Search Within
Applied Filters:
Palabra clave:'71643'
Showing 1-27 of 27 resultados for "

71643

" within Papeles
Sohini Mukherjee et al.
Nature communications, 6, 8467-8467 (2015-10-13)
Creating an artificial functional mimic of the mitochondrial enzyme cytochrome c oxidase (CcO) has been a long-term goal of the scientific community as such a mimic will not only add to our fundamental understanding of how CcO works but may...
Mehrnoosh Shirangi et al.
Pharmaceutical research, 32(9), 3044-3054 (2015-04-03)
Polyesters with hydrophilic domains, i.e., poly(D,L-lactic-co-glycolic-co-hydroxymethyl glycolic acid) (PLGHMGA) and a multiblock copolymer of poly(ε-caprolactone)-PEG-poly(ε-caprolactone) and poly(L-lactide) ((PC-PEG-PC)-(PL)) are expected to cause less acylation of encapsulated peptides than fully hydrophobic matrices. Our purpose is to assess the extent and sites...
R.C. Ogden et al.
Methods in Enzymology, 152, 66-66 (1987)
Anja Täuber et al.
Molecular pharmaceutics, 11(7), 1991-1996 (2014-02-05)
Onychomycosis is a fungal infection mostly induced by dermatophytes such as Trichophyton rubrum. Due to slow nail growth, the treatment takes 3-9 months depending on the nail size and infected area. Hence, high efficacy of the active ingredient without systemic...
Ana Serralheiro et al.
International journal of pharmaceutics, 490(1-2), 39-46 (2015-05-17)
Pharmacoresistance is considered one of the major causes underlying the failure of the anticonvulsant therapy, demanding the development of alternative and more effective therapeutic approaches. Due to the particular anatomical features of the nasal cavity, intranasal administration has been explored...
M J Hilhorst et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 965, 45-53 (2014-07-06)
A liquid chromatography-tandem mass spectrometry method is described for the quantitative determination of artemether (ART) and its metabolite dihydroartimisinin (DHA) in human plasma samples. Quantitation of ART and DHA in plasma is challenging due to the presence of malaria related...
M O Besenhard et al.
International journal of pharmaceutics, 475(1-2), 198-207 (2014-08-12)
We present a proof-of-concept study of a continuous coating process of single API crystals in a tubular reactor using coacervation as a microencapsulation technique. Continuous API crystal coating can have several advantages, as in a single step (following crystallization) individual...
Brecht Gorissen et al.
Analytical and bioanalytical chemistry, 407(15), 4447-4457 (2015-01-31)
The most important source of Salmonella spp. infection in humans is by the consumption of contaminated poultry products. Due to the risk of resistance development and its transfer from animals to humans, the Belgian Royal Decree concerning the eradication of...
E L Menzies et al.
Drug testing and analysis, 6(6), 506-515 (2014-02-28)
The classic approach of controlled volunteer studies to study drug metabolism is difficult or impossible to undertake for novel psychoactive substances (NPS), as there is generally very limited information available to allow appropriate dose finding and safety. A viable and...
Selective transduction of astrocytic and neuronal CNS subpopulations by lentiviral vectors pseudotyped with Chikungunya virus envelope
Eleftheriadou I, et al.
Biomaterials, 123, 1-14 (2017)
Raquel Bridi et al.
Journal of food science, 80(6), C1188-C1195 (2015-05-07)
Propolis has been proposed as a polyphenolic-rich natural product potentially able to be used for human consumption or even for medicinal proposes. To guarantee a minimum phenolic and flavonoid content and as consequence of their related-biological activities, international requirements of...
Patrizia Iavicoli et al.
Journal of chromatography. A, 1422, 260-269 (2015-10-27)
Asymmetric Flow Field-Flow Fractionation (AF4) combined with multidetector analysis form a promising technique in the field of nanoparticle characterization. This system is able to measure the dimensions and physicochemical properties of nanoparticles with unprecedented accuracy and precision. Here, for the...
Susann K J Ludwig et al.
Analytical and bioanalytical chemistry, 406(27), 6857-6866 (2014-06-29)
Current contaminant and residue monitoring throughout the food chain is based on sampling, transport, administration, and analysis in specialized control laboratories. This is a highly inefficient and costly process since typically more than 99% of the samples are found to...
Ziyi Yin et al.
Autophagy, 16(5), 900-916 (2019-07-18)
Cells are faced with various stresses during their growth and development, and autophagy is a degradative process in which cells can break down their own components to recycle macromolecules and provide energy under these stresses. For pathogenic fungi that utilize...
Sry D Hujaya et al.
