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Christine Touma et al.
Nucleic acids research, 45(14), 8609-8620 (2017-06-14)
The maintenance of genome stability depends on the ability of the cell to repair DNA efficiently. Single-stranded DNA binding proteins (SSBs) play an important role in DNA processing events such as replication, recombination and repair. While the role of human...
K Ikwap et al.
BMC veterinary research, 17(1), 31-31 (2021-01-20)
The development of antimicrobial resistance is of global concern, and is commonly monitored by the analysis of certain bacteria. The aim of the present study was to study the antibiotic susceptibility in isolates of Staphylococcus spp. and Escherichia (E.) coli...
Simone Brogi et al.
European journal of medicinal chemistry, 135, 479-490 (2017-05-10)
Giardia duodenalis is a microaerophilic parasite that colonizes the upper portions of the small intestine of humans. Giardia infection is a major contributor to diarrheal disease worldwide. Nitroheterocycles (e.g. metronidazole) or benzimidazoles (e.g. albendazole) are the most commonly used therapeutic...
Uchechukwu I Okafor et al.
Food science & nutrition, 6(2), 424-439 (2018-03-23)
Maize was cofermented with pigeon pea for ogi production and evaluated for nutritional (proximate composition, minerals, vitamins, and amino acid profile analyses) and antinutritional (phytate, tannin, and trypsin inhibitor activity analyses) qualities. White maize and pigeon pea were mixed at...
Wen-Si Hu et al.
Anaerobe, 52, 115-121 (2018-06-25)
Clostridium perfringens is one of the leading causes of food poisoning worldwide. The aims of this study were to investigate the presence of C. perfringens in food supplied to school cafeterias, to assess the presence of toxin genes in the isolates...
Xiaofen Li et al.
EBioMedicine, 39, 159-172 (2018-12-12)
Ubiquitin-proteasome system (UPS) is integral to cell survival by maintaining protein homeostasis, and its dysfunction has been linked to cancer and several other human diseases. Through counteracting ubiquitination, deubiquitinases (DUBs) can either positively or negatively regulate UPS function, thereby representing...
Ana Isabel Santos et al.
Antioxidants & redox signaling, 28(1), 15-30 (2017-06-27)
Nitric oxide (NO) is involved in the upregulation of endogenous neurogenesis in the subventricular zone and in the hippocampus after injury. One of the main neurogenic pathways activated by NO is the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway...
Tahmineh Khazaei et al.
Science advances, 6(33), eaba0353-eaba0353 (2020-08-28)
Major changes in the microbiome are associated with health and disease. Some microbiome states persist despite seemingly unfavorable conditions, such as the proliferation of aerobe-anaerobe communities in oxygen-exposed environments in wound infections or small intestinal bacterial overgrowth. Mechanisms underlying transitions...
Yu Wu et al.
Biochemical and biophysical research communications, 464(4), 1275-1281 (2015-07-30)
The osteoblastic expression of RANKL, which is essential for the communication between osteoblastic cells and osteoclastogenic cells, is stimulated by locally acting or circulating osteotropic cytokines and hormones such as PTH and 1,25-(OH)2-D3 during the bone remodeling process. However, mechanisms...
Ai-Yue Hao et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 249, 119310-119310 (2020-12-19)
A smartphone-combined dual-emission ratiometric fluorescence probe for specifically and visibly detecting cephalexin was first designed. In the probe, blue-emitting fluorescent carbon dots (CDs) was synthesized and covered with a layer of silica spacer. Red-emitting fluorescent CdTe QDs (r-QDs) was grafted...
Van Quan Do et al.
Archives of toxicology, 95(2), 541-556 (2020-10-20)
Chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) are biocidal preservatives and the active ingredients in Kathon CG, which contains ca. 1.5% mixture of CMIT and MIT at a ratio of 3:1 (CMIT/MIT). CMIT/MIT was misused as humidifier disinfectant products, which caused serious...
Federica Cruciani et al.
Antimicrobial agents and chemotherapy, 59(5), 2825-2834 (2015-03-04)
The healthy vaginal microbiota is generally dominated by lactobacilli that confer antimicrobial protection and play a crucial role in health. Bacterial vaginosis (BV) is the most prevalent lower genital tract infection in women in reproductive age and is characterized by...
Esther Moens et al.
AMB Express, 10(1), 79-79 (2020-04-26)
Hops is an almost unique source of the potent phytoestrogen 8-prenylnaringenin (8-PN). As hops contain only low levels of 8-PN, synthesis may be more attractive than extraction. A strain of the Gram-positive Eubacterium limosum was isolated previously for 8-PN production...
Yowan Nerthigan et al.
Mikrochimica acta, 186(3), 130-130 (2019-02-02)
A method is reported for the synthesis of highly luminescent copper/molybdenum bimetallic nanoclusters (Cu/Mo NCs) using cysteine as both a capping and reducing agent. The nanoclusters display bluish-green luminescence (excitation/emission peaks at 370/490 nm) and a relative quantum yield of 26%....
Celine Bouclier et al.
Theranostics, 10(5), 2008-2028 (2020-02-28)
CDK4/cyclin D kinase constitutes an attractive pharmacological target for development of anticancer therapeutics, in particular in KRAS-mutant lung cancer patients, who have a poor prognosis and no targeted therapy available yet. Although several ATP-competitive inhibitors of CDK4 have been developed...
