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Palabra clave:'m6250'
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m6250

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Sunil K Panigrahi et al.
Nucleic acids research, 43(9), 4531-4546 (2015-04-16)
RAD9 participates in DNA damage-induced cell cycle checkpoints and DNA repair. As a member of the RAD9-HUS1-RAD1 (9-1-1) complex, it can sense DNA damage and recruit ATR to damage sites. RAD9 binding can enhance activities of members of different DNA
S Bertin et al.
Mucosal immunology, 8(3), 505-515 (2014-09-18)
Mitogen-activated protein kinase (MAPK) phosphatases are dual-specificity phosphatases (DUSPs) that dephosphorylate phosphothreonine and phosphotyrosine residues within MAPKs. DUSP6 preferentially dephosphorylates extracellular signal-regulated kinases 1 and 2 (ERK1/2) rendering them inactive. Here, we study the role of DUSP6 in CD4(+) T-cell
Chek Meng Poh et al.
Infection and immunity, 82(11), 4854-4864 (2014-08-27)
CD8(+) T cells play a pathogenic role in the development of murine experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA) infection in C57BL/6 mice. Only a limited number of CD8(+) epitopes have been described. Here, we report the
Pierre Duffau et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(12), 3146-3157 (2015-09-01)
Polymorphisms in the transcription factor interferon regulatory factor 5 (IRF5) are associated with an increased risk of developing rheumatoid arthritis (RA). This study was undertaken to determine the role of IRF5 in a mouse model of arthritis development. K/BxN serum-transfer
Patrick Scheiermann et al.
Scientific reports, 5, 8521-8521 (2015-02-18)
Overdosing of the analgesic acetaminophen (APAP, paracetamol) is a major cause of acute liver injury. Whereas toxicity is initiated by hepatocyte necrosis, course of disease is regulated by mechanisms of innate immunity having the potential to serve in complex manner
Caterina Morabito et al.
BioMed research international, 2015, 754283-754283 (2015-02-06)
We propose a human-derived neuro-/glial cell three-dimensional in vitro model to investigate the effects of microgravity on cell-cell interactions. A rotary cell-culture system (RCCS) bioreactor was used to generate a modelled microgravity environment, and morphofunctional features of glial-like GL15 and
Tamires Marielem Carvalho-Costa et al.
Parasites & vectors, 8, 22-22 (2015-01-15)
Dendritic cells (DCs) are professional antigen-presenting cells with vital roles in the activation of host immunity. Ticks are bloodsucking arthropods that secrete bioactive compounds with immunomodulatory properties via their saliva. It is known that some tick species modulate the biology
Hiromitsu Asashima et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(8), 2213-2225 (2015-04-22)
Autoreactive CD4+ T cells are involved in the pathogenesis of Sjögren's syndrome (SS). The aim of the present study was to clarify the dominant T cell epitopes of M3 muscarinic acetylcholine receptor (M3R) and to establish a new antigen-specific therapy
Sara Benedé et al.
International archives of allergy and immunology, 165(2), 83-90 (2014-11-02)
This paper reports the case of an egg-allergic pediatric patient who, once desensitized to egg following a successful rush oral immunotherapy protocol, could also tolerate Lizipaina®, a drug containing lysozyme (LYS) and papain, which had previously caused him a severe
Layasadat Khorsandi et al.
Cell and tissue research, 361(3), 745-753 (2015-03-22)
The aim of this study is to evaluate the collagen/hyaluronic acid (Col/HA) scaffold effect on the differentiation of insulin-producing cells (IPCs) from adipose-derived mesenchymal stem cells (ASCs). In this experimental study, ASCs were cultured and seeded in a Col/HA scaffold
J Fichna et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 26(11), 1539-1550 (2014-07-22)
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a functional gastrointestinal (GI) disorder, defined by the presence of loose stools and abdominal pain. In search for a novel anti-IBS-D therapy, here we investigated the nociceptin receptor (NOP)-dependent effects in the GI tract.
Tomoyuki Tsukiyama et al.
PloS one, 9(4), e95329-e95329 (2014-04-17)
Embryonic stem cells (ESCs) can contribute to the tissues of chimeric animals, including the germline. By contrast, epiblast stem cells (EpiSCs) barely contribute to chimeras. These two types of cells are established and maintained under different culture conditions. Here, we
Monique F Smeets et al.
The Journal of clinical investigation, 124(8), 3551-3565 (2014-06-25)
Mutations within the gene encoding the DNA helicase RECQL4 underlie the autosomal recessive cancer-predisposition disorder Rothmund-Thomson syndrome, though it is unclear how these mutations lead to disease. Here, we demonstrated that somatic deletion of Recql4 causes a rapid bone marrow
Andrea Dichlberger et al.
Journal of lipid research, 55(12), 2471-2478 (2014-08-13)
Human mast cells (MCs) contain TG-rich cytoplasmic lipid droplets (LDs) with high arachidonic acid (AA) content. Here, we investigated the functional role of adipose TG lipase (ATGL) in TG hydrolysis and the ensuing release of AA as substrate for eicosanoid
Yifeng Wei et al.
