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Kristin Zscharnack et al.
Analytica chimica acta, 834, 51-57 (2014-06-15)
Here, we present a fast and simple hydrogen peroxide assay that is based on time-resolved fluorescence. The emission intensity of a complex consisting of terbium ions (Tb(3+)) and phthalic acid (PA) in HEPES buffer is quenched in the presence of
Akihiro Tai et al.
Bioscience, biotechnology, and biochemistry, 78(10), 1723-1730 (2014-10-03)
The antioxidative properties of ascorbigen, one of the major indole-derived compounds of Brassica vegetables, were systematically evaluated using multiple assay systems with comparison to the well-known antioxidants ascorbic acid and Trolox. We first performed assays using model radicals, DPPH radical
Amit Kumar De et al.
Journal of microencapsulation, 31(8), 725-737 (2014-06-26)
Abstract Context: Ursodeoxycholic acid (UDCA) exerts dose-dependent chemoprevention in colonic inflammation. Polycationic UDCA nanoparticles (UNPs) are envisaged for solubility enhancement and site directed drug delivery. The objective was to study the ameliorative efficacy of UNPs through localized delivery of the
Soon Ok Kim et al.
Endocrinology, 155(4), 1466-1475 (2014-02-11)
Prostaglandin E2 (PGE2) is a key mediator of ovulation. All 4 PGE2 receptors (EP receptors) are expressed in the primate follicle, but the specific role of each EP receptor in ovulatory events is poorly understood. To examine the ovulatory events
Julia Thierauf et al.
Melanoma research, 25(6), 503-509 (2015-09-10)
Mucosal melanoma of the head and neck is a rare and aggressive tumor entity with a poor prognosis. The standard treatment is radical tumor resection, with or without adjuvant radiation, where conventional chemotherapies in advanced stage or recurrent diseases have
Catherine To et al.
PloS one, 9(11), e112106-e112106 (2014-11-25)
Eph and ephrin proteins are essential cell guidance cues that orchestrate cell navigation and control cell-cell interactions during developmental tissue patterning, organogenesis and vasculogenesis. They have been extensively studied in animal models of embryogenesis and adult tissue regeneration, but less
Yuan He et al.
Investigative ophthalmology & visual science, 55(10), 6742-6755 (2014-09-13)
Oxidative stress plays an important role in health and aging. We have shown that oxidative stress impairs mitochondrial function and promotes RPE cell death in an age-dependent manner. This study investigates the role of pigment epithelium-derived factor (PEDF) in limiting
Shinya Hayashi et al.
Arthritis research & therapy, 17, 314-314 (2015-11-08)
Osteoarthritis (OA) is a multifactorial disease, and recent studies have suggested that cell cycle-related proteins play a role in OA pathology. p21 was initially identified as a potent inhibitor of cell cycle progression. However, it has been proposed that p21
Amin M D Shakhawat et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(41), 14070-14075 (2015-10-16)
Arc ensembles in adult rat olfactory bulb (OB) and anterior piriform cortex (PC) were assessed after discrimination training on highly similar odor pairs. Nonselective α- and β-adrenergic antagonists or saline were infused in the OB or anterior PC during training.
Chi Keung Lam et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(47), E6466-E6475 (2015-11-11)
The major underpinning of massive cell death associated with myocardial infarction involves opening of the mitochondrial permeability transition pore (mPTP), resulting in disruption of mitochondria membrane integrity and programmed necrosis. Studies in human lymphocytes suggested that the hematopoietic-substrate-1 associated protein
Justin E Mirus et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(7), 1764-1771 (2015-01-16)
Pancreatic ductal adenocarcinoma (PDA) is the fourth leading cause of cancer-related death in the United States, and its incidence is on the rise. Advanced disease is nearly uniformly lethal, emphasizing the need to identify PDA at its earliest stages. To
Grazielle V B Huguenin et al.
Microcirculation (New York, N.Y. : 1994), 22(8), 687-699 (2015-07-28)
To investigate the effects of dietary supplementation with GBNs on microvascular endothelial function in hypertensive and dyslipidemic patients. Ninety-one patients of both sexes aged 62.1 ± 9.3 years received 13 g/day of GBNs or a placebo for three months with
Masahiro Sano et al.
The Journal of reproduction and development, 61(5), 439-448 (2015-07-15)
The corpus luteum (CL) is a temporary endocrine gland producing a large amount of progesterone, which is essential for the establishment and maintenance of pregnancy. Galectin-1 is a β-galactose-binding protein that can modify functions of membrane glycoproteins and is expressed
Damián Dorfman et al.
PloS one, 9(7), e101829-e101829 (2014-07-09)
Diabetic retinopathy is a leading cause of reduced visual acuity and acquired blindness. Available treatments are not completely effective. We analyzed the effect of environmental enrichment on retinal damage induced by experimental diabetes in adult Wistar rats. Diabetes was induced
Li-Hua Mu et al.
Biological & pharmaceutical bulletin, 37(6), 1035-1041 (2014-06-03)
The aim of this study was to explore whether the ethanolic extract of Ardisia gigantifolia rhizomes (AGB-5), a traditional herbal medicine from China, could affect the proliferation of human breast adenocarcinoma (MCF-7) cells in vitro and to explore the antitumor
Yulei Wang et al.