Elizabeth M Bafaro et al.
Metallomics : integrated biometal science, 7(9), 1319-1330 (2015-04-18)
The human (h) ZIP4 transporter is a plasma membrane protein which functions to increase the cytosolic concentration of zinc. hZIP4 transports zinc into intestinal cells and therefore has a central role in the absorption of dietary zinc. hZIP4 has eight...
Nicolas Taulet et al.
Scientific reports, 9(1), 10311-10311 (2019-07-18)
To build and maintain mitotic spindle architecture, molecular motors exert spatially regulated forces on microtubules (MT) minus-ends. This spatial regulation is required to allow proper chromosomes alignment through the organization of kinetochore fibers (k-fibers). NuMA was recently shown to target...
Polyphyllin VII induces apoptosis and autophagy via mediating H2O2 levels and the JNK pathway in human osteosarcoma U2OS cells.
Li, et al.
Oncology Reports, 45, 180-190 (2021)
Florina Zakany et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1864(3), 312-325 (2018-12-17)
Cholesterol, an essential lipid component of cellular plasma membranes, regulates fluidity, mechanical integrity, raft structure and may specifically interact with membrane proteins. Numerous effects on ion channels by cholesterol, including changes in current amplitude, voltage dependence and gating kinetics, have...
Qingsu Cheng et al.
Scientific reports, 5, 13685-13685 (2015-09-09)
To date, in situ visualization of microbial density has remained an open problem. Here, functionalized buckyballs (e.g., C60-pyrrolidine tris acid) are shown to be a versatile platform that allows internalization within a microorganism without either adhering to the cell wall...
Fabian Bumbak et al.
Biochimica et biophysica acta, 1860(6), 1372-1383 (2018-03-30)
Neurotensin is a 13-residue peptide that acts as a neuromodulator of classical neurotransmitters such as dopamine and glutamate in the mammalian central nervous system, mainly by activating the G protein-coupled receptor (GPCR), neurotensin receptor 1 (NTS1). Agonist binding to GPCRs...
Yan-Hong Shi et al.
Food & function, 10(1), 289-295 (2018-12-20)
Humans are frequently exposed to the residues of various neonicotinoids, highlighting the need to understand human exposure through oral ingestion of contaminated foods. In this study, the effects of different food matrices (tomato, cucumber, and carrot) and their interaction with...
Sebastian Neuss et al.
Journal of immunology (Baltimore, Md. : 1950), 201(4), 1275-1286 (2018-07-08)
AICL glycoproteins are cognate activation-induced ligands of the C-type lectin-like receptor NKp80, which is expressed on virtually all mature human NK cells, and NKp80-AICL interaction stimulates NK cell effector functions such as cytotoxicity and cytokine secretion. Notably, AICL and NKp80...
Mingfang Feng et al.
Applied microbiology and biotechnology (2018-05-08)
M2 protein, a highly conserved protein of influenza A virus (IAV), plays an important role in virus particle uncoating, assembly, and budding. In the present study, eight monoclonal antibodies (mAbs) against the M2 protein of the H3N2 IAV strain were...
Aline Lueckgen et al.
Biomaterials, 217, 119294-119294 (2019-07-06)
Enzymatically-degradable materials recapitulate the dynamic and reciprocal interactions between cells and their native microenvironment by allowing cells to actively shape the degradation process. In order to engineer a synthetic 3D environment enabling cells to orchestrate the degradation of the surrounding...
Mohammad Mahdi Bordbar et al.
Analytica chimica acta, 1141, 28-35 (2020-11-30)
Volatile organic compounds (VOCs) in blood samples can be used as useful biomarkers to diagnose various human diseases. This study describes the potential of a paper-based sensor array for detecting leukemia using blood VOCs. Blood samples were collected from 59...
Nimisha Singh et al.
Materials science & engineering. C, Materials for biological applications, 109, 110645-110645 (2020-04-02)
Different blood groups of ABO system have specific antigen which bestows them with different biochemical properties and hence they can show different hemolytic activity. In this report, hemolytic activity of thiol-functionalized Fe3O4-Au nanoparticles were studied in presence and absence of...
Miriam Cipullo et al.
Nucleic acids research, 49(1), 354-370 (2020-12-08)
Human mitoribosomes are macromolecular complexes essential for translation of 11 mitochondrial mRNAs. The large and the small mitoribosomal subunits undergo a multistep maturation process that requires the involvement of several factors. Among these factors, GTP-binding proteins (GTPBPs) play an important...
Anna Katharina Weyrauch et al.
PloS one, 12(9), e0184968-e0184968 (2017-09-22)
Histidine-Proline-rich Glycoprotein (HPRG) is a plasma protein of vertebrates and several marine bivalves. Due to its multidomain structure consisting of several regions HPRG can interact with a variety of ligands, however the exact physiological role has not been discovered yet....
T J Simmons et al.
Nature communications, 8(1), 1064-1064 (2017-10-24)
Lytic polysaccharide monooxygenases (LPMOs) are industrially important copper-dependent enzymes that oxidatively cleave polysaccharides. Here we present a functional and structural characterization of two closely related AA9-family LPMOs from Lentinus similis (LsAA9A) and Collariella virescens (CvAA9A). LsAA9A and CvAA9A cleave a...
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