Showing 1-30 of 335 resultados for "H9268"
Takashi Nagase et al.
American journal of translational research, 12(6), 2652-2663 (2020-07-14)
This study sought to confirm the difference of the wound-healing effect, cell survival, and immune response between autologous fibroblast sheets and allogeneic fibroblast sheets. Regarding wound healing, autologous or allogeneic fibroblast sheets were transplanted onto a mouse cutaneous wound healing...
Qiyi Zhao et al.
Cell, 183(1), 76-93 (2020-09-16)
Mitochondria, which play central roles in immunometabolic diseases, have their own genome. However, the functions of mitochondria-located noncoding RNAs are largely unknown due to the absence of a specific delivery system. By circular RNA (circRNA) expression profile analysis of liver...
Alessia Di Nardo et al.
STAR protocols, 1(3), 100189-100189 (2020-12-31)
Genetic manipulations of dissociated rodent neurons provide translatable in vitro models for disease-driven phenotypes. Cilia are cellular antenna with a role in neuronal maturation and function often perturbed in neurodevelopmental disorders. Efforts for automated imaging of these microscopic protrusions are...
Yulan Zhao et al.
Life sciences, 246, 117382-117382 (2020-02-01)
Our preliminary research revealed that metformin, a classic anti-diabetic drug, could rescue Parkin protein expression and mitophagy in high glucose-challenged human renal epithelial cells in vitro, but the molecular mechanism remains to be explored. In the study, Human Renal Cortical...
Ana P Gomes et al.
Cancer cell, 36(4), 402-417 (2019-10-01)
Metastasis is the leading cause of cancer mortality. Chromatin remodeling provides the foundation for the cellular reprogramming necessary to drive metastasis. However, little is known about the nature of this remodeling and its regulation. Here, we show that metastasis-inducing pathways...
Ming-Jie Jiang et al.
Biochemical and biophysical research communications, 494(1-2), 372-378 (2017-10-08)
MicroRNA is a large class of non-coding small RNA that exerts critical roles in many physiological processes including cell proliferation. MicroRNA-7 (miR-7) has been considered as a tumor suppressor in most malignant tumors versus a tumor promoter in some other...
Shuang Liu et al.
Cellular and molecular life sciences : CMLS, 72(15), 2949-2960 (2015-03-11)
Multipotent skin-derived precursors (SKPs) are dermal stem cells with the capacity to reconstitute the dermis and other tissues, such as muscles and the nervous system. Thus, the easily available human SKPs (hSKPs) hold great promises in regenerative medicine. However, long-term...
Raquel V G de Castro et al.
Stem cells international, 2020, 8814989-8814989 (2021-01-19)
The cellular reprogramming into pluripotency is influenced by external and internal cellular factors, such as in vitro culture conditions (e.g., environmental oxygen concentration), and the aging process. Herein, we aimed to generate and maintain equine iPSCs (eiPSCs) derived from fibroblasts...
Fangfang Wang et al.
EBioMedicine, 60, 102993-102993 (2020-09-20)
This study explored the mechanisms underlying altered neurobehavioural development of female offspring born to mothers with polycystic ovary syndrome (PCOS). In total, 20 women with PCOS and 32 healthy women who underwent caesarean deliveries with a single female foetus were...
Blood (2013)
Roberta Azzarelli et al.
Biology open, 10(2) (2021-02-24)
Emerging three-dimensional (3D) cultures of glioblastoma are becoming powerful models to study glioblastoma stem cell behavior and the impact of cell-cell and cell-microenvironment interactions on tumor growth and invasion. Here we describe a method for culturing human glioblastoma stem cells...
Jesús García-Cano et al.
Molecular oncology, 14(1), 69-86 (2019-10-31)
The p53 tumor suppressor protein is a transcription factor that plays a prominent role in protecting cells from malignant transformation. Protein levels of p53 and its transcriptional activity are tightly regulated by the ubiquitin E3 ligase MDM2, the gene expression...
Federica Gaudino et al.
Antioxidants & redox signaling, 31(15), 1150-1165 (2019-08-29)
Aim: Nicotinamide adenine dinucleotide (NAD+) plays central roles in a wide array of normal and pathological conditions. Inhibition of...
Robin Schwarzer et al.
Immunity, 52(6), 978-993 (2020-05-05)
Pathways controlling intestinal epithelial cell (IEC) death regulate gut immune homeostasis and contribute to the pathogenesis of inflammatory bowel diseases. Here, we show that caspase-8 and its adapter FADD act in IECs to regulate intestinal inflammation downstream of Z-DNA binding...
Carles Cornet et al.
Pharmaceuticals (Basel, Switzerland), 13(1) (2019-12-28)
The xenograft of human cancer cells in model animals is a powerful tool for understanding tumor progression and metastatic potential. Mice represent a validated host, but their use is limited by the elevated experimental costs and low throughput. To overcome...
Federico F Cifuentes et al.
