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Fei Huang et al.
General physiology and biophysics, 39(1), 79-87 (2020-02-11)
Glucose triggers glucagon-like peptide (GLP)-1 secretion from L cells involving several glucose sensors including sodium-glucose transporter (SGLT)1, glucose transporter (GLUT)2, and sweet taste receptors (STRs). This study investigated the effects of different glucose concentrations on GLP-1 secretion, intracellular concentrations of
Caigang Zhu et al.
Scientific reports, 7(1), 13772-13772 (2017-10-25)
While the demand for metabolic imaging has increased in recent years, simultaneous in vivo measurement of multiple metabolic endpoints remains challenging. Here we report on a novel technique that provides in vivo high-resolution simultaneous imaging of glucose uptake and mitochondrial
Nathalia Pinho et al.
PLoS neglected tropical diseases, 14(8), e0008509-e0008509 (2020-08-18)
Leishmania species are responsible for a broad spectrum of diseases, denominated Leishmaniasis, affecting over 12 million people worldwide. During the last decade, there have been impressive efforts for sequencing the genome of most of the pathogenic Leishmania spp. as well
Qiang Zhang et al.
Journal of ethnopharmacology, 225, 202-210 (2018-07-10)
The edible plant Physalis alkekengi (PA) is used in traditional medicine to treat diabetes. However, the anti-diabetic effects and constituents of the fruit and aerial parts of this plant have not been studied extensively. The purpose of this study was
Eman Khatib-Massalha et al.
Nature communications, 11(1), 3547-3547 (2020-07-17)
Neutrophils provide first line of host defense against bacterial infections utilizing glycolysis for their effector functions. How glycolysis and its major byproduct lactate are triggered in bone marrow (BM) neutrophils and their contribution to neutrophil mobilization in acute inflammation is
Zhisheng Wu et al.
PLoS pathogens, 16(6), e1008568-e1008568 (2020-06-10)
Human herpesvirus 6 (HHV-6) is an important immunosuppressive and immunomodulatory virus worldwide. However, whether and how HHV-6 infection influences the metabolic machinery of the host cell to provide the energy and biosynthetic resources for virus propagation remains unknown. In this
Zhen-Dong Xiao et al.
Nature communications, 8(1), 783-783 (2017-10-06)
The roles of long non-coding RNAs in cancer metabolism remain largely unexplored. Here we identify FILNC1 (FoxO-induced long non-coding RNA 1) as an energy stress-induced long non-coding RNA by FoxO transcription factors. FILNC1 deficiency in renal cancer cells alleviates energy
Youn Hee Nam et al.
Nutrients, 12(2) (2020-01-30)
Ginger (Zingiber officinale Roscoe) and its active compounds (gingerols, shogaols and paradols) have been reported as having beneficial functions for several diseases, including diabetes. In this study, we revealed that the steaming process could enhance the anti-diabetic potential of ginger.
Pengfei Li et al.
Cancer management and research, 12, 9665-9678 (2020-10-30)
Constitutively activated signal transducer and activator of transcription 3 (STAT3) has been linked to cisplatin (DDP)-resistance in a wide range of cancers. Recent work has indicated that Rho GTPase-activating protein 6 (ARHGAP6) promotes cell cycle arrest and apoptosis in cervical
Ryo Hoshikawa et al.
Microcirculation (New York, N.Y. : 1994), 23(6), 416-425 (2016-04-27)
This study aimed to develop a new method for mapping blood flow velocity based on the spatial evolution of fluorescent dye transit times captured with CLSFM in the cerebral microcirculation of anesthetized rodents. The animals were anesthetized with isoflurane, and
Yamil Gerena et al.
Peptides, 96, 38-43 (2017-09-12)
A growing body of evidence demonstrates an association between Angiotensin II (Ang II) receptor blockers (ARBs) and enhanced glucose metabolism during ischemic heart disease. Despite these encouraging results, the mechanisms responsible for these effects during ischemia remain poorly understood. In
Guanjun Song et al.
Frontiers in pharmacology, 11, 561956-561956 (2021-02-12)
Aloperine (ALO), a quinolizidine alkaloid isolated from Sophora alopecuroides L. used in the traditional Uygur medicine, induced a significant increase in cellular glucose uptake of L6 cells, suggesting it has the potential to relieve hyperglycemia. Therefore, we investigated the effects
Sara A Gibson et al.
Journal of immunology (Baltimore, Md. : 1950), 198(11), 4244-4254 (2017-05-05)
CK2 is a highly conserved and pleiotropic serine/threonine kinase that promotes many prosurvival and proinflammatory signaling pathways, including PI3K/Akt/mTOR and JAK/STAT. These pathways are essential for CD4
Wei Xin et al.
Metabolism: clinical and experimental, 65(9), 1307-1315 (2016-08-11)
Insulin resistance is correlated with the progress of albuminuria in diabetic patients, and podocytes are crucial for maintaining the normal function of the glomerular filtration barrier. In the present study, we aimed to investigate the high glucose-induced insulin resistance and
Fadi Almouhanna et al.
Cancer & metabolism, 9(1), 5-5 (2021-01-24)
Aerobic glycolysis, discovered by Otto Warburg, is a hallmark of cancer metabolism even though not yet fully understood. The low activity of the cancerous pyruvate kinase isozyme (M2) is thought to play an important role by facilitating the conversion of
Hao Wu et al.
