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Yuri Mizuno et al.
Oxidative medicine and cellular longevity, 2021, 8635088-8635088 (2022-01-01)
Oxidative stress is a major risk factor for Alzheimer's disease (AD), which is characterized by brain atrophy, amyloid plaques, neurofibrillary tangles, and loss of neurons. 8-Oxoguanine, a major oxidatively generated nucleobase highly accumulated in the AD brain, is known to
Simon Kaja et al.
Experimental eye research, 138, 159-166 (2015-06-07)
Optic nerve head astrocytes (ONHAs) are the major glia cell type in the non-myelinated optic nerve head where they contribute critically to extracellular matrix synthesis during development and throughout life. In glaucoma, and in related disorders affecting the optic nerve
Hideki Kondo et al.
Journal of virology, 87(13), 7423-7434 (2013-04-26)
Orchid fleck virus (OFV) has a unique two-segmented negative-sense RNA genome that resembles that of plant nucleorhabdoviruses. In infected plant cells, OFV and nucleorhabdoviruses induce an intranuclear electron-lucent viroplasm that is believed to be the site for virus replication. In
Takuya Osakada et al.
Nature communications, 13(1), 556-556 (2022-02-05)
The vomeronasal system plays an essential role in sensing various environmental chemical cues. Here we show that mice exposed to blood and, consequently, hemoglobin results in the activation of vomeronasal sensory neurons expressing a specific vomeronasal G protein-coupled receptor, Vmn2r88
Xing Tian et al.
Cellular and molecular neurobiology, 35(3), 335-344 (2014-10-30)
Accumulated evidence has shown that excessive reactive oxygen species (ROS) have been implicated in neuronal cell death related with various chronic neurodegenerative disorders. This study was designed to explore neuroprotective effects of ethyl acetate extract of Arctium lappa L. roots
María M Milesi et al.
Molecular and cellular endocrinology, 401, 248-259 (2014-12-09)
We investigated whether neonatal exposure to low doses of endosulfan affects fertility and uterine functional differentiation at pre-implantation in rats. Newborn female rats received the vehicle, 0.2 µg/kg/d of diethylstilbestrol (DES), 6 µg/kg/d of endosulfan (Endo6) or 600 µg/kg/d of endosulfan (Endo600) on
Barbara Oldrini et al.
Nature communications, 11(1), 3883-3883 (2020-08-06)
Temozolomide (TMZ) is an oral alkylating agent used for the treatment of glioblastoma and is now becoming a chemotherapeutic option in patients diagnosed with high-risk low-grade gliomas. The O-6-methylguanine-DNA methyltransferase (MGMT) is responsible for the direct repair of the main
Huifang Zhou et al.
Biomaterials, 35(26), 7398-7406 (2014-06-17)
The main functions of the conjunctiva, an essential part of the ocular surface, are to maintain the equilibrium of the tear film and to protect the eye. Upon injuries, the prerequisite to successful ocular surface repair is conjunctival reconstruction. Tissue
Anneleen Steels et al.
mAbs, 10(7), 1045-1059 (2018-08-17)
The tumor suppressor p53 is of crucial importance in the prevention of cellular transformation. In the presence of cellular stress signals, the negative feedback loop between p53 and Mdm2, its main negative regulator, is disrupted, which results in the activation
Elham Hoveizi et al.
Journal of biomedical materials research. Part A, 102(11), 4027-4036 (2013-11-28)
Human-induced pluripotent stem cells (hiPSCs) are considered to be potentially able to differentiate into all human cell lineages and thus hold promise as an unlimited source for cell replacement therapies in clinical applications. Definitive endoderm (DE) formation is the first
Xudong Sun et al.
Journal of dairy science, 103(9), 8388-8397 (2020-07-06)
Exogenous molecules derived from catabolic states (e.g., fatty acids, β-hydroxybutyrate) during periods of stress such as the periparturient period or pathogen challenges [e.g., lipopolysaccharide (LPS)] can trigger an inflammatory response in tissues such as the liver and the mammary gland.
Ela Elyada et al.
Cancer discovery, 9(8), 1102-1123 (2019-06-15)
Cancer-associated fibroblasts (CAF) are major players in the progression and drug resistance of pancreatic ductal adenocarcinoma (PDAC). CAFs constitute a diverse cell population consisting of several recently described subtypes, although the extent of CAF heterogeneity has remained undefined. Here we
Wiktor A Janczewski et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(13), 5454-5465 (2013-03-29)
Postsynaptic inhibition is a key element of neural circuits underlying behavior, with 20-50% of all mammalian (nongranule) neurons considered inhibitory. For rhythmic movements in mammals, e.g., walking, swimming, suckling, chewing, and breathing, inhibition is often hypothesized to play an essential
Xiangxun Chen et al.
Drug design, development and therapy, 15, 171-183 (2021-01-21)
Sodium cantharidinate (SC) has been broadly applied in lung cancer treatment in China, while its specific function in cervical cancer (CC), a great contributor to death of female reproductive system cancers, remains unclear. Our research evaluated the anti-tumor effects of
Yang Li et al.
Cancer letters, 355(1), 130-140 (2014-09-15)
Epithelial-to-mesenchymal transition (EMT) is considered to play an essential role in progression and metastasis. This study aims to investigate the expression and underlying molecular targets of high-mobility group AT-hook 2 (HMGA2) in the progression of colon cancer. The expression of
Kevin C Allan et al.
