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Yongzhang Liu et al.
Oncotarget, 5(22), 11209-11224 (2014-12-20)
ATP-dependent Lon protease within mitochondrial matrix contributes to the degradation of abnormal proteins. The oxidative or hypoxic stress which represents the stress phenotype of cancer leads to up-regulation of Lon. However, the role of Lon in bladder cancer remains undefined.
Felix Grases et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(4), 475-482 (2014-12-11)
Calcific tendinopathy of the tendons of the rotator cuff is common in adults. These calcifications tend to be reabsorbed after a period of acute pain. This study evaluated the morphologic characteristics of calcific deposits and the participation of phytate and
Jun Jiang et al.
Molecules (Basel, Switzerland), 19(11), 18690-18704 (2014-11-19)
Central-icaritin (CIT) is a flavonoid aglycone first discovered in our laboratory, which is an isomeric aglycone of icaritin (IT). We wanted to know whether CIT also had anti-osteoporosis activity. In this study, CIT was investigated in an ovariectomized rat (OVX)
Bing Wang et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(5), 781-793 (2015-01-08)
The consequences of therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy are poorly understood. Adverse effects from suboptimal rewarming could diminish neuroprotection from hypothermia. Therefore, we tested whether rewarming is associated with apoptosis. Piglets underwent hypoxia-asphyxia followed by normothermic or hypothermic recovery
J Megan Gray et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(9), 3879-3892 (2015-03-06)
Corticotropin-releasing hormone (CRH) is a central integrator in the brain of endocrine and behavioral stress responses, whereas activation of the endocannabinoid CB1 receptor suppresses these responses. Although these systems regulate overlapping functions, few studies have investigated whether these systems interact.
Keya De Mukhopadhyay et al.
PloS one, 10(4), e0121136-e0121136 (2015-04-04)
In postmenopausal women, local estrogen produced by adipose stromal cells in the breast is believed to support estrogen receptor alpha (ERα) positive breast cancer cell survival and growth. This raises the question of how the ERα positive metastatic breast cancer
Irit Gil-Ad et al.
Journal of molecular neuroscience : MN, 55(2), 552-560 (2014-07-30)
Laquinimod is a novel oral immunomodulatory drug for the treatment of multiple sclerosis (MS). Considering the frequent co-morbidity of MS with anxiety and depression, we sought to assess the antidepressant and anxiolytic effects of laquinimod in mouse models. Laquinimod (0.5-25
Sergi Torres-Puig et al.
Nucleic acids research, 43(10), 4923-4936 (2015-05-01)
The Mycoplasma genitalium MG428 protein shows homology to members of the sigma-70 family of sigma factors. Herein, we found that MG428 activates transcription of recA, ruvA and ruvB as well as several genes with unknown function. Deletion of MG_428 or
Timothy L Turner et al.
Applied microbiology and biotechnology, 99(19), 8023-8033 (2015-06-06)
Production of lactic acid from renewable sugars has received growing attention as lactic acid can be used for making renewable and bio-based plastics. However, most prior studies have focused on production of lactic acid from glucose despite that cellulosic hydrolysates
Ning Zhang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 69, 306-310 (2015-02-11)
Thyroid cancers are the most common malignant tumors of the endocrine system. The survival-promoting role of autophagy in tumor cells has been received universally. This study aimed to explore autophagy-related protein light chain 3 (LC3)-II expression levels in thyroid diseases
Bo Wang et al.
Parasites & vectors, 8, 424-424 (2015-08-19)
Fruit flies and mammals protect themselves against infection by mounting immune and metabolic responses that must be balanced against the metabolic needs of the pathogens. In this context, p38 mitogen-activated protein kinase (MAPK)-dependent signaling is critical to regulating both innate
Aaron B Sullivan et al.
Infection and immunity, 83(4), 1629-1640 (2015-02-11)
Pseudomonas aeruginosa is invasive or cytotoxic to host cells, depending on the type III secretion system (T3SS) effectors encoded. While the T3SS is known to be involved in disease in vivo, how it participates remains to be clarified. Here, mouse
Shou-Sheng Liu et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 68(8), 1031-1036 (2014-10-15)
The aim of this study was to investigate the antitumor effect of zoledronic acid (ZOL) in the NB4 human acute promyelocytic leukemia (APL) cell line and explore the potential mechanism of action of this compound. NB4 cells were exposed to
Kang Gao et al.
Scandinavian cardiovascular journal : SCJ, 49(5), 264-269 (2015-07-15)
Overwhelming evidence shows that dietary supplementation with n-3 polyunsaturated fatty acids (PUFAs) elicits protective effects on patients with cardiovascular disease. However, the detailed mechanisms underlying n-3 PUFA-mediated cardioprotection are unknown, and examined in the present study. We evaluated heart performances
Madoka Ikemoto-Uezumi et al.
Stem cells (Dayton, Ohio), 33(8), 2456-2468 (2015-04-29)
Sarcopenia, age-related muscle weakness, increases the frequency of falls and fractures in elderly people, which can trigger severe muscle injury. Rapid and successful recovery from muscle injury is essential not to cause further frailty and loss of independence. In fact
Dongfeng Qu et al.
