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Anne Müller et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(39), 13723-13731 (2015-08-08)
Azobenzene linker molecules can be utilized to control peptide/protein function when they are ligated to appropriately spaced amino acid side chains of the peptide. This is because the photochemical E/Z isomerization of the azobenzene N=N double bond allows to switch
Ling Cen et al.
BMC cancer, 9, 99-99 (2009-04-01)
Colorectal carcinoma is one of the major causes of morbidity and mortality in the Western World. Novel therapeutic approaches are needed for colorectal carcinoma. Curcumin, the active component and yellow pigment of turmeric, has been reported to have several anti-cancer
Mannar R Maurya et al.
Journal of inorganic biochemistry, 147, 181-192 (2015-03-10)
The polymer-supported oxidovanadium(IV) complex PS-[V(IV)O(sal-dahp)] (2) (PS=chloromethylated polystyrene crosslinked with 5% divinylbenzene, and H3sal-dahp=dibasic pentadentate ligand derived from salicylaldehyde and 1,3-diamino-2-hydroxypropane) was prepared from the corresponding monomeric oxidovanadium(IV) complex [V(IV)O(Hsal-dahp)(DMSO)] (1), characterized and successfully used as catalyst for the peroxidase-like
Gabriella Klausz et al.
Biomedical chromatography : BMC, 29(12), 1859-1865 (2015-06-25)
A liquid chromatography-electrospray-mass spectrometry method (LC/MS) has been developed and validated for determination of praziquantel (PZQ), pyrantel (PYR), febantel (FBT), and the active metabolites fenbendazole (FEN) and oxfendazole (OXF), in dog plasma, using mebendazole as internal standard (IS). The method
Anni Sorkio et al.
Tissue engineering. Part A, 21(17-18), 2301-2314 (2015-05-07)
Human embryonic stem cell-derived retinal pigment epithelial (hESC-RPE) cells are currently undergoing clinical trials to treat retinal degenerative diseases. Transplantation of hESC-RPE cells in conjuction with a supportive biomaterial carrier holds great potential as a future treatment for retinal degeneration.
Diana Guzman-Villanueva et al.
International journal of pharmaceutics, 473(1-2), 579-590 (2014-07-27)
The RNA interference (RNAi) constitutes a conservative mechanism in eukaryotic cells that induces silencing of target genes. In mammalians, the RNAi is triggered by siRNA (small interfering RNA) molecules. Due to its potential in silencing specific genes, the siRNA has
Ciric To et al.
Carcinogenesis, 36(7), 769-781 (2015-05-06)
Lung cancer accounts for the highest number of cancer-related deaths in the USA, highlighting the need for better prevention and therapy. Activation of the Nrf2 pathway detoxifies harmful insults and reduces oxidative stress, thus preventing carcinogenesis in various preclinical models.
Takaki Yamauchi et al.
Plant physiology, 169(1), 180-193 (2015-06-04)
In rice (Oryza sativa) roots, lysigenous aerenchyma, which is created by programmed cell death and lysis of cortical cells, is constitutively formed under aerobic conditions, and its formation is further induced under oxygen-deficient conditions. Ethylene is involved in the induction
Xiaoqin Xiong et al.
Scientific reports, 5, 9254-9254 (2015-03-26)
A flexible membrane consisting of MoS2/carbon nanofibers has been fabricated by a simple electrospinning method. MoS2 nanosheets are uniformly encapsulated in the inter-connected carbon nanofibers with diameters of ~150 nm. When evaluated as a binder-free electrode for sodium-ion batteries, the as-obtained
Chengyun Wang et al.
Experimental eye research, 129, 74-82 (2014-12-03)
Dexamethasone is a glucocorticoid that is widely used in the ophthalmic arena. The recent FDA approved dexamethasone implant can provide a three month efficacy but with high rate of drug related cataract and high intraocular pressure (IOP). It seems that
Gengzhi Sun et al.
Angewandte Chemie (International ed. in English), 54(15), 4651-4656 (2015-02-20)
One of challenges existing in fiber-based supercapacitors is how to achieve high energy density without compromising their rate stability. Owing to their unique physical, electronic, and electrochemical properties, two-dimensional (2D) nanomaterials, e.g., molybdenum disulfide (MoS2 ) and graphene, have attracted
Vikas Duhan et al.
Frontiers in immunology, 11, 607889-607889 (2021-02-16)
Early and strong production of IFN-I by dendritic cells is important to control vesicular stomatitis virus (VSV), however mechanisms which explain this cell-type specific innate immune activation remain to be defined. Here, using a genome wide association study (GWAS), we
Yongguang Tu et al.
Nanoscale, 7(48), 20539-20546 (2015-11-21)
A compact TiO(2) layer is crucial to achieve high-efficiency perovskite solar cells. In this study, we developed a facile, low-cost and efficient method to fabricate a pinhole-free and ultrathin blocking layer based on highly crystallized TiO(2) quantum dots (QDs) with
Hamed Gilzad Kohan et al.
PloS one, 10(5), e0126786-e0126786 (2015-05-16)
The aim of this study was to synthesize a peptide prodrug of glucosamine (GlcN) with increased gut permeability through the gut peptide transporter 1 (PepT1). Glycine-Valine ester derivative of GlcN (GVG) was synthesised using solid phase synthesis followed by characterization
Li Lin et al.
