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Kazuaki Kawaura et al.
Behavioural brain research, 278, 186-192 (2014-10-11)
Glutamatergic dysfunction, particularly the hypofunction of N-methyl-D-aspartate (NMDA) receptors, is involved in the pathophysiology of schizophrenia. The positive modulation of the glycine site on the NMDA receptor has been proposed as a novel therapeutic approach for schizophrenia. However, its efficacy
Hai Zhang et al.
Journal of ethnopharmacology, 154(3), 645-652 (2014-05-06)
Aconitum carmichaelii (AC) is a well-known herbal medicine for its excellent pharmacological effects and toxicity. The monoester-diterpenoid alkaloids (MDAs), including benzoylmesaconine (BMC), benzoylaconine (BAC) and benzoylhyaconine (BHC), are the main active components in AC. It was found that the diester
Fei Ye et al.
PloS one, 10(11), e0142082-e0142082 (2015-11-07)
Chronic hepatitis C virus (HCV) infection is one of the leading causes of severe hepatitis. The molecular mechanisms underlying HCV replication and pathogenesis remain unclear. The development of the subgenome replicon model system significantly enhanced study of HCV. However, the
Zhifeng Li et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 988, 45-52 (2015-03-10)
An ultra performance liquid chromatography (UHPLC) coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (ESI-Q-TOF-MS/MS) was used in the structural determination of natural compounds in Gastrodia elata. A total of 64 compounds were identified or tentatively characterized. The strategy used
Taylor A Poor et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(25), E2596-E2605 (2014-06-14)
To infect a cell, the Paramyxoviridae family of enveloped viruses relies on the coordinated action of a receptor-binding protein (variably HN, H, or G) and a more conserved metastable fusion protein (F) to effect membrane fusion and allow genomic transfer.
Kalaiselvi Senthil et al.
PloS one, 10(4), e0123360-e0123360 (2015-04-16)
Free radical scavenging activity (FRSA), total phenolic content (TPC), and total flavonoid content (TFC) of in vitro cultured and field grown Withania somnifera (Ashwagandha) roots were investigated. Withanolides analysis and comprehensive metabolic profiling between 100% methanol extracts of in vitro
Sung Ha Ryu et al.
Journal of toxicology and environmental health. Part A, 78(20), 1299-1309 (2015-10-31)
Red ginseng (RG) is one of the top selling herbal medicines in Korea, but is not recommended in hypertensive patients. In this study, the pharmacokinetic (PK) interaction between RG and losartan, an antihypertensive drug, was examined. RG was orally administered
Lei Wang et al.
Environment international, 78, 45-50 (2015-03-10)
The extensive use of environmental phenols (e.g., bisphenol A) and heterocyclic aromatic compounds (e.g., benzothiazole) in consumer products as well as widespread exposure of humans to these compounds have been well documented. Biomonitoring studies have used urinary measurements to assess
Jun Yang et al.
Molecular and cellular biology, 35(18), 3225-3243 (2015-07-08)
LIN28 is an evolutionarily conserved RNA-binding protein with critical functions in developmental timing and cancer. However, the molecular mechanisms underlying LIN28's oncogenic properties are yet to be described. RNA-protein immunoprecipitation coupled with genome-wide sequencing (RIP-Seq) analysis revealed significant LIN28 binding
Athena K Petrides et al.
Clinical biochemistry, 47(15), 73-79 (2014-08-05)
Depression is a rapidly growing issue in the United States. There are many drug classes that may be used to treat depression, including the selective serotonin-reuptake inhibitors (SSRIs) citalopram (Celexa®) and sertraline (Zoloft®), as well as the aminoketone bupropion (Wellbutrin®).
Khushwant S Bhullar et al.
Food chemistry, 168, 595-605 (2014-08-31)
Partridgeberry (Vaccinium vitis-idaea) is a polyphenol-rich berry of the Ericaceous family, grown in Newfoundland and Labrador province of Canada. The aims of this study were to identify extraction solvents for the maximum recovery of polyphenols, to establish fractionation technique for
Soo Hyeon Bae et al.
Xenobiotica; the fate of foreign compounds in biological systems, 44(12), 1099-1107 (2014-06-17)
1. BST204, a purified ginseng dry extract containing a high concentration of racemic Rh2 and Rg3 mixtures, is being developed for supportive care use in cancer patients in Korea. This study investigates the pharmacokinetics and tissue distribution of BST204 in
Sai Duan et al.
Physical chemistry chemical physics : PCCP, 15(13), 4625-4633 (2013-02-21)
Local structures and adsorption energies of a formic acid molecule and its decomposed intermediates (H, O, OH, CO, HCOO, and COOH) on highly electrocatalytically active mushroom-like Au-core@Pd-shell@Pt-cluster nanoparticles with two atomic layers of the Pd shell and stoichiometric Pt coverage
Jun Cheng et al.
Food chemistry, 168, 90-99 (2014-08-31)
The aim of this study was to investigate the applicability of artificial neural network (ANN) and multiple linear regression (MLR) models for the estimation of acrylamide reduction by flavonoids, using multiple antioxidant capacities of Maillard reaction products as variables via
Fen Chen et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(2), 171-176 (2014-09-05)
1. Capsaicin (CAP) is the primary pungent principle in peppers and an inhibitor of CYP3A subfamily and P-gp. 2. Pitavastatin is mainly metabolized via glucuronidation and metabolism by hepatic CYPs is minimal. Pitavastatin is taken up by Oatp1b2 (encoded by Slco1b2) in
Pei Wang et al.