Oncology reports, 34(6), 2837-2844 (2015-10-28)
Metastatic prostate cancer (mPCa) is one of the most prevalent cancers in men worldwide. The main cause of death in these patients is androgen-resistant metastatic disease. Surgery of the primary tumor has been avoided in these patients as there is...
Lucile Delespaul et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 23(3), 857-867 (2016-08-17)
Despite various differences, nontranslocation-related sarcomas (e.g., comprising undifferentiated pleomorphic sarcoma, leiomyosarcoma, myxofibrosarcoma) are unified by their complex genetics. Extensive analysis of the tumor genome using molecular cytogenetic approaches showed many chromosomal gains, losses, and translocations per cell. Genomic quantitative alterations...
Carmen Aguilar et al.
Nature microbiology, 5(1), 192-205 (2019-12-04)
MicroRNAs (miRNAs) are increasingly recognized for their role in infection by bacterial pathogens, although the effect of each individual miRNA remains largely unknown. Here, we used a comparative genome-wide microscopy-based functional screening approach to identify miRNAs controlling infection by two...
Jianjun Hu et al.
American journal of translational research, 11(6), 3722-3736 (2019-07-18)
T follicular helper (TFH) cells are crucial for effective humoral immunity by providing the required signals to cognate B cells and promoting germinal center (GC) formation. Many intrinsic and extrinsic factors have been reported to be involved in the multistage...
Lynn Yap et al.
Cell reports, 26(12), 3231-3245 (2019-03-21)
Regeneration of injured human heart muscle is limited and an unmet clinical need. There are no methods for the reproducible generation of clinical-quality stem cell-derived cardiovascular progenitors (CVPs). We identified laminin-221 (LN-221) as the most likely expressed cardiac laminin. We...
Yufeng Liu et al.
The Journal of clinical investigation, 129(10), 4261-4275 (2019-09-05)
Inflammation plays a critical role in the development of severe neonatal morbidities. Myeloid-derived suppressor cells (MDSCs) were recently implicated in the regulation of immune responses in newborns. Here, we report that the presence of MDSCs and their functional activity in...
Annamil Alvarez-Trotta et al.
Oncotarget, 11(33), 3174-3187 (2020-09-12)
The Hedgehog/GLI (HH/GLI) signaling pathway plays a critical role in human oncogenesis. Unfortunately, the clinical use of HH inhibitor(s) has been associated with serious adverse effects and mutation-related drug resistance. Since the efficacy of SMO (Smoothened) and GLI inhibitors is...
Y Shi et al.
Cell death & disease, 6, e1841-e1841 (2015-08-08)
Dual specificity protein phosphatase 26 (DUSP26) is overexpressed in high-risk neuroblastoma (NB) and contributes to chemoresistance by inhibiting p53 function. In vitro, DUSP26 has also been shown to effectively inhibit p38 MAP kinase. We hypothesize that inhibiting DUSP26 will result...
Bizunesh Abere et al.
PLoS pathogens, 13(9), e1006639-e1006639 (2017-09-25)
Kaposi's sarcoma-associated herpesvirus (KSHV) is the infectious cause of the highly vascularized tumor Kaposi's sarcoma (KS), which is characterized by proliferating spindle cells of endothelial origin, extensive neo-angiogenesis and inflammatory infiltrates. The KSHV K15 protein contributes to the angiogenic and...
Hee Chan Yoo et al.
Cell metabolism, 31(2), 267-283 (2019-12-24)
Glutamine is an essential nutrient that regulates energy production, redox homeostasis, and signaling in cancer cells. Despite the importance of glutamine in mitochondrial metabolism, the mitochondrial glutamine transporter has long been unknown. Here, we show that the SLC1A5 variant plays...
Genetic deletion of SEPT7 reveals a cell type-specific role of septins in microtubule destabilization for the completion of cytokinesis.
Menon MB, Sawada A, Chaturvedi A, et al.
PLoS Genetics, 10(8), e1004558-e1004558 (2014)
Yanxia Liu et al.
Cell stem cell, 23(5), 758-771 (2018-10-16)
Comprehensive identification of factors that can specify neuronal fate could provide valuable insights into lineage specification and reprogramming, but systematic interrogation of transcription factors, and their interactions with each other, has proven technically challenging. We developed a CRISPR activation (CRISPRa)...
Erika Liktor-Busa et al.
PloS one, 15(5), e0227463-e0227463 (2020-05-30)
Disruption of blood-brain barrier integrity and dramatic failure of brain ion homeostasis including fluctuations of pH occurs during cortical spreading depression (CSD) events associated with several neurological disorders, including migraine with aura, traumatic brain injury and stroke. NHE1 is the...
Ruben Bulkescher et al.
Genome research, 27(10), 1752-1758 (2017-09-07)
Delivery of large and functionally active biomolecules across cell membranes presents a challenge in cell biological experimentation. For this purpose, we developed a novel solid-phase reverse transfection method that is suitable for the intracellular delivery of proteins into mammalian cells...

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