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A M Sirunyan et al.
Physical review letters, 125(10), 102001-102001 (2020-09-22)
The first study of charm quark diffusion with respect to the jet axis in heavy ion collisions is presented. The measurement is performed using jets with p_{T}^{jet}>60  GeV/c and D^{0} mesons with p_{T}^{D}>4  GeV/c in lead-lead (Pb-Pb) and proton-proton (pp) collisions at...
Kecheng Li et al.
Macromolecular rapid communications, 41(18), e2000208-e2000208 (2020-06-13)
Although a range of polymer-protein polyion complex (PIC) micelle systems have been developed in the literature, relatively little attention has been paid to the influence of polymer structure on the assembly, or to the mechanism of disassembly. In this work...
Wa Zhong et al.
Pathology oncology research : POR, 21(1), 83-95 (2014-05-31)
Identifying predictive biomarkers for colorectal cancer would facilitate diagnosis and treatment of the disease. This study aimed to investigate the association of the serological biomarkers CEA, CA19-9, CA125, CYFRA21-1 and CA72-4 with patient characteristics and disease outcomes in colorectal cancer....
Yue Liu et al.
Drug design, development and therapy, 12, 2645-2654 (2018-09-15)
Interleukin-15 (IL-15) is an immunomodulatory cytokine. It can activate and expand cytotoxic CD8 T lymphocytes and natural killer cells, leading to potent antitumor effects. Various forms of IL-15 are now in different stages of development for cancer immunotherapy. One of...
Peiyun Long et al.
OncoTargets and therapy, 13, 2093-2102 (2020-03-27)
There is a large difference in postoperative survival in patients with non-metastatic colorectal cancer. We aimed to develop nomograms incorporating both hematological biomarkers and clinical characteristics to predict overall survival (OS) in patients with radical surgery for non-metastatic colorectal cancer....
Zhongqing Chen et al.
Cancer medicine, 9(4), 1392-1399 (2019-12-28)
The study of tumor markers (TM) in pleural effusion (PE) was not extensive. TM in PE and serum were analyzed to determine whether TM was expressed in intrathoracic and extrathoracic tissues. To further verify the correlations between serum TM and...
Turan Yaman et al.
Nutrition and cancer, 73(1), 133-146 (2019-10-17)
The aim of this study was to investigate the chemopreventive effects of juniper berry (JB) oil on azoxymethane (AOM)-induced colon cancer in rats. Thirty-two male Wistar albino rats were allocated into four groups: Control, AOM, AOM + JB, and JB groups. Whereas...
Manon Van-Straaten et al.
Macromolecular rapid communications, 41(14), e2000200-e2000200 (2020-06-11)
The integration of porous thin films using microelectronic compatible processes sometimes requires the protection of the interior of the pores during the critical integration steps. In this paper, the polymerization of neo-pentyl methacrylate (npMA) is performed via initiated chemical vapor...
Xiaomei Yan et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 70, 299-304 (2015-03-18)
Specific enzymes are involved in altered glycosylation of cancer. Fucosyltransferase IV (FUT4) is associated with the proliferation and metastasis of breast cancer. The application of FUT4 assay in the serum has not been reported yet. Here, the expression level of...
Mahsa Rahbari et al.
PloS one, 12(4), e0174837-e0174837 (2017-04-04)
Hydrogen peroxide is an important antimicrobial agent but is also crucially involved in redox signaling and pathogen-host cell interactions. As a basis for systematically investigating intracellular H2O2 dynamics and regulation in living malaria parasites, we established the genetically encoded fluorescent...
Mahmut Bulut et al.
Psychiatry research, 272, 73-79 (2018-12-24)
Mania is accompanied with immune activation as indicated by increased pro-inflammatory cytokines, acute phase proteins; and carcinoembryonic antigen (CEA) is known to accompany signs of immune-inflammatory responses in bipolar disorder (BD) and medical disorders. In this study, it was aimed...
Chia-Ho Chu et al.
Scientific reports, 7(1), 5256-5256 (2017-07-14)
In this study, a new type of field-effect transistor (FET)-based biosensor is demonstrated to be able to overcome the problem of severe charge-screening effect caused by high ionic strength in solution and detect proteins in physiological environment. Antibody or aptamer-immobilized...
Ruben Jansen et al.
Scientific reports, 8(1), 10637-10637 (2018-07-15)
Lymph node metastases (LNM) are an important prognostic factor for patients with intrahepatic cholangiocarcinoma, but underlying genetic alterations are poorly understood. Whole genome array comparative genomic hybridization (aCGH) was performed in 37 tumors and 14 matched LNM. Genomic analyses of...
Yan Gu et al.
Chinese medical journal, 129(3), 253-258 (2016-02-03)
It is often challenging to distinguish tuberculous pleural effusion (TPE) from malignant pleural effusion (MPE); thoracoscopy is among the techniques with the highest diagnostic ability in this regard. However, such invasive examinations cannot be performed on the elderly, or on...
Olga V Nadei et al.
Biological trace element research, 197(2), 495-506 (2019-12-05)
The study was designed to evaluate an influence of excessive fluoride (F-) intake on cognitive capacities of adult rats and on proteins of memory-related calpain signaling in hippocampus. Control animals were given water with natural F- content of 0.4 ppm; rats...
Xabier Rios et al.
