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Ikrame Lazar et al.
Pigment cell & melanoma research, 28(4), 464-475 (2015-05-08)
Exosomes are important mediators in cell-to-cell communication and, recently, their role in melanoma progression has been brought to light. Here, we characterized exosomes secreted by seven melanoma cell lines with varying degrees of aggressivity. Extensive proteomic analysis of their exosomes
Ruijun Han et al.
Scientific reports, 5, 12348-12348 (2015-08-06)
Adipocytes are the primary cells in adipose tissue, and adipocyte dysfunction causes lipodystrophy, obesity and diabetes. The dipeptidyl peptidase (DPP) 4 family includes four enzymes, DPP4, DPP8, DPP9 and fibroblast activation protein (FAP). DPP4 family inhibitors have been used for
Jessica Schmitt et al.
Molecular medicine (Cambridge, Mass.), 21, 185-196 (2015-03-27)
Parent-of-origin imprints have been implicated in the regulation of neural differentiation and brain development. Previously we have shown that, despite the lack of a paternal genome, human parthenogenetic (PG) embryonic stem cells (hESCs) can form proliferating neural stem cells (NSCs)
Caroline Louis et al.
PloS one, 9(9), e106495-e106495 (2014-09-12)
Polychlorinated biphenyls (PCBs) are persistent organic pollutants. Due to their lipophilic character, they are preferentially stored within the adipose tissue. During the mobilisation of lipids, PCBs might be released from adipocytes into the bloodstream. However, the mechanisms associated with the
Toshihiro Nagai et al.
Arthritis research & therapy, 16(5), 427-427 (2014-09-19)
Angiogenesis is an important factor in the development of osteoarthritis (OA). We investigated the efficacy of bevacizumab, an antibody against vascular endothelial growth factor and an inhibitor of angiogenesis, in the treatment of OA using a rabbit model of anterior
Xin Chen et al.
PloS one, 9(12), e115652-e115652 (2014-12-23)
Maduramicin, a polyether ionophore antibiotic derived from the bacterium Actinomadura yumaensis, is currently used as a feed additive against coccidiosis in poultry worldwide. It has been clinically observed that maduramicin can cause skeletal muscle and heart cell damage, resulting in
Christian T Madsen et al.
Nature communications, 6, 7726-7726 (2015-07-15)
The essential vitamin biotin is a covalent and tenaciously attached prosthetic group in several carboxylases that play important roles in the regulation of energy metabolism. Here we describe increased acetyl-CoA levels and mitochondrial hyperacetylation as downstream metabolic effects of biotin
Julian Hellmann-Regen et al.
Journal of neural transmission (Vienna, Austria : 1996), 122(9), 1329-1338 (2015-05-20)
Recent evidence from animal and human studies suggests neuroprotective effects of the SSRI fluoxetine, e.g., in the aftermath of stroke. The underlying molecular mechanisms remain to be fully defined. Because of its effects on the cytochrome P450 system (CYP450), we
Shu-En Wu et al.
Virology, 483, 83-95 (2015-05-13)
Human cytomegalovirus (HCMV) resides in a latent form in hematopoietic progenitors and undifferentiated cells within the myeloid lineage. Maturation and differentiation along the myeloid lineage triggers lytic replication. Here, we used peripheral blood monocytes and the monocytic cell line THP-1
Jomien Mouton et al.
Experimental cell research, 331(2), 338-351 (2014-12-03)
Myosin binding protein H (MyBPH) is a protein of unknown function, which shares sequence and structural similarities with myosin binding protein C (cMyBPC), a protein frequently implicated in hypertrophic cardiomyopathy (HCM). Given the similarity between cMyBPC and MyBPH, we proposed
K Friedauer et al.
Journal of animal physiology and animal nutrition, 99(5), 950-961 (2014-10-30)
Early lactating cows mobilize adipose tissue (AT) to provide energy for milk yield and maintenance and are susceptible to metabolic disorders and impaired immune response. Conjugated linoleic acids (CLA), mainly the trans-10, cis-12 isomer, reduce milk fat synthesis and may
Samuel C Kim et al.
Lab on a chip, 15(15), 3163-3169 (2015-06-25)
Microfluidic devices can form double emulsions with uniform properties, but require cumbersome fabrication steps to pattern their wettability. We demonstrate spatially-controlled plasma oxidation to create wettability patterns for forming double emulsions. Our method performs comparably to chemical techniques but is
Christopher A Elkins et al.
Antimicrobial agents and chemotherapy, 51(3), 923-929 (2007-01-11)
AcrAB-TolC is the major, constitutively expressed tripartite multidrug efflux system in Escherichia coli that recognizes various structurally unrelated molecules, including many antibiotics, dyes, and steroids. The AcrB inner membrane pump portion of the efflux system has been shown in recent
Pai-Tsang Huang et al.
PloS one, 10(2), e0116372-e0116372 (2015-02-12)
Alterations in microtubule-dependent trafficking and certain signaling pathways in neuronal cells represent critical pathogenesis in neurodegenerative diseases. Huntingtin (Htt)-associated protein-1 (Hap1) is a brain-enriched protein and plays a key role in the trafficking of neuronal surviving and differentiating cargos. Lack
Serap Simavli et al.
Endocrinology, 156(6), 2313-2322 (2015-04-10)
Puberty is a tightly regulated process that leads to reproductive capacity. Kiss1 neurons are crucial in this process by stimulating GnRH, yet how Kiss1 neurons are regulated remains unknown. Substance P (SP), an important neuropeptide in pain perception, induces gonadotropin
Nobuyuki Takenaka et al.
