Showing 1-30 of 58 resultados for "

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Tae-Wook Chung et al.
Biochemical and biophysical research communications, 439(4), 580-585 (2013-09-17)
Metastasis is major cause of malignant cancer-associated mortality. Fucoxanthin has effect on various pharmacological activities including anti-cancer activity. However, the inhibitory effect of fucoxanthin on cancer metastasis remains unclear. Here, we show that fucoxanthin isolated from brown alga Saccharina japonica...
Adah Fung et al.
Food chemistry, 136(2), 1055-1062 (2012-11-06)
This study investigated the fucoxanthin content of New Zealand (NZ) Undaria pinnatifida harvested from two locations in the Marlborough Sounds, New Zealand across its growing season. Fucoxanthin content and antioxidant properties of processed New Zealand U. pinnatifida and commercial wakame...
Kazuo Miyashita et al.
Journal of the science of food and agriculture, 91(7), 1166-1174 (2011-03-25)
Obesity and type 2 diabetes are pathologies with rapidly growing prevalence throughout the world. A few molecular targets offer the most hope for anti-obesity and anti-diabetic therapeutics. One of the keys to success will be the induction of uncoupling protein...
Senji Tafuku et al.
Oncology reports, 28(4), 1512-1518 (2012-08-04)
Fucoxanthin (FX) is a natural carotenoid with reported antitumorigenic activity. This study explored the effects of FX and its deacetylated product, fucoxanthinol (FXOH), on B-cell malignancies, including Burkitt's lymphoma, Hodgkin's lymphoma and Epstein-Barr virus-immortalized B cells. Both FX and FXOH...
Li Zhang et al.
Scientific reports, 7, 46763-46763 (2017-04-22)
Fucoxanthin is abundant in seaweed and is considered as a powerful antioxidant. It has been proposed to possess anti-cancer, anti-obesity and anti-diabetes effects. However, its roles in brain injury models have not been fully understood. The objective of this study...
Guoliu Ye et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(11), 11261-11267 (2014-08-13)
Cervical cancer (CC) is a malignant neoplasm arising from cells originating in the cervix uteri, among the top causes of death from cancer in women. In a gene expression profiling study of metabolic response to treatment, PI3K/Akt signaling pathway are...
Srinivasan Muthuirulappan et al.
Asian Pacific journal of cancer prevention : APJCP, 14(4), 2213-2216 (2013-06-04)
Recently, use of natural products available from marine sources, and especially algae products, are receiving more attention. Scientific evidence for claimed nutraceutical and therapeutical effects of one such marine algae product, fucoxanthin, is discussed in this paper with a summary...
Jun Wang et al.
Marine drugs, 10(9), 2055-2068 (2012-11-03)
Previous in vitro researches have showed that fucoxanthin, a natural carotenoid isolated from sargassum, can inhibit proliferation or induce apoptosis in human neuroblastoma, hepatoma, leukemia, colon carcinoma, prostate cancer or urinary bladder cancer cells. But the precise mechanism by which...
Tim Lachnit et al.
FEMS microbiology ecology, 84(2), 411-420 (2013-01-15)
The macroalga Fucus vesiculosus carries a specific community of surface bacteria. To identify chemical compounds that possibly mediate abundance and community composition of algae-associated bacteria, we tested the effect of surface-available algal compounds on bacterial settlement and community composition under...
Marilena Di Valentin et al.
Biochemical and biophysical research communications, 427(3), 637-641 (2012-10-03)
In this work we present an optically detected magnetic resonance (ODMR) study on the triplet states populated under illumination in the isolated fucoxanthin-chlorophyll light-harvesting complex from the diatom Cyclotella meneghiniana. Evidence for the quenching of chlorophyll triplet states by fucoxanthin...
Thamaraiselvan Rengarajan et al.
Nutrients, 5(12), 4978-4989 (2013-12-11)
Epidemiological investigations have shown that overcoming the risk of cancer is related to the consumption of green vegetables and fruits. Many compounds from different origins, such as terrestrial plants and marine and microbial sources, have been reported to have therapeutic...
Arthitaya Kawee-ai et al.
Natural product communications, 8(10), 1381-1386 (2013-12-21)
Hot extraction with acetone was the most efficient method for the extraction of fucoxanthin from Phaeodactylum tricornutum. The purified compound resulted in three main peaks consisted of the trans form along with two isomers. The structure of microalgal fucoxanthin was...
Seong-Il Kang et al.
Journal of agricultural and food chemistry, 60(13), 3389-3395 (2012-03-10)
In this study, we investigated the antiobesity properties of Petalonia binghamiae extract (PBE) in mice in which obesity was induced with a high-fat diet (HFD). PBE administration (150 mg/kg/day) for 70 days decreased body weight gain, adipose tissue weight, and...
Kazuto Takahashi et al.
Oncology letters, 10(3), 1463-1467 (2015-12-02)
Colorectal cancer is one of the most malignant neoplasms worldwide. Fucoxanthin is a carotenoid present in the chloroplasts of brown seaweeds. In the present study, the anticancer effects of fucoxanthin and its metabolite, fucoxanthinol, on 6 colorectal cancer cell lines...
Tatiana I Imbs et al.
Marine biotechnology (New York, N.Y.), 15(5), 606-612 (2013-06-12)
Fucoxanthin (FX) and highly unsaturated monogalactosyldiacylglycerol (MGDG) were isolated from the ethanol extract of brown alga Fucus evanescens. Their structures were identified by nuclear magnetic resonance, complemented by electrospray ionization mass spectrometry (ESIMS). MGDG was identified as 1-O-(5Z,8Z,11Z,14Z,17Z-eicosapentanoyl)-2-O-(6Z,9Z,12Z,15Z-octadecatetraenoyl)-3-O-β-D-galactopiranosyl-sn-glycerol. Antitumor activity...
