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Danielle Bongero et al.
Leukemia & lymphoma, 56(10), 2945-2952 (2015-04-11)
The kinesin spindle protein (KSP) is a mitotic protein essential for cell cycle control and motility. SB-743921 (hereafter SB-921) is an inhibitor that selectively targets the ATP-binding domain of the KSP. The preclinical activity of SB-921 was evaluated in models
Matthew S Elitt et al.
Nature, 585(7825), 397-403 (2020-07-02)
Mutations in PLP1, the gene that encodes proteolipid protein (PLP), result in failure of myelination and neurological dysfunction in the X-chromosome-linked leukodystrophy Pelizaeus-Merzbacher disease (PMD)1,2. Most PLP1 mutations, including point mutations and supernumerary copy variants, lead to severe and fatal disease.
Si Hui Chen et al.
Journal of environmental management, 150, 274-280 (2014-12-22)
Triphenylmethane dyes (TPM) are recalcitrant colorants brought into the environment. In this study, a lesser-known white rot fungus Coriolopsis sp. (1c3), isolated from compost of Empty Fruit Bunch (EFB) of oil palm, was explored for its decolorization potential of TPM
Rong Lin et al.
Journal of digestive diseases, 15(11), 597-605 (2014-08-16)
To investigate the influence of gut microbiota on autophagy activation in intestinal epithelial cells (IEC) and to evaluate the IEC autophagy response to different types of Bifidobacteria. IEC-18 cells were treated with lipopolysaccharide (LPS) derived from enteropathogenic Escherichia coli (EPEC)
Francesco Balestri et al.
Biochemical and biophysical research communications, 456(4), 891-895 (2014-12-22)
Although glucose is one of the most important physio-pathological substrates of aldose reductase, it is not an easy molecule for in vitro investigation into the enzyme. In many cases alternative aldoses have been used for kinetic characterization and inhibition studies.
John P H Wilding
Metabolism: clinical and experimental, 63(10), 1228-1237 (2014-08-12)
The kidneys play an important role in regulating glucose homeostasis through utilization of glucose, gluconeogenesis, and glucose reabsorption via sodium glucose co-transporters (SGLTs) and glucose transporters. The renal threshold for glucose excretion (RTG) is increased in patients with type 2
Raimunda Sâmia Nogueira Brilhante et al.
Mycopathologia, 180(5-6), 421-426 (2015-09-14)
The aim of this study was to evaluate the antifungal susceptibility of Candida spp. recovered from tortoises (Chelonoidis spp.) and sea turtles (Chelonia mydas, Caretta caretta, Lepidochelys olivacea, Eretmochelys imbricata). For this purpose, material from the oral cavity and cloaca
Matthias Totzeck et al.
Molecular and cellular biochemistry, 401(1-2), 175-183 (2014-12-17)
Skeletal muscle tissue has a remarkable high regenerative capacity. The underlying cellular events are governed by complex signaling processes, and the proliferation of skeletal myoblasts is a key initial event. The role of nitric oxide (NO) in cell cycle regulation
Verónica Brito et al.
The Journal of clinical investigation, 124(10), 4411-4428 (2014-09-03)
Learning and memory deficits are early clinical manifestations of Huntington's disease (HD). These cognitive impairments have been mainly associated with frontostriatal HD pathology; however, compelling evidence provided by several HD murine models suggests that the hippocampus may contribute to synaptic
James M Battisti et al.
PLoS neglected tropical diseases, 9(10), e0004128-e0004128 (2015-10-06)
Bartonella bacilliformis is a pathogenic bacterium transmitted to humans presumably by bites of phlebotomine sand flies, infection with which results in a bi-phasic syndrome termed Carrión's disease. After constructing a low-passage GFP-labeled strain of B. bacilliformis, we artificially infected Lutzomyia
Alexis Courbet et al.
Science translational medicine, 7(289), 289ra83-289ra83 (2015-05-29)
Whole-cell biosensors have several advantages for the detection of biological substances and have proven to be useful analytical tools. However, several hurdles have limited whole-cell biosensor application in the clinic, primarily their unreliable operation in complex media and low signal-to-noise
Kyung-Min Lee et al.
Cellular signalling, 27(2), 228-235 (2014-12-03)
The Warburg effect is an oncogenic metabolic switch that allows cancer cells to take up more glucose than normal cells and favors anaerobic glycolysis. Extracellular matrix protein 1 (ECM1) is a secreted glycoprotein that is overexpressed in various types of
Liwei Zhang et al.
Environmental technology, 35(9-12), 1064-1076 (2014-04-08)
The purpose of this study was to develop a mathematical model that can describe glucose degradation in a microbial fuel cell (MFC) with the use of finite difference approach. The dynamic model can describe both substrate and pH changes in
Cesar Echeverría et al.
Journal of hypertension, 33(5), 981-992 (2015-04-25)
To study whether transient receptor potential melastatin 4 (TRPM4) participates in endothelial fibrosis and to investigate the underlying mechanism. Primary human endothelial cells were used and pharmacological and short interfering RNA-based approaches were used to test the transforming growth factor
A Zywert et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 65(3), 425-433 (2014-06-17)
Cyclic adenosine monophosphate (cAMP) plays important role in the potentiation of insulin secretion in pancreatic B-cells. However, the relevance of cAMP-degrading enzymes in the regulation of insulin secretion is not fully elucidated. The present work was undertaken to determine effects
Eliseo A Eugenin et al.
