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Alison C Macleod et al.
Molecular cancer therapeutics, 13(12), 2840-2851 (2014-09-26)
Resistant KIT mutations have hindered the development of KIT kinase inhibitors for treatment of patients with systemic mastocytosis. The goal of this research was to characterize the synergistic effects of a novel combination therapy involving inhibition of KIT and calcineurin...
Catarina Mota et al.
Journal of immunology (Baltimore, Md. : 1950), 193(12), 5854-5862 (2014-11-05)
FOXP3-expressing regulatory T cells (Treg) are essential for the prevention of autoimmunity and were shown to be reduced and/or dysfunctional in several autoimmune diseases. Although Treg-based adoptive transfer represents a promising therapy, the large cell number required to achieve clinical...
C M Lee et al.
Genes and immunity, 16(5), 356-361 (2015-04-24)
Epithelium-specific Ets transcription factor 1 (ESE-1) is a member of the E26 transformation-specific family of transcription factors that has an epithelial-restricted constitutive expression but is induced by inflammatory stimuli in non-epithelial cells. Here we report that ESE-1 is constitutively expressed...
Ina Kurth et al.
Oncotarget, 6(33), 34494-34509 (2015-10-16)
Despite recent advances in understanding of the molecular pathogenesis and improvement of treatment techniques, locally advanced head and neck squamous cell carcinoma (HNSCC) remains associated with an unfavorable prognosis. Compelling evidence suggests that cancer stem cells (CSC) may cause tumor...
Filip Bochner et al.
Scientific reports, 5, 12446-12446 (2015-07-25)
The ovary is a dynamic organ that undergoes dramatic remodeling throughout the ovulatory cycle. Maturation of the ovarian follicle, release of the oocyte in the course of ovulation as well as formation and degradation of corpus luteum involve tightly controlled...
Jenni Küblbeck et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(7), 1759-1765 (2015-07-19)
Discovery of receptor-dependent mechanisms for regulation of drug metabolism has provided a new way to evaluate the propensity of drug candidates to cause induction of cytochrome P450 enzymes. Therefore, receptor-based reporter assays have become common in early stages of drug...
Chen Dai et al.
Journal of immunology (Baltimore, Md. : 1950), 194(12), 5980-5989 (2015-05-13)
CXCL14 is a chemokine with an atypical, yet highly conserved, primary structure characterized by a short N terminus and high sequence identity between human and mouse. Although it induces chemotaxis of monocytic cells at high concentrations, its physiological role in...
Manuel Torres et al.
Apoptosis : an international journal on programmed cell death, 20(5), 712-724 (2015-02-11)
The unfolded protein response (UPR) and autophagy are two cellular processes involved in the clearing of intracellular misfolded proteins. Both pathways are targets for molecules that may serve as treatments for several diseases, including neurodegenerative disorders like Alzheimer's disease (AD)....
Florian Noulin et al.
PloS one, 9(11), e112496-e112496 (2014-11-14)
The predilection of Plasmodium vivax (P. vivax) for reticulocytes is a major obstacle for its establishment in a long-term culture system, as this requires a continuous supply of large quantities of reticulocytes, representing only 1-2% of circulating red blood cells....
Sebastien Gingras et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(29), 10510-10522 (2015-07-24)
Neuronal death caused by excessive excitatory signaling, excitotoxicity, plays a central role in neurodegenerative disorders. The mechanisms regulating this process, however, are still incompletely understood. Here we show that the coated vesicle-associated kinase SCYL2/CVAK104 plays a critical role for the...
M Di Giovangiulio et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 27(11), 1542-1552 (2015-08-01)
The orexigenic peptide ghrelin has anti-inflammatory properties in colitis, however, the mechanism of action and the immune cells targeted remain still to be elucidated. Here, we assessed the possible effect of ghrelin on T helper (Th) cells in a T...
Katherine J Reid et al.
Toxicon : official journal of the International Society on Toxinology, 106, 79-88 (2015-09-26)
Undifferentiated mouse embryonic stem cell (mES) proliferation in vitro resembles aspects of in vivo pre-implantation embryonic development. mES were used to assess the embryo-toxicity of cylindrospermopsin (CYN), a water contaminant with an Australian Drinking Water Guideline (ADWG) of 1 μg/L....
Ting Zhao et al.
Journal of immunology (Baltimore, Md. : 1950), 193(4), 1942-1953 (2014-07-09)
The underlying mechanisms that lysosomal acid lipase (LAL) deficiency causes infiltration of myeloid-derived suppressor cells (MDSCs) in multiple organs and subsequent inflammation remain incompletely understood. Endothelial cells (ECs), lining the inner layer of blood vessels, constitute barriers regulating leukocytes transmigration...
Patrícia Severino et al.
European journal of medicinal chemistry, 81, 28-34 (2014-05-14)
Insulin was used as model protein to developed innovative Solid Lipid Nanoparticles (SLNs) for the delivery of hydrophilic biotech drugs, with potential use in medicinal chemistry. SLNs were prepared by double emulsion with the purpose of promoting stability and enhancing...
Elaine M Jagoda et al.
Molecular imaging, 14, 499-515 (2015-10-16)
Developing an imaging agent targeting the hepatocyte growth factor receptor protein (Met) status of cancerous lesions would aid in the diagnosis and monitoring of Met-targeted tyrosine kinase inhibitors (TKIs). A peptide targeting Met labeled with [(99m)Tc] had high affinity in...
