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H6908

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Ronghua Wang et al.
Oncotarget, 8(41), 70142-70155 (2017-10-21)
The small ubiquitin-related modifier (SUMO) system is essential for smooth progression of cell cycle at the G2/M phase. Many centromeric proteins are reversibly SUMOylated to ensure proper chromosome segregation at the mitosis. SUMOylation of centromeric Origin Recognition Complex subunit 2...
Jianxin Jiang et al.
Molecular therapy oncolytics, 17, 384-393 (2020-05-15)
Cancer stem cells are the main reason for drug resistance and tumor relapse, and screening the targets for cancer stem cells is essential for tumor therapy. Here, we studied the role and regulatory mechanism of a G protein-coupled receptor named...
Hyo Jeong Kang et al.
Oncotarget, 8(16), 27263-27276 (2017-05-04)
The non-receptor tyrosine phosphatase SHP2 has scaffolding functions in signal transduction cascades downstream of growth receptors. A recent study suggested that SHP2 acts as a tumor suppressor during hepatocellular carcinoma (HCC) development. Herein we examined whether SHP2 links the HBx-NF-κB...
Xi Tang et al.
Oncotarget, 5(5), 1352-1362 (2014-03-25)
The development of effective therapies inhibiting prostate cancer progression and metastasis may substantially impact prostate cancer mortality and potentially reduce the rates of invasive treatments by enhancing the safety of active surveillance strategies. Hepsin (HPN) is a cell surface serine...
Luca Bellucci et al.
PloS one, 8(1), e54102-e54102 (2013-01-26)
Differential positioning of the histone variant H2A.Z in a p53 dependent manner was shown to regulate p21 transcription. Whether H2A.Z is involved in p21 activity in the absence of p53 is not known. The p21 gene is repressed in estrogen...
Mirjam W M van den Bosch et al.
The Journal of biological chemistry, 289(33), 22980-22990 (2014-07-02)
Programmed cell death protein 4 (PDCD4) is a tumor suppressor and has also been shown to suppress production of the immunomodulatory cytokine IL-10. The precise role of PDCD4 in IL-10 induction in macrophages is still not fully understood. Incubation of...
Zhi Wen et al.
Molecular and cellular biology, 32(1), 26-35 (2011-10-26)
Since inactivation of tumor suppressor p53 functions is one of the most common features of human cancer cells, restoring p53 expression and activity is an important focus in cancer therapy. Here we report identification of photoreceptor-specific nuclear receptor (PNR)/NR2E3 as...
Hanjing Yang et al.
Nature communications, 11(1), 632-632 (2020-02-02)
APOBEC3G, a member of the double-domain cytidine deaminase (CD) APOBEC, binds RNA to package into virions and restrict HIV-1 through deamination-dependent or deamination-independent inhibition. Mainly due to lack of a full-length double-domain APOBEC structure, it is unknown how CD1/CD2 domains...
Diana M Monsalve et al.
Biochimica et biophysica acta, 1863(4), 760-769 (2016-02-13)
NBS1 is an early component in DNA-Damage Response (DDR) that participates in the initiation of the responses aiming to repair double-strand breaks caused by different mechanisms. Early steps in DDR have to react to local alterations in chromatin that are...
Xiaofeng Gu et al.
PLoS biology, 11(9), e1001649-e1001649 (2013-09-11)
The developmental transition from a vegetative to a reproductive phase (i.e., flowering) is timed by the seasonal cue day length or photoperiod in many plant species. Through the photoperiod pathway, inductive day lengths trigger the production of a systemic flowering...
Luciano Pirone et al.
The FEBS journal, 286(13), 2505-2521 (2019-04-08)
About 90% of congenital central hypoventilation syndrome (CCHS) patients show polyalanine triplet expansions in the coding region of transcription factor PHOX2B, which renders this protein an intriguing target to understand the insurgence of this syndrome and for the design of...
Judith Mesicek et al.
Cellular signalling, 22(9), 1300-1307 (2010-04-22)
The role of ceramide neo-genesis in cellular stress response signaling is gaining increasing attention with recent progress in elucidating the novel roles and biochemical properties of the ceramide synthase (CerS) enzymes. Selective tissue and subcellular distribution of the six mammalian...
Taha Azad et al.
Oncogene, 39(2), 334-355 (2019-09-04)
The Hippo pathway has emerged as a key signaling pathway that regulates various biological functions. Dysregulation of the Hippo pathway has been implicated in a broad range of human cancer types. While a number of stimuli affecting the Hippo pathway...
Kristina Heyne et al.
Nucleic acids research, 38(10), 3159-3171 (2010-02-04)
p63 Is a sequence-specific transcription factor that regulates epithelial stem cell maintenance and epithelial differentiation. In addition, the TAp63 isoform with an N-terminal transactivation domain functions as an inducer of apoptosis during the development of sympathetic neurons. Previous work has...
Jyoti Batra et al.
Cell, 175(7), 1917-1930 (2018-12-15)
Ebola virus (EBOV) infection often results in fatal illness in humans, yet little is known about how EBOV usurps host pathways during infection. To address this, we used affinity tag-purification mass spectrometry (AP-MS) to generate an EBOV-host protein-protein interaction (PPI)...
Curtis J Layton et al.
