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D0260
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Palabra clave:'D0260'
Mostrando 1-30 of 115 resultados para "D0260" en el plazo de Papeles
Stephanie Dooves et al.
Cells, 10(1) (2021-01-16)
Tuberous sclerosis complex (TSC) is a genetic disease affecting the brain. Neurological symptoms like epilepsy and neurodevelopmental issues cause a significant burden on patients. Both neurons and glial cells are affected by TSC mutations. Previous studies have shown changes in
Mikihiro Yoshie et al.
International journal of molecular sciences, 22(19) (2021-10-14)
Previous in vitro studies have suggested that calreticulin (CALR), which is responsible for the folding and quality control of glycoproteins, may be associated with decidualization. However, its precise role in regulating decidualization has not been explored in vivo. Here, we
Lindsey M Williams et al.
Fluids and barriers of the CNS, 19(1), 10-10 (2022-02-07)
Human induced pluripotent stem cell (hiPSC)-derived brain endothelial-like cells (iBECs) are a robust, scalable, and translatable model of the human blood-brain barrier (BBB). Prior works have shown that high transendothelial electrical resistance (TEER) persists in iBECs for at least 2 weeks
Feline W Lindhout et al.
eLife, 9 (2020-09-18)
The differentiation of neuronal stem cells into polarized neurons is a well-coordinated process which has mostly been studied in classical non-human model systems, but to what extent these findings are recapitulated in human neurons remains unclear. To study neuronal polarization
Sara Fukushima et al.
iScience, 24(7), 102778-102778 (2021-07-20)
Emerging evidence has shown that amino acids act as metabolic regulatory signals. Here, we showed that glucose-6-phosphatase (G6Pase) mRNA levels in cultured hepatocyte models were downregulated in an amino-acid-depleted medium. Inversely, stimulation with amino acids increased G6Pase mRNA levels, demonstrating
De-Yi Liu et al.
Fertility and sterility, 99(1), 86-91 (2012-09-19)
To determine association between defective protein kinases C (PKC) and A (PKA) and disordered zona pellucida (ZP)-induced acrosome reaction (DZPIAR) in normozoospermic infertile men with normal sperm-ZP binding. Sperm from DZPIAR infertile men were treated without (control) or with (test)
Yilin Ren et al.
Hypertension (Dallas, Tex. : 1979), 59(6), 1139-1144 (2012-04-18)
Carbon monoxide (CO) is a physiological messenger with diverse functions in the kidney, including controlling afferent arteriole tone both directly and via tubuloglomerular feedback (TGF). We have reported that CO attenuates TGF, but the mechanisms underlying this effect remain unknown.
Homa Majd et al.
Cell stem cell, 30(5), 632-647 (2023-05-06)
Schwann cells (SCs) are the primary glia of the peripheral nervous system. SCs are involved in many debilitating disorders, including diabetic peripheral neuropathy (DPN). Here, we present a strategy for deriving SCs from human pluripotent stem cells (hPSCs) that enables
[Cellular and molecular mechanisms in drug-induced nephrotoxicity and its prevention].
Takahisa Yano
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 142(4), 172-177 (2013-10-11)
Yulia Gryaznova et al.
The EMBO journal, 40(7), e106797-e106797 (2021-03-02)
Partitioning of the genome in meiosis occurs through two highly specialized cell divisions, named meiosis I and meiosis II. Step-wise cohesin removal is required for chromosome segregation in meiosis I, and sister chromatid segregation in meiosis II. In meiosis I
Lilianne Barbar et al.
STAR protocols, 1(3), 100172-100172 (2020-12-31)
Given the critical roles of astrocytes in neuroinflammation and neurological diseases, models for studying human astrocyte biology are in increasing demand. Here, we present a protocol to isolate human astrocytes from induced pluripotent stem cell (iPSC)-based cultures, neural organoids, and
Reza Nadafi et al.
Cell reports, 30(12), 4110-4123 (2020-03-27)
Within lymph nodes (LNs), T follicular helper (TFH) cells help B cells to produce antibodies, which can either be protective or autoreactive. Here, we demonstrate that murine LN stromal cells (LNSCs) suppress the formation of autoreactive TFH cells in an
Zachary T Olmsted et al.
iScience, 24(8), 102827-102827 (2021-08-13)
To repair neural circuitry following spinal cord injury (SCI), neural stem cell (NSC) transplantation has held a primary focus; however, stochastic outcomes generate challenges driven in part by NSC differentiation and tumor formation. The recent ability to generate regionally specific
Alba Sabaté-Pérez et al.
Autophagy, 19(3), 904-925 (2022-08-11)
Brown adipose tissue (BAT) thermogenesis affects energy balance, and thereby it has the potential to induce weight loss and to prevent obesity. Here, we document a macroautophagic/autophagic-dependent mechanism of peroxisome proliferator-activated receptor gamma (PPARG) activity regulation that induces brown adipose
Marian Hruska-Plochan et al.
Nature, 626(8001), 1073-1083 (2024-02-15)
Human cellular models of neurodegeneration require reproducibility and longevity, which is necessary for simulating age-dependent diseases. Such systems are particularly needed for TDP-43 proteinopathies1, which involve human-specific mechanisms2-5 that cannot be directly studied in animal models. Here, to explore the
Laura Fernández et al.