Molecular pharmaceutics, 16(3), 1025-1035 (2019-02-07)
Monoclonal antibodies (mAbs) are currently used as therapeutic agents in different types of cancer. However, mAbs and antibody fragments developed so far show suboptimal properties in terms of circulation time and tumor penetration/retention. Here, we report the radiolabeling, pharmacokinetic evaluation...
Daniela Mazzaccaro et al.
Journal of vascular surgery, 70(2), 522-529 (2019-03-07)
The objective of this study was to analyze preoperative risk factors affecting long-term survival and the occurrence of stroke in patients older than 80 years undergoing either carotid endarterectomy (CEA) or carotid artery stenting (CAS) for carotid stenosis. Data of all...
Xiaojing Pei et al.
The Analyst, 145(10), 3612-3619 (2020-04-15)
Cancer biomarker quantification in human serum is of great importance for accurate patient diagnosis and informed clinical management. To date, ultrasensitive multiplexed detection of proteins without amplification is still a major challenge. Herein, we proposed a competitive aptasensor strategy for...
Zhonghe Ji et al.
Translational oncology, 9(1), 18-24 (2016-03-08)
To assess the effect of hyperthermic intraperitoneal chemotherapy (HIPEC) to eradicate intraperitoneal free cancer cells and to explore the feasibility of cytological cure for peritoneal carcinomatosis (PC). The peritoneal lavage fluid (or ascites) from 50 PC patients was collected before...
Björn Konukiewitz et al.
Human pathology, 77, 70-79 (2018-03-30)
Pancreatic neuroendocrine carcinoma is a rare aggressive tumor commonly harboring TP53 and RB1 alterations and lacking neuroendocrine-related genetic changes such as mutations in MEN1 and ATRX/DAXX. Little is known about its genetic profile with regard to that of pancreatic ductal...
Shang-Wen Chen et al.
Molecular imaging and biology, 21(1), 183-190 (2018-06-28)
To understand the association between genetic mutations and radiomics of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET)/x-ray computed tomography (CT) in patients with colorectal cancer (CRC). This study included 74 CRC patients who had undergone preoperative [18F]FDG PET/CT. A total of...
Steven C Katz et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(14), 3149-3159 (2015-04-09)
Chimeric antigen receptor-modified T cells (CAR-T) have demonstrated encouraging results in early-phase clinical trials. Successful adaptation of CAR-T technology for CEA-expressing adenocarcinoma liver metastases, a major cause of death in patients with gastrointestinal cancers, has yet to be achieved. We...
Robert N Jorissen et al.
International journal of cancer, 145(1), 132-142 (2019-01-09)
Adjuvant! Online Inc (A!O), the Memorial Sloan Kettering Cancer Center (MSKCC), MD Anderson (MDA) and Mayo Clinic (MC) provide calculators to predict survival probabilities for patients with resected early-stage colon cancer, trained on data from United States (US) patient cohorts...
Rongqin Ren et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 34(2), 438-444 (2020-08-15)
Diagnostic testing of pancreatic cyst fluid obtained by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) has traditionally utilized elevated carcinoembryonic antigen (CEA) (≥192 ng/ml) and cytomorphologic examination to differentiate premalignant mucinous from benign pancreatic cystic lesions (PCLs). Molecular testing for KRAS/GNAS mutations...
Xiaoyan Liao et al.
Diagnostic pathology, 15(1), 29-29 (2020-03-27)
Perianal Paget's disease (PPD) is rare and mostly described in clinical literature as case reports or small series. We investigated the clinicopathologic and immunohistochemical features of PPD in a total of 13 cases retrieved from multiple academic institutions. The median...
M Aaboud et al.
Physical review letters, 122(15), 151801-151801 (2019-05-06)
This Letter presents a search for the production of a long-lived neutral particle (Z_{d}) decaying within the ATLAS hadronic calorimeter, in association with a standard model (SM) Z boson produced via an intermediate scalar boson, where Z→ℓ^{+}ℓ^{-} (ℓ=e, μ). The...
Jonathan C DeLong et al.
The Journal of surgical research, 218, 139-143 (2017-10-08)
The success of a curative surgery for cancer is dependent on the complete removal of all cancer cells. Tumor visualization by the surgeon can be enhanced through fluorescent-antibody targeting. To further develop such technology, we selected humanized anti-carcinoembryonic antigen (CEA)...
Hanaa Dakour-Aridi et al.
Journal of vascular surgery, 69(3), 738-751 (2019-01-28)
Anemia is associated with increased cardiac adverse events during the early postoperative period because of high physiologic stress and increased cardiac demand. The aim of this study was to assess the surgical outcomes and prognostic implications of anemia in patients...
Erhao Zhang et al.
Journal of hematology & oncology, 11(1), 102-102 (2018-08-15)
The therapeutic application of T cells endowing with chimeric antigen receptors (CARs) is faced with "on-target, off-tumor" toxicity against solid tumors, particularly in the treatment of the pancreatic cancer. To our best knowledge, the pancreatic cancer cell line AsPC-1 often...
Fabien Le Chevalier et al.
Microbial cell factories, 19(1), 178-178 (2020-09-08)
Cyclodipeptide oxidases (CDOs) are enzymes involved in the biosynthesis of 2,5-diketopiperazines, a class of naturally occurring compounds with a large range of pharmaceutical activities. CDOs belong to cyclodipeptide synthase (CDPS)-dependent pathways, in which they play an early role in the...
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