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" within Papeles
Yi-Lun Lee et al.
The American journal of pathology, 187(9), 1945-1959 (2017-08-23)
Ketamine-induced ulcerative cystitis (KIC) initially damaged the bladder mucosa and induced contracted bladder thereafter. Hyaluronan (hyaluronic acid; HA) instillation to the bladder has been used to treat KIC. The present study investigated bladder injury by urothelial defect and HA degeneration...
Hana Sharaf et al.
Biochimica et biophysica acta, 1852(3), 429-441 (2014-12-17)
Diabetic patients have increased likelihood of developing breast cancer. Advanced glycation endproducts (AGEs) underlie the pathogenesis of diabetic complications but their impact on breast cancer cells is not understood. This study aims to determine the effects of methylglyoxal-derived bovine serum...
Alexandra Pallottie et al.
Scientific reports, 8(1), 8723-8723 (2018-06-09)
Spinal cord (SC) trauma elicits pathological changes at the primary lesion and in regions distant from the injury epicenter. Therapeutic agents that target mechanisms at the injury site are likely to exert additional effects in these remote regions. We previously...
Shaoqing Shi et al.
Thoracic cancer, 9(1), 136-141 (2017-11-07)
CRTC2 is highly expressed in lung cancer and contributes to lung cancer pathogenesis; however, whether CRTC2 promotes lung cancer metastasis remains unknown. In the present study, we investigated the role of CRTC2 in lung cancer metastasis in vitro. CRTC2 stable...
Qi-Fen Mao et al.
Annals of translational medicine, 7(16), 384-384 (2019-09-27)
This study aimed to investigate immunoregulatory role of IL-2/STAT5/CD4+CD25+Foxp3 Treg pathway in pathogenesis of chronic osteomyelitis (COM). Sprague-Dawley (SD) rats were injected with Staphylococcus aureus to establish COM model. 4 weeks later, the lesioned bones were collected and subjected to...
Shitu Chen et al.
Translational oncology, 13(2), 441-451 (2020-01-09)
Vemurafenib, an inhibitor of mutant BRAF activity, is a promising anticancer agent for patients with BRAF-mutant metastatic melanoma. However, it is less effective in BRAF-mutant thyroid cancer, and the reason for this discrepancy is not yet fully elucidated. By RNA...
Beili Chen et al.
Molecular and cellular endocrinology, 505, 110731-110731 (2020-01-27)
In the mammalian ovary, the proteolysis of the extracellular matrix is dynamically regulated by plasminogen activator and plasminogen activator inhibitor (PAI), and it is a critical event that influences various physiological and pathological processes. Activin A is a member of...
Silvia Panseri et al.
Journal of materials science. Materials in medicine, 32(1), 3-3 (2021-01-21)
Biomaterial science increasingly seeks more biomimetic scaffolds that functionally augment the native bone tissue. In this paper, a new concept of a structural scaffold design is presented where the physiological multi-scale architecture is fully incorporated in a single-scaffold solution. Hydroxyapatite...
Anindita Basak et al.
Nature genetics, 52(2), 138-145 (2020-01-22)
Increased production of fetal hemoglobin (HbF) can ameliorate the severity of sickle cell disease and β-thalassemia1. BCL11A represses the genes encoding HbF and regulates human hemoglobin switching through variation in its expression during development2-7. However, the mechanisms underlying the developmental...
Jessica M Overstreet et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(10), 4407-4421 (2017-06-20)
Epidermal growth factor receptor (EGFR) has been implicated in the pathogenesis of diabetic nephropathy and renal fibrosis; however, the causative role of sustained EGFR activation is unclear. Here, we generated a novel kidney fibrotic mouse model of persistent EGFR activation...
Wan-Tai Dang et al.
Chinese journal of integrative medicine, 24(1), 24-31 (2017-11-01)
To study the expression level and role of apoptosis-associated speck-like protein containing a caspase recruitment domain (PYCARD) gene transcript variant mRNA in peripheral blood mononuclear cells (PBMCs) of primary gout (PG) patients with different Chinese medicine (CM) syndromes. The expressions...
Huimeng Qi et al.
Experimental cell research, 394(2), 112138-112138 (2020-06-15)
The role of microRNA (miR)-183 has been elucidated in systemic lupus erythematosus, while whether it is also engaged in the lupus nephritis (LN) development remains opaque. The intention of this study is to examine the relevance of miR-183 downregulation in...
N J Lee et al.
Molecular metabolism, 13, 30-44 (2018-05-26)
The skeleton, which is strongly controlled by endocrine factors, has recently been shown to also play an active endocrine role itself, specifically influencing energy metabolism. However, much less is known about this role. Therefore, we sought to identify novel endocrine...
Patricia Piñol-Jurado et al.
The American journal of pathology, 187(8), 1814-1827 (2017-06-16)
Duchenne muscular dystrophy (DMD) is characterized by a progressive loss of muscle fibers, and their substitution by fibrotic and adipose tissue. Many factors contribute to this process, but the molecular pathways related to regeneration and degeneration of muscle are not...
Josiane Elia et al.
Iranian journal of pharmaceutical research : IJPR, 19(1), 321-330 (2020-09-15)
Marine macroalgae have attracted much attention in recent years as a valuable source of bioactive metabolites. The cytotoxic potential of the Laurencia papillosa red alga collected from the Lebanese coast has been investigated on human breast cancer cells MCF-7. The...
Shasha He et al.