Yang Yang et al.
Scientific reports, 5, 17554-17554 (2015-12-04)
Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel and highly pathogenic human coronavirus and has quickly spread to other countries in the Middle East, Europe, North Africa and Asia since 2012. Previous studies have shown that MERS-CoV ORF4b antagonizes...
Arjunan Subramanian et al.
PloS one, 10(6), e0127992-e0127992 (2015-06-11)
The human umbilical cord (UC) is an attractive source of mesenchymal stem cells (MSCs) with unique advantages over other MSC sources. They have been isolated from different compartments of the UC but there has been no rigorous comparison to identify...
Fereshteh Mehraein et al.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 13(3), 256-261 (2015-06-19)
Very small embryoniclike stem cells are a population of small stem cells with embryonic characteristics that were identified in adult murine bone marrow. During the past decade, researchers have examined different alternatives for functional recovery after spinal cord injury. The...
Wipada Samprasit et al.
International journal of pharmaceutics, 487(1-2), 213-222 (2015-04-23)
Fast release and taste masking of meloxicam (MX)-loaded polyvinylpyrrolidone (PVP)/cyclodextrin (CD) nanofiber mats were developed using an electrospinning process. CDs were blended to improve the stability of the mats. The morphology and diameter of the mats were determined using scanning...
P Mabeta
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 68(5), 611-617 (2014-04-30)
The phosphoinositide 3-kinase (PI3k) signaling pathway is involved in the regulation of numerous cellular activities. The pathway has also been implicated in the development of various tumors. In the context of vascular tumors, the role of the PI3k signaling still...
Zhonglu Yang et al.
Medical oncology (Northwood, London, England), 31(12), 337-337 (2014-11-25)
3-Phosphoinositide-dependent protein kinase-1 (PDK1) has been reported to be closely correlated with proliferation, apoptosis and invasion of esophageal cancer cells. However, its expression pattern and clinical significance in human esophageal squamous cell carcinoma (ESCC) remain unclear. To address this problem...
Gerald Bachler et al.
Particle and fibre toxicology, 12, 18-18 (2015-06-28)
The lung epithelial tissue barrier represents the main portal for entry of inhaled nanoparticles (NPs) into the systemic circulation. Thus great efforts are currently being made to determine adverse health effects associated with inhalation of NPs. However, to date very...
Frantiescoli Dimer et al.
Pharmaceutical research, 32(12), 3850-3861 (2015-06-27)
The aim of this work was to develop clarithromycin microparticles (CLARI-MP) and evaluate their aerodynamic behavior, safety in bronchial cells and anti-bacterial efficacy. Microparticles containing clarithromycin were prepared as dry powder carrier for inhalation, using leucine and chitosan. CLARI-MP were...
Reed A Goodwin et al.
Journal of bacteriology, 196(10), 1901-1907 (2014-03-19)
In Sinorhizobium meliloti, catabolite repression is influenced by a noncanonical nitrogen-type phosphotransferase system (PTS(Ntr)). In this PTS(Ntr), the protein HPr is phosphorylated on histidine-22 by the enzyme EI(Ntr) and the flux of phosphate through this residue onto downstream proteins leads...
Daorong Feng et al.
PloS one, 10(6), e0126240-e0126240 (2015-06-05)
In non-alcoholic fatty liver disease (NAFLD) and insulin resistance, hepatic de novo lipogenesis is often elevated, but the underlying mechanisms remain poorly understood. Recently, we show that CDK8 functions to suppress de novo lipogenesis. Here, we identify the mammalian target...
Hila Confino et al.
Cancer immunology, immunotherapy : CII, 64(2), 191-199 (2014-10-19)
The current systemic anti-metastatic treatment is chemotherapy. Chemotherapy reacts mostly against replicating cells, which makes this therapy not specific. Moreover, resting cancer cells will not be destroyed. A better alternative is an engagement of the host immune system to react...
Qing Zhu et al.
Viral immunology, 28(9), 495-503 (2015-09-24)
Human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein 120 (gp120) has been reported to be toxic to the hippocampal neurons, and to be involved in the pathogenesis of HIV-1-associated neurocognitive disorders (HAND). Accumulating evidence has demonstrated that voltage-gated potassium (Kv)...
Marialuisa Moccia et al.
PloS one, 10(6), e0128364-e0128364 (2015-06-06)
Oncogenic mutation of the RET receptor tyrosine kinase is observed in several human malignancies. Here, we describe three novel type II RET tyrosine kinase inhibitors (TKI), ALW-II-41-27, XMD15-44 and HG-6-63-01, that inhibit the cellular activity of oncogenic RET mutants at...
Armin Wiegering et al.
Neoplasia (New York, N.Y.), 16(11), 972-981 (2014-11-27)
Clinical prognosis of metastasized colorectal carcinoma (CRC) is still not at desired levels and novel drugs are needed. Here, we focused on the multi-tyrosine kinase inhibitor E7080 (Lenvatinib) and assessed its therapeutic efficacy against human CRC cell lines in vitro...
Morteza Abkar et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 123(8), 667-675 (2015-05-06)
Brucellosis is a world prevalent endemic illness that is transmitted from domestic animals to humans. Brucella spp. exploits urease for survival in the harsh conditions of stomach during the gastrointestinal infection. In this study, we examined the immune response and...
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