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Y B Shaik-Dasthagirisaheb et al.
Journal of biological regulators and homeostatic agents, 27(2), 291-295 (2013-07-09)
Inflammatory responses are operationally characterized by pain, redness, heat and swelling at the site of infection and trauma. Mast cells reside near small blood vessels and, when activated, release potent mediators involved in allergy and inflammation. Vitamin D modulates contraction
J L Adolphe et al.
Journal of animal physiology and animal nutrition, 99(4), 767-776 (2014-12-06)
Peas are increasing in popularity as a source of carbohydrate, protein and fibre in extruded canine diets. The aim of this study was to test the health effects of two canine diets with identical macronutrient profiles, but containing either yellow
Wei Liu et al.
Journal of materials science. Materials in medicine, 26(7), 203-203 (2015-07-15)
The β-titanium alloy is thought to be a promising alloy using as orthopedic or dental implants owing to its characteristics, which contains low elastic modulus, high corrosion resistance and well biocompatibility. Our previous study has reported that a new β-titanium
M S Attia et al.
Analytica chimica acta, 835, 56-64 (2014-06-24)
A new method in which a nano optical sensor for diagnosis of different diseases of seminal vesicle and sexual gland was prepared. The working principle of the method depends on the determination of the fructose concentration in semen of different
Ratih Yuniartha et al.
Pediatric surgery international, 30(9), 907-914 (2014-08-06)
The aim of this study was to evaluate the efficacy of mesenchymal stem cells (MSCs) in a nitrofen-induced congenital diaphragmatic hernia (CDH) rat model. Pregnant rats were exposed to nitrofen on embryonic day 9.5 (E9.5). MSCs were isolated from the
C Li et al.
Journal of dental research, 94(3), 455-463 (2015-01-15)
Recent studies have demonstrated that erythropoietin (EPO) has extensive nonhematopoietic biological functions. However, little is known about how EPO regulates bone formation, although several studies suggested that EPO can affect bone homeostasis. In this study, we investigated the effects of
Srinivasan Senthilkumari et al.
Experimental eye research, 124, 24-30 (2014-05-13)
We have previously reported low concentrations of plasma ascorbate and low dietary vitamin C intake in the older Indian population and a strong inverse association of these with cataract. Little is known about ascorbate levels in aqueous humor and lens
Mário Mil-Homens et al.
The Science of the total environment, 540, 231-240 (2015-07-27)
Twenty century time-resolved variability of riverine deposits of polychlorobiphenyls (PCBs), DDTs, hexachlorocyclohexanes (HCHs) and hexachlorobenzene (HCB) was studied in three (210)Pb dated sediment cores collected in a depositional shelf area adjacent to the Tagus estuary (the Tagus Prodelta). The geographic
Werner E G Müller et al.
Chembiochem : a European journal of chemical biology, 16(9), 1323-1332 (2015-04-15)
Studies indicate that mammalian bone formation is initiated at calcium carbonate bioseeds, a process that is driven enzymatically by carbonic anhydrase (CA). We show that amorphous calcium carbonate (ACC) and bicarbonate (HCO3 (-) ) cause induction of expression of the
P Manojkumar et al.
European journal of medicinal chemistry, 44(11), 4690-4694 (2009-08-04)
A series of novel 1-(4-methylcoumarinyl-7-oxyacetyl)-3,5-dimethyl-4(arylazo)pyrazoles and 1-(4-methylcoumarinyl-7-oxyacetyl)-3-methyl-4-(substituted phenyl) hydrazono-2-pyrazolin-5-ones were synthesised and evaluated for antibacterial and antioxidant activities. Compounds 3b, 3g, 5b, 5d and 5g showed good antibacterial activity and compound 5e was found to be the most active antioxidant
Andreas Herchenhan et al.
The Journal of biological chemistry, 290(26), 16440-16450 (2015-05-17)
Lysyl oxidases (LOXs) are a family of copper-dependent oxido-deaminases that can modify the side chain of lysyl residues in collagen and elastin, thereby leading to the spontaneous formation of non-reducible aldehyde-derived interpolypeptide chain cross-links. The consequences of LOX inhibition in
Nobuko Tano et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(10), 1864-1871 (2014-06-17)
Transplantation of bone marrow mesenchymal stromal cells (MSCs) is an emerging treatment for heart failure. We have reported that epicardial placement of MSC-sheets generated using temperature-responsive dishes markedly increases donor MSC survival and augments therapeutic effects in an acute myocardial
Ilkka Alahuhta et al.
Experimental cell research, 336(1), 130-140 (2015-06-27)
The turnover of extracellular matrix liberates various cryptic molecules with novel biological activities. Endostatin is an endogenous angiogenesis inhibitor that is derived from the non-collagenous domain of collagen XVIII. Although there are a large number of studies on its anti-tumor
Yuan Zhang et al.
Antioxidants & redox signaling, 21(12), 1693-1707 (2014-02-22)
Mitofilin was originally described as a heart muscle protein because of its abundance in the heart tissue; however, its function in the heart is still to be elucidated. Thus, this study aims at investigating the role of mitofilin in the
Fiona Allum et al.
Nature communications, 6, 7211-7211 (2015-05-30)
Most genome-wide methylation studies (EWAS) of multifactorial disease traits use targeted arrays or enrichment methodologies preferentially covering CpG-dense regions, to characterize sufficiently large samples. To overcome this limitation, we present here a new customizable, cost-effective approach, methylC-capture sequencing (MCC-Seq), for
Afrouz Yousefi et al.
