Showing 1-30 of 95 resultados for "A1895"
Samuel A Wells et al.
Thyroid : official journal of the American Thyroid Association, 25(6), 567-610 (2015-03-27)
The American Thyroid Association appointed a Task Force of experts to revise the original Medullary Thyroid Carcinoma: Management Guidelines of the American Thyroid Association. The Task Force identified relevant articles using a systematic PubMed search, supplemented with additional published materials...
Jana Koo et al.
BMC cancer, 15, 905-905 (2015-11-18)
BRF2 is a transcription factor required for synthesis of a small group of non-coding RNAs by RNA polymerase III. Overexpression of BRF2 can transform human mammary epithelial cells. In both breast and lung cancers, the BRF2 gene is amplified and...
Anthony N Gerber et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(12), 4929-4934 (2009-03-04)
Glucocorticoids are widely used to suppress inflammation and treat various immune-mediated diseases. Some glucocorticoid receptor (GR)-regulated genes mediate the therapeutic response, whereas others cause debilitating side effects. To discover selective modulators of the GR response, we developed a high-throughput, multiplexed...
Jian-Bao Zheng et al.
Molecular medicine reports, 12(3), 3409-3415 (2015-05-26)
Caudal‑related homeobox transcription factor 2 (CDX2) is a transcription factor, which is specifically expressed in the adult intestine. It is essential for the development and homeostasis of the intestinal epithelium and its functions as a tumor suppressor have been demonstrated...
The medicinal chemistry of dengue fever.
Andrew J Stevens et al.
Journal of medicinal chemistry, 52(24), 7911-7926 (2009-09-11)
Mélanie K Rich et al.
Plant physiology, 168(3), 788-797 (2015-05-15)
Arbuscular mycorrhiza (AM) is a mutual symbiosis that involves a complex symbiotic interface over which nutrients are exchanged between the plant host and the AM fungus. Dozens of genes in the host are required for the establishment and functioning of...
Jan Seifert et al.
Scientific reports, 7(1), 4810-4810 (2017-07-08)
Platelets are small anucleate blood cells involved in haemostasis. Platelet activation, caused by agonists such as thrombin or by contact with the extracellular matrix, leads to platelet adhesion, aggregation, and coagulation. Activated platelets undergo shape changes, adhere, and spread at...
Elif Ayvali et al.
Annals of biomedical engineering, 43(8), 1828-1840 (2014-12-17)
Image-guided interventions have become the standard of care for needle-based procedures. The success of the image-guided procedures depends on the ability to precisely locate and track the needle. This work is primarily focused on 2D ultrasound-based tracking of a hollow...
Yi-Pei Chen et al.
Bioscience, biotechnology, and biochemistry, 72(11), 3021-3024 (2008-11-11)
The filamentous fungus Monascus pilosus was genetically transformed with a reporter plasmid, pMS-1.5hp, by aurintricarboxylic acid (ATA) treatment to obtain an efficient red-pigment producing mutant. The transformation efficiency of Monascus pilosus was higher with the ATA-treatment than with either a...
Berthold Löhrke et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 77(4), 310-320 (2010-02-13)
N-acetylcysteine (NAC) is known as an antioxidant and used for mucus viscosity reduction. However, this drug prevents or induces cell death depending on the cell type. The response of steroidogenic luteal cells to NAC is unknown. Our data shows that...
Jing Yuan et al.
Nature chemical biology, 5(10), 765-771 (2009-09-08)
Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279 bioactive chemicals. Hundreds of compounds were...
Jeremy D Baker et al.
SLAS discovery : advancing life sciences R & D, 26(3), 400-409 (2020-09-29)
Tauopathies are neurological disorders characterized by intracellular tau deposits forming neurofibrillary tangles, neuropil threads, or other disease-specific aggregates composed of the protein tau. Tauopathy disorders include frontotemporal lobar degeneration, corticobasal degeneration, Pick's disease, and the largest cause of dementia, Alzheimer's...
Alicja Kuban-Jankowska et al.
Anticancer research, 37(9), 4799-4806 (2017-09-06)
Rapidly-dividing cancer cells have higher requirement for iron compared to non-transformed cells, making iron chelating a potential anticancer strategy. In the present study we compared the anticancer activity of uncommon iron chelator aurintricarboxylic acid (ATA) with the known deferoxamine (DFO)....
Tyson Howell et al.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 127(12), 2695-2709 (2014-10-18)
This study identifies a small distal region of the 1RS chromosome from rye that has a positive impact on wheat yield. The translocation of the short arm of rye (Secale cereale L.) chromosome one (1RS) onto wheat (Triticum aestivum L.)...
Luminita Damian et al.
Biochemical and biophysical research communications, 385(3), 296-301 (2009-05-22)
Is single-strand DNA translatable? Since the 60s, the question still remains whether or not DNA could be directly translated into protein. Some discrepancies in the results were reported about functional translation of single-strand DNA but all results converged on a...
J Eriksson et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 45(1), 211-219 (2014-06-26)
Population-based studies on aspirin-intolerant asthma (AIA) are very few, and no previous population study has investigated risk factors for the condition. To investigate the prevalence and risk factors of AIA in the general population. A questionnaire on respiratory health was...