Inflammation, 43(1), 220-230 (2019-11-14)
Periodontitis is an inflammation characterized by alveolar bone resorption caused by imbalance in bone homeostasis. It is known that autophagy is related to inflammation and bone metabolism. However, whether autophagy inhibitors could be used for periodontitis in animal models remains...
Debottam Sinha et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(9), 4984-4999 (2018-04-24)
Spermatogenesis is a dynamic process involving self-renewal and differentiation of spermatogonial stem cells, meiosis, and ultimately, the differentiation of haploid spermatids into sperm. Centrosomal protein 55 kDa (CEP55) is necessary for somatic cell abscission during cytokinesis. It facilitates equal segregation...
Lihua Dong et al.
International journal of molecular sciences, 20(21) (2019-11-02)
Spermatogonial stem cell (SSC) transplantation therapy is a promising strategy to renew spermatogenesis for prepubertal boys whose fertility is compromised. However, propagation of SSCs is required due to a limited number of SSCs in cryopreserved testicular tissue. This propagation must...
Michael P Smrtka et al.
Reproductive sciences (Thousand Oaks, Calif.), 24(8), 1154-1163 (2016-11-18)
Thrombin (Thr) generation at the uteroplacental interface induces inflammation and weakens fetal membranes. Tissue factor (TF) is a powerful procoagulant that is increased by Thr in decidual cells (DCs). The TF expression may play an important role in modulating Thr-induced...
Yongkang Zhong et al.
Journal of cardiovascular pharmacology, 69(6), 389-397 (2017-06-06)
Trimetazidine (TMZ), a metabolic agent, may protect against myocardial ischemia/reperfusion injury. Because of the critical role of autophagy in cardioprotection, we aimed to evaluate whether autophagy was involved in TMZ-induced protection during hypoxia/reoxygenation (H/R). Neonatal rat cardiomyocytes were subjected to...
Tingting Song et al.
Plant physiology and biochemistry : PPB, 159, 301-311 (2021-01-09)
Alkaline salt is one of the most devastating environmental factors limiting alfalfa productivity, however, the mechanisms underlying adaptation of alfalfa to alkaline remain unclear. Our aim is to investigate proteomic and metabolomic differences in growth and root of alfalfa under...
Alfredo Panebra et al.
Avian diseases, 63(2), 342-350 (2019-06-30)
The current study was undertaken to assess the vaccine efficacy of Eimeria tenella EF-1α/chicken IL-7 (chIL-7) DNA vaccine when administered with Montanide Gel 01 adjuvant against live Eimeria acervulina challenge in commercial broiler chickens. The criteria used for the evaluation...
Shinobu Takagi et al.
Bioscience, biotechnology, and biochemistry, 84(11), 2241-2252 (2020-07-23)
A simple intracellular proteomic study was conducted to investigate the biological activities of Aspergillus niger during industrial enzyme production. A strain actively secreting a heterologous enzyme was compared to a reference strain. In total, 1824 spots on 2-D gels were...
Qiuhuan Yuan et al.
Journal of cardiovascular pharmacology, 73(4), 248-256 (2019-02-26)
Pathological stimulus-triggered differentiation of cardiac fibroblasts plays a major role in the development of myocardial fibrosis. Aldehyde dehydrogenase 2 (ALDH2) was reported to exert a protective role in cardiovascular disease, and whether ALDH2 is involved in cardiac fibroblast differentiation remains...
Marina Quartu et al.
Journal of anatomy, 229(6), 755-767 (2016-07-28)
This work presents new data concerning the immunohistochemical occurrence of the transient receptor potential vanilloid type-1 (TRPV1) receptor in the human trigeminal ganglion (TG) and spinal nucleus of subjects at different ontogenetic stages, from prenatal life to postnatal old age....
Rashid A Aldahhan et al.
Molecular and cellular endocrinology, 498, 110546-110546 (2019-08-20)
Heat reversibly disrupts spermatogenesis, but the effects on Sertoli cell (SC) function and inhibin/activin-related proteins are less well-defined. Adult rat testis weights decreased by 40% within 2 weeks after heat-treatment (43 °C, 15 min), due to loss of pachytene spermatocytes and round...
Maria B Lebron et al.
Cancer biology & therapy, 15(9), 1208-1218 (2014-06-13)
Stem cell factor receptor (c-Kit) exerts multiple biological effects on target cells upon binding its ligand stem cell factor (SCF). Aberrant activation of c-Kit results in dysregulated signaling and is implicated in the pathogenesis of numerous cancers. The development of...
Shila Shahbazian et al.
The Journal of comparative neurology, 529(4), 811-827 (2020-07-14)
Polysialic acid (polySia), a homopolymer of α2,8-linked glycans, is a posttranslational modification on a few glycoproteins, most commonly in the brain, on the neural cell adhesion molecule. Most research in the adult central nervous system has focused on its expression...
Ursolic acid potentiated oxaliplatin to induce apoptosis in colorectal cancer RKO cells.
Zheng, et al.
Pharmazie, 75, 246-249 (2020)
Won Hye Ka et al.
Breast cancer (Tokyo, Japan), 25(5), 529-538 (2018-03-09)
The E3 ubiquitin ligase constitutive photomorphogenic 1 (COP1) mediates cell survival, growth, and development, and interacts with the tumor suppressor protein p53 to induce its ubiquitination and degradation. Recent studies reported that COP1 overexpression is associated with increased cell proliferation...
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