International journal of pharmaceutics, 472(1-2), 175-184 (2014-06-21)
Angiogenesis is one of the hallmarks of cancer which renders it an attractive target for therapy of malignancies. Tumor growth suppression can be achieved by inhibiting angiogenesis since it would deprive tumor cells of oxygen and vital nutrients. Activation of
Rebecca Josowitz et al.
PloS one, 9(7), e101316-e101316 (2014-07-11)
The use of human stem cell-derived cardiomyocytes to study atrial biology and disease has been restricted by the lack of a reliable method for stem cell-derived atrial cell labeling and purification. The goal of this study was to generate an
Koji Y Arai et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 22(6), 701-711 (2014-09-17)
Epidermal-dermal interaction plays important roles in physiological events such as wound healing. In this study, we examined a double paracrine mechanism between keratinocytes and fibroblasts through interleukin-1 (IL-1) and an IL-1-induced inflammatory mediator prostaglandin E₂ (PGE₂) using the skin equivalent.
Minseok Seo et al.
Lab on a chip, 15(17), 3581-3590 (2015-07-30)
Perfluorocarbon (PFC) nanodroplet agents are exciting new biomaterials that can be remotely vapourized by ultrasound or light to change into micron-scale gas bubbles in situ. After PFC nanodroplet vapourization, the micron-scale gas bubble can interact strongly with ultrasound radiation, such
Akif Güneş et al.
The journal of international advanced otology, 11(1), 48-52 (2015-08-01)
In the present study, tympanic membranes (TM) harvested from myringotomized rats were analyzed histopathologically to compare the systemic and local effects of ascorbic acid on the development of myringosclerosis. Forty male Wistar-Albino rats weighing between 350-400 g were included in
Qing Tong et al.
Journal of pharmaceutical and biomedical analysis, 114, 455-461 (2015-07-03)
Ampelopsis grossedentata (Hand.-Mazz.) W.T. Wang has long been used as a traditional Chinese medicinal herb among the indigenous people in the Yangtze River region of China. Dihydromyricetin (DMY) is the most abundant (approximately 30%) and bioactive constituent in A. grossedentata
Clémentine Bosch-Bouju et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(48), 15836-15850 (2014-11-28)
Motor thalamus (Mthal) is a key node in the corticobasal ganglia (BG) loop that controls complex, cognitive aspects of movement. In Parkinson's disease (PD), profound alterations in neuronal activity occur in BG nuclei and cortex. Because Mthal is located between
Francisca Alcayaga-Miranda et al.
Stem cell research & therapy, 6, 32-32 (2015-04-19)
Stem cells isolated from menstrual fluid (MenSCs) exhibit mesenchymal stem cell (MSCs)-like properties including multi-lineage differentiation capacity. Besides, menstrual fluid has important advantages over other sources for the isolation of MSCs, including ease of access and repeated sampling in a
Jie Yu et al.
Theranostics, 5(9), 931-945 (2015-07-15)
The ability to selectively destroy cancer cells while sparing normal tissue is highly desirable during the cancer therapy. Here, magnetic targeted photothermal therapy was demonstrated by the integration of MoS2 (MS) flakes and Fe3O4 (IO) nanoparticles (NPs), where MoS2 converted
Nermina Vejzagić et al.
Parasitology research, 114(7), 2705-2714 (2015-05-27)
Eggs of the pig whipworm, Trichuris suis ova (TSO), are currently tested in human clinical trials for their potential immunomodulatory capacity. The biological potency of TSO (egg viability and infectivity) is traditionally assessed in Göttingen minipigs as the establishment of
Marc C Ford et al.
Nature communications, 6, 8073-8073 (2015-08-26)
Action potential timing is fundamental to information processing; however, its determinants are not fully understood. Here we report unexpected structural specializations in the Ranvier nodes and internodes of auditory brainstem axons involved in sound localization. Myelination properties deviated significantly from
B X E Desbiolles et al.
Nano letters, 19(9), 6173-6181 (2019-08-20)
Micronanotechnology-based multielectrode arrays have led to remarkable progress in the field of transmembrane voltage recording of excitable cells. However, providing long-term optoporation- or electroporation-free intracellular access remains a considerable challenge. In this study, a novel type of nanopatterned volcano-shaped microelectrode
Changhao Fu et al.
Cell biology international, 39(7), 777-787 (2015-06-19)
We isolated human embryonic cartilage stem cells (hECSCs), a novel stem cell population, from the articular cartilage of eight-week-old human embryos. These stem cells demonstrated a marker expression pattern and differentiation potential intermediate to those of human embryonic stem cells
Courtney Washington et al.
Archives of biochemistry and biophysics, 577-578, 24-34 (2015-05-20)
Tyrosinase (EC catalyzes the monophenolase and diphenolase reaction associated with vertebrate pigmentation and fruit/vegetable browning. Tyrosinase is an oxygen-dependent, dicopper enzyme that has three states: Emet, Eoxy, and Edeoxy. The diphenolase activity can be carried out by both the
Judit Bartalis et al.
Bioorganic & medicinal chemistry, 19(8), 2757-2766 (2011-04-05)
The aim of this study was to evaluate cucurbitacins (Cucs) liver protective activity in vitro and conduct QSAR studies against lipophilicity and ab initio descriptors. Nine Cucs were isolated from Cucurbitaceae plants and eight prepared by C2-alkylation or C16-acylation. Ten
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