Protein science : a publication of the Protein Society, 20(8), 1432-1438 (2011-06-16)
Assays that integrate detection of binding with cell-free protein expression directly from DNA can dramatically increase the pace at which protein-protein interactions (PPIs) can be analyzed by mutagenesis. In this study, we present a method that combines in vitro protein...
Dongning Pan et al.
PLoS genetics, 8(6), e1002761-e1002761 (2012-06-22)
Hepatic gluconeogenesis is required for maintaining blood glucose homeostasis; yet, in diabetes mellitus, this process is unrestrained and is a major contributor to fasting hyperglycemia. To date, the impacts of chromatin modifying enzymes and chromatin landscape on gluconeogenesis are poorly...
Longfei Li et al.
Molecular neurobiology, 56(9), 6168-6183 (2019-02-09)
Microtubule-associated protein tau in Alzheimer's disease (AD) brain is hyperphosphorylated, truncated, and aggregated into neurofibrillary tangles. Oligomeric and hyperphosphorylated tau (Oligo-tau) isolated from AD brain captures and templates normal tau into filaments both in vitro and in vivo; this prion-like...
Michael Rosenberg et al.
Cell systems, 5(4), 368-385 (2017-10-27)
Interaction networks between chromatin complexes and long noncoding RNAs have become a recurrent theme in epigenetic regulation. However, technical limitations have precluded identification of RNA binding motifs for chromatin-associated proteins. Here, we add a denaturation step to UV-crosslink RNA immunoprecipitation...
Meng Yang et al.
The Plant cell, 30(7), 1582-1595 (2018-06-01)
Autophagy is a conserved defense strategy against viral infection. However, little is known about the counterdefense strategies of plant viruses involving interference with autophagy. Here, we show that γb protein from Barley stripe mosaic virus (BSMV), a positive single-stranded RNA...
Xiangling Chen et al.
Theranostics, 8(9), 2348-2360 (2018-05-04)
The X-linked deubiquitinase, USP9X, is implicated in multiple cancers by targeting various substrates. Increased expression of USP9X is observed in non-small-cell lung cancer (NSCLC) and is correlated with poor prognosis. However, the molecular mechanism for USP9X regulation of tumor cell...
Wouter P R Verdurmen et al.
Scientific reports, 7(1), 13194-13194 (2017-10-19)
Over many years, a variety of delivery systems have been investigated that have the capacity to shuttle macromolecular cargoes, especially proteins, into the cytosol. Due to the lack of an objective way to quantify cytosolic delivery, relative delivery efficiencies of...
Dilshan Balasuriya et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(46), 18219-18224 (2013-11-15)
The σ-1 receptor (Sig1R) is widely expressed in the CNS, where it has a neuroprotective role in ischemia and stroke and an involvement in schizophrenia. The Sig1R interacts functionally with a variety of ion channels, including the NMDA receptor (NMDAR)....
Edward C Goodwin et al.
PloS one, 9(4), e94322-e94322 (2014-04-16)
DNAJB12 and DNAJB14 are transmembrane proteins in the endoplasmic reticulum (ER) that serve as co-chaperones for Hsc70/Hsp70 heat shock proteins. We demonstrate that over-expression of DNAJB12 or DNAJB14 causes the formation of elaborate membranous structures within cell nuclei, which we...
Ersin Selcuk Unal et al.
The Journal of biological chemistry, 284(26), 17846-17857 (2009-04-25)
This report addresses the functional role of His residues in the proton-coupled folate transporter (PCFT; SLC46A1), which mediates intestinal folate absorption. Of ten His residues, only H247A and H281A mutations altered function. The folic acid influx Kt at pH 5.5...
Roger A J Habets et al.
The Journal of biological chemistry, 290(23), 14705-14716 (2015-04-29)
Cell surface receptors of the NOTCH family of proteins are activated by ligand induced intramembrane proteolysis. Unfolding of the extracellular negative regulatory region (NRR), enabling successive proteolysis by the enzymes Adam10 and γ-secretase, is rate-limiting in NOTCH activation. Mutations in...
Yuanzhi Lyu et al.
Journal of virology, 91(21) (2017-08-25)
Bivalent histone modifications are defined as repressive and activating epigenetic marks that simultaneously decorate the same genomic region. The H3K27me3 mark silences gene expression, while the H3K4me3 mark prevents the region from becoming permanently silenced and prepares the domain for...
Rosa Viñas-Castells et al.
Nucleic acids research, 42(2), 1079-1094 (2013-10-26)
The zinc finger transcription factor Snail1 regulates epithelial to mesenchymal transition, repressing epithelial markers and activating mesenchymal genes. Snail1 is an extremely labile protein degraded by the cytoplasmic ubiquitin-ligases β-TrCP1/FBXW1 and Ppa/FBXL14. Using a short hairpin RNA screening, we have...
Jörg Deiwick et al.
Infection and immunity, 74(12), 6965-6972 (2006-10-04)
The facultative intracellular pathogen Salmonella enterica causes a variety of diseases, including gastroenteritis and typhoid fever. Inside epithelial cells, Salmonella replicates in vacuoles, which localize in the perinuclear area in close proximity to the Golgi apparatus. Among the effector proteins...
Lingfang Zeng et al.
Circulation, 127(16), 1712-1722 (2013-03-27)
Vascular endothelial cell growth factor plays a pivotal role in angiogenesis via regulating endothelial cell proliferation. The X-box binding protein 1 (XBP1) is believed to be a signal transducer in the endoplasmic reticulum stress response. It is unknown whether there...
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