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E9884
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Palabra clave:'E9884'
Mostrando 1-30 of 9235 resultados para "E9884" en el plazo de Papeles
Azzah M Bannunah et al.
Molecular pharmaceutics, 11(12), 4363-4373 (2014-10-21)
This study investigated the effect of nanoparticle size (50 and 100 nm) and surface charge on their interaction with Caco-2 monolayers as a model of the intestinal epithelium, including cell internalization pathways and the level of transepithelial transport. Initially, toxicity
Erin J Golden et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(29), E3864-E3873 (2015-07-04)
Proper tissue development requires strict coordination of proliferation, growth, and differentiation. Strict coordination is particularly important for the auditory sensory epithelium, where deviations from the normal spatial and temporal pattern of auditory progenitor cell (prosensory cell) proliferation and differentiation result
ZhaoHui Luo et al.
BMC medical genomics, 8, 13-13 (2015-04-19)
A novel class of transcripts, long non-coding RNAs (lncRNAs), has recently emerged as a key player in several biological processes, and important roles for these molecules have been reported in a number of complex human diseases, such as autoimmune diseases
Feng Li et al.
STAR protocols, 2(2), 100392-100392 (2021-04-16)
Transposon insertion sequencing (TIS) is a highly effective method used with bacteria to identify genes important for growth in any condition of interest. Previously, we adapted this method to identify essential genes of the yeast Schizosaccharomyces pombe. Here, we describe
M K Nøhr et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 69, 10-18 (2015-01-07)
The aim of the study was to investigate the intestinal transport mechanisms responsible for vigabatrin absorption in rats by developing a population pharmacokinetic (PK) model of vigabatrin oral absorption. The PK model was used to investigate whether vigabatrin absorption was
Y Nguyen et al.
mBio, 6(2) (2015-04-02)
Bacteria engage in chemical signaling, termed quorum sensing (QS), to mediate intercellular communication, mimicking multicellular organisms. The LuxR family of QS transcription factors regulates gene expression, coordinating population behavior by sensing endogenous acyl homoserine lactones (AHLs). However, some bacteria (such
Aleksei Sorokin et al.
Plant signaling & behavior, 15(8), 1780037-1780037 (2020-06-20)
In plant biology, transient expression analysis plays a vital role to provide a fast method to study the gene of interest. In this study, we report a rapid and efficient method for transient expression in Cannabis sativa seedlings using Agrobacterium
Dorota Gurda et al.
Amino acids, 47(7), 1319-1339 (2015-03-25)
Genetic or nutritional deficiencies in homocysteine (Hcy) metabolism lead to hyperhomocysteinemia (HHcy) and cause endothelial dysfunction, a hallmark of atherosclerosis. In addition to Hcy, related metabolites accumulate in HHcy but their role in endothelial dysfunction is unknown. Here, we examine
Biao Wang et al.
Oncotarget, 6(18), 16019-16030 (2015-04-25)
The oncolytic measles virus Edmonston (MV-Edm) strain shows considerable oncolytic activity against a variety of human tumors. In this study, we report MV-Edm is able to trigger apoptosis pathways in infected tumor cells and elucidate the roles of cellular apoptosis
Maria De Luca et al.
ACS applied materials & interfaces, 7(27), 15052-15060 (2015-06-19)
Acidification of eukaryotic cell compartments is accomplished by vacuolar H+-ATPases (V-ATPases), large multisubunit complexes able to pump protons into the lumen of organelles or in the extracellular medium. V-ATPases are involved in a number of physiological cellular processes, and thus
Alice Wong et al.
Bone, 81, 97-103 (2015-07-08)
Osteoblasts perceive and respond to changes in their pericellular environment, including biophysical signals and oxygen availability, to elicit an anabolic or catabolic response. Parathyroid hormone (PTH) affects each arm of skeletal remodeling, with net anabolic or catabolic effects dependent upon
S Franzè et al.
International journal of pharmaceutics, 481(1-2), 79-83 (2015-02-07)
Low molecular weight heparins (LMWHs) are obtained from unfractionated heparin (UFH) through different depolymerization methods (DM), which produce compounds having specific chemical features and biological activity. It is then supposed that LMWHs also exhibit different skin permeability properties. The current
Zhuoyang Fan et al.
PloS one, 10(4), e0120129-e0120129 (2015-04-02)
Genexol-PM, produced by Samyang Company (Korea) is an excellent preparation of paclitaxel (PTX) for clinical cancer treatment. However, it cannot resolve the issue of multidrug resistance (MDR)-a significant problem in the administration of PTX to cancer patients. To increase the
Rossella Melchiotti et al.
BMC medical genetics, 15, 73-73 (2014-06-28)
Extracellular ATP is a pro-inflammatory molecule released by damaged cells. Regulatory T cells (Treg) can suppress inflammation by hydrolysing this molecule via ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1), also termed as CD39. Multiple studies have reported differences in CD39+ Treg percentages
Sheng-Yi Chen et al.
Biochimica et biophysica acta, 1853(5), 929-939 (2015-02-18)
Cancer-associated fibroblasts play a crucial role in accelerating tumor progression, but there is a knowledge gap regarding the chemotactic signal activated in a tumor microenvironment. In this study, the expression of type IV collagen was knocked down using a lentiviral-mediated
Xiang-en Meng et al.