The Biochemical journal, 469(3), 445-454 (2015-07-25)
Insulin-stimulated glucose uptake in skeletal muscle is mediated by the translocation of the glucose transporter GLUT4 from intracellular storage sites to the plasma membrane. The small GTPase Rac1 has been implicated in this insulin signalling, but the mechanism whereby Rac1
Fei Zhang et al.
Molecular and cellular endocrinology, 411, 75-85 (2015-04-29)
Anxa2 is dysregulated in many types of carcinomas and implicated in several pivotal biological functions, such as angiogenesis, cell proliferation, invasion, and metastasis. We previously demonstrated that upregulation of Anxa2 enhances the proliferation and invasion of breast cancer cells. However
Li-Bo Yang et al.
Journal of microbiology and biotechnology, 25(7), 1056-1069 (2015-03-05)
Osmotic pressure is a critical factor for erythritol production with osmophilic yeast. Protein expression patterns of an erythritol-producing yeast, Yarrowia lipolytica, were analyzed to identify differentially-expressed proteins in response to osmotic pressure. In order to analyze intracellular protein levels quantitatively
Jisun Lee et al.
Life sciences, 119(1-2), 47-55 (2014-12-03)
Despite recent advances in prostate cancer diagnostics and therapeutics, the overall survival rate still remains low. This study was aimed to assess potential anti-cancer activity of maysin, a major flavonoid of corn silk (CS, Zea mays L.), in androgen-independent human
Praveen K Mandapalli et al.
Drug delivery, 21(8), 605-614 (2013-12-18)
The objective of this study is to investigate the influence of charge of model small molecules on their encapsulation and release behavior in layer-by-layer microcapsules (LbL-MC). Poly(styrene sulfonate) and poly(ethylene imine) were sequentially adsorbed on calcium carbonate sacrificial templates to
Wyatt J Musnicki et al.
Langmuir : the ACS journal of surfaces and colloids, 30(37), 11019-11030 (2014-08-20)
Holographic interferometry was used to obtain new results for the four coefficients that determine rates of multicomponent diffusion of hydrophobic solutes and surfactants in microemulsions. The three solutes pentanol, octanol, and heptane were examined in microemulsions formed from decaethylene glycol
Mandar S Paingankar et al.
Virus research, 208, 98-109 (2015-06-19)
Lack of robust cell culture systems for Hepatitis E virus (HEV) infection has hampered understanding of HEV biology. We attempted to identify the host cellular factors that interact with HEV 5' and 3' untranslated regions (UTRs) by RNA affinity chromatography
Yen-You Lin et al.
Marine drugs, 13(5), 2559-2579 (2015-04-30)
In recent years, several marine-derived compounds have been clinically evaluated. Diterpenes are secondary metabolites from soft coral that exhibit anti-inflammatory, anti-tumor and cytotoxic activities. In the present study, we isolated a natural diterpene product, excavatolide B, from cultured Formosan gorgonian
Chao Li et al.
World journal of gastroenterology, 21(20), 6215-6228 (2015-06-03)
To investigate the mechanism underlying the promoting role of CD97 in gastric cancer cell proliferation and invasion. Two types of exosomes released by gastric cancer cells with high (SGC/wt) or low (SGC/kd) CD97 expression were isolated by ultracentrifugation and identified
Randall Logan et al.
Journal of pharmaceutical sciences, 103(10), 3287-3296 (2014-07-22)
Many weakly basic amine-containing drugs are known to be extensively sequestered in acidic lysosomes by an ion trapping-type mechanism. The entrapment of drugs in lysosomes has been shown to influence drug activity, cancer cell selectivity, and pharmacokinetics and can cause
Fei Chen et al.
Genes & development, 29(22), 2377-2390 (2015-11-22)
Alternative polyadenylation (APA) is widespread in neuronal development and activity-mediated neural plasticity. However, the underlying molecular mechanisms are largely unknown. We used systematic genetic studies and genome-wide surveys of the transcriptional landscape to identify a context-dependent regulatory pathway controlling APA
Sin-Fen Hu et al.
PloS one, 10(6), e0130139-e0130139 (2015-06-16)
PHYL1 and SAP54 are orthologs of pathogenic effectors of Aster yellow witches'-broom (AYWB) phytoplasma and Peanut witches'-broom (PnWB) phytoplasma, respectively. These effectors cause virescence and phyllody symptoms (hereafter leafy flower) in phytoplasma-infected plants. T0 lines of transgenic Arabidopsis expressing the
Vijayashankar Suganya et al.
Clinica chimica acta; international journal of clinical chemistry, 450, 210-219 (2015-08-25)
Autism is a complex developmental disability for which no specific diagnostic markers have been identified so far. The present study aimed to evaluate whether there is any abnormal protein(s) excreted in the urine of autistic children by proteome analysis which
Amarel Saieg et al.
Pediatric research, 77(2), 356-362 (2014-11-25)
Chronic rhinosinusitis (CRS) is characterized by mucous overproduction and submucosal gland hyperplasia. The global protein profile of sinonasal secretions in pediatric CRS has not been studied. We hypothesized that MUC5B, a glandular mucin, would be relatively increased in CRS secretions
Xue Yuan et al.
PloS one, 10(6), e0130618-e0130618 (2015-06-23)
Intraflagellar transport proteins (IFT) play important roles in cilia formation and organ development. Partial loss of IFT80 function leads Jeune asphyxiating thoracic dystrophy (JATD) or short-rib polydactyly (SRP) syndrome type III, displaying narrow thoracic cavity and multiple cartilage anomalies. However
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