Xiaojie Hu et al.
Archives of biochemistry and biophysics, 519(1), 59-65 (2012-02-01)
The present study investigated the effects of combined fucoxanthin (Fc) and conjugated linoleic acid (CLA) on high-fat diet-induced obese rats. Thirty five rats were divided into four groups, fed a high-fat diet (Control, 15% fat, wt/wt), supplemented with low Fc...
Takashi Kadono et al.
Marine drugs, 13(8), 5334-5357 (2015-08-27)
Carotenoids exert beneficial effects on human health through their excellent antioxidant activity. To increase carotenoid productivity in the marine Pennales Phaeodactylum tricornutum, we genetically engineered the phytoene synthase gene (psy) to improve expression because RNA-sequencing analysis has suggested that the...
Saravana Periaswamy Sivagnanam et al.
Marine drugs, 13(6), 3422-3442 (2015-06-04)
The bioactive materials in brown seaweeds hold great interest for developing new drugs and healthy foods. The oil content in brown seaweeds (Saccharina japonica and Sargassum horneri) was extracted by using environmentally friendly supercritical CO2 (SC-CO2) with ethanol as a...
Cheng-Ling Liu et al.
Marine drugs, 10(1), 242-257 (2012-03-01)
Pregnane X receptor (PXR) has been reported to regulate the expression of drug-metabolizing enzymes, such as the cytochrome P450 3A (CYP3A) family and transporters, such as multiple drug resistance 1 (MDR1). Fucoxanthin, the major carotenoid in brown sea algae, is...
D Bhaya et al.
Nucleic acids research, 21(19), 4458-4466 (1993-09-25)
We are studying the multigene family encoding the fucoxanthin-chlorophyll binding proteins (fcp genes) that constitute the major component of the photosystem II-associated light harvesting complex in diatoms and brown algae. The characteristics of clusters of fcp genes on the genome...
Siyu Li et al.
Food & function, 11(4), 3361-3370 (2020-04-02)
In this study, we aimed to examine the effects of fucoxanthin on inflammation triggered by palmitate in macrophages. Raw 264.7 cells were treated with palmitate with or without fucoxanthin co-treatment. Fucoxanthin greatly alleviated palmitate-induced decrease in cell viability and loss...
Takayuki Kajikawa et al.
Organic letters, 14(3), 808-811 (2012-01-20)
Fucoxanthin exhibits high energy transfer efficiencies to Chlorophyll a (Chl a) in photosynthesis in the sea. In order to reveal how each characteristic functional group, such as the length of the polyene chain, allene, and conjugated carbonyl groups, of this...
Ching-Shu Lai et al.
Journal of agricultural and food chemistry, 60(4), 1094-1101 (2012-01-10)
Xanthigen is a source of punicic acid and fucoxanthin derived from pomegranate seed and brown seaweed, respectively with recognized triacylglycerol-lowering effects in humans, yet the mechanism remains to be fully elucidated. The present study investigated the inhibitory effects of Xanthigen...
Yiping Zhang et al.
Marine drugs, 13(10), 6521-6536 (2015-10-30)
Fucoxanthin and its deacetylated metabolite fucoxanthinol are two major carotenoids that have been confirmed to possess various pharmacological properties. In the present study, fucoxanthinol was identified as the deacetylated metabolite of fucoxanthin, after intravenous (i.v.) and intragastric gavage (i.g.) administration...
Lavinia-Lorena Pruteanu et al.
PloS one, 15(9), e0239551-e0239551 (2020-09-19)
Pathway analysis is an informative method for comparing and contrasting drug-induced gene expression in cellular systems. Here, we define the effects of the marine natural product fucoxanthin, separately and in combination with the prototypic phosphatidylinositol 3-kinase (PI3K) inhibitor LY-294002, on...
Marilena Di Valentin et al.
Biochimica et biophysica acta, 1827(10), 1226-1234 (2013-07-17)
Although the major light harvesting complexes of diatoms, called FCPs (fucoxanthin chlorophyll a/c binding proteins), are related to the cab proteins of higher plants, the structures of these light harvesting protein complexes are much less characterized. Here, a structural/functional model...
Ekaterina Lashmanova et al.
Pharmacological research, 100, 228-241 (2015-08-21)
The pharmacological activation of stress-defense mechanisms is one of the perspective ways to increase human lifespan. The goal of the present study was to study the effects on lifespan of Drosophila melanogaster and Caenorhabditis elegans of two carotenoids: ß-carotene and...
Fucoxanthin: A promising medicinal and nutritional ingredient
Zhang H, et al.
Evidence-Based Complementary and Alternative Medicine : ECAM, 2015 (2015)
Mizuki Takashima et al.
Free radical research, 46(11), 1406-1412 (2012-08-21)
Carotenoids act as physiological antioxidant by scavenging reactive-free radicals as well as quenching singlet oxygen. Fucoxanthin is one of the abundant carotenoids found in edible brown seaweeds. The assessment of radical scavenging capacity of carotenoids has been the subject of...
Ji-Young Lee et al.
European journal of nutrition, 52(1), 409-421 (2012-04-06)
Laminaria japonica is a representative marine brown alga used as a culinary item in East Asia. L. japonica extract was shown to exert various biological activities; however, its anti-inflammatory activity has not been reported. The aim of this study is...