Cellular and molecular neurobiology, 35(2), 159-165 (2014-09-06)
The aim of the present study was to investigate the relationship between acute ischemic stroke and glutamate levels and to determine the prognosis value of plasma glutamate levels to predict the functional outcome. Two hundred and forty-two patients with acute
Dhilushi D Wijayakumara et al.
The Journal of pharmacology and experimental therapeutics, 354(3), 417-425 (2015-07-15)
Given the prime importance of UDP-glucuronosyltransferase (UGT) 2B15 and UGT2B17 in inactivating testosterone and dihydrotestosterone, control of their expression and activity in the prostate is essential for androgen signaling homeostasis in this organ. Although several studies provide evidence of transcriptional
Jeannette Werner et al.
Nucleic acids research, 42(21), 13061-13073 (2014-11-13)
Engineered transcription activator-like effectors, or TALEs, have emerged as a new class of designer DNA-binding proteins. Their DNA recognition sites can be specified with great flexibility. When fused to appropriate transcriptional regulatory domains, they can serve as designer transcription factors
Diana Gaspar et al.
Biochimica et biophysica acta, 1853(2), 308-316 (2014-12-03)
Cancer remains a major cause of morbidity and mortality worldwide. Although progress has been made regarding chemotherapeutic agents, new therapies that combine increased selectivity and efficacy with low resistance are still needed. In the search for new anticancer agents, therapies
Min Li et al.
Nature communications, 6, 6720-6720 (2015-04-09)
DNA topoisomerase I (TOP1) has an important role in maintaining DNA topology by relaxing supercoiled DNA. Here we show that the K391 and K436 residues of TOP1 are SUMOylated by the PIAS1-SRSF1 E3 ligase complex in the chromatin fraction containing
Agnieszka Blitek et al.
Theriogenology, 84(6), 969-982 (2015-07-04)
The prostacyclin (PGI2) signaling pathway plays an important role during early pregnancy in rodents and ruminants. Abundant concentrations of PGI2 were also found in the endometrium and uterine lumen of gilts during the period of implantation. The present study was
Peng Ye et al.
Molecular and cellular biology, 34(18), 3421-3434 (2014-07-09)
The ubiquitin-proteasome pathway degrades ubiquitinated proteins to remove damaged or misfolded protein and thus plays an important role in the maintenance of many important cellular processes. Because the pathway is also crucial for tumor cell growth and survival, proteasome inhibition
Sophea Heng et al.
Analytical biochemistry, 475, 14-21 (2015-01-03)
Embryo implantation requires a healthy embryo and a receptive uterus. In women, the inner lining of the uterus, the endometrium, remains in a hostile state and becomes receptive for embryo implantation for only a short period during each menstrual cycle.
Shinji Sakuma et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 92, 56-64 (2015-02-28)
We evaluated cross-reactivity of immunoglobulin A (IgA) secreted on the nasal mucosa in mice that were nasally inoculated 4 times with a mixture of inactivated H1N1 influenza A viruses and poly(N-vinylacetamide-co-acrylic acid) (PNVA-co-AA) bearing d-octaarginine at 7-day intervals. Three viral
Supansa Pantoom et al.
Autophagy, 17(9), 2290-2304 (2020-09-23)
Autophagosome formation is a fundamental process in macroautophagy/autophagy, a conserved self-eating mechanism in all eukaryotes, which requires the conjugating ATG (autophagy related) protein complex, ATG12-ATG5-ATG16L1 and lipidated MAP1LC3/LC3 (microtubule associated protein 1 light chain 3). How the ATG12-ATG5-ATG16L1 complex is
Sarmah B Nayeem et al.
Molecular and cellular endocrinology, 405, 52-62 (2015-02-15)
Wnt signalling has important roles in decidualisation, implantation and placentation. We investigated the role of decidua-trophoblast communication and Wnt signalling in the placenta using a co-culture model. Expression of a wide range of Wnt-related genes was observed in both decidual
Tatiana V Ilchibaeva et al.
Behavioural brain research, 290, 45-50 (2015-05-03)
The brain-derived neurotrophic factor (BDNF), its precursor (proBDNF) and BDNF mRNA levels were studied in the brain of wild rats selectively bred for more than 70 generations for either high level or for the lack of affective aggressiveness towards man.
Cheng Ma et al.
PloS one, 10(11), e0143010-e0143010 (2015-11-26)
Membrane proteins play key roles in many biological processes, from acquisition of nutrients to neurotransmission, and are targets for more than 50% of current therapeutic drugs. However, their investigation is hampered by difficulties in their production and purification on a
Zhong-Fu Zuo et al.
Diabetes research and clinical practice, 108(1), 128-136 (2015-02-07)
The present study aims to test whether astrocytes contribute to glucocorticoid-mediated diabetic mechanical allodynia. Streptozotocin (STZ)-induced diabetic rats were used in our study. The intrathecal operation was performed 21 days after the onset of diabetes. Diabetic mechanical allodynia was present
Elizabeth A Wellberg et al.
Breast cancer research : BCR, 16(6), 481-481 (2014-12-05)
Spot14 (S14), encoded by the THRSP gene, regulates de novo fatty acid synthesis in the liver, adipose, and lactating mammary gland. We recently showed that S14 stimulated fatty acid synthase (FASN) activity in vitro, and increased the synthesis of fatty
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