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Yang Cheng et al.
Microbes and infection, 16(5), 419-428 (2014-02-25)
The newly identified GPI-anchored Plasmodium vivax merozoite surface protein 1 paralog (MSP1P) has a highly antigenic C-terminus that binds erythrocytes. To characterize the antigenicity and immunogenicity of two regions (PvMSP1P-19 and -33) of the highly conserved C-terminus of MSP1P relative
Jianxuan Zou et al.
Cancer science, 106(5), 512-521 (2015-02-11)
Bispecific antibodies play an important role in immunotherapy. They have received intense interest from pharmaceutical enterprises. The first antibody drug, OKT3 (muromonab-CD3), showed great performance in clinical treatment. We have successfully developed a single-chain variable fragment (ScFv) combination of anti-CD3
Xiaohu Xia et al.
ACS nano, 9(10), 9994-10004 (2015-09-04)
Peroxidase mimics with dimensions on the nanoscale have received great interest as emerging artificial enzymes for biomedicine and environmental protection. While a variety of peroxidase mimics have been actively developed recently, limited progress has been made toward improving their catalytic
Elizabeth F Wallin et al.
Blood, 124(17), 2666-2674 (2014-09-17)
The monoclonal anti-CD20 antibody rituximab (RTX) depletes B cells in the treatment of lymphoma and autoimmune disease, and contributes to alloantibody reduction in transplantation across immunologic barriers. The effects of RTX on T cells are less well described. T-follicular helper
Li-Chun Cui et al.
Vaccine, 33(27), 3092-3099 (2015-05-20)
Spring viremia of carp virus (SVCV) and koi herpesvirus (KHV) are highly contagious and pathogenic to cyprinid fish, causing enormous economic losses in aquaculture. Although DNA vaccines reported in recent years could induce protective immune responses in carps against these
Jari Intra et al.
Insect biochemistry and molecular biology, 63, 133-143 (2015-06-24)
Sperm-oocyte interaction during fertilization is multiphasic, with multicomponent events, taking place between egg's glycoproteins and sperm surface receptors. Protein-carbohydrate complementarities in gamete recognition have observed in cases throughout the whole evolutionary scale. Sperm-associated α-L-fucosidases have been identified in various organisms.
Agnès Fleury et al.
PLoS neglected tropical diseases, 9(8), e0003980-e0003980 (2015-08-08)
Human neurocysticercosis (NC) is caused by the establishment of Taenia solium larvae in the central nervous system. NC is a severe disease still affecting the population in developing countries of Latin America, Asia, and Africa. While great improvements have been
Weiwei Zhang et al.
Parasites & vectors, 8, 37-37 (2015-01-22)
Schistosomiasis is a chronic parasitic disease that affects approximately 200 million people. In Schistosomiasis japonica and mansoni, parasite eggs were trapped in host liver and stimulated the CD4(+)T cell responses to regulate the formation of the granulomas. Subsequently, excessive granulomatous
Giovanni Pacioni et al.
Phytochemistry, 110, 104-110 (2014-12-01)
Truffles are the fruiting body of fungi, members of the Ascomycota phylum endowed with major gastronomic and commercial value. The development and maturation of their reproductive structure are dependent on melanin synthesis. Since anandamide, a prominent member of the endocannabinoid
Esma Altunoglu et al.
Geriatrics & gerontology international, 15(7), 872-880 (2014-10-28)
The aim of the present study was to determine the systemic levels of oxidative stress markers, such as ischemia-modified albumin (IMA), advanced oxidation protein products (AOPP), ferric reducing antioxidant power (FRAP) and the prooxidant-antioxidant balance (PAB), to clarify protein redox
Rajesh Radhakrishnan et al.
Phytotherapy research : PTR, 28(8), 1252-1259 (2014-04-09)
Indukantha Ghritha (IG), a polyherbal drug used for centuries in Ayurveda, is claimed to be successful in the treatment of respiratory diseases and as a rejuvenating drug. To date, little is known about the immunomodulatory role of IG in recurrent
Matthew J Gold et al.
The Journal of allergy and clinical immunology, 136(3), 725-736 (2015-03-10)
Inpp5d (Src homology 2 domain-containing inositol-5-phosphatase [Ship1])-deficient mice experience spontaneous airway inflammation and have enhanced sensitivity to allergen-induced airway inflammation. We hypothesized that lineage-specific deletion of Ship1 expression in cells known to be crucial for adaptive TH2 responses would uncover
Yacong Zhao et al.
International immunopharmacology, 24(2), 219-223 (2014-12-24)
BLyS antagonists have become the therapeutic reagents in the treatment of autoimmune disorders. BLyS binding peptides and their Fc fusion proteins may be alternative BLyS antagonists in such application. In this study, the activity of BLyS binding peptide 814 obtained
Hao Li et al.
The Journal of clinical investigation, 125(7), 2877-2890 (2015-06-23)
Systemic lupus erythematosus (SLE) is a severe autoimmune disease that is associated with increased circulating apoptotic cell autoantigens (AC-Ags) as well as increased type I IFN signaling. Here, we describe a pathogenic mechanism in which follicular translocation of marginal zone
Julia Elisa Sepulveda-Diaz et al.