American journal of reproductive immunology (New York, N.Y. : 1989), 87(1), e13423-e13423 (2021-03-26)
Decidualized cells display an active role during embryo implantation sensing blastocyst quality, allowing the implantation of normal developed blastocysts and preventing the invasion of impaired developed ones. Here, we characterized the immune microenvironment generated by decidualized cells in response to
Allison Knupp et al.
Cell reports, 31(9), 107719-107719 (2020-06-04)
SORL1/SORLA is a sorting receptor involved in retromer-related endosomal traffic and an Alzheimer's disease (AD) risk gene. Using CRISPR-Cas9, we deplete SORL1 in hiPSCs to ask if loss of SORL1 contributes to AD pathogenesis by endosome dysfunction. SORL1-deficient hiPSC neurons
Lifeng Wang et al.
Cell, 183(3), 684-701 (2020-10-16)
Positive selection in Europeans at the 2q21.3 locus harboring the lactase gene has been attributed to selection for the ability of adults to digest milk to survive famine in ancient times. However, the 2q21.3 locus is also associated with obesity
Kuan-Min Fang et al.
Journal of cellular biochemistry, 113(9), 3019-3028 (2012-05-09)
Astrocytes, the major glial population in the central nervous system (CNS), play an important role in neuronal homeostasis, neurogenesis, and synaptogenesis. The cells have a stellate shape with elaborated processes in the developing CNS. Cultured astrocytes become stellate when the
Nathan A Sallee et al.
SLAS discovery : advancing life sciences R & D, 25(9), 1047-1063 (2020-07-28)
The identification of novel peptide hormones by functional screening is challenging because posttranslational processing is frequently required to generate biologically active hormones from inactive precursors. We developed an approach for functional screening of novel potential hormones by expressing them in
Elizabeth Palmer et al.
Molecular immunology, 52(2), 88-95 (2012-05-23)
The C5a receptor (C5aR) is a 7 transmembrane G-protein coupled receptor (GPCR) that mediates the powerful pro-inflammatory effect of the complement activation product C5a. Excess C5a generated under pathological conditions has been implicated in a variety of conditions including sepsis
Laura Menendez et al.
Nature protocols, 8(1), 203-212 (2013-01-05)
Multipotent neural crest stem cells (NCSCs) have the potential to generate a wide range of cell types including melanocytes; peripheral neurons; and smooth muscle, bone, cartilage and fat cells. This protocol describes in detail how to perform a highly efficient
Chang-Ki Oh et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 42(14), 3011-3024 (2022-02-17)
Dysregulation of autophagic pathways leads to accumulation of abnormal proteins and damaged organelles in many neurodegenerative disorders, including Parkinson's disease (PD) and Lewy body dementia (LBD). Autophagy-related dysfunction may also trigger secretion and spread of misfolded proteins, such as α-synuclein
Jason T K Hwang et al.
Stem cells and development, 21(17), 3220-3232 (2012-05-23)
One of the earliest epithelial-to-mesenchymal transitions in mouse embryogenesis involves the differentiation of inner cell mass cells into primitive and then into parietal endoderm. These processes can be recapitulated in vitro using F9 teratocarcinoma cells, which differentiate into primitive endoderm
Molecular and Functional Characterization of Different BrainSphere Models for Use in Neurotoxicity Testing on Microelectrode Arrays.
Hartmann, et al.
Cells, 12 (2023)
Katsuro Iwase et al.
Journal of neurochemistry, 128(2), 233-245 (2013-10-12)
Cooperative gene regulation by different neurotransmitters likely underlies the long-term forms of associative learning and memory, but this mechanism largely remains to be elucidated. Following cDNA microarray analysis for genes regulated by Ca(2+) or cAMP, we found that the secretogranin
SARS-CoV-2 Enters Human Leydig Cells and Affects Testosterone Production In Vitro.
Li, et al.
Cells, 12 (2023)
T Valero et al.
Neurochemistry international, 61(8), 1333-1343 (2012-10-02)
Reactive oxygen species (ROS) have been widely considered as harmful for cell development and as promoters of cell aging by increasing oxidative stress. However, ROS have an important role in cell signaling and they have been demonstrated to be beneficial
Jae-Wook Lee et al.
Anticancer research, 34(7), 3447-3455 (2014-07-02)
Cyclic AMP (cAMP) activates both protein kinase A (PKA) and guanine-nucleotide exchange factor exchange protein directly activated by CAMP (EPAC)-mediated Ras-related Protein1 (RAP1) GTPase that regulates various cellular functions including cell migration. Herein, we investigated whether cAMP-mediated PKA and EPAC1/RAP1
Gabsang Lee et al.
Nature protocols, 5(4), 688-701 (2010-04-03)
Human pluripotent stem cell (hPSC)-derived neural crest (NC) cells present a valuable tool for modeling aspects of human NC development, including cell fate specification, multipotency and cell migration. hPSC-derived NC cells are also suitable for modeling human disease and as
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