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Meili Zheng et al.
Medicine, 93(29), e262-e262 (2014-12-30)
Blood pressure (BP) changes with age. We conducted a cross-sectional study in rural Chinese adults to investigate: (1) what is the relationship between age, arterial stiffness, and BP in Chinese men and women; and (2) to what degree can the...
Kyoko Kumagai et al.
Journal of hypertension, 33(2), 323-329 (2014-11-08)
Although central blood pressure (BP) is considered to be more closely associated with large arterial remodeling and cardiovascular outcomes than brachial BP, few studies have investigated these associations with changes in small arteries. As morphological changes in retinal vessels might...
Alpesh Mistry et al.
Molecular pharmaceutics, 12(8), 2755-2766 (2015-05-23)
The ability to deliver therapeutically relevant amounts of drugs directly from the nasal cavity to the central nervous system to treat neurological diseases is dependent on the availability of efficient drug delivery systems. Increased delivery and/or therapeutic effect has been...
Jinbo Cheng et al.
Autophagy, 16(12), 2193-2205 (2020-02-01)
Microglial activation-induced neuroinflammation is closely associated with the development of Parkinson disease (PD). Macroautophagy/autophagy regulates many biological processes, but the role of autophagy in microglial activation during PD development remains largely unclear. In this study, we showed that deletion of...
Nobuya Inagaki et al.
Journal of diabetes investigation, 6(2), 210-218 (2015-03-25)
Canagliflozin is a sodium-glucose cotransporter 2 inhibitor under development for the treatment of type 2 diabetes. Our aim was to examine its efficacy and safety as monotherapy or in combination with commonly used oral antihyperglycemic drugs in Japanese patients with...
Jeong Eun Song et al.
Journal of tissue engineering and regenerative medicine, 9(11), E98-107 (2013-03-06)
Demineralized bone particle (DBP), which is widely used as a biomaterial in the field of tissue engineering, contains various bioactive molecules, such as cytokines. For this reason, in this study we investigated the effects of injectable DBP gels on cell...
Yimin Yao et al.
Journal of hypertension, 33(6), 1249-1260 (2015-03-13)
The effect of angiotensin II type I receptor (AT1R) inhibition on the pattern of reflex sympathetic nerve activity (SNA) to multiple target organs in the Lewis polycystic kidney (LPK) rat model of chronic kidney disease was determined. Mean arterial pressure...
Viktor Švigelj et al.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 25(6), 383-390 (2015-09-17)
The arterial baroreflex depends on the integrity of the afferent limb, which can be quantified using the baroreceptor's sensitivity (BRS) during the Valsalva maneuver (VM). The aim of this study was to evaluate, using autonomic nervous system tests, the autonomic...
Samuel Beck et al.
Nature communications, 5, 5490-5490 (2014-11-19)
Both transcriptional and epigenetic regulations are fundamental for the control of eukaryotic gene expression. Here we perform a compendium analysis of >200 large sequencing data sets to elucidate the regulatory logic of global gene expression programs in mouse embryonic stem...
Myrna Medlej-Hashim et al.
Annals of human genetics, 79(6), 394-401 (2015-09-26)
Bioactive vitamin D is a steroid hormone transported in blood via the vitamin D binding protein (DBP). Our study aimed to investigate the vitamin D status in a young Lebanese population and study the association of hypovitaminosis with levels of...
Eun Sil Lee et al.
The Australian & New Zealand journal of obstetrics & gynaecology, 55(3), 262-267 (2015-06-06)
Blood transfusions may be associated with risks and the risk: benefit ratio is not always clear, even in the setting of haemorrhage. To describe the management practices and outcomes in women with profound anaemia who refused blood transfusion. Retrospective analysis...
Sunaro C Ngourn et al.
Langmuir : the ACS journal of surfaces and colloids, 28(33), 12151-12158 (2012-07-27)
A quartz crystal microbalance (QCM) sensor was developed for the quantitation of calcium phosphate mineralization and the assessment of DNA as a template molecule. Inherent advantages of QCM, such as nanogram sensitivity, temporal resolution, surface-based measurements, and flow capabilities, were...
Samuel Adler et al.
Gastrointestinal endoscopy, 76(6), 1170-1174 (2012-10-03)
Colon capsule endoscopy (CCE) is a noninvasive technique for the detection of colorectal lesions. However, for CCE to be offered as an out-of-clinic procedure, the system needs to automatically alert the patient when to ingest the laxative (booster). We tested...
Caroline Kizilyaprak et al.
Journal of structural biology, 189(2), 135-146 (2014-11-30)
In the last two decades, the third-dimension has become a focus of attention in electron microscopy to better understand the interactions within subcellular compartments. Initially, transmission electron tomography (TEM tomography) was introduced to image the cell volume in semi-thin sections...
Colonoscopy preperations.
The Medical letter on drugs and therapeutics, 55(1408), 6-6 (2013-01-26)
Fatal electrolyte abnormalities following enema administration.
Dominika Szoke et al.
Clinical chemistry, 58(11), 1515-1518 (2012-10-30)
Cameron P Brewer et al.
