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Palabra clave:'M4278'
Mostrando 1-15 of 15 resultados para "M4278" en el plazo de Papeles
Deb Kumar Mojumder et al.
The Journal of physiology, 586(10), 2551-2580 (2008-04-05)
Voltage-gated sodium channels (Na(v) channels) in retinal neurons are known to contribute to the mammalian flash electroretinogram (ERG) via activity of third-order retinal neurons, i.e. amacrine and ganglion cells. This study investigated the effects of tetrodotoxin (TTX) blockade of Na(v)
Ramon Velazquez et al.
Aging cell, 17(4), e12775-e12775 (2018-05-12)
Misfolded and hyperphosphorylated tau accumulates in several neurodegenerative disorders including Alzheimer's disease, frontotemporal dementia with Parkinsonism, corticobasal degeneration, progressive supranuclear palsy, Down syndrome, and Pick's disease. Tau is a microtubule-binding protein, and its role in microtubule stabilization is well defined.
A G Miriam Leenders et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(44), 11333-11346 (2008-10-31)
Ca(v)2.2 channels are localized at nerve terminals where they play a critical role in neurotransmission. However, the determinant that controls surface retention of these channels has not been identified. Here, we report that presynaptic surface localization of Ca(v)2.2 is mediated
Mark Rapoport et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(9), 6364-6369 (2002-04-18)
Senile plaques and neurofibrillary tangles, the two hallmark lesions of Alzheimer's disease, are the results of the pathological deposition of proteins normally present throughout the brain. Senile plaques are extracellular deposits of fibrillar beta-amyloid peptide (Abeta); neurofibrillary tangles represent intracellular
Alejandra Bosco et al.
The Journal of comparative neurology, 519(4), 599-620 (2011-01-20)
Changes in microglial cell activation and distribution are associated with neuronal decline in the central nervous system (CNS), particularly under pathological conditions. Activated microglia converge on the initial site of axonal degeneration in human glaucoma, yet their part in its
Xiang-Ping Wang et al.
BMC molecular biology, 10, 109-109 (2009-12-17)
Cytoplasmic polyadenylation element binding proteins (CPEBs) regulate translation by binding to regulatory motifs of defined mRNA targets. This translational mechanism has been shown to play a critical role in oocyte maturation, early development, and memory formation in the hippocampus. Little
Drosophila Futsch/22C10 is a MAP1B-like protein required for dendritic and axonal development
Hummel T, et al.
Neuron, 26(2), 357-370 (2000)
Cytoskeletons in the Closet-Subversion in Alphaherpesvirus Infections
Denes C, et al.
Viruses, 10(2), 79-79 (2018)
Alan Jerusalmi et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 8(6), 886-894 (2003-12-11)
We have initiated studies to determine the feasibility of employing the Semliki Forest virus (SFV) expression system as a central nervous system (CNS) vector. We investigated the effects of infecting Balb/c mice intranasally (i.n.) with recombinant SFV particles expressing the
Ye Liu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(11), 4587-4598 (2015-03-20)
The structural microtubule-associated proteins (MAPs) are critical for the organization of neuronal microtubules (MTs). Microtubule-associated protein 1A (MAP1A) is one of the most abundantly expressed MAPs in the mammalian brain. However, its in vivo function remains largely unknown. Here we
The calcium-sensitive large-conductance potassium channel (BK/MAXI K) is present in the inner mitochondrial membrane of rat brain
Douglas RM, et al.
Neuroscience, 139(4), 1249-1261 (2006)
C DeFranco et al.
Molecular biology of the cell, 9(7), 1695-1708 (1998-07-11)
Association of mRNA with the cytoskeleton represents a fundamental aspect of RNA physiology likely involved in mRNA transport, anchoring, translation, and turnover. We report the initial characterization of a protein complex that binds RNA in a sequence-independent but size-dependent manner
Effect of intranasal administration of semliki forest virus recombinant particles expressing reporter and cytokine genes on the progression of experimental autoimmune encephalomyelitis
Jerusalmi A, et al.
Molecular Therapy, 8(6), 886-894 (2003)
David M Sherry et al.
BMC neuroscience, 14, 70-70 (2013-07-13)
Phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac Exchanger 2 (P-Rex2) is a guanine nucleotide exchange factor (GEF) that specifically activates Rac GTPases, important regulators of actin cytoskeleton remodeling. P-Rex2 is known to modulate cerebellar Purkinje cell architecture and function, but P-Rex2 expression and function
David M Sherry et al.
PloS one, 7(6), e39702-e39702 (2012-06-30)
To investigate the role(s) of protein-tyrosine sulfation in the retina and to determine the differential role(s) of tyrosylprotein sulfotransferases (TPST) 1 and 2 in vision, retinal function and structure were examined in mice lacking TPST-1 or TPST-2. Despite the normal
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