Brain : a journal of neurology, 138(Pt 5), 1339-1354 (2015-04-07)
Heparan sulphate (glucosamine) 3-O-sulphotransferase 2 (HS3ST2, also known as 3OST2) is an enzyme predominantly expressed in neurons wherein it generates rare 3-O-sulphated domains of unknown functions in heparan sulphates. In Alzheimer's disease, heparan sulphates accumulate at the intracellular level in
Chen-Ting Lee et al.
PloS one, 10(3), e0120327-e0120327 (2015-03-21)
Traditional treatments, including a variety of thermal therapies have been known since ancient times to provide relief from rheumatoid arthritis (RA) symptoms. However, a general absence of information on how heating affects molecular or immunological targets relevant to RA has
Jesse H Erasmus et al.
PLoS neglected tropical diseases, 9(10), e0004119-e0004119 (2015-10-23)
In December of 2013, chikungunya virus (CHIKV), an alphavirus in the family Togaviridae, was introduced to the island of Saint Martin in the Caribbean, resulting in the first autochthonous cases reported in the Americas. As of January 2015, local and
Ju-Hyung Shin et al.
PloS one, 10(6), e0130684-e0130684 (2015-06-19)
Influenza is one of the critical infectious diseases globally and vaccination has been considered as the best way to prevent. In this study, immunogenicity and protection efficacy between intranasal (IN) and microneedle (MN) vaccination was compared using inactivated swine-origin influenza
Ying Huang et al.
Developmental and comparative immunology, 52(2), 155-165 (2015-05-26)
Integrins belong to a superfamily of conserved α β heterodimeric cell surface receptors that have critical function in cell migration, differentiation, and survival. In this study, an integrin called EsIntegrin was identified from Chinese mitten crab Eriocheir sinensis. EsIntegrin cDNA
Martín A Rossotti et al.
Analytical chemistry, 87(23), 11907-11914 (2015-11-07)
Single domain heavychain binders (nanobodies) obtained from camelid antibody libraries hold a great promise for immunoassay development. However, there is no simple method to select the most valuable nanobodies from the crowd of positive clones obtained after the initial screening.
Jiang Chen et al.
ACS applied materials & interfaces, 7(7), 4423-4432 (2015-02-14)
Recently, UV irradiation has been reported as a new approach to significantly improve the anticoagulant properties of titanium dioxide (TiO2) films by suppressing fibrinogen adsorption and platelet adhesion. This study focuses on how fibrinogen adsorption of and platelet adhesion to
Marie Hagbom et al.
Scientific reports, 5, 11431-11431 (2015-06-24)
By the use of a modified ionizer device we describe effective prevention of airborne transmitted influenza A (strain Panama 99) virus infection between animals and inactivation of virus (>97%). Active ionizer prevented 100% (4/4) of guinea pigs from infection. Moreover
Dionisia Quiroga et al.
Cancer immunology, immunotherapy : CII, 64(4), 479-491 (2015-02-07)
The need for novel, effective adjuvants that are capable of eliciting stronger cellular and humoral adaptive immune responses to antigenic targets is well understood in the vaccine development field. Unfortunately, many adjuvants investigated thus far are either too toxic for
Daniel Menezes-Souza et al.
PloS one, 9(6), e99216-e99216 (2014-06-13)
The search toward the establishment of novel serological tests for the diagnosis of leishmaniasis and proper differential diagnosis may represent one alternative to the invasive parasitological methods currently used to identify infected individuals. In the present work, we investigated the
K J Taylor et al.
Parasite immunology, 37(1), 23-31 (2014-11-08)
Translationally controlled tumour protein (TCTP) may play an important role in the establishment or maintenance of parasitemia in a malarial infection. In this study, the potential of TCTP as a malaria vaccine was investigated in two trials. In the initial
Liquan Yu et al.
Journal of medical microbiology, 63(Pt 12), 1732-1740 (2014-10-08)
Staphylococcal and streptococcal species are the most common pathogens that cause bovine mastitis. Induction of a broad-spectrum protective immunity against staphylococci and streptococci by combining multiple antigens into a single vaccine is highlighted. To develop a universal vaccine candidate, a
Erin K Johnston et al.
In vitro cellular & developmental biology. Animal, 51(7), 730-738 (2015-05-08)
Angiogenesis, or the formation of new blood vessels, is stimulated by angiogenic factors such as vascular endothelial growth factor (VEGF). Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis. To explore the mechanism by which PEDF acts, recombinant PEDF
Dinesh Kumar et al.
Nutrition (Burbank, Los Angeles County, Calif.), 30(7-8), 903-914 (2014-07-06)
Broad bean (Vicia faba L.), a common vegetable, belongs to the family Fabaceae and is consumed worldwide. Limited studies have been done on allergenicity of broad beans. The aim of this study was to determine if broad bean proteins have
Shanshan Cao et al.
Immunological investigations, 44(5), 438-450 (2015-06-25)
An enzyme-linked immunosorbent assay (ELISA) and an immunochromatographic assay were constructed for the detection of lincomycin (LIN) in both milk and honey samples based on the monoclonal antibody named 5F6. The half-maximum inhibition of ELISA was 0.3 ng/mL after optimizing pH
Nobuhiko Fukuda et al.
Brain research, 1602, 62-74 (2015-01-21)
Oa1 is the casual gene for ocular albinism-1 in humans. The gene product OA1, alternatively designated as GPR143, belongs to G-protein coupled receptors. It has been reported that OA1 is a specific receptor for 3, 4-dihydroxy- L-phenylalanine (DOPA) in retinal
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