International journal of sport nutrition and exercise metabolism, 23(2), 187-194 (2012-11-02)
Research into supplementation with sodium phosphate has not investigated the effects of a repeated supplementation phase. Therefore, this study examined the potential additive effects of repeated sodium phosphate (SP) supplementation on cycling time-trial performance and peak oxygen uptake (VO2peak). Trained...
Michael Mauer et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 30(6), 918-923 (2014-09-04)
Studies of structural-functional relationships have improved understanding of the natural history of diabetic nephropathy (DN). However, in order to consider structural end points for clinical trials, the robustness of the resultant models needs to be verified. This study examined whether...
Benedict T Costello et al.
American journal of hypertension, 28(4), 480-486 (2014-09-07)
Central blood pressure (BP) can be estimated noninvasively by analyzing brachial artery waveforms. In this study, our aim was to assess the validity of a brachial cuff-based (suprasystolic) technique for estimating central BP (CBPestimated) by comparison with invasive aortic BP...
Arfat Idrees et al.
Acta poloniae pharmaceutica, 71(2), 287-295 (2014-10-03)
This study was aimed to determine effects of penetration enhancers and plasticizers on drug release from rationally designed formulations of flurbiprofen based transdermal drug delivery system. Matrix type transdermal patches were formulated with ethyl cellulose (EC) as a polymer by...
Ziyi Yin et al.
Autophagy, 16(5), 900-916 (2019-07-18)
Cells are faced with various stresses during their growth and development, and autophagy is a degradative process in which cells can break down their own components to recycle macromolecules and provide energy under these stresses. For pathogenic fungi that utilize...
Gordon C C Yang et al.
Journal of hazardous materials, 277, 53-61 (2014-04-08)
This study monitored the occurrence and removal efficiencies of 8 phthalate esters (PAEs) and 13 pharmaceuticals present in the drinking water of Kaohsiung City, Taiwan. The simultaneous electrocoagulation and electrofiltration (EC/EF) process was used to remove the contaminants. To this...
Matthew R Weir et al.
Journal of clinical hypertension (Greenwich, Conn.), 16(12), 875-882 (2014-10-21)
The effects of canagliflozin, a sodium glucose co-transporter 2 inhibitor, on blood pressure (BP) and osmotic diuresis- and intravascular volume reduction-related adverse events (AEs) were evaluated using pooled data from four placebo-controlled, phase 3 studies in patients with type 2...
Kazutaka Kimura et al.
Journal of cardiology, 66(2), 135-142 (2014-12-04)
Elevated serum levels of cardiac troponin T (cTnT) and N-terminal fragment of B-type natriuretic peptide (NT-proBNP), and also increased arterial stiffness/abnormal central hemodynamics, are well-known risk factors for future cardiovascular events. The present study was conducted to clarify which of...
A Bagchi et al.
Journal of viral hepatitis, 22(2), 192-200 (2014-04-30)
This prospective study was designed to evaluate whether early changes in actin-free Gc-globulin levels were associated with complications and outcomes and to identify factors associated with persistent low actin-free Gc-globulin levels in acute liver failure (ALF). Thirty-two consecutive ALF patients...
Hannah N Ladenhauf et al.
Pediatric surgery international, 28(8), 805-814 (2012-07-24)
Sodium phosphate-containing laxatives are commonly used as first-line treatment option for constipation in children and adolescents. Hyperphosphatemia is an infrequent, but potentially life-threatening complication of laxative application. We report a case series of three children exhibiting severe hyperphosphatemia and hypocalcemia...
Lusliany Josefina Rondón et al.
Magnesium research, 27(3), 113-130 (2015-01-07)
The renin-angiotensin system is critically involved in regulating arterial blood pressure (BP). Inappropriate angiotensin type-1 receptor activation by angiotensin-II (Ang-II) is related to increased arterial BP. Mg has a role in BP; it can affect cardiac electrical activity, myocardial contractility...
Dion H Zappe et al.
Journal of hypertension, 33(2), 385-392 (2014-09-27)
Studies suggest that bedtime dosing of an angiotensin-converting enzyme (ACE)-inhibitor or angiotensin receptor blocker shows a more sustained and consistent 24-h antihypertensive profile, including greater night-time blood pressure (BP) reduction. We compared the antihypertensive effects of morning (a.m.) and evening...
R A Hooker et al.
Journal of musculoskeletal & neuronal interactions, 15(1), 83-94 (2015-03-03)
Activated Leukocyte Cell Adhesion Molecule (ALCAM/CD166), is expressed on osteoblasts (OB) and hematopoietic stem cells (HSC) residing in the hematopoietic niche, and may have important regulatory roles in bone formation. Because HSC numbers are reduced 77% in CD166(-/-) mice, we...
J I Cacho et al.
Journal of chromatography. A, 1380, 156-161 (2015-01-15)
A method using direct sample introduction (DSI) coupled to gas chromatography-mass spectrometry (GC-MS) is developed for the determination of six phthalate esters (dimethyl, diethyl, dibutyl, butylbenzyl, diethylhexyl and dioctyl phthalate) in cleaning products. The different variables involved in the DSI...
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