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Bernadette Carroll et al.
eLife, 5 (2016-01-08)
The mammalian target of rapamycin complex 1 (mTORC1) is the key signaling hub that regulates cellular protein homeostasis, growth, and proliferation in health and disease. As a prerequisite for activation of mTORC1 by hormones and mitogens, there first has to
TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9
Heinz LX, et al.
Nature, 1-7 (2020)
TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9
Heinz LX, et al.
Nature, 1-7 (2020)
Jingyue Jia et al.
Molecular cell, 70(1), 120-135 (2018-04-07)
The Ser/Thr protein kinase mTOR controls metabolic pathways, including the catabolic process of autophagy. Autophagy plays additional, catabolism-independent roles in homeostasis of cytoplasmic endomembranes and whole organelles. How signals from endomembrane damage are transmitted to mTOR to orchestrate autophagic responses
Sofie V Hellsten et al.
PloS one, 12(2), e0172917-e0172917 (2017-02-25)
SLC38A9 is characterized as a lysosomal component of the amino acid sensing Ragulator-RAG GTPase complex, controlling the mechanistic target of rapamycin complex 1 (mTORC1). Here, immunohistochemistry was used to map SLC38A9 in mouse brain and staining was detected throughout the
Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects.
Schioth HB
Molecular Aspects of Medicine, 34, 571-585 (2013)
The gene expression of the neuronal protein, SLC38A9, changes in mouse brain after in vivo starvation and high-fat diet
Hellsten SV, et al.
PLoS ONE, 12(2), e0172917-e0172917 (2017)
Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity.
Carroll B
eLife (2016)
Galectins control mTOR in response to endomembrane damage
Jia J, et al.
Molecular Cell, 70(1), 120-135 (2018)
TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9
Heinz LX, et al.
Nature, 1-7 (2020)
Manuele Rebsamen et al.
Nature, 519(7544), 477-481 (2015-01-07)
Cell growth and proliferation are tightly linked to nutrient availability. The mechanistic target of rapamycin complex 1 (mTORC1) integrates the presence of growth factors, energy levels, glucose and amino acids to modulate metabolic status and cellular responses. mTORC1 is activated
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.
Wang S
Science, 347, 188-194 (2015)
Jennifer Jung et al.
Molecular and cellular biology, 35(14), 2479-2494 (2015-05-13)
The serine/threonine kinase mTORC1 regulates cellular homeostasis in response to many cues, such as nutrient status and energy level. Amino acids induce mTORC1 activation on lysosomes via the small Rag GTPases and the Ragulator complex, thereby controlling protein translation and
Leonhard X Heinz et al.
Nature, 581(7808), 316-322 (2020-05-21)
Toll-like receptors (TLRs) have a crucial role in the recognition of pathogens and initiation of immune responses1-3. Here we show that a previously uncharacterized protein encoded by CXorf21-a gene that is associated with systemic lupus erythematosus4,5-interacts with the endolysosomal transporter
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