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Yong Qin et al.
International journal of clinical and experimental pathology, 7(11), 7536-7544 (2015-01-01)
DAPK1 can induce apoptosis in several cells; to determine the effect of DAPK1 would provide a new potential therapeutic strategy for treating pancreatic cancer. The aim of the present study was to investigate the effect of DAPK1 gene on proliferation
Juliano Alves Pereira et al.
Clinical and experimental pharmacology & physiology, 42(7), 788-794 (2015-05-12)
The standard therapy used in the treatment of Duchenne muscle dystrophy (DMD) is corticoids, such as deflazacort and prednisone. However, they have limited therapeutic value, and their combination with drugs already in use to treat other human diseases could potentially
José F Huertas-Pérez et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 32(8), 1352-1357 (2015-07-01)
A rapid, simple and effective method for the determination of citrinin in rice by UHPLC coupled to fluorescence detection has been developed and validated. Extraction of citrinin from rice samples was achieved by applying a QuEChERS-based extraction/partitioning process with water
Shuxin Han et al.
Nature communications, 6, 7231-7231 (2015-06-05)
Circadian control of nutrient availability is critical to efficiently meet the energetic demands of an organism. Production of bile acids (BAs), which facilitate digestion and absorption of nutrients, is a major regulator of this process. Here we identify a KLF15-Fgf15
T Minashima et al.
Osteoarthritis and cartilage, 22(6), 852-861 (2014-04-22)
To determine the role of progressive ankylosis protein (ANK)/Myb-binding protein 1a (MYBBP1a) and sphingosine kinase 1 (SPHK1) interactions in catabolic events of articular chondrocytes. ANK/MYBBP1a and SPHK1 interactions were identified using yeast two-hybrid screening and co-immunoprecipitation. To determine the role
Shlomit Dachir et al.
Cutaneous and ocular toxicology, 33(4), 317-326 (2014-03-20)
Macrophages are known to have key functions in almost every stage of wound healing and there is evidence for their beneficial effects in treating decubital ulcers and deep sternal wound infections in human. This study aimed to investigate the efficacy
Dafne Franz et al.
Journal of neuroimmunology, 284, 18-29 (2015-05-31)
Dopamine receptors have been described in T-cells, however their signalling pathways coupled remain unknown. Since cAMP and ERKs play key roles regulating T-cell physiology, we aim to determine whether cAMP and ERK1/2-phosphorylation are modulated by dopamine receptor 3 (D3R) and
Kui Cheng et al.
Colloids and surfaces. B, Biointerfaces, 126, 387-393 (2014-12-17)
Design of an implant surface with appropriate nanostructures has been considered to be an effective way to promote osteoblast cell growth and osseointegration. In this work, TiO2 nanorods were integrated into TiO2 nanodot films by hydrothermal growth to engineer a
Junhua Geng et al.
Journal of molecular neuroscience : MN, 55(1), 251-259 (2014-05-03)
The identification of tau fragments generated by proteolysis in the neurons of AD patients and in neurofibrillary tangles encourages research on the toxicity of truncated tau. However, the detailed mechanism underlying the proteolysis-induced toxicity of tau is not clear and
Takahiro Koyama et al.
Experimental cell research, 338(2), 194-202 (2015-08-25)
The balance between bone formation and bone resorption is maintained by osteoblasts and osteoclasts, and an imbalance in this bone metabolism leads to osteoporosis. Here, we found that osteoblast differentiation in MC3T3-E1 cells is promoted by the inactivation of O-linked
Noah P Zimmerman et al.
Molecular carcinogenesis, 54(3), 203-215 (2013-10-12)
Aggressive dissemination and metastasis of pancreatic ductal adenocarcinoma (PDAC) results in poor prognosis and marked lethality. Rho monomeric G protein levels are increased in pancreatic cancer tissue. As the mechanisms underlying PDAC malignancy are little understood, we investigated the role
Suganthi Chittaranjan et al.
Oncotarget, 5(17), 7960-7979 (2014-10-04)
The majority of oligodendrogliomas (ODGs) exhibit combined losses of chromosomes 1p and 19q and mutations of isocitrate dehydrogenase (IDH1-R132H or IDH2-R172K). Approximately 70% of ODGs with 1p19q co-deletions harbor somatic mutations in the Capicua Transcriptional Repressor (CIC) gene on chromosome
Juan Ding et al.
Cornea, 34(6), 686-692 (2015-03-19)
Corneal wound healing is a highly regulated process that requires the proliferation and migration of epithelial cells and interactions between epithelial cells and stromal fibroblasts. Compounds that can be applied topically to the ocular surface and that have the capability
Kathryn Bartley et al.
International journal for parasitology, 45(13), 819-830 (2015-08-25)
An aqueous extract of the haematophagous poultry ectoparasite, Dermanyssus gallinae, was subfractionated using anion exchange chromatography. Six of these subfractions were used to immunise hens and the blood from these hens was fed, in vitro, to poultry red mites. Mite
Bernhard J Jank et al.
Biomaterials, 61, 246-256 (2015-05-26)
The loss of an extremity is a disastrous injury with tremendous impact on a patient's life. Current mechanical prostheses are technically highly sophisticated, but only partially replace physiologic function and aesthetic appearance. As a biologic alternative, approximately 70 patients have
Satoshi Nishiwada et al.