Redox biology, 12, 300-310 (2017-03-13)
Polychlorinated biphenyls (PCB) is a major type of persistent organic pollutants (POPs) that act as endocrine-disrupting chemicals. In the current study, we examined the mechanism underlying the effect of PCB-153 on glucose and lipid metabolism in vivo and in vitro.
Francesca Urbano et al.
American journal of physiology. Cell physiology, 310(7), C558-C567 (2016-01-08)
Glucagon-like peptide-1 (GLP-1) is a gut L-cell hormone that enhances glucose-stimulated insulin secretion. Several approaches that prevent GLP-1 degradation or activate the GLP-1 receptor are being used to treat type 2 diabetes mellitus (T2DM) patients. In T2DM, GLP-1 secretion has
Z Teo et al.
Oncogene, 36(46), 6408-6419 (2017-07-27)
Metastatic cancer cells acquire energy-intensive processes including increased invasiveness and chemoresistance. However, how the energy demand is met and the molecular drivers that coordinate an increase in cellular metabolic activity to drive epithelial-mesenchymal transition (EMT), the first step of metastasis
Md Badrul Alam et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 129, 337-343 (2019-05-10)
This study assesses the ability of anthraquinone derivative, 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTAQ) to decrease postprandial hyperglycemia or enhance glucose uptake and to elucidate the underlying molecular mechanism. We investigated α-glucosidase inhibition, glucose uptake, and translocation of glucose transporter 4 (GLUT4) in C2C12
Heather A McCauley et al.
Nature communications, 11(1), 4791-4791 (2020-09-24)
The ability to absorb ingested nutrients is an essential function of all metazoans and utilizes a wide array of nutrient transporters found on the absorptive enterocytes of the small intestine. A unique population of patients has previously been identified with
Li-Li Zhao et al.
Journal of molecular medicine (Berlin, Germany), 95(2), 181-192 (2016-09-16)
The insulin-sensitive glucose transporter 4 (GLUT4) is a predominant facilitative glucose transporter in vascular smooth muscle cells (VSMCs) and is significantly upregulated in rabbit neointima. This study investigated the role of GLUT4 in VSMC proliferation, the cellular mechanism underlying PDGF-BB-stimulated
Ahmad Alfares et al.
Frontiers in cell and developmental biology, 7, 365-365 (2020-02-06)
Very-long-chain acyl-coenzyme A dehydrogenase (VLCAD) is a coenzyme encoded by ACADVL that converts very-long-chain fatty acids into energy. This process is disrupted by c.65C > A; p.Ser22∗ mutation. To clarify mechanisms by which this mutation leads to VLCAD deficiency, we
Fangfang Tie et al.
International journal of molecular sciences, 21(6) (2020-03-20)
Proanthocyanidins are the major active compounds extracted from Irislactea Pall. var. Chinensis (Fisch.) Koidz (I. lactea). Proanthocyanidins exhibit a variety of pharmacological activities such as anti-oxidation, anti-inflammation, anti-tumor, and lowering blood lipids. However, the underlying mechanism of its regulating effect
Thomas Sithara et al.
Frontiers in pharmacology, 8, 640-640 (2017-09-29)
The study under investigation focuses on
Phutthida Kongthitilerd et al.
Nutrients, 12(8) (2020-08-23)
Riceberry rice (Oryza sativa L.) is a new pigmented variety of rice from Thailand. Despite its high anthocyanin content, its effect on adipogenesis and adipocyte function remains unexplored. We investigated whether Riceberry rice extract (RBE) impacted cell proliferation by examining
Fang Ye et al.
Toxicology letters, 323, 25-34 (2019-12-25)
Mitochondrial permeability transition (MPT), which is mainly regulated by cyclophilin D (CypD) encoded by ppif gene, is an early event that occurs during mitochondrial stimuli exposure. Lead (Pb) induces MPT and subsequently causes mitochondrial abnormality, followed by events, including oxidative
Ke Ren et al.
Journal of virology, 90(16), 7313-7322 (2016-06-03)
Respiratory syncytial virus (RSV) infection is a common cause of lower respiratory tract illness in infants and children. RSV is a negative-sense, single-strand RNA (ssRNA) virus that mainly infects airway epithelial cells. Accumulating evidence indicates that reactive oxygen species (ROS)
Lu Wan et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(7), 8530-8542 (2019-04-11)
The mechanism of exosomes derived from activated hepatic stellate cells (HSCs) involved in liver fibrosis is poorly understood. We previously reported that hypoxia-inducible factor 1 (Hif-1) regulated HSC activation, and, therefore, we investigated in current work whether Hif-1 regulates exosome
Doumet Georges Helou et al.
Nature communications, 11(1), 3998-3998 (2020-08-12)
Allergic asthma is a leading chronic disease associated with airway hyperreactivity (AHR). Type-2 innate lymphoid cells (ILC2s) are a potent source of T-helper 2 (Th2) cytokines that promote AHR and lung inflammation. As the programmed cell death protein-1 (PD-1) inhibitory
Ruirui Wang et al.
Life sciences, 229, 46-56 (2019-05-16)
Tumor growth is an angiogenesis-dependent process that requires sustained new vessel growth. Interleukin-17 (IL-17A) is a key cytokine that modulates tumor progression. However, whether IL-17A affects the metabolism of endothelial cells is unknown. A xenograft model was established by implanting
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