Journal of chromatographic science, 53(2), 263-273 (2014-06-13)
Ling-Gui-Zhu-Gan decoction (LGZGD), a well-known traditional Chinese medicine (TCM) formula, has been extensively used for the treatment of cardiovascular disease in clinic. However, the chemical constituents in LGZGD had not been investigated so far. In this study, an ultra performance
S M Illamola et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 965, 216-223 (2014-07-23)
Lopinavir is an HIV protease inhibitor with high protein binding (98-99%) in human plasma. This study was designed to develop an ultrafiltration method to measure the unbound concentrations of lopinavir overcoming the non-specific binding issue. A liquid chromatography-tandem mass spectrometry
J C Bloomer et al.
Xenobiotica; the fate of foreign compounds in biological systems, 25(9), 917-927 (1995-09-01)
1. Caffeine N3-demethylation, the major pathway of caffeine metabolism in man, is mediated by P4501A2. The carbon of the methyl group lost during N3-demethylation is eliminated as carbon dioxide in vivo, or as formaldehyde and formic acid in vitro. 2.
Xiao-Lin Hou et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 962, 20-29 (2014-06-03)
A simple, sensitive and reliable analytical method was developed for the simultaneous determination of 38 veterinary drugs (18 sulfonamides, 11 quinolones and 9 benzimidazoles) and 8 metabolites of benzimidazoles in bovine milk by ultra high performance liquid chromatography-positive electrospray ionization
Jörg Ziegler et al.
Amino acids, 46(12), 2799-2808 (2014-09-15)
A new method for the determination of amino acids is presented. It combines established methods for the derivatization of primary and secondary amino groups with 9-fluorenylmethoxycarbonyl chloride (Fmoc-Cl) with the subsequent amino acid specific detection of the derivatives by LC-ESI-MS/MS
Rabea Parveen et al.
Drug development and industrial pharmacy, 40(9), 1206-1212 (2013-07-06)
Diterpenoidal anti-cancer drug andrographolide (AD) was encapsulated into solid lipid nanoparticle (SLN) because of poor aqueous solubility and high lipophilicity. AD-SLNs were prepared by solvent injection method and characterized for droplet size, surface morphology, zeta potential, etc. In vitro drug
Ryan Haryadi et al.
PloS one, 10(2), e0116878-e0116878 (2015-02-24)
Translocation of a nascent protein from the cytosol into the ER mediated by its signal peptide is a critical step in protein secretion. The aim of this work was to develop a platform technology to optimize the signal peptides for
Marion Girod et al.
The Analyst, 139(21), 5523-5530 (2014-09-10)
Improvement of the fragmentation specificity may streamline data processing of bottom-up proteomic experiments by drastically reducing either the amount of MS/MS data to process in the discovery phase or the detection of interfering signals in targeted quantification. Photodissociation at appropriate
Nilesh K Sharma et al.
PloS one, 10(11), e0141897-e0141897 (2015-11-06)
Camptothecin (CPT), a topoisomerase I poison, is an important drug for the treatment of solid tumors in the clinic. Nitric oxide (·NO), a physiological signaling molecule, is involved in many cellular functions, including cell proliferation, survival and death. We have
Wenkui Li et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 983-984, 117-124 (2015-02-04)
A high-performance liquid chromatography-tandem mass spectrometric (LC-MS/MS) method has been developed and validated for the quantitative analysis of loratadine, an H1 histamine antagonist, in human dried blood spot (DBS) samples following a single self-administered 10 or 20mg oral dose. The
Vera Hillewaert et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 981-982, 40-47 (2015-01-21)
Tapentadol is a novel, centrally acting analgesic with 2 mechanisms of action, MOR agonism and noradrenaline (NA) reuptake inhibition in a single molecule. It is the first member of a new therapeutic class, MOR-NRI. A high throughput liquid chromatography-tandem mass
Navid Adnani et al.
Marine drugs, 13(10), 6082-6098 (2015-09-26)
With respect to bacterial natural products, a significant outcome of the genomic era was that the biosynthetic potential in many microorganisms surpassed the number of compounds isolated under standard laboratory growth conditions, particularly among certain members in the phylum Actinobacteria.
Bio-inspired catalytic imine reduction by rhodium complexes with tethered Hantzsch pyridinium groups: evidence for direct hydride transfer from dihydropyridine to metal-activated substrate.
Alex McSkimming et al.
Angewandte Chemie (International ed. in English), 52(12), 3411-3416 (2013-02-27)
Lolo Wal Marzan et al.
Archives of microbiology, 195(3), 161-171 (2013-01-01)
Effect of acidic condition on the fermentation characteristics was investigated by the continuous culture of Escherichia coli. In accordance with down-regulation of crp gene transcript level as well as up-regulation of arcA, the expressions of the TCA cycle genes were
Theresa A Isbell et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 980, 65-71 (2015-01-16)
The determination of morphine and its isobaric metabolites morphine-3-beta-d-glucuronide (M3G) and morphine-6-beta-d-glucuronide (M6G) is useful for therapeutic drug monitoring and forensic identification of drug use. In particular, capillary electrophoresis with mass spectrometry (CE-MS) represents an attractive tool for opioid analysis.
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