Free radical biology & medicine, 79, 186-196 (2014-12-03)
Selenium is an essential trace element and has been extensively studied for preventive effects on cancers. Recent emerging evidence has also shown that selenium at supranutritional dosage has a preferential cytotoxicity in cancer cells and chemotherapeutic drug-resistant cells, but the
Hao Meng et al.
Acta biomaterialia, 17, 160-169 (2015-02-14)
To decouple the extracellular oxidative toxicity of catechol adhesive moiety from its intracellular non-oxidative toxicity, dopamine was chemically bound to a non-degradable polyacrylamide hydrogel through photo-initiated polymerization of dopamine methacrylamide (DMA) with acrylamide monomers. Network-bound dopamine released cytotoxic levels of
A L Anding et al.
Cell death and differentiation, 22(3), 457-464 (2014-10-25)
Autophagy is a catabolic process used to deliver cellular material to the lysosome for degradation. The core Vps34/class III phosphatidylinositol 3-kinase (PI3K) complex, consisting of Atg6, Vps15, and Vps34, is highly conserved throughout evolution, critical for recruiting autophagy-related proteins to
Macarena Munoz et al.
Chemosphere, 109, 34-41 (2014-05-31)
The application of the Fenton process for the treatment of sawmill wastewater has been investigated. The sawmill wastewater was characterized by a moderate COD load (≈3gL(-1)), high ecotoxicity (≈ 40 toxicity units) and almost negligible BOD/COD ratio (5×10(-3)) due to
Rosalia Leonardi et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 44(10), 870-875 (2014-12-06)
Temporomandibular joint (TMJ) internal derangement (ID) is one of the most common form of temporomandibular disorders. There is evidence showing the increased expression of matrix metalloproteinases (MMPs) in the cells from degenerated TMJ disc. ADAMTS are a large family of
Seydou Sylla et al.
Microbiology and immunology, 58(7), 398-408 (2014-05-23)
Post-weaning multisystemic wasting syndrome (PMWS) associated with porcine circovirus type 2 (PCV2) has caused the swine industry significant health challenges and economic damage. Although inactivated and subunit vaccines against PMWS have been used widely, so far no DNA vaccine is
Yusuke Ohara et al.
Cancer science, 104(8), 1127-1134 (2013-05-18)
CD44(+) /CD24(+) /EpCAM(+) cells have been reported to be cancer stem cells in pancreatic cancer; however, the histological and clinical importance of these cells has not yet been investigated. Here we clarified the characteristics of CD44(+) /CD24(+) /EpCAM(+) cells in
Erik Berglund et al.
Experimental cell research, 326(2), 315-325 (2014-05-16)
DOG1, a Ca(2+)-activated Cl(-) channel (CaCC), was identified in 2004 to be robustly expressed in gastrointestinal stromal tumors (GIST). It was rapidly included as a tumor marker in routine diagnostics, but the functional role remained unknown. CaCCs are important regulators
Sveta Chakrabarti et al.
PLoS genetics, 10(9), e1004659-e1004659 (2014-09-26)
The p38 mitogen-activated protein (MAP) kinase signaling cassette has been implicated in stress and immunity in evolutionarily diverse species. In response to a wide variety of physical, chemical and biological stresses p38 kinases phosphorylate various substrates, transcription factors of the
Kazuya Hasegawa et al.
Endocrine journal, 62(10), 939-947 (2015-08-08)
Guanylin (Gn), a bioactive peptide, and its receptor, guanylyl cyclase-C (GC-C), are primarily present in the intestine and maintain homeostasis in body fluids. Recently, rats whose macrophages overexpress Gn and GC-C were found to be resistant to diet-induced obesity. Considering
Alessandra Stacchiotti et al.
PloS one, 9(10), e111141-e111141 (2014-10-28)
Obesity is a common and complex health problem, which impacts crucial organs; it is also considered an independent risk factor for chronic kidney disease. Few studies have analyzed the consequence of obesity in the renal proximal convoluted tubules, which are
Soonmi Won et al.
PloS one, 10(3), e0122821-e0122821 (2015-03-31)
Maintaining blood-brain barrier integrity and minimizing neuronal injury are critical components of any therapeutic intervention following ischemic stroke. However, a low level of vitamin D hormone is a risk factor for many vascular diseases including stroke. The neuroprotective effects of
Chi Yang et al.
Toxicology letters, 224(3), 371-379 (2013-11-12)
Aflatoxin B1 (AFB1) is a potent hepatocarcinogen that causes carcinogenesis in many animal species. In previous study, we found that isocitrate dehydrogenase 3α subunit (IDH3α) was upregulated in AFB1-induced carcinogenesis process. In this study, the sequences of IDH3α from various
Gábor Raffai et al.
International journal of nanomedicine, 9, 2557-2566 (2014-06-07)
Cinnamaldehyde, a major component of cinnamon, induces the generation of reactive oxygen species and exerts vasodilator and anticancer effects, but its short half-life limits its clinical use. The present experiments were designed to compare the acute relaxing properties of cinnamaldehyde
Deborah M Hegarty et al.
Journal of chemical neuroanatomy, 61-62, 1-12 (2014-07-06)
We examined the substrates for ocular nociception in adult male Sprague-Dawley rats. Capsaicin application to the ocular surface in awake rats evoked nocifensive responses and suppressed spontaneous grooming responses. Thus, peripheral capsaicin was able to activate the central pathways encoding
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