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" within Papeles
Tai An et al.
Journal of cell science, 133(11) (2020-05-13)
The human parasite Trypanosoma brucei transitions from the trypomastigote form to the epimastigote form in the insect vector by repositioning its mitochondrial genome and flagellum-associated cytoskeleton. The molecular mechanisms underlying such changes in cell morphology remain elusive, but recent works...
Kristina Heyne et al.
Nucleic acids research, 42(6), 3565-3579 (2014-01-15)
NIR (novel INHAT repressor) can bind to p53 at promoters and inhibit p53-mediated gene transactivation by blocking histone acetylation carried out by p300/CBP. Like NIR, the E3 ubiquitin ligase MDM2 can also bind and inhibit p53 at promoters. Here, we...
Yanan Wang et al.
Virology journal, 16(1), 97-97 (2019-08-07)
Transmissible gastroenteritis virus (TGEV), a member of the family Coronaviridae, causes lethal watery diarrhea in piglets. Previous studies have revealed that the coronaviruses develop various strategies to evade the host innate immunity through the inhibition of nuclear factor kappa B...
Qing Zhou et al.
Nucleic acids research, 46(16), 8216-8231 (2018-06-23)
Faithful chromosome segregation depends on correct spindle microtubule-kinetochore attachment and requires certain spindle-associated proteins (SAPs) involved in regulating spindle dynamics and chromosome segregation. Little is known about the spindle-associated proteome in the early divergent Trypanosoma brucei and its roles in...
Jason R Wilson et al.
Antiviral research, 135, 48-55 (2016-10-28)
Zoonotic A(H7N9) avian influenza viruses emerged in China in 2013 and continue to be a threat to human public health, having infected over 800 individuals with a mortality rate approaching 40%. Treatment options for people infected with A(H7N9) include the...
Tony Ngo et al.
PLoS biology, 18(4), e3000656-e3000656 (2020-04-10)
Chemokines and their receptors are orchestrators of cell migration in humans. Because dysregulation of the receptor-chemokine system leads to inflammation and cancer, both chemokines and receptors are highly sought therapeutic targets. Yet one of the barriers for their therapeutic targeting...
Megan R Hockman et al.
Journal of virological methods, 280, 113878-113878 (2020-05-01)
Reassortment of segmented viruses can be an important source of genetic diversity underlying viral evolution and emergence. Methods for the quantification of reassortment have been described but are often cumbersome and best suited for the analysis of reassortment between highly...
Dongxiao Shen et al.
Circulation research, 109(6), 616-628 (2011-07-23)
Integrin-linked kinase (ILK) is located at focal adhesions and links the extracellular matrix (ECM) to the actin cytoskeleton via β1- and β3-integrins. ILK plays a role in the activation of kinases including protein kinase B/Akt and glycogen synthase kinase 3β...
Stephen C Land et al.
The Journal of biological chemistry, 282(28), 20534-20543 (2007-05-16)
Tumors that form as a result of heightened mammalian target of rapamycin (mTOR) signaling are highly vascularized. This process of angiogenesis is regulated through hypoxia-inducible factor (HIF)-mediated transcription of angiogenic factors. It is recognized that inhibition of mTOR with rapamycin...
James A Stapleton et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(31), 9632-9637 (2015-07-23)
Advances in computational design methods have made possible extensive engineering of soluble proteins, but designed β-barrel membrane proteins await improvements in our understanding of the sequence determinants of folding and stability. A subset of the amino acid residues of membrane...
Katherine Brandao et al.
Cellular and molecular life sciences : CMLS, 71(24), 4853-4867 (2014-05-27)
The channel kinases TRPM6 and TRPM7 are both members of the melastatin-related transient receptor potential (TRPM) subfamily of ion channels and the only known fusions of an ion channel pore with a kinase domain. TRPM6 and TRPM7 form functional, tetrameric...
Judith M Fonville et al.
PLoS pathogens, 11(10), e1005204-e1005204 (2015-10-07)
A high particle to infectivity ratio is a feature common to many RNA viruses, with ~90-99% of particles unable to initiate a productive infection under low multiplicity conditions. A recent publication by Brooke et al. revealed that, for influenza A...
Aortic aneurysm generation in mice with targeted deletion of integrin-linked kinase in vascular smooth muscle cells
Shen D, et al.
Circulation Research, 109(6), 616-628 (2011)
Marla M Spain et al.
The Journal of biological chemistry, 285(35), 27457-27467 (2010-06-23)
The SIN3 corepressor serves as a scaffold for the assembly of histone deacetylase (HDAC) complexes. SIN3 and its associated HDAC have been shown to have critical roles in both development and the regulation of cell cycle progression. Although multiple SIN3...
Huiqing Hu et al.