Pharmaceutical research, 32(9), 3066-3086 (2015-04-09)
To investigate the properties of phenylboronic acid-functional poly(amido amine) polymers (BA-PAA) in forming multilayered thin films with poly(vinyl alcohol) (PVA) and chondroitin sulfate (ChS), and to evaluate their compatibility with COS-7 cells. Copolymers of phenylboronic acid-functional poly(amido amine)s, differing in...
Christopher Polonyi et al.
Dalton transactions (Cambridge, England : 2003), 43(31), 11941-11949 (2014-06-27)
The ability of the anticancer active drug cisplatin to exert biological activity through interference with nucleic acid function is well documented. Since kinetics play a key role in determining product distributions in these systems, methods for accurate documentation of reactivity...
K F Chan et al.
Materials science & engineering. C, Materials for biological applications, 58, 666-674 (2015-10-20)
Immunosensors based on gold nanoparticles and reduced graphene oxide (AuNPs/rGO)-modified screen-printed electrodes (SPEs) were successfully synthesized using an electrochemical deposition method. The modified SPEs were characterized using a field emission scanning electron microscope (FESEM) and Raman spectroscopy to analyze the...
Anna Flis et al.
Pharmacological reports : PR, 67(1), 1-8 (2015-01-07)
Human prostate cancer (hPCa) is the most commonly diagnosed cancer in elderly men and is the second leading cause of male cancer death. Data from epidemiological, eco-environmental, nutritional prevention and clinical trials suggest that selenium Se(IV) can prevent prostate cancer....
Elenaz Naderkhani et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 73, 64-71 (2015-04-04)
A prerequisite for successful oral drug therapy is the drug's ability to cross the gastrointestinal barrier. Considering the increasing number of new chemical entities in modern drug discovery, reliable and fast in vitro models are required for early and efficient...
Pro-and anti-inflammatory cytokines during immune stimulation: modulation of iron status and red blood cell profile
Koorts A M, et al.
Mediators of Inflammation, 2011 (2011)
Darja Gramec Skledar et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(6), 511-519 (2014-12-31)
1. Bisphenol S (BPS) and bisphenol F (BPF) are bisphenol A (BPA) analogues commonly used in the manufacturing of industrial and consumer products. 2. Bisphenols are often detoxified through conjugation with glucuronic acid or sulfate. In this work, we have...
Toine F H Bovee et al.
Mutation research, 778, 1-10 (2015-05-30)
It has previously been demonstrated by others that acetone extracts of Senecio jacobaea (syn. Jacobaea vulgaris, common or tansy ragwort) test positive in the Salmonella/microsome mutagenicity test (Ames test). Pyrrolizidine alkaloids (PAs) are thought to be responsible for these mutagenic...
Oliver Wahl et al.
Journal of pharmaceutical and biomedical analysis, 102, 100-109 (2014-09-30)
Magnesium supplementation in form of organic magnesium salts is a very popular practice. We examined the enantiomeric purity of "Magnesium aspartate dihydrate" monographed in the European Pharmacopeia. A chiral capillary zone electrophoresis using (2-hydroxypropyl)-β-cyclodextrin coupled to laser induced fluorescence detection...
Sry D Hujaya et al.
Acta biomaterialia, 22, 19-31 (2015-05-02)
Dip-coated multilayered thin films of poly(amido amine)s (PAAs) and DNA have been developed to provide surfaces with cell-transfecting capabilities. Three types of PAAs, differing in side chain functional groups, were synthesized and characterized for their properties in forming multilayered structures...
Lore Geldof et al.
Biomedical chromatography : BMC, 28(7), 974-985 (2014-02-06)
Anti-doping laboratories need to be aware of evolutions on the steroid market and elucidate steroid metabolism to identify markers of misuse. Owing to ethical considerations, in vivo and in vitro models are preferred to human excretion for nonpharmaceutical grade substances....
Raphael Paus et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 96, 53-64 (2015-07-15)
In this paper, the intrinsic dissolution profiles of naproxen (NAP) at pH values of 1.5 and 3.0 and of trimethoprim (TMP) at pH values of 1.5, 3.0, 5.0, 6.5 and 7.2 were measured. Meanwhile, the dissolution profiles of NAP and...
Anissa El Arfani et al.
Neurochemistry international, 88, 88-96 (2015-07-15)
Parkinson's disease (PD) is hallmarked by progressive degeneration of the substantia nigra pars compacta (SNc) neurons and is associated with aberrant glutamatergic activity. However, studies on the glutamatergic system in the motor cortex and striatum, two motor loop-related areas, are...