Biochemistry, 54(47), 7019-7028 (2015-11-05)
Two subtypes of class III anaerobic ribonucleotide reductases (RNRs) studied so far couple the reduction of ribonucleotides to the oxidation of formate, or the oxidation of NADPH via thioredoxin and thioredoxin reductase. Certain methanogenic archaea contain a phylogenetically distinct third
Nathalie Kersual et al.
mAbs, 6(5), 1314-1326 (2014-12-18)
Ovarian cancer has the highest mortality rate among gynecologic malignancies. The monoclonal antibody 12G4 specifically recognizes the human Müllerian inhibiting substance type II receptor (MISRII) that is strongly expressed in human granulosa cell tumors (GCT) and in the majority of
Ji-Yun Ko et al.
Stem cells and development, 23(15), 1788-1797 (2014-03-22)
The purpose of this study was to examine the in vitro and in vivo osteogenic potential of human induced pluripotent stem cells (hiPSCs) against that of human bone marrow mesenchymal stem cells (hBMMSCs). Embryoid bodies (EBs), which were formed from
Brian O Diekman et al.
Tissue engineering. Part A, 21(7-8), 1261-1274 (2014-12-18)
The limited regenerative capacity of articular cartilage contributes to progressive joint dysfunction associated with cartilage injury or osteoarthritis. Cartilage tissue engineering seeks to provide a biological substitute for repairing damaged or diseased cartilage, but requires a cell source with the
Noriko Ichino et al.
eLife, 9 (2020-08-12)
One key bottleneck in understanding the human genome is the relative under-characterization of 90% of protein coding regions. We report a collection of 1200 transgenic zebrafish strains made with the gene-break transposon (GBT) protein trap to simultaneously report and reversibly
Lynette Steele et al.
Molecular cancer, 10, 20-20 (2011-02-23)
As well as inducing direct oncolysis, reovirus treatment of melanoma is associated with activation of innate and adaptive anti-tumour immune responses. Here we characterise the effects of conditioned media from reovirus-infected, dying human melanoma cells (reoTCM), in the absence of
Justin L Eddy et al.
Cellular immunology, 290(1), 120-130 (2014-07-01)
Although glucocorticoids are well known for their capacity to suppress the immune response, glucocorticoids can also promote immune responsiveness. It was the purpose of this investigation to evaluate the molecular basis for this apparent dichotomous immunologic effect. Glucocorticoid treatment of
Jianchao Gui et al.
Current stem cell research & therapy, 10(4), 353-363 (2015-05-20)
The successful surgical restoration of damaged meniscus has been a challenge, largely owing to a lack of characterization of meniscus cells and their precursors. Numerous strategies to repair or replace meniscus have achieved only limited success. Several recent studies have
Brian Wiggins et al.
Journal of pharmaceutical sciences, 104(4), 1362-1372 (2015-01-30)
Two US FDA-approved antibody-drug conjugates (ADCs; Kadcyla(®) and Adcetris(®) ) have accelerated clinical interest in the potential of targeted cancer therapeutics as the next generation of oncology drugs that are designed to increase efficacy while reducing overall toxicity. Thiol conjugates
Jin Woo Park et al.
Scientific reports, 5, 12485-12485 (2015-07-25)
Histone lysine methylation contributes to transcriptional regulation by serving as a platform for the recruitment of various cofactors. Intense studies have been conducted for elucidating the functional meaning of H3K79 methylation, and to date, the only known HMTase responsible for
Qian-Yi Wang et al.
Biochemical and biophysical research communications, 448(4), 454-460 (2014-05-08)
Embryonic stem (ES) cells are pluripotent cells that are capable of giving rise to any type of cells in the body and possess unlimited self-renewal potential. However, the exact regulatory mechanisms that govern the self-renewal ability of ES cells remain
Shih-Cheng Shen et al.
PloS one, 9(12), e114990-e114990 (2014-12-18)
Pluripotent human embryonic stem cells (hESCs) can be efficiently directed to become immature neuroepithelial precursor cells (NPCs) and functional mature neural cells, including neurotransmitter-secreting neurons and glial cells. Investigating the susceptibility of these hESCs-derived neural cells to neurotrophic viruses, such
Natania S Field et al.
Methods in molecular biology (Clifton, N.J.), 2111, 239-256 (2020-01-15)
Ubiquitination is a crucial component of many immune processes. While ubiquitin-mediated degradation is essential to T cell activation via T cell receptor signaling, the specific E3 ligases and substrates involved are not well-understood. Here, we describe a strategy integrating RNA
Stéphane Mann et al.
Analytical biochemistry, 432(2), 90-96 (2012-10-17)
7,8-Diaminopelargonic acid (DAPA) aminotransferase is an enzyme of the biotin biosynthetic pathway that plays an essential role in Mycobacterium tuberculosis virulence. Inhibition of this enzyme is a potential strategy to combat this microorganism, the causative agent of tuberculosis. To identify
Ruchi Sharma et al.
Stem cells and development, 23(13), 1524-1534 (2014-02-20)
Pluripotent stem cells (PSCs) offer unprecedented biomedical potential not only in relation to humans but also companion animals, particularly the horse. Despite this, attempts to generate bona fide equine embryonic stem cells have been unsuccessful. A very limited number of
Xuesong Li et al.
International journal of nanomedicine, 10, 821-838 (2015-02-06)
To investigate the sonoactivity of hypericin (HY), together with its sonodynamic effect on THP-1 macrophages and the underlying mechanism. CCK-8 was used to examine cell viability. Confocal laser scanning microscopy was performed to assess the localization of HY in cells
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