Cancer science, 100(9), 1719-1727 (2009-06-30)
Curcumin, the active component of turmeric, has been shown to protect against carcinogenesis and prevent tumor development in cancer. To enhance its potency, we tested the efficacy of synthetic curcumin analogues, known as FLLL11 and FLLL12, in cancer cells. We
Yang Li et al.
Macromolecular bioscience, 15(1), 52-62 (2014-12-06)
To address the downside of conventional photo-patterning which can alter the chemical composition of protein scaffolds, we developed a non-covalent photo-patterning strategy for gelatin (denatured collagen) hydrogels that utilizes UV activated triple helical hybridization of caged collagen mimetic peptide (caged
Neal T Sweeney et al.
Developmental neurobiology, 75(6), 584-593 (2015-02-05)
In the retinocollicular projection, the axons from functionally distinct retinal ganglion cell (RGC) types form synapses in a stereotypical manner along the superficial to deep axis of the superior colliculus (SC). Each lamina contains an orderly topographic map of the
Nidhi Bhargava et al.
Infection and immunity, 82(8), 3417-3425 (2014-06-04)
Acinetobacter baumannii and Pseudomonas aeruginosa are nosocomial pathogens with overlapping sites of infection. This work reports that the two can coexist stably in mixed-culture biofilms. In a study intended to improve our understanding of the mechanism of their coexistence, it
Stefano Casalini et al.
ACS nano, 9(5), 5051-5062 (2015-04-15)
Antibody-antigen (Ab-Ag) recognition is the primary event at the basis of many biosensing platforms. In label-free biosensors, these events occurring at solid-liquid interfaces are complex and often difficult to control technologically across the smallest length scales down to the molecular
Cristina Dumitriu et al.
Materials science & engineering. C, Materials for biological applications, 45, 56-63 (2014-12-11)
Various TiO2 nanofibers on Ti surface have been fabricated via electrospinning and calcination. Due to different elaboration conditions the electrospun fibers have different surface feature morphologies, characterized by scanning electronic microscopy, surface roughness, and contact angle measurements. The results have
Chiara Testa et al.
Journal of medicinal chemistry, 57(22), 9424-9434 (2014-10-28)
Side chain-to-side chain cyclizations represent a strategy to select a family of bioactive conformations by reducing the entropy and enhancing the stabilization of functional ligand-induced receptor conformations. This structural manipulation contributes to increased target specificity, enhanced biological potency, improved pharmacokinetic
Liang Chen et al.
Autophagy, 11(12), 2233-2246 (2015-11-14)
Autophagy involves massive degradation of intracellular components and functions as a conserved system that helps cells to adapt to adverse conditions. In mammals, hypoxia rapidly stimulates autophagy as a cell survival response. Here, we examine the function of autophagy in
Hyun Jin Kim et al.
Drug delivery and translational research, 4(1), 50-60 (2015-03-20)
For systemic small interfering RNA (siRNA) delivery to tumor mass, a multifunctional polyion complex micelle was constructed with a block copolymer bearing a targeting ligand and a micelle-stabilizing moiety as well as an endosome-disrupting cationic unit. The block copolymer was
Alessandro Bertucci et al.
Biosensors & bioelectronics, 63, 248-254 (2014-08-12)
Microstructured optical fibers containing microchannels and Bragg grating inscribed were internally functionalized with a peptide nucleic acid (PNA) probe specific for a gene tract of the genetically modified Roundup Ready soy. These fibers were used as an optofluidic device for
Thaqif El Khassawna et al.
Histochemistry and cell biology, 144(5), 491-507 (2015-07-27)
Bone loss is a symptom related to disease and age, which reflects on bone cells and ECM. Discrepant regulation affects cell proliferation and ECM localization. Rat model of osteoporosis (OVX) was investigated against control rats (Sham) at young and old
Sabyasachi Maiti et al.
International journal of biological macromolecules, 70, 37-43 (2014-06-24)
Herein, C16 alkyl chain-grafted-xanthan copolymer was synthesized and characterized. The copolymer self-assembled into nanometer-size spherical micellar structures in water and incorporated ∼100% glibenclamide into its deeper lipophilic confines. The micellar dispersion exhibited negative zeta potential value (-27.6 mV). The copolymer
Slavko Klobčar et al.
Biomedical chromatography : BMC, 29(12), 1901-1906 (2015-05-27)
The isolation of four oxidative degradation products of atorvastatin using preparative high-performance liquid chromatography applying at least two chromatographic steps is known from the literature. In this paper it is shown that the same four impurities could be isolated from
Abeba Demelash et al.
The Journal of biological chemistry, 290(36), 21962-21975 (2015-07-25)
Unlike other antiapoptotic Bcl-2 family members, Mcl-1 also mediates resistance to cancer therapy by uniquely inhibiting chemotherapy-induced senescence (CIS). In general, Bcl-2 family members regulate apoptosis at the level of the mitochondria through a common prosurvival binding groove. Through mutagenesis
Ye Li et al.
Biochemical and biophysical research communications, 454(2), 257-261 (2014-10-12)
Degradation of collagen type II caused by pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) is one of the major pathological characteristics of osteoarthritis (OA). Dimethyl fumarate (DMF) is a medication approved by the US Food and Drug Administration
Liz O'Donovan et al.
Nucleic acid therapeutics, 25(1), 1-10 (2014-11-21)
We describe two new methods of parallel chemical synthesis of libraries of peptide conjugates of phosphorodiamidate morpholino oligonucleotide (PMO) cargoes on a scale suitable for cell screening prior to in vivo analysis for therapeutic development. The methods represent an extension
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