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Yu-Feng Zhang et al.
Clinical laboratory, 61(8), 999-1008 (2015-10-03)
Advanced glycation end products (AGEs) accumulate in the retinal vascular cells, neurons, and glias of patients with diabetes mellitus and lead to the pathogenesis of diabetic retinopathy (DR). In the present study, to elucidate the orchestrated interactions of high mobility
Patrick Sherwood et al.
Tree physiology, 35(5), 549-562 (2015-04-23)
Plants experiencing drought stress are frequently more susceptible to pathogens, likely via alterations in physiology that create favorable conditions for pathogens. Common plant responses to drought include the production of reactive oxygen species (ROS) and the accumulation of free amino
Mio Okada et al.
Journal of breath research, 8(4), 046004-046004 (2014-11-02)
Transplantation of insulin (INS)-secreting cells differentiated in vitro from stem cells promises a safer and easier treatment of severe diabetes mellitus. A volatile bioactive compound, hydrogen sulfide (H2S), promotes cell differentiation; human tooth-pulp stem cells undergo hepatic differentiation. The aim
Digar Singh et al.
Biotechnology progress, 30(5), 1196-1205 (2014-07-22)
Swainsonine, a secondary metabolite from Metarhizium anisopliae has been extensively studied in the complementary areas of therapeutics and toxicology. This work aims to develop a simple UV-HPLC method of analyses for swainsonine in Metarhizium fermentation broth and to explore its
Dimitrios Moustakas et al.
PloS one, 10(4), e0123310-e0123310 (2015-04-17)
The stimulant effect of energy drinks is primarily attributed to the caffeine they contain. Many energy drinks also contain other ingredients that might enhance the tonic effects of these caffeinated beverages. One of these additives is guarana. Guarana is a
Paola Occhetta et al.
Scientific reports, 5, 10288-10288 (2015-05-20)
The development of in vitro models to screen the effect of different concentrations, combinations and temporal sequences of morpho-regulatory factors on stem/progenitor cells is crucial to investigate and possibly recapitulate developmental processes with adult cells. Here, we designed and validated
J Gui et al.
Placenta, 36(4), 410-418 (2015-02-17)
Gestational diabetes (GDM) is associated with long-term cardiovascular and metabolic diseases in offspring. However, the mechanisms are not well understood. We explored whether fetal exposure to a diabetic environment is associated with fetal endothelial progenitor cell dysfunction, and whether vitamin
Ilia Zhernov et al.
Current biology : CB, 30(17), 3342-3351 (2020-07-11)
In addition to their force-generating motor domains, kinesin motor proteins feature various accessory domains enabling them to fulfill a variety of functions in the cell. Human kinesin-3, Kif14, localizes to the midbody of the mitotic spindle and is involved in
Aghil Sharifzadeh et al.
Mycoses, 58(8), 478-484 (2015-07-15)
The purposes of this study were to investigate the enzymatic activity of different Candida species and their antifungal susceptibility patterns. The study involved a total of 83 isolates of Candida from the genital tract of the female Camelus dromedarius. After
Sung Ouk Nam et al.
Cancer medicine, 4(4), 575-587 (2015-02-04)
Colorectal cancer (CRC) is one of the most frequently occurring cancers with high morbidity and mortality worldwide. Amphiregulin (AREG), a member of the epidermal growth factor family and a rational target for CRC therapy, is essential for the three-dimensional structure
Woong Jin Bae et al.
Journal of Korean medical science, 30(9), 1313-1320 (2015-09-05)
Diabetes is related with a number of cystopathic complications. However, there have been no studies about the influence of alcohol consumption in the bladder of type 2 diabetes. Thus, we investigated the effect of moderate alcohol intake in the bladder
Ender Gedik et al.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 13 Suppl 1, 294-300 (2015-04-22)
The goal of this study was to compare the effects of 2 different regimens on blood glucose levels of living-donor liver transplant. The study participants were randomly allocated to the dextrose in water plus insulin infusion group (group 1, n
Johan B Fagman et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(4), 1540-1550 (2015-01-01)
Androgens have important cardiometabolic actions in males, but their metabolic role in females is unclear. To determine the physiologic androgen receptor (AR)-dependent actions of androgens on atherogenesis in female mice, we generated female AR-knockout (ARKO) mice on an atherosclerosis-prone apolipoprotein
Riccardo D'Elia et al.
BMC genomics, 10, 492-492 (2009-10-27)
Trichuris muris in the mouse is an invaluable model for infection of man with the gastrointestinal nematode Trichuris trichiura. Three T. muris isolates have been studied, the Edinburgh (E), the Japan (J) and the Sobreda (S) isolates. The S isolate
Regulation of glucose homeostasis using radiogenetics and magnetogenetics in mice.
Ingo B Leibiger et al.
Nature medicine, 21(1), 14-16 (2015-01-09)
Jennifer A-L M Pirotte et al.
The Journal of experimental biology, 221(Pt 20) (2018-09-13)
Winged aphids are described as hosts of lesser quality for parasitoids because a part of their resources is used to produce wings and associated muscles during their development. Host lipid content is particularly important for parasitoid larvae as they lack
Nadya Shusharina et al.
