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Amit Pathania et al.
Journal of bacteriology, 197(12), 2036-2047 (2015-04-08)
In Escherichia coli, argO encodes an exporter for L-arginine (Arg) and its toxic analogue canavanine (CAN), and its transcriptional activation and repression, by Arg and L-lysine (Lys), respectively, are mediated by the regulator ArgP. Accordingly argO and argP mutants are
David Westover et al.
Molecular cancer, 14, 92-92 (2015-05-01)
Irinotecan is a camptothecin analogue currently used in clinical practice to treat advanced colorectal cancer. However, acquired resistance mediated by the drug efflux pump ABCG2 is a recognized problem. We reported on a novel camptothecin analogue, FL118, which shows anticancer
Qingwen Meng et al.
Vaccine, 33(31), 3758-3765 (2015-06-04)
To prevent a future influenza A virus subtype pandemic outbreak, developing a broad-spectrum vaccine would be highly beneficial. The ion channel protein M2 is highly conserved in a diverse number of influenza A virus subtypes. This distinguishing characteristic makes M2
Xuan-thanh Mai et al.
Journal of peptide science : an official publication of the European Peptide Society, 21(7), 561-568 (2015-04-01)
A 15-mer cationic α-helical antimicrobial peptide HPRP-A1 was used as the parent peptide to study the effects of peptide secondary structure on the biophysical properties and biological activities. Without changing the amino acid composition of HPRP-A1, we designed two α-helical
Izabela Waclawska et al.
Biological chemistry, 396(9-10), 1117-1126 (2015-07-07)
The trimeric transporter BetP counteracts hyperosmotic stress by a fast increase in transport rate in order to accumulate the compatible solute betaine. The positively charged α-helical C-terminal domain acts as an osmosensor perceiving the increase in the internal potassium (K+)
Bruno M Andrade et al.
PloS one, 10(6), e0127561-e0127561 (2015-06-04)
Skeletal muscle injury is the most common problem in orthopedic and sports medicine, and severe injury leads to fibrosis and muscle dysfunction. Conventional treatment for successive muscle injury is currently controversial, although new therapies, like cell therapy, seem to be
Jonathon C B Davies et al.
Biochemical pharmacology, 90(4), 406-413 (2014-06-24)
Endothelin-1 (ET-1) induces lipolysis in adipocytes, where ET-1 chronic exposure results in insulin resistance (IR) through suppression of glucose transporter (GLUT)4 translocation to the plasma membrane and consequently glucose uptake. ARF6 small GTPase, which plays a vital role in cell
Sakshi Khosa et al.
Acta crystallographica. Section F, Structural biology communications, 71(Pt 6), 671-675 (2015-06-10)
Nisin is a 34-amino-acid antimicrobial peptide produced by Lactococcus lactis belonging to the class of lantibiotics. Nisin displays a high bactericidal activity against various Gram-positive bacteria, including some human-pathogenic strains. However, there are some nisin-non-producing strains that are naturally resistant
Jolanda Brummelman et al.
Infection and immunity, 83(1), 227-238 (2014-10-29)
Bordetella pertussis is a Gram-negative bacterium and the causative agent of whooping cough. Despite high vaccination coverage, outbreaks are being increasingly reported worldwide. Possible explanations include adaptation of this pathogen, which may interfere with recognition by the innate immune system.
Kathryn E Hamilton et al.
Molecular cancer research : MCR, 13(11), 1478-1486 (2015-07-22)
The colon tumor microenvironment is becoming increasingly recognized as a complex but central player in the development of many cancers. Previously, we identified an oncogenic role for the mRNA-binding protein IMP1 (IGF2BP1) in the epithelium during colon tumorigenesis. In the
Tsz Yan Wong et al.
The British journal of nutrition, 113(12), 1844-1852 (2015-05-16)
Sterol regulatory element-binding protein-2 (SREBP-2) is a pivotal transcriptional factor in cholesterol metabolism. Factors interfering with the proper functioning of SREBP-2 potentially alter plasma lipid concentrations. Consuming fruits and vegetables is associated with beneficial plasma lipid profile. The mechanism by
Muhammad Amir Yunus et al.
Journal of virology, 89(2), 1218-1229 (2014-11-14)
All members of the Caliciviridae family of viruses produce a subgenomic RNA during infection. The subgenomic RNA typically encodes only the major and minor capsid proteins, but in murine norovirus (MNV), the subgenomic RNA also encodes the VF1 protein, which
Vincenzo Maione et al.
PloS one, 10(11), e0142807-e0142807 (2015-11-18)
Mycobacterium tuberculosis latent infection is maintained for years with no clinical symptoms and no adverse effects for the host. The mechanism through which dormant M. tuberculosis resuscitates and enters the cell cycle leading to tuberculosis is attracting much interest. The
Byung-Hak Kim et al.
British journal of pharmacology, 172(15), 3875-3889 (2015-04-29)
Abnormally induced angiogenesis and lymphangiogenesis are associated with human diseases, including neovascular eye disease. Substances that inhibit these processes may have potential as an attractive therapeutic strategy for these diseases. In vitro and in vivo angiogenesis and/or lymphangiogenesis were assessed
Grzegorz L Ciesielski et al.
The Journal of biological chemistry, 290(48), 28697-28707 (2015-10-09)
The activity of the mitochondrial replicase, DNA polymerase γ (Pol γ) is stimulated by another key component of the mitochondrial replisome, the mitochondrial single-stranded DNA-binding protein (mtSSB). We have performed a comparative analysis of the human and Drosophila Pols γ
Ik-Rak Jung et al.