PloS one, 10(8), e0134212-e0134212 (2015-08-19)
Doublecortin-like kinase 1 (Dclk1), a microtubule-associated kinase, marks the fifth lineage of intestinal epithelial cells called tuft cells that function as tumor stem cells in Apc mutant models of colon cancer. In order to determine the role of Dclk1 in
Daisuke Asanuma et al.
Nature communications, 6, 6463-6463 (2015-03-15)
Fluorescence-guided diagnostics is one of the most promising approaches for facile detection of cancer in situ. Here we focus on β-galactosidase, which is overexpressed in primary ovarian cancers, as a molecular target for visualizing peritoneal metastases from ovarian cancers. As
Márton Pipicz et al.
British journal of pharmacology, 172(14), 3472-3483 (2015-04-02)
Rapid ventricular pacing (RVP) applied before an index ischaemia has anti-ischaemic effects. Here, we investigated whether RVP applied after index ischaemia attenuates reperfusion injury and whether peroxynitrite, reperfusion injury salvage kinase (RISK) and survival activating factor enhancement (SAFE) pathways as
Wen Yue et al.
Oncotarget, 6(25), 21208-21224 (2015-06-10)
Metformin and aspirin have been studied extensively as cancer preventive or therapeutic agents. However, the effects of their combination on pancreatic cancer cells have not been investigated. Herein, we evaluated the effects of metformin and aspirin, alone or in combination
Xiaoli Wang et al.
Atherosclerosis, 239(2), 552-556 (2015-03-04)
To perform clinical and genetic analysis of a family with familial hypobetalipoproteinemia in which the proband had been diagnosed with diabetes mellitus. Direct sequencing was performed on candidate genes such as APOB, PCSK9, and ANGPTL3. The effect of the mutant
Bingyang Chen et al.
Neurochemical research, 40(3), 531-541 (2014-12-17)
(E)-2-(1-hydroxyl-4-oxocyclohexyl) ethyl caffeine (HOEC), a naturally caffeic ester isolated from Incarvillea mairei, has been reported to possess anti-inflammatory activity by targeting 5-lipoxygenase. However, its other potential activities have yet to be explored. In this study, we measured antioxidant activity of
Virender Kumar et al.
Molecular pharmaceutics, 12(4), 1289-1298 (2015-02-14)
Successful treatment of pancreatic ductal adenocarcinoma (PDAC) remains a challenge due to the desmoplastic microenvironment that promotes both tumor growth and metastasis and forms a barrier to chemotherapy. Hedgehog (Hh) signaling is implicated in initiation and progression of PDAC and
E Stragier et al.
Molecular psychiatry, 20(3), 405-412 (2014-04-30)
High ethanol intake is well known to induce both anxiolytic and anxiogenic effects, in correlation with chromatin remodeling in the amygdaloid brain region and deficits in cell proliferation and survival in the hippocampus of rodents. Whether only moderate but chronic
Dorottya Kalapis et al.
PLoS biology, 13(11), e1002291-e1002291 (2015-11-07)
Translational errors occur at high rates, and they influence organism viability and the onset of genetic diseases. To investigate how organisms mitigate the deleterious effects of protein synthesis errors during evolution, a mutant yeast strain was engineered to translate a
Nathalie Vigneron et al.
Analytical biochemistry, 482, 7-15 (2015-04-29)
Because of its crucial role in various cellular processes, the proteasome is the focus of intensive research for the development of proteasome inhibitors to treat cancer and autoimmune diseases. Here, we describe a new and easy assay to measure the
Yi Guan et al.
Fungal genetics and biology : FG & B, 82, 85-94 (2015-07-15)
Two Ras ATPases (Ras1 and Ras2) are well known to regulate antagonistically or cooperatively various cellular events in many fungi. Here we show the significance of a novel Ras homolog (Ras3) for Beauveria bassiana. Ras3 possesses five domains and two
Yong-Xi Chen et al.
PloS one, 9(11), e112936-e112936 (2014-11-19)
Renal fibrosis is the final common pathway of chronic kidney disease (CKD). Moesin is a member of Ezrin/Radixin/Moesin (ERM) protein family but its role in renal fibrosis is not clear. Human proximal tubular cells (HK-2) were stimulated with or without
Bo Pan et al.
Scientific reports, 5, 16053-16053 (2015-11-04)
The presence of IL-17-positive cells is observed in a variety of inflammatory associated cancers and IL-17 has been found to be involved in angiogenesis. However, it remains unclear how IL-17 might contribute to tumor angiogenesis. In our study, IL-17 enhanced
Courtney E Cross et al.
BioMed research international, 2015, 257090-257090 (2015-09-05)
The relationship between oxidative stress and miRNA changes in placenta as a potential mechanism involved in preeclampsia (PE) is not fully elucidated. We investigated the impact of oxidative stress on miRNAs and mRNA expression profiles of genes associated with PE
Wenwen Wang et al.
Experimental gerontology, 70, 61-70 (2015-07-15)
Endoplasmic reticulum (ER) stress triggers the unfolded protein response (UPR) to prevent the accumulation of proteins in an aberrant conformation. The UPR can restore homeostasis by upregulating ER chaperones, such as glucose-regulated protein 78kD (GRP78), to refold the incorrectly handled
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