vascular smooth muscle cells (hVSMCs). This positive feedback mechanism is thus highly efficient to promote the formation...
Yin-Liang Tang et al.
International journal of molecular sciences, 16(11), 27850-27864 (2015-11-28)
Dengue virus (DENV) infection is currently at pandemic levels, with populations in tropical and subtropical regions at greatest risk of infection. Early diagnosis and management remain the cornerstone for good clinical outcomes, thus efficient and accurate diagnostic technology in the...
Hannelore Rücker et al.
Organic & biomolecular chemistry, 13(10), 3040-3047 (2015-01-27)
Inflammatory signaling pathways orchestrate the cellular response to infection and injury. These pathways are known to be modulated by compounds that alkylate cysteinyl thiols. One class of phytochemicals with strong thiol alkylating activity is the chalcones. In this study we...
Maria del Carmen Montero-Calasanz et al.
BioMed research international, 2014, 914767-914767 (2014-08-13)
A novel Gram-reaction-positive, aerobic actinobacterium, tolerant to mitomycin C, heavy metals, metalloids, hydrogen peroxide, desiccation, and ionizing- and UV-radiation, designated G18T, was isolated from dolomitic marble collected from outcrops in Samara (Namibia). The growth range was 15-35°C, at pH 5.5-9.5...
Wen Wang et al.
Organic letters, 13(17), 4514-4517 (2011-08-03)
A novel way of synthesizing quinoxalines efficiently through cyclization of o-phenylenediamine and terminal alkyne by Cu(II) and bases is developed. This reaction proceeds smoothly to give the products in moderate to good yields.
Chung-Tao Tang et al.
PloS one, 10(8), e0136328-e0136328 (2015-08-27)
The four serotypes of dengue virus (DENV1-4) pose a serious threat to global health. Cross-reactive and non-neutralizing antibodies enhance viral infection, thereby exacerbating the disease via antibody-dependent enhancement (ADE). Studying the epitopes targeted by these enhancing antibodies would improve the...
Justyna M Meissner et al.
Journal of controlled release : official journal of the Controlled Release Society, 220(Pt A), 515-528 (2015-11-21)
Antisense gene therapy using molecules such as antisense oligodeoxynucleotides, siRNA or miRNA is a very promising strategy for the treatment of neoplastic diseases. It can be combined with other treatment strategies to enhance therapeutic effect. In acute leukemias, overexpression of...
Xiaolin Wang et al.
International journal of colorectal disease, 30(1), 105-110 (2014-11-06)
Enterocolitis (EC) is the most common and serious postoperative complication of Hirschsprung's disease (HD). Probiotics potentially play a protective role in maintaining intestinal mucosal integrity. Based on the beneficial effects of probiotics, we hypothesized that oral probiotics could decrease the...
Hanni Uusi-Kerttula et al.
Microbes and infection, 16(6), 472-480 (2014-03-19)
Blocking of norovirus-like particle binding to their cellular ligands, histo-blood group antigens with immune sera, is considered a surrogate norovirus neutralization assay. We compared human secretor positive saliva and synthetic biotinylated carbohydrates as a source of histo-blood group antigens in...
Cristian Gabriel Miranda et al.
Acta tropica, 152, 8-16 (2015-08-15)
Chagas disease is a major unsolved health issue in Latin America and an emerging threat worldwide. New drugs are urgently needed for chemotherapy as those available (benznidazole and nifurtimox) have variable efficacy and elevated toxicity. Efforts are actually oriented to...
M Li et al.
Free radical research, 49(8), 946-953 (2015-03-22)
(-)-Epigallocatechin-3-gallate (EGCg) is a naturally occurring polyphenol found in plant-based foods and beverages such as green tea. Although EGCg can eliminate carbonyl species produced by glucose autoxidation and thus can inhibit protein glycation, it is also reported to be a...
Natália S Hojo-Souza et al.
Malaria journal, 14, 5-5 (2015-01-07)
Reduction in the number of circulating blood lymphocytes (lymphocytopaenia) has been reported during clinical episodes of malaria and is normalized after treatment with anti-malaria drugs. While this phenomenon is well established in malaria infection, the underlying mechanisms are still not...
Sae-Kwang Ku et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 68, 23-29 (2014-03-19)
Withaferin A (WFA), an active compound from Withania somnifera, has been widely researched for its anti-inflammatory and cardioactive properties and effects on the central nervous system. The endothelial cell protein C receptor (EPCR) plays important roles in blood coagulation and...
Mahmoud Abdel-Latif et al.
International immunopharmacology, 24(2), 173-181 (2014-12-17)
Diethylcarbamazine citrate (DEC) had a significance in anti-filarial chemotherapy, while excretory-secretory product (ES) is released from adult filarial females. The target of the current study was to examine the immunomodulatory effect of DEC, Setaria equina ES or a combination of...
Annabelle Lim et al.
Microbes and infection, 16(1), 51-60 (2013-10-22)
Despite high vaccination coverage, pertussis remains an important respiratory infectious disease and the least-controlled vaccine-preventable infectious disease in children. Natural infection with Bordetella pertussis is known to induce strong and long-lasting immunity that wanes later than vaccine-mediated immunity. Therefore, a...
Lilla Makszin et al.