Dana C Danielson et al.
Biochemical and biophysical research communications, 463(4), 1135-1140 (2015-06-17)
RNA silencing is a gene regulatory and host defense mechanism whereby small RNA molecules are engaged by Argonaute (AGO) proteins, which facilitate gene knockdown of complementary mRNA targets. Small molecule inhibitors of AGO represent a convenient method for reversing this...
Bingzhi Li et al.
Analytical chemistry, 93(6), 3287-3294 (2021-02-03)
Flap endonuclease 1 (FEN1), an endogenous nuclease with the ability to cleave the 5' overhang of branched dsDNA, is of significance in DNA replication and repair. The overexpression of FEN1 is common in cancer because of the ubiquitous upregulation of...
Junmei Wang et al.
Journal of medicinal chemistry, 48(7), 2432-2444 (2005-04-02)
In this work, an efficient strategy was presented to search drug leads for human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) using hierarchical database screenings, which included a pharmacophore model, multiple-conformation rigid docking, solvation docking, and molecular mechanics-Poisson-Boltzmann/surface area...
Pawel Leznicki et al.
EMBO reports, 21(5), e48835-e48835 (2020-03-28)
The endoplasmic reticulum (ER) is a major site for membrane protein synthesis in eukaryotes. The majority of integral membrane proteins are delivered to the ER membrane via the co-translational, signal recognition particle (SRP)-dependent route. However, tail-anchored proteins employ an alternative...
Hyun Kyung Kim et al.
Xenotransplantation, 15(4), 246-256 (2008-10-30)
In the xenotransplantation of vascularized organs, such as the lung, a large area of endothelial cell layer is a big hurdle to be overcome. We investigated the potential protective effect of aurintricarboxylic acid (ATA), a known inhibitor of platelet adhesion...
Jakyung Yoo et al.
Advances in protein chemistry and structural biology, 87, 219-247 (2012-05-23)
DNA methyltransferases (DNMTs) are promising epigenetic targets for the development of novel anticancer drugs and other diseases. Molecular modeling and experimental approaches are being used to identify and develop inhibitors of human DNMTs. Most of the computational efforts conducted so...
Krystin Fong et al.
Pharmaceutical development and technology, 14(4), 341-342 (2009-02-24)
Factors associated with the intravaginal release of an anti-HIV agent from an alginate complex were considered. Among these is citrate associated with prostatic fluid. This study demonstrates that citrate, at a physiologically appropriate concentration, facilitates the release of an anti-HIV...
Erion Lipo et al.
Investigative ophthalmology & visual science, 54(10), 7107-7114 (2013-10-10)
Immunocytochemical and genetic data implicate a significant role for the activation of complement in the pathology of AMD. Individuals homozygous for a Y402H polymorphism in Factor H have elevated levels of membrane attack complex (MAC) in their choroidal blood vessels...
Moonhee Lee et al.
Neurobiology of aging, 34(5), 1451-1461 (2012-11-28)
Aberrant complement activation is known to exacerbate the pathology in a spectrum of degenerative diseases of aging. We previously reported that aurin tricarboxylic acid (ATA) is an orally effective agent which prevents formation of the membrane attack complex of complement....
B Winkler et al.
Pediatric blood & cancer, 62(1), 72-79 (2014-09-30)
Cytokines and their genes have been described to have an influence on incidence and prognosis in malignant, infectious and autoimmune disease. We previously described the impact of cytokine production on prognosis in paediatric standard-risk acute lymphoblastic leukaemia (ALL). In this...
Pablo Godoy et al.
International journal for parasitology, 45(1), 85-93 (2014-12-09)
Haemonchus contortus is a veterinary nematode that infects small ruminants, causing serious decreases in animal production worldwide. Effective control through anthelmintic treatment has been compromised by the development of resistance to these drugs, including the macrocyclic lactones. The mechanisms of...
Shogo Wada et al.
Pflugers Archiv : European journal of physiology, 467(2), 389-398 (2014-04-24)
Skeletal muscles contain several subtypes of myofibers that differ in contractile and metabolic properties. Transcriptional control of fiber-type specification and adaptation has been intensively investigated over the past several decades. Recently, microRNA (miRNA)-mediated posttranscriptional gene regulation has attracted increasing attention....
Yuta Shinohara et al.
Molecular cell, 67(5), 783-798 (2017-09-09)
Temperature compensation is a striking feature of the circadian clock. Here we investigate biochemical mechanisms underlying temperature-compensated, CKIδ-dependent multi-site phosphorylation in mammals. We identify two mechanisms for temperature-insensitive phosphorylation at higher temperature: lower substrate affinity to CKIδ-ATP complex and higher...
Maciej Tarnowski et al.
International journal of oncology, 46(5), 2241-2250 (2015-02-25)
Insulin-like growth factor 2 (IGF2) and 1 (IGF1) and insulin (INS) promote proliferation of rhabdomyosarcoma (RMS) cells by interacting with the insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor (INSR). Loss of imprinting (LOI) by DNA hypermethylation at...

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