International journal of radiation oncology, biology, physics, 89(1), 137-144 (2014-04-15)
To investigate the spatial correlation between high uptake regions of 2-deoxy-2-[(18)F]-fluoro-D-glucose positron emission tomography ((18)F-FDG PET) before and after therapy in recurrent lung cancer. We enrolled 106 patients with inoperable lung cancer into a prospective study whose primary objectives were
Mahzad Akbarpour et al.
Science translational medicine, 7(289), 289ra81-289ra81 (2015-05-29)
Antigen (Ag)-specific tolerance in type 1 diabetes (T1D) in human has not been achieved yet. Targeting lentiviral vector (LV)-mediated gene expression to hepatocytes induces active tolerance toward the encoded Ag. The insulin B chain 9-23 (InsB9-23) is an immunodominant T
Prithy Rupa et al.
Journal of agricultural and food chemistry, 62(39), 9479-9487 (2014-09-13)
Food allergies are attributed to an imbalance in immune response to ubiquitous antigens. A previous study demonstrated that mannose glycation (mannosylation) of ovalbumin decreased allergenicity in vivo. The proposed research targets mannosylation of various common allergens that may help prevent
Ki-Young Lee et al.
Nucleic acids research, 43(10), 5194-5207 (2015-04-29)
HP0268 is a conserved, uncharacterized protein from Helicobacter pylori. Here, we determined the solution structure of HP0268 using three-dimensional nuclear magnetic resonance (NMR) spectroscopy, revealing that this protein is structurally most similar to a small MutS-related (SMR) domain that exhibits
Jie Zhang et al.
Phytochemistry, 108, 157-170 (2014-12-03)
The MeOH extract of defatted shea (Vitellaria paradoxa; Sapotaceae) kernels was investigated for its constituents, and fifteen oleanane-type triterpene acids and glycosides, two steroid glucosides, two pentane-2,4-diol glucosides, seven phenolic compounds, and three sugars, were isolated. The structures of five
Jason M Tonne et al.
Diabetologia, 58(2), 313-323 (2014-10-24)
Achieving a better understanding of beta cell regeneration after immunological destruction is crucial for the development of immunotherapy approaches for type 1 diabetes. In previous type 1 diabetes models, sustained immune activation eliminates regenerating beta cells, thus limiting the study
Maria Clerya Alvino Leite et al.
Medical mycology, 53(3), 275-284 (2014-12-07)
Candida albicans can be a yeast that is a commensal on the human body but can cause opportunistic or pathogenic infections. Candida infections may create serious health problems and as a result has initiated a search for new drugs with
Saidan Ding et al.
The international journal of biochemistry & cell biology, 55, 252-263 (2014-09-16)
We previously demonstrated that dopamine (DA) overload may be a key mechanism behind development of minimal hepatic encephalopathy (MHE) in rats. It has been shown that low-grade cerebral oedema and oxidative stress play important roles in the pathogenesis of MHE.
Peng Wang et al.
Fitoterapia, 103, 1-8 (2015-03-17)
Six new indole glucosides (1-6) and fifteen known alkaloids (7-21) were isolated from the fruit of Camptotheca acuminata. The planar structures of 1-6 were determined on the basis of spectroscopic data analysis and their absolute configurations were established by CD.
Vijayashankar Nataraj et al.
PloS one, 10(3), e0122804-e0122804 (2015-04-22)
Lipooligosaccharides are glycolipids found in the cell wall of many mycobacterial species including the opportunistic pathogen Mycobacterium kansasii. The genome of M. kansasii ATCC12478 contains a cluster with genes orthologous to Mycobacterium marinum LOS biosynthesis genes. To initiate a genetic
Kim Tardif et al.
Cardiovascular diabetology, 13, 119-119 (2014-08-21)
Nestin was reported to directly contribute to cell proliferation and the intermediate filament protein was detected in vascular smooth muscle cells. In experimental type I diabetes, nestin downregulation in the heart was identified as an incipient pathophysiological event. The following
Chun-Yi Chiu et al.
Ultrasound in medicine & biology, 41(7), 1842-1852 (2015-04-30)
This study was performed to investigate osteoblastogenesis of human mesenchymal stem cells (hMSCs) cultured in 3-D scaffolds stimulated with low-intensity pulsed ultrasound and to identify the underlying mechanism mediated by soluble receptor activator of nuclear factor kappa B ligand (sRANKL)
Diego F Garcia-Diaz et al.
Journal of medicinal food, 18(4), 489-496 (2014-08-01)
Increased adiposity has been associated with macrophage infiltration into the adipose tissue which, in turn, leads to obesity comorbidities, including type 2 diabetes. The objective of this study was to evaluate the effect of anthocyanin (ANC)-enriched fractions from blackberry-blueberry beverages
Steven K Pregizer et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(1), 64-70 (2014-07-22)
Transcription of BMPs and their antagonists in precise spatiotemporal patterns is essential for proper skeletal development, maturation, maintenance, and repair. Nevertheless, transcriptional activity of these molecules in skeletal tissues beyond embryogenesis has not been well characterized. In this study, we
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