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" within Papeles
Maoyong Fu et al.
PloS one, 6(5), e19945-e19945 (2011-06-04)
Endometrial cancer is the most common gynecologic malignancy diagnosed among women in developed countries. One recent biomarker strongly associated with disease progression and survival is epithelial membrane protein-2 (EMP2), a tetraspan protein known to associate with and modify surface expression...
Yuqing Gong et al.
Scientific reports, 10(1), 3835-3835 (2020-03-04)
The use of antiretroviral therapy (ART) has remarkably decreased the morbidity associated with HIV-1 infection, however, the prevalence of HIV-1-associated neurocognitive disorders (HAND) is still increasing. The blood-brain barrier (BBB) is the major impediment for penetration of antiretroviral drugs, causing...
Hayeong Kwon et al.
Biochimica et biophysica acta, 1853(5), 1022-1034 (2015-02-11)
Here, we demonstrate that insulin receptor (IR) tyrosine kinase catalyzes Tyr-19 and Tyr-27 phosphorylation of caveolin-2 (cav-2), leading to stimulation of signaling proteins downstream of IR, and that the catalysis is dependent on fatty acylation status of cav-2, promoting its...
Philip R Nicovich et al.
Biophysical journal, 114(12), 2855-2864 (2018-06-21)
The coexistence of lipid domains with different degrees of lipid packing in the plasma membrane of mammalian cells has been postulated, but direct evidence has so far been challenging to obtain because of the small size and short lifetime of...
Valentino J Stella et al.
Toxicologic pathology, 36(1), 30-42 (2008-03-14)
beta-cyclodextrin (beta-CD) and other cyclodextrins (CDs) have utility for solubilizing and stabilizing drugs; however, some are nephrotoxic when administered parenterally. A number of workers have attempted to identify, prepare, and evaluate various CD derivatives with superior inclusion complexation and maximal...
Studies of cyclodextrin inclusion complexes.
Cabra Marques, et al.
Int. J. Pharmacol., 77, 297-297 (1991)
Leonie Fingerhut et al.
Cells, 8(12) (2019-12-01)
Equine recurrent uveitis (ERU) is considered one of the most important eye diseases in horses and typically appears with relapsing inflammatory episodes without systemic effects. Various disorders have been described as an initial trigger, including infections. Independent of the initiating...
Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle.
Badgujar, et al.
PLoS Pathogens, 16, e1009016-e1009016 (2021)
Imaging of mobile long-lived nanoplatfroms in the live cell plasma membrane
Brameshuber M, et al.
The Journal of Biological Chemistry, 118(2-4), jbc-M110 (2010)
Jaspreet Sandhu et al.
Cell, 175(2), 514-529 (2018-09-18)
The mechanisms underlying sterol transport in mammalian cells are poorly understood. In particular, how cholesterol internalized from HDL is made available to the cell for storage or modification is unknown. Here, we describe three ER-resident proteins (Aster-A, -B, -C) that...
Jie Gao et al.
Virology journal, 16(1), 80-80 (2019-06-15)
Rabies virus (RABV), a member of Lyssavirus of Rhabdoviridae family, is a kind of negative-strand RNA virus. The zoonosis caused by RABV leads to high mortality in animals and humans. Though with the extensive investigation, the mechanisms of RABV entry...
Kecheng Zhou et al.
The American journal of pathology, 190(10), 2018-2028 (2020-07-18)
Studies of lysosome associated protein transmembrane 4B (LAPTM4B) have mainly focused on the 35-kDa isoform and its association with poor prognosis in cancers. Here, by employing a novel monoclonal antibody, the authors found that the 24-kDa LAPTM4B isoform predominated in...
?-Hemolysin suppresses osteogenesis by inducing lipid rafts accumulation in bone marrow stromal cells.
Liu, et al.
Food And Chemical Toxicology, 145, 111689-111689 (2020)
C J Cambier et al.
eLife, 9 (2020-11-24)
Several virulence lipids populate the outer cell wall of pathogenic mycobacteria. Phthiocerol dimycocerosate (PDIM), one of the most abundant outer membrane lipids, plays important roles in both defending against host antimicrobial programs and in evading these programs altogether. Immediately following...
Mario Menschikowski et al.
Cancer cell international, 11, 4-4 (2011-02-16)
Increasing evidences show that beyond its role in coagulation, endothelial protein C receptor (EPCR) interferes with carcinogenesis. Pro-carcinogenic effects of EPCR were linked with a raised generation of activated protein C (aPC) and anti-apoptotic signalling. This study was carried out...
Phatcharee Chukaew et al.
