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Palabra clave:'g2025'
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Huyen Trang Ha Thi et al.
Molecular and cellular biology, 35(16), 2841-2850 (2015-06-10)
Epidermal growth factor (EGF) regulates various cellular events, including proliferation, differentiation, migration, and tumorigenesis. For the maintenance of homeostasis, EGF signaling should be tightly regulated to prevent the aberrant activation. Smad7 has been known as inhibitory Smad that blocks the
Semih Can Akıncılar et al.
FEBS letters, 589(9), 974-984 (2015-03-10)
Besides its canonical function of catalyzing the formation of telomeric repeats, many groups have recently reported non-canonical functions of hTERT in particular, and telomerase in general. Regulating transcription is the central basis of non-canonical functions of telomerase. However, unlike reverse
Kui Yang et al.
Analytical and bioanalytical chemistry, 407(17), 5199-5210 (2015-03-31)
Diglycerides play a central role in lipid metabolism and signaling in mammalian cells. Although diacylglycerol molecular species comprise the majority of cellular diglycerides that are commonly measured using a variety of approaches, identification of extremely low abundance vinyl ether diglycerides
Adrian Gerber et al.
Microbial cell factories, 14, 107-107 (2015-07-29)
Cholesterol, the precursor of all steroid hormones, is the most abundant steroid in vertebrates and exhibits highly hydrophobic properties, rendering it a difficult substrate for aqueous microbial biotransformations. In the present study, we developed a Bacillus megaterium based whole-cell system
Andrei V Perepelov et al.
Carbohydrate research, 411, 33-36 (2015-05-13)
An acidic O-polysaccharide (O-antigen) was isolated from the lipopolysaccharide of Escherichia coli O140 and studied by sugar analysis along with 1D and 2D (1)H and (13)C NMR spectroscopy. The following structure of the branched hexasaccharide repeating unit was established: [Formula:
Paola Lorena Smaldini et al.
PloS one, 10(10), e0141116-e0141116 (2015-10-31)
The induction of peripheral tolerance may constitute a disease-modifying treatment for allergic patients. We studied how oral immunotherapy (OIT) with milk proteins controlled allergy in sensitized mice (cholera toxin plus milk proteins) upon exposure to the allergen. Symptoms were alleviated
Kyung Min Jeong et al.
Archives of pharmacal research, 38(12), 2143-2152 (2015-11-05)
Deep eutectic solvents (DESs) were investigated as tunable, environmentally benign, yet superior extraction media to enhance the extraction of anthocyanins from grape skin, which is usually discarded as waste. Ten DESs containing choline chloride as hydrogen bond acceptor combined with
Yoshifumi Tsuchiya et al.
Metabolism: clinical and experimental, 64(9), 1042-1050 (2015-06-18)
We determined detailed time-course changes in the irisin response to acute exercise using different exercise modes. In experiment 1, seven healthy males rested for 12h (8:00-20:00) to determine the diurnal variation in plasma irisin concentration. In experiment 2, 10 healthy
Simon Jon McIlroy et al.
PloS one, 10(9), e0136424-e0136424 (2015-09-05)
An in depth understanding of the ecology of activated sludge nutrient removal wastewater treatment systems requires detailed knowledge of the community composition and metabolic activities of individual members. Recent 16S rRNA gene amplicon surveys of activated sludge wastewater treatment plants
Junqi Song et al.
PLoS genetics, 11(5), e1005200-e1005200 (2015-05-08)
Poly (ADP-ribose) polymerases (PARPs) catalyze the transfer of multiple poly(ADP-ribose) units onto target proteins. Poly(ADP-ribosyl)ation plays a crucial role in a variety of cellular processes including, most prominently, auto-activation of PARP at sites of DNA breaks to activate DNA repair
Susana Rodrigues et al.
Carbohydrate polymers, 123, 369-380 (2015-04-07)
Chitosan/carrageenan/tripolyphosphate nanoparticles were previously presented as holding potential for an application in transmucosal delivery of macromolecules, with tripolyphosphate demonstrating to contribute for both size reduction and stabilisation of the nanoparticles. This work was aimed at evaluating the capacity of the
Greta A Van Slyke et al.
PLoS pathogens, 11(6), e1005009-e1005009 (2015-06-27)
High rates of error-prone replication result in the rapid accumulation of genetic diversity of RNA viruses. Recent studies suggest that mutation rates are selected for optimal viral fitness and that modest variations in replicase fidelity may be associated with viral
Uwe Richter et al.
The Journal of cell biology, 211(2), 373-389 (2015-10-28)
Mitochondrial ribosomes synthesize a subset of hydrophobic proteins required for assembly of the oxidative phosphorylation complexes. This process requires temporal and spatial coordination and regulation, so quality control of mitochondrial protein synthesis is paramount to maintain proteostasis. We show how
Douglas Barrows et al.
The Journal of biological chemistry, 290(48), 28915-28931 (2015-10-07)
Phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger 2 (PREX2) is a guanine nucleotide exchange factor (GEF) for the Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase, facilitating the exchange of GDP for GTP on Rac1. GTP-bound Rac1 then activates its downstream effectors
Min Jee Park et al.
Cellular reprogramming, 17(3), 199-210 (2015-05-20)
Bovine somatic cell nuclear transfer (SCNT) using vitrified-thawed (VT) oocytes has been studied; however, the cloning efficiency of these oocytes is not comparable with that of nonvitrified (non-V) fresh oocytes. This study sought to optimize the survival and cryopreservation of
Daniel Andersson et al.