Anticancer research, 35(4), 2287-2297 (2015-04-12)
CD155 is expressed in many types of human cells and has diverse functions. We herein evaluated the clinical importance of CD155 in pancreatic cancer. We investigated CD155 expression in 134 patients with pancreatic cancer, and evaluated the correlations of CD155
Xiupeng Lv et al.
Molecular medicine reports, 12(1), 1265-1271 (2015-03-18)
The identification of mutated genes in glioblastoma multiforme (GBM) is an essential step towards improving current understanding of the molecular mechanism underlying the disease and establishing novel targets for diagnostic and therapeutic purposes. The present study used direct sequencing to
Tejinder Singh et al.
American journal of physiology. Renal physiology, 309(3), F189-F203 (2015-06-19)
ANG II type 1 receptor blockade (AT1R-BLK) is used extensively to slow down the progression of proteinuric kidney diseases. We hypothesized that AT1R-BLK provides podocyte protection through regulation of silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) and
Wan Chen et al.
The Journal of steroid biochemistry and molecular biology, 152, 16-24 (2015-04-25)
Glucocorticoid-induced tendon rupture is very common in clinical practice, and the overall outcome of surgical suture repair is rather poor. The mechanism remains unclear, and effective treatments are still lacking. In the present study, we investigated the effect of dexamethasone
Jiying Liu et al.
FEBS letters, 588(23), 4497-4503 (2014-12-03)
Smad7 has a key role in apoptosis of mammalian ovarian granulosa cells (GCs), as it antagonizes and fine-tunes transforming growth factor β (TGFβ) signaling. This study demonstrates that miR-92a regulates GC apoptosis in pig ovaries by targeting Smad7 directly. The
Nicoletta Ferradini et al.
PloS one, 10(5), e0126051-e0126051 (2015-05-08)
Heat shock proteins (HSPs) are molecular chaperones involved in many cellular functions. It has been shown that mammalian cytosolic HSP70 binds antigenic peptides mediating the activation of the immune system, and that it plays a determining role in tumour immunogenicity.
Qingchun Mu et al.
Cancer biology & therapy, 16(4), 623-633 (2015-02-27)
Glioblastomas multiforme (GBM) are the most frequently occurring malignant brain cancers. Treatment for GBM consists of surgical resection and subsequent adjuvant radiation therapy and chemotherapy. Despite this, GBM patient survival is limited to 12-15 months, and researchers are continually trying to
Jessica Schmitt et al.
Molecular medicine (Cambridge, Mass.), 21, 185-196 (2015-03-27)
Parent-of-origin imprints have been implicated in the regulation of neural differentiation and brain development. Previously we have shown that, despite the lack of a paternal genome, human parthenogenetic (PG) embryonic stem cells (hESCs) can form proliferating neural stem cells (NSCs)
Karl J Erlandson et al.
Journal of virology, 88(19), 11576-11585 (2014-08-01)
Specific gene duplications can enable double-stranded DNA viruses to adapt rapidly to environmental pressures despite the low mutation rate of their high-fidelity DNA polymerases. We report on the rapid positive selection of a novel vaccinia virus genomic duplication mutant in
Hui Zhang et al.
Theriogenology, 84(6), 846-852 (2015-07-22)
RNA interference is an important tool to study the gene function. Microinjection and electroporation are usually used to transfer DNA, small interference RNA (siRNA), morpholinos, and protein into oocytes or embryos. This study used a simple and effective method to
Junhui Xing et al.
PloS one, 9(12), e116165-e116165 (2014-12-30)
SIRT1 is central to the lifespan and vascular health, but undergoes degradation that contributes to several medical conditions, including diabetes. How SIRT1 turnover is regulated remains unclear. However, emerging evidence suggests that endothelial nitric oxide synthase (eNOS) positively regulates SIRT1
Sima Rahimian et al.
Biomaterials, 37, 469-477 (2014-12-03)
Particulate antigen delivery systems aimed at the induction of antigen-specific T cells form a promising approach in immunotherapy to replace pharmacokinetically unfavorable soluble antigen formulations. In this study, we developed a delivery system using the model protein antigen ovalbumin (OVA)
Mehrorang Ghaedi et al.
Journal of chromatographic science, 53(7), 1222-1231 (2015-02-01)
A novel vortex-assisted surfactant-enhanced dispersive liquid-liquid microextraction combined with high-performance liquid chromatography (VASEDLLME-HPLC) was developed for the determination of thymol and carvacrol (phenolic compound). In this method, the extraction solvent (CHCl3) was dispersed into the aqueous samples via a vortex
Hiroyuki Awano et al.
Neuromuscular disorders : NMD, 25(6), 474-484 (2015-05-06)
In dystroglycanopathies, lack of glycosylated alpha-dystroglycan (α-DG) alters membrane fragility leading to fiber damage and repetitive cycles of muscle degeneration and regeneration. However the effect of the glycosylation of α-DG on muscle regeneration is not clearly understood. In this study
Moritz J Strowitzki et al.
Clinical & experimental metastasis, 31(7), 795-803 (2014-07-24)
Liver failure after extended hepatectomy represents a major challenge in the surgery of hepatic colorectal metastasis. A previous study has indicated that inhibition of phosphodiesterase type 3 (PDE 3) stimulates liver regeneration. However, little is known whether PDE 3 inhibitors
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