Journal of neurochemistry, 151(5), 558-569 (2019-08-06)
Chemical and electrical synapses are the two major communication systems that permit cell-to-cell communication within the nervous system. Although most studies are focused on chemical synapses (glutamate, γ-aminobutyric acid, and other neurotransmitters), clearly both types of synapses interact and cooperate
Angella Charnot-Katsikas et al.
Journal of medical microbiology, 63(Pt 2), 235-241 (2013-11-15)
This study assessed the accuracy of bacterial and yeast identification using the VITEK MS, and the time to reporting of isolates before and after its implementation in routine clinical practice. Three hundred and sixty-two isolates of bacteria and yeast, consisting
Lu Li et al.
Nature communications, 6, 6319-6319 (2015-02-19)
Neurons have complex dendritic trees, receiving numerous inputs at various distances from the cell body. Yet the rules of molecular signal propagation from dendrites to nuclei are unknown. DARPP-32 is a phosphorylation-regulated signalling hub in striatal output neurons. We combine
Brad Hall et al.
Optometry and vision science : official publication of the American Academy of Optometry, 92(7), 781-789 (2015-05-24)
To compare the adsorption of lysozyme, lactoferrin, and albumin to various contact lens materials, between single-protein solutions and a multicomponent artificial tear solution (ATS). Additionally, extra steps were taken to distinguish loosely and tightly bound protein, the latter of which
Huey-Ling Tseng et al.
PloS one, 10(3), e0120380-e0120380 (2015-03-24)
Circadian rhythms are intrinsic rhythms that are coordinated with the rotation of the Earth and are also generated by a set of circadian-clock genes at the intracellular level. Growing evidence suggests a strong link between circadian rhythms and energy metabolism;
Shi Yu et al.
Biotechnology letters, 37(9), 1853-1859 (2015-05-15)
A novel, high-level expression, thermostable mannan endo-1,4-beta-mannosidase is urgently needed for industrial applications. The mannan endo-1,4-β-mannosidase gene (MAN) from Aspergillus niger CBS 513.88 was optimized based on the codon usage bias in Pichia pastoris and synthesized by overlapping PCR to
Ayan K Ghosh et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(5), 2081-2098 (2015-02-19)
Understanding the mechanism that allows the intracellular protozoan parasite Leishmania donovani (Ld) to respond to reactive oxygen species (ROS) is of increasing therapeutic importance because of the continuing resistance toward antileishmanial drugs and for determining the illusive survival strategy of
Julia Keller et al.
Journal of physiology and biochemistry, 71(3), 577-587 (2015-04-05)
Opuntia species have been used for thousands of years as a folk medicine in the treatment of diseases. However, the components and protective mechanisms are still unclear. We make the hypothesis that Opuntia species may protect the development of oxidative
Min-Kyung Kang et al.
Journal of molecular medicine (Berlin, Germany), 93(7), 759-772 (2015-06-13)
Renal fibrosis is a crucial event in the pathogenesis of diabetic nephropathy (DN). The process known as epithelial to mesenchymal transition (EMT) contributes to the accumulation of matrix proteins in kidneys, in which renal tubular epithelial cells play an important
Matthew Fletcher et al.
Cancer research, 75(2), 275-283 (2014-11-20)
Enzymatic depletion of the nonessential amino acid l-Arginine (l-Arg) in patients with cancer by the administration of a pegylated form of the catabolic enzyme arginase I (peg-Arg I) has shown some promise as a therapeutic approach. However, l-Arg deprivation also
Magdalena Kondeva-Burdina et al.
Pharmacognosy magazine, 10(Suppl 3), S487-S493 (2014-10-10)
Astragalus hamosus L. (Fabaceae) is used in herbal medicine as emollient, demulcent, phrodisiac, diuretic, laxative, and good for inflammation, ulcers, and leukoderma. It is useful in treating irritation of the mucous membranes, nervous affections, and catarrh. Rhamnocitrin 4-β-D-galactopyranoside (RGP), isolated
William Lee et al.
Frontiers in neuroengineering, 1, 2-2 (2009-01-09)
Astrocytes play an important role in cell-cell signaling in the mammalian central nervous system. The ability of astrocytes to communicate with surrounding cells through gap-junctional coupling or signaling via the release of transmitters makes characterization of these cells difficult in
Ceren Erdem et al.
Artificial cells, nanomedicine, and biotechnology, 42(4), 237-244 (2013-06-26)
In the present work, we designed an amperometric glucose biosensor based on nickel oxide nanoparticles (NiONPs)-modified carbon paste electrode. The biosensor was prepared by incorporation of glucose oxidase and NiONPs into a carbon paste matrix. It showed good analytical performances
Christel Thauvin-Robinet et al.
American journal of human genetics, 93(1), 141-149 (2013-07-03)
Short stature, hyperextensibility of joints and/or inguinal hernia, ocular depression, Rieger anomaly, and teething delay (SHORT) syndrome is a developmental disorder with an unknown genetic cause and hallmarks that include insulin resistance and lack of subcutaneous fat. We ascertained two
Yumi Kohara et al.
Physiology & behavior, 140, 15-22 (2014-12-08)
Cognitive dysfunction due to higher blood glucose level has been reported previously. Genistein (GEN) is a phytoestrogen that we hypothesized might lead to improved memory, despite elevated blood glucose levels at the time of memory consolidation. To investigate this hypothesis
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