Cell stem cell, 28(2), 257-272 (2020-10-23)
Mammalian cells respond to insufficient oxygen through transcriptional regulators called hypoxia-inducible factors (HIFs). Although transiently protective, prolonged HIF activity drives distinct pathological responses in different tissues. Using a model of chronic HIF1a accumulation in pluripotent-stem-cell-derived oligodendrocyte progenitors (OPCs), we demonstrate
Kohei Sasaki et al.
PloS one, 10(3), e0121205-e0121205 (2015-03-21)
It is generally accepted that live attenuated influenza vaccine (LAIV) has the potential for use as a vaccination against flu. In this study, we demonstrated the nature of an influenza A virus (IAV) mutant induced by treating the IAV with
Clea Bárcena et al.
Methods in molecular biology (Clifton, N.J.), 965, 243-251 (2013-01-09)
Gene mutations that cause defects in the nuclear envelope are responsible for progeroid syndromes, characterized by exacerbated cell senescence and accelerated aging. Consequently, morphological abnormalities of the nucleus represent a cellular phenotype whose analysis allows for both the characterization of
Judith Guasch et al.
Advanced materials (Deerfield Beach, Fla.), 27(25), 3737-3747 (2015-05-20)
Orthogonally functionalized binary micropatterned substrates are produced using a novel protocol. The use of adequate peptido-mimetics enables an unprecedented segregation of purified αvβ3 and α5β1 integrins in adjacent microislands and evidences the preference of U2OS cells to colocalize such receptors.
Somying Patntirapong et al.
Acta histochemica, 121(4), 400-406 (2019-03-11)
Long-term administration of bisphosphonates (BPs) may cause osteonecrosis of the jaw (BRONJ). After administration, 50% of BPs in the circulation rapidly binds to calcium phosphate of bone. Two forms, bound and free BPs, may affect cells residing in bone including
Sirisha M Cheedipudi et al.
The journal of cardiovascular aging, 1(3) (2021-08-28)
Arrhythmogenic cardiomyopathy (ACM) is a genetic disease of the myocardium, characterized by cardiac arrhythmias, dysfunction, and sudden cardiac death. The pathological hallmark of ACM is fibro-adipocytes replacing cardiac myocytes. The canonical WNT pathway is implicated in the pathogenesis of ACM.
Abdelaziz Adam Idriss Arbab et al.
Frontiers in veterinary science, 8, 661380-661380 (2021-07-16)
The objective of this research was to explore the effect of metformin on the lipoteichoic acid (LTA)-induced mastitis model using isolated primary bovine mammary epithelial cells (PBMECs). The PBMECs were exposed to either 3 mM metformin for 12 h as
Zhongfan Liu et al.
Journal of orthopaedic surgery and research, 16(1), 564-564 (2021-09-17)
The tumor necrosis factor-stimulated gene-6 (TSG-6) has been confirmed to inhibit inflammation. It is now generally accepted that local inflammatory stimulation around shoulder capsule causes proliferative fibrosis. This study aims to investigate the mechanism of recombinant TSG-6 protein inhibiting the
Xuejing Yue et al.
Neuropsychiatric disease and treatment, 16, 891-900 (2020-04-21)
IL-12 inhibition of the endothelial cell functions and angiogenesis is mediated by the cross-talk between the lymphocyte and the endothelial cells, which plays a key role in inhibiting the process of angiogenesis in the eyeballs and in malignant tumors. We
Zhi-Qi Song et al.
CNS neuroscience & therapeutics, 20(8), 737-747 (2014-03-19)
Prion diseases are a group of infectious neurodegenerative diseases characterized by neuronal death and degeneration. Human leukocyte antigen-B-associated transcript 3 (BAT3) is an important apoptosis regulator. We therefore investigated the interactions between BAT3 and prion protein and the potential role
Mariia S Bogacheva et al.
Pharmaceuticals (Basel, Switzerland), 14(6) (2021-07-03)
Human induced pluripotent stem cells (hiPSCs) hold great potential as an unlimited source for obtaining hepatocyte-like cells (HLCs) for drug research. However, current applications of HLCs have been severely limited by the inability to produce mature hepatocytes from hiPSCs in
Pao-Huan Chen et al.
International journal of molecular sciences, 22(2) (2021-01-21)
Cardiac fibrosis plays a vital role in the pathogenesis of heart failure. Fibroblast activity is enhanced by increases in store-operated Ca2+ entry (SOCE) and calcium release-activated calcium channel protein 1 (Orai1) levels. Lithium regulates SOCE; however, whether therapeutic concentrations of
Imran S Khan et al.
The Journal of experimental medicine, 211(5), 761-768 (2014-04-23)
Thymic central tolerance is a critical process that prevents autoimmunity but also presents a challenge to the generation of anti-tumor immune responses. Medullary thymic epithelial cells (mTECs) eliminate self-reactive T cells by displaying a diverse repertoire of tissue-specific antigens (TSAs)
Koji Itahana et al.
Methods in molecular biology (Clifton, N.J.), 965, 143-156 (2013-01-09)
Most normal human cells have a finite replicative capacity and eventually undergo cellular senescence, whereby cells cease to proliferate. Cellular senescence is also induced by various stress signals, such as those generated by oncogenes, DNA damage, hyperproliferation, and an oxidative
Jin Zhao et al.
International journal of biological macromolecules, 56, 106-113 (2013-02-07)
Small-diameter vascular grafts can easily lead to thrombosis and intimal hyperplasia. So the rate of the long-term patency is not satisfactory. Scaffolds that can support the growth of cells and remain stable and passable in vivo are in great demand.
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