Electrophoresis, 36(11-12), 1336-1343 (2015-01-30)
The structure of the oligosaccharide repeating units of endotoxins from Gram-negative bacteria is characteristic for the different serogroups and serotypes of bacteria. Detailed examination of the cross-reactions of three enterobacterial serotypes, Proteus morganii O34, Escherichia coli O111, and Salmonella enterica...
Liang Weng et al.
The EMBO journal, 33(18), 2098-2112 (2014-07-26)
In clathrin-mediated endocytosis (CME), specificity and selectivity for cargoes are thought to be tightly regulated by cargo-specific adaptors for distinct cellular functions. Here, we show that the actin-binding protein girdin is a regulator of cargo-selective CME. Girdin interacts with dynamin...
Rina Ogawa et al.
PloS one, 10(7), e0131668-e0131668 (2015-07-07)
We employed a multivalent peptide-library screening technique to identify a peptide motif that binds to phosphatidic acid (PA), but not to other phospholipids such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylserine (PS). A tetravalent peptide with the sequence motif of...
Vesna Blazevic et al.
European journal of pediatrics, 174(12), 1679-1683 (2015-07-15)
Studies investigating the magnitude and breath of protective immune responses after primary and subsequent norovirus infections in pediatric populations are limited. We investigated incidence of norovirus infections and serological responses in a child from longitudinal stool and serum samples collected...
Sally-Anne Stephenson et al.
Oncotarget, 6(10), 7554-7569 (2015-04-02)
EphB4 is a membrane-bound receptor tyrosine kinase (RTK) commonly over-produced by many epithelial cancers but with low to no expression in most normal adult tissues. EphB4 over-production promotes ligand-independent signaling pathways that increase cancer cell viability and stimulate migration and...
Sridhar Velineni et al.
Clinical and vaccine immunology : CVI, 21(9), 1246-1252 (2014-07-06)
Acute hemorrhagic pneumonia caused by Streptococcus zooepidemicus has emerged as a major disease of shelter dogs and greyhounds. S. zooepidemicus strains differing in multilocus sequence typing (MLST), protective protein (SzP), and M-like protein (SzM) sequences were identified from 9 outbreaks...
Ishaat M Khan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 77(2), 437-441 (2010-07-03)
Newly proton or charge transfer complex [(OPDH)(+)(PA)(-)] was synthesized by the reaction of the donor, o-phenylenediamine (OPD) with acceptor, 2,4,6-trinitrophenol (PAH). The chemical reaction has occurred via strong hydrogen bonding followed by migration of proton from acceptor to donor. UV-vis...
Carolyn M Nielsen et al.
Journal of immunology (Baltimore, Md. : 1950), 194(10), 4657-4667 (2015-04-10)
NK cells contribute to postvaccination immune responses after activation by IL-2 from Ag-specific memory T cells or by cross-linking of the low-affinity IgG receptor, CD16, by Ag-Ab immune complexes. Sensitivity of NK cells to these signals from the adaptive immune...
M Montazerozohori et al.
Materials science & engineering. C, Materials for biological applications, 55, 462-470 (2015-06-29)
Some new cadmium(II) Schiff base complexes CdLX2 (where X=Cl(-), Br(-), I(-), SCN(-) and N3(-) and L=N,N-bis((E)-3-(4-(dimethylamino)phenyl)allylidene)benzene-1,2-diamine) were synthesized and characterized by elemental analysis, FT-IR, UV-visible, (1)HNMR spectra, and conductivity measurements. Moreover, the structure of the CdLI2 was determined by single...
Michaela Čadková et al.
Analytical biochemistry, 484, 4-8 (2015-05-13)
Screen-printed platinum electrodes as transducer and magnetic beads as solid phase were combined to develop a particle-based electrochemical immunosensor for monitoring the serious food allergen ovalbumin. The standard arrangement of enzyme-linked immunosorbent assay became the basis for designing the immunosensor....
Alycia M Palmer et al.
ChemMedChem, 9(6), 1260-1265 (2014-04-23)
Two new complexes, cis-H,H-[Rh2 (OCCH3 NH)2 (LL)(CH3 CN)2 ](2+) , where LL=bpy (2, bpy=2,2'-bipyridine) and dppz (3, dppz=dipyrido[3,2-a:2',3'-c]phenazine), were prepared from the reaction of cis-H,H-[Rh2 (OCCH3 NH)2 (CH3 CN)6 ](2+) (1) with the corresponding bidentate ligand. The bpy and dppz...
Maiken L Henriksen et al.
Journal of immunological methods, 413, 25-31 (2014-07-30)
Immunoaffinity chromatography is a powerful fractionation technique that has become indispensable for protein purification and characterization. However, it is difficult to retrieve bound proteins without using harsh or denaturing elution conditions, and the purification of scarce antigens to homogeneity may...
Morteza Abkar et al.
Veterinary research communications, 39(4), 217-228 (2015-09-24)
Brucellosis is the most common zoonotic bacterial disease. Prevention of human brucellosis is achieved through pasteurization of dairy products, appropriate sanitation and vaccination of domestic animals against the Brucella species. B. abortus unlipidated 19 kDa outer membrane protein (U-Omp19) is...
Xinmei Zhao et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 13(18), 4142-4147 (2012-11-13)
1,2-Diaminobenzene, popularly known as ortho-phenylenediamine (PDA), is found to be a prototype spacer for the deposition of gold nanoparticles on the surfaces of Fe(3)O(4) microspheres. Upon carbonization with PDA, the morphology of the product changes significantly, and the resulting nanocomposites...

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