Molecular psychiatry (2020-04-25)
While several therapeutic strategies exist for depression, most antidepressant drugs require several weeks before reaching full biochemical efficacy and remission is not achieved in many patients. Therefore, biomarkers for depression and drug-response would help tailor treatment strategies. This study made...
Cholesterol addition protects membrane intactness during cryopreservation of stallion sperm
Oliveira CH de, et al.
Animal Reproduction Science, 118(2-4), 194-200 (2010)
Laurie Hamtiaux et al.
PloS one, 6(10), e26823-e26823 (2011-11-03)
The antitumoral properties of endocannabinoids received a particular attention these last few years. Indeed, these endogenous molecules have been reported to exert cytostatic, apoptotic and antiangiogenic effects in different tumor cell lines and tumor xenografts. Therefore, we investigated the cytotoxicity...
Henri J Huttunen et al.
Journal of molecular neuroscience : MN, 37(1), 6-15 (2008-07-12)
A common pathogenic event that occurs in all forms of Alzheimer's disease is the progressive accumulation of amyloid beta-peptide (Abeta) in brain regions responsible for higher cognitive functions. Inhibition of acyl-coenzyme A: cholesterol acyltransferase (ACAT), which generates intracellular cholesteryl esters...
Shima Hassan Baien et al.
Frontiers in immunology, 9, 1570-1570 (2018-07-28)
Granulocytes play a key role in the defense against invading pathogens. To study granulocyte functions, the isolation of a pure and active cell population from fresh blood is required. Anticoagulants and red blood cells (RBCs) lysis used in the isolation...
Jun Lin et al.
Small (Weinheim an der Bergstrasse, Germany), 12(41), 5759-5768 (2016-11-03)
Many nanomaterials are reported to disrupt lysosomal function and homeostasis, but how cells sense and then respond to nanomaterial-elicited lysosome stress is poorly understood. Nucleus translocation of transcription factor EB (TFEB) plays critical roles in lysosome biogenesis following lysosome stress...
Rui Liu et al.
Autophagy, 10(7), 1241-1255 (2014-06-07)
Glioblastoma is one of the most aggressive human cancers with poor prognosis, and therefore a critical need exists for novel therapeutic strategies for management of glioblastoma patients. Itraconazole, a traditional antifungal drug, has been identified as a novel potential anticancer...
Jyoti Asundi et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(14), 3252-3262 (2015-04-12)
Chemotherapies are limited by a narrow therapeutic index resulting in suboptimal exposure of the tumor to the drug and acquired tumor resistance. One approach to overcome this is through antibody-drug conjugates (ADC) that facilitate greater potency via target-specific delivery of...
Ecancermedicalscience, 60(3), 187-193 (2008)
Nicole Steffensen et al.
International journal of molecular sciences, 22(14) (2021-07-25)
Methylprednisolone is a glucocorticoid and can negatively influence immune defense mechanisms. During bacterial infections in the dog, neutrophils infiltrate infected tissue and mediate antimicrobial effects with different mechanisms such as phagocytosis and neutrophil extracellular trap (NET) formation. Here, we investigated...
Rik van der Kant et al.
Cell stem cell, 24(3), 363-375 (2019-01-29)
Genetic, epidemiologic, and biochemical evidence suggests that predisposition to Alzheimer's disease (AD) may arise from altered cholesterol metabolism, although the molecular pathways that may link cholesterol to AD phenotypes are only partially understood. Here, we perform a phenotypic screen for...
Takashi Kimitsuki
Auris, nasus, larynx, 44(1), 46-51 (2016-05-24)
There is a correlation between serum hyperlipidemia and hearing loss. Cholesterol is an integral component of the cell membrane and regulates the activity of ion channels in the lipid bilayer. The aim of this study was to investigate the effects...
Redox Cell Biology and Genetics, Part 2
Methods in Enzymology, 60(3), 187-193 (2002)
Pietro Ridone et al.
The Journal of general physiology, 152(8) (2020-06-26)
The human mechanosensitive ion channel PIEZO1 is gated by membrane tension and regulates essential biological processes such as vascular development and erythrocyte volume homeostasis. Currently, little is known about PIEZO1 plasma membrane localization and organization. Using a PIEZO1-GFP fusion protein...
Ailian Du et al.
Autophagy, 13(11), 1981-1994 (2017-09-22)
Myasthenia gravis is an autoimmune disorder of the neuromuscular junction manifested as fatigable muscle weakness, which is typically caused by pathogenic autoantibodies against postsynaptic CHRN/AChR (cholinergic receptor nicotinic) in the endplate of skeletal muscle. Our previous studies have identified CA3...
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