Molecular and cellular endocrinology, 407, 74-84 (2015-03-18)
High levels of plasma free fatty acid are thought to contribute to the loss of pancreatic beta-cells in type 2 diabetes. In particular, saturated fatty acid such as palmitate or stearate can induce apoptosis in cultured beta cells (lipotoxicity). Endoplasmic
Norihito Shibata et al.
The Journal of biological chemistry, 290(47), 28428-28437 (2015-10-08)
During translation, stop codon read-through occasionally happens when the stop codon is misread, skipped, or mutated, resulting in the production of aberrant proteins with C-terminal extension. These extended proteins are potentially deleterious, but their regulation is poorly understood. Here we
Steven L Roseno et al.
Nutrition & metabolism, 12, 39-39 (2015-11-06)
A short-term high-fat diet impairs mitochondrial function and the ability of skeletal muscle to respond to growth stimuli, but it is unknown whether such a diet alters the ability to respond to atrophy signals. The purpose of this study was
Johannes Woitzik et al.
Stroke, 45(4), 1183-1185 (2014-03-20)
We investigated to what extent excitotoxicity and metabolic changes in the peri-infarct region of patients with malignant hemispheric stroke are associated with delayed infarct progression. In 18 patients with malignant hemispheric stroke, 2 microdialysis probes were implanted within the peri-infarct
Wissal El-Assaad et al.
Diabetologia, 58(1), 149-157 (2014-11-10)
Obesity is a global epidemic resulting from increased energy intake, which alters energy homeostasis and results in an imbalance in fat storage and breakdown. G0/G1 switch gene 2 (G0s2) has been recently characterised in vitro as an inhibitor of adipose
Audrey Cheung et al.
Muscle & nerve, 51(4), 505-513 (2014-08-19)
The pathophysiology of neuropathic pain (NeP) in diabetic peripheral neuropathy (DPN) is unclear. A potential pathological feature associated with intraepidermal nerve fiber density (IENFD) loss in DPN is axonal swellings. We determined the prevalence of intraepidermal axonal swellings in DPN
Leon H Chew et al.
Autophagy, 11(6), 891-905 (2015-05-23)
The Atg1 complex, which contains 5 major subunits: Atg1, Atg13, Atg17, Atg29, and Atg31, regulates the induction of autophagy and autophagosome formation. To gain a better understanding of the overall architecture and assembly mechanism of this essential autophagy regulatory complex
Giorgia Radicioni et al.
Biochimica et biophysica acta, 1848(11 Pt A), 2868-2877 (2015-09-02)
Saliva contains hundreds of small proline-rich peptides most of which derive from the post-translational and post-secretory processing of the acidic and basic salivary proline-rich proteins. Among these peptides we found that a 20 residue proline-rich peptide (p1932), commonly present in
Eberhard Schlatter et al.
Pflugers Archiv : European journal of physiology, 466(8), 1581-1589 (2013-11-16)
The proximal tubule of mouse kidney expresses mouse organic cation transporter 1 (mOCT1), mOCT2, and much less mOCT3. Therefore, mOCT-mediated transport across the basolateral membrane of proximal tubules reflects properties of at least mOCT1 and mOCT2. Here, we unraveled substrate
Yongli Qiao et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(18), 5850-5855 (2015-04-23)
A broad range of parasites rely on the functions of effector proteins to subvert host immune response and facilitate disease development. The notorious Phytophthora pathogens evolved effectors with RNA silencing suppression activity to promote infection in plant hosts. Here we
Eleni-Maria Amaniti et al.
PloS one, 10(10), e0141525-e0141525 (2015-10-29)
Formation of the lateral olfactory tract (LOT) and innervation of the piriform cortex represent fundamental steps to allow the transmission of olfactory information to the cerebral cortex. Several transcription factors, including the zinc finger transcription factor Gli3, influence LOT formation
Elke Rufer et al.
Journal of immunology (Baltimore, Md. : 1950), 195(11), 5482-5494 (2015-11-01)
The transporter associated with Ag processing (TAP) translocates proteasomally derived cytosolic peptides into the endoplasmic reticulum. TAP is a central component of the peptide-loading complex (PLC), to which tapasin (TPN) recruits MHC class I (MHC I) and accessory chaperones. The
Petr Tesina et al.
Nature communications, 6, 7968-7968 (2015-08-08)
Lens epithelium-derived growth factor (LEDGF/p75) is an epigenetic reader and attractive therapeutic target involved in HIV integration and the development of mixed lineage leukaemia (MLL1) fusion-driven leukaemia. Besides HIV integrase and the MLL1-menin complex, LEDGF/p75 interacts with various cellular proteins
Monica I Abrudan et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(35), 11054-11059 (2015-07-29)
Despite their importance for humans, there is little consensus on the function of antibiotics in nature for the bacteria that produce them. Classical explanations suggest that bacteria use antibiotics as weapons to kill or inhibit competitors, whereas a recent alternative
Giancarlo la Marca
Journal of pharmaceutical and biomedical analysis, 101, 174-182 (2014-05-23)
Newborn screening (NBS) program is a complex and organized system consisting of family and personnel education, biochemical tests, confirmatory biochemical and genetic tests, diagnosis, therapy, and patient follow up. The program identifies treatable metabolic disorders possibly when asymptomatic by using
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