Journal of cell science, 130(24), 4108-4119 (2017-10-28)
Cytokinesis in trypanosomes occurs uni-directionally along the longitudinal axis from the cell anterior towards the cell posterior and requires a trypanosome-specific CIF1-CIF2 protein complex. However, little is known about the contribution of the structural motifs in CIF1 and CIF2 to...
Xianlong Gao et al.
Scientific reports, 8(1), 2730-2730 (2018-02-11)
Recently, we reported that chemokine (C-X-C motif) receptor (CXCR)4 and atypical chemokine receptor 3 regulate α1-adrenergic receptors (α1-AR) through the formation of hetero-oligomeric complexes. Whether α1-ARs also regulate chemokine receptor function within such heteromeric receptor complexes is unknown. We observed...
Annalena La Porte et al.
Journal of virology, 90(21), 9889-9904 (2016-08-26)
INI1/hSNF5/SMARCB1/BAF47 is an HIV-specific integrase (IN)-binding protein that influences HIV-1 transcription and particle production. INI1 binds to SAP18 (Sin3a-associated protein, 18 kDa), and both INI1 and SAP18 are incorporated into HIV-1 virions. To determine the significance of INI1 and the...
Faithful chromosome segregation in Trypanosoma brucei requires a cohort of divergent spindle-associated proteins with distinct functions
Zhou Q, et al.
Nucleic Acids Research, 46(16), 8216-8231 (2018)
Padmaja Jakka et al.
Journal of immunology (Baltimore, Md. : 1950), 200(2), 704-714 (2017-12-10)
Cytoplasmic linker protein 170 (CLIP170) is a CAP-Gly domain-containing protein that is associated with the plus end of growing microtubules and implicated in various cellular processes, including the regulation of microtubule dynamics, cell migration, and intracellular transport. Our studies revealed...
Yiqiang Cai et al.
The Journal of clinical investigation, 124(12), 5129-5144 (2014-11-05)
The most severe form of autosomal dominant polycystic kidney disease occurs in patients with mutations in the gene (PKD1) encoding polycystin-1 (PC1). PC1 is a complex polytopic membrane protein expressed in cilia that undergoes autoproteolytic cleavage at a G protein-coupled...
Use of FITC-labeled influenza virus and flow cytometry to assess binding and internalization of virus by monocytes-macrophages and lymphocytes
Nichols JE, et al.
Archives of Virology, 130(3-4), 441-455 (1993)
Martin Gustavsson et al.
Methods in enzymology, 570, 233-260 (2016-02-29)
The development of methods for expression and purification of seven-transmembrane receptors has led to an increase in structural and biophysical data and greatly improved the understanding of receptor structure and function. For chemokine receptors, this has been highlighted by the...
Irina Kufareva et al.
Methods in enzymology, 570, 389-420 (2016-02-29)
Despite the recent breakthrough advances in GPCR crystallography, structure determination of protein-protein complexes involving chemokine receptors and their endogenous chemokine ligands remains challenging. Here, we describe disulfide trapping, a methodology for generating irreversible covalent binary protein complexes from unbound protein...
Gonzalo Federico Mayol et al.
Biochimica et biophysica acta. Molecular cell research, 1867(1), 118566-118566 (2019-11-02)
Nuclear-cytoplasmic trafficking of proteins is a highly regulated process that modulates multiple biological processes in eukaryotic cells. In Giardia lamblia, shuttling has been described from the cytoplasm to nuclei of proteins during the biological cell cycle of the parasite. This...
Kieu T M Pham et al.
Journal of cell science, 132(14) (2019-06-21)
Trypanosoma brucei possesses a motile flagellum that determines cell morphology and the cell division plane. Inheritance of the newly assembled flagellum during the cell cycle is controlled by the Polo-like kinase homolog TbPLK, which also regulates cytokinesis initiation. How TbPLK...
Nathan T Jacobs et al.
Nature communications, 10(1), 3526-3526 (2019-08-08)
Segmentation of viral genomes into multiple RNAs creates the potential for replication of incomplete viral genomes (IVGs). Here we use a single-cell approach to quantify influenza A virus IVGs and examine their fitness implications. We find that each segment of...
Martin Gustavsson et al.
Science signaling, 12(598) (2019-09-12)
Chemokines bind to membrane-spanning chemokine receptors, which signal through G proteins and promote cell migration. However, atypical chemokine receptor 3 (ACKR3) does not appear to couple to G proteins, and instead of directly promoting cell migration, it regulates the extracellular...
Xianlong Gao et al.
The Journal of biological chemistry, 295(44), 14893-14905 (2020-08-26)
The chemokine receptor CXCR4, a G protein-coupled receptor (GPCR) capable of heteromerizing with other GPCRs, is involved in many processes, including immune responses, hematopoiesis, and organogenesis. Evidence suggests that CXCR4 activation reduces thrombin/protease-activated receptor 1 (PAR1)-induced impairment of endothelial barrier...
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