Expert review of molecular diagnostics, 15(8), 1085-1100 (2015-07-02)
Quantification of small molecule numbers often requires preamplification to generate enough copies for accurate downstream enumerations. Here, we studied experimental parameters in targeted preamplification and their effects on downstream quantitative real-time PCR (qPCR). To evaluate different strategies, we monitored the
Christopher T Cummings et al.
Oncotarget, 5(21), 10434-10445 (2014-11-06)
The successes of targeted therapeutics against EGFR and ALK in non-small cell lung cancer (NSCLC) have demonstrated the substantial survival gains made possible by precision therapy. However, the majority of patients do not have tumors with genetic alterations responsive to
Sophie Forrest et al.
The Journal of general virology, 95(Pt 12), 2649-2657 (2014-08-07)
We have previously documented the inhibitory activity of RNA aptamers to the RNA-dependent RNA polymerase of foot-and-mouth disease virus (3D(pol)). Here we report their modification and use with a subgenomic replicon incorporating GFP (pGFP-PAC replicon), allowing replication to be monitored
J Barbosa et al.
Food microbiology, 52, 77-83 (2015-09-05)
The demand for new functional non-dairy based products makes the production of a probiotic orange juice powder an encouraging challenge. However, during drying process and storage, loss of viability of the dried probiotic cultures can occur, since the cells are
Yan Yan et al.
Journal of immunology (Baltimore, Md. : 1950), 195(1), 329-338 (2015-05-23)
There is a lack of an HSV-2 vaccine, in part as the result of various factors that limit robust and long-term memory immune responses at the mucosal portals of viral entry. We previously demonstrated that chemokine CCL19 augmented mucosal and
Ningfeng Tang et al.
Alcoholism, clinical and experimental research, 38(11), 2722-2730 (2014-11-26)
Fetal alcohol spectrum disorder, the leading known cause of mental retardation, is caused by alcohol exposure during pregnancy. One mechanism of ethanol (EtOH) teratogenicity is the disruption of the functions of L1 cell adhesion molecule (L1). These functions include enhancement
Lingfang Zhu et al.
Antonie van Leeuwenhoek, 107(4), 1001-1008 (2015-01-28)
A yellow-pigmented bacterium, designated strain GZGR-4(T), was isolated from the root of Hylomecon japonica (Thunb.) Prantl et Kündig collected from Taibai Mountain in Shaanxi Province, north-west China. Cells of strain GZGR-4(T) were Gram-negative, rod-shaped, strictly aerobic, non-endospore-forming and non-motile. Phylogenetic
Paul A Turner et al.
Tissue engineering. Part A, 21(11-12), 1837-1847 (2015-03-18)
To improve treatment of obesity, a contributing factor to multiple systemic and metabolic diseases, a better understanding of metabolic state and environmental stress at the cellular level is essential. This work presents development of a three-dimensional (3D) in vitro model
Young-Sam Cho et al.
Molecular medicine reports, 12(2), 1796-1802 (2015-04-22)
Ulinastatin is a urinary trypsin inhibitor, originally extracted and purified from human urine. Ulinastatin has cytoprotective effects against ischemic injury in several organs. In the present study, the neuroprotective effects of ulinastatin following ischemic cerebral injury in the hippocampus of
M Kosová et al.
Journal of clinical pharmacy and therapeutics, 40(4), 436-440 (2015-05-28)
Parabens have been commonly used as preservatives in pharmaceutical and cosmetics industries for almost 50 years. These compounds are thermostable, pH-stable and inexpensive and have a wide antimicrobial effect. The antimicrobial activity of parabens in emulsion system is limited by
Pau Doñate-Macian et al.
Biochemical and biophysical research communications, 462(3), 221-226 (2015-05-10)
Transient Receptor Potential (TRP) channels are related to adaptation to the environment and somatosensation. The transient receptor potential vanilloid (TRPV) subfamily includes six closely evolutionary related ion channels sharing the same domain organization and tetrameric arrangement in the membrane. In
Peter Draxler et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(36), 12015-12028 (2014-09-05)
Sensory nerve fibers differ not only with respect to their sensory modalities and conduction velocities, but also in their relative roles for pain hypersensitivity. It is presently largely unknown which types of sensory afferents contribute to various forms of neuropathic
Yunhui Peng et al.
International journal of molecular sciences, 16(11), 27270-27287 (2015-11-19)
Mutations in KDM5C gene are linked to X-linked mental retardation, the syndromic Claes-Jensen-type disease. This study focuses on non-synonymous mutations in the KDM5C ARID domain and evaluates the effects of two disease-associated missense mutations (A77T and D87G) and three not-yet-classified
Johanna Bertrand et al.
European journal of pharmacology, 765, 337-345 (2015-08-13)
TRPC6 plays important human physiological functions, notably in artery and arterioles constriction, in regulation of vascular volume and in bronchial muscle constriction. It is implicated in pulmonary hypertension, cardiovascular disease, and focal segmental glomerulosclerosis and seems to play a role
Fang Xu et al.
The Plant cell, 27(5), 1547-1562 (2015-05-15)
Nod-like receptors (NLRs) serve as immune receptors in plants and animals. The stability of NLRs is tightly regulated, though its mechanism is not well understood. Here, we show the crucial impact of N-terminal acetylation on the turnover of one plant
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