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Diana Karnas et al.
PloS one, 8(8), e73343-e73343 (2013-08-21)
Intrinsically photosensitive retinal ganglion cells (ipRGCs) represent a new class of photoreceptors which support a variety of non-image forming physiological functions, such as circadian photoentrainment, pupillary light reflex and masking responses to light. In view of the recently proposed role...
Gianluca Civenni et al.
Cancer research, 71(8), 3098-3109 (2011-03-12)
Human melanoma is composed of distinct cell types reminiscent of neural crest derivatives and contains multipotent cells that express the neural crest stem cell markers CD271(p75(NTR)) and Sox10. When isolated from solid tumors by using a method that leaves intact...
Michael K E Schaefer et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(33), 8779-8789 (2007-08-19)
Axonal degeneration represents one of the earliest pathological features in motor neuron diseases. We here studied the underlying molecular mechanisms in progressive motor neuronopathy (pmn) mice mutated in the tubulin-specific chaperone TBCE. We demonstrate that TBCE is a peripheral membrane-associated...
Stephen M F Jamieson et al.
Molecular pain, 5, 66-66 (2009-11-20)
Oxaliplatin and related chemotherapeutic drugs cause painful chronic peripheral neuropathies in cancer patients. We investigated changes in neuronal size profiles and neurofilament immunoreactivity in L5 dorsal root ganglion (DRG) tissue of adult female Wistar rats after multiple-dose treatment with oxaliplatin...
Tiziana Bisogno et al.
The Journal of cell biology, 163(3), 463-468 (2003-11-12)
Diacylglycerol (DAG) lipase activity is required for axonal growth during development and for retrograde synaptic signaling at mature synapses. This enzyme synthesizes the endocannabinoid 2-arachidonoyl-glycerol (2-AG), and the CB1 cannabinoid receptor is also required for the above responses. We now...
Rac1 and Rac3 have opposing functions in cell adhesion and differentiation of neuronal cells.
Hajdo-MilasinoviA?, et al.
Journal of Cell Science, 120, 555-566 (2007)
Amanda M Pocratsky et al.
eLife, 9 (2020-09-10)
Within the cervical and lumbar spinal enlargements, central pattern generator (CPG) circuitry produces the rhythmic output necessary for limb coordination during locomotion. Long propriospinal neurons that inter-connect these CPGs are thought to secure hindlimb-forelimb coordination, ensuring that diagonal limb pairs...
D M Panchision et al.
Genes & development, 15(16), 2094-2110 (2001-08-21)
Bone morphogenetic proteins (BMPs) have diverse and sometimes paradoxical effects during embryonic development. To determine the mechanisms underlying BMP actions, we analyzed the expression and function of two BMP receptors, BMPR-IA and BMPR-IB, in neural precursor cells in vitro and...
C Balaratnasingam et al.
Neuroscience, 177, 269-282 (2011-01-11)
Oligodendrocyte-derived myelin retards the ability of CNS axons to regenerate following transection. The intrinsic response of CNS axons to an axotomy insult may be vastly different in the absence of myelin. However, the paucity of adequate experimental models has limited...
Ian L McWilliams et al.
Cell reports, 26(7), 1718-1726 (2019-02-14)
Zaire Ebola virus (ZEBOV) survivors experience visual and CNS sequelae that suggests the ZEBOV glycoprotein can mediate neurotropism. Replication-competent rVSVΔG-ZEBOV-GP vaccine candidate is generally well tolerated; however, its potential neurotropism requires careful study. Here, we show that a single inoculation...
M K Lee et al.
Current opinion in cell biology, 6(1), 34-40 (1994-02-01)
Neurofilaments make up the major intermediate filament system in mature neurons. Recent studies demonstrate that neurofilaments in vivo are obligate heteropolymers and are required for proper radial growth of axons. Furthermore, forced over-expression of neurofilament subunits in transgenic mice shows...
Arnaud Bocquet et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(35), 11043-11054 (2009-09-04)
Neurofilaments assemble from three intermediate-filament proteins, contribute to the radial growth of axons, and are exceptionally stable. Microtubules are dynamic structures that assemble from tubulin dimers to support intracellular transport of molecules and organelles. We show here that neurofilaments, and...
Hak Hyun Ryu et al.
Journal of veterinary science, 10(4), 273-284 (2009-11-26)
In this study, we evaluated if the implantation of allogenic adipose-derived stem cells (ASCs) improved neurological function in a canine spinal cord injury model. Eleven adult dogs were assigned to three groups according to treatment after spinal cord injury by...
Roxanne Larivière et al.
Human molecular genetics, 24(3), 727-739 (2014-09-28)
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS [MIM 270550]) is an early-onset neurodegenerative disorder caused by mutations in the SACS gene. Over 170 SACS mutations have been reported worldwide and are thought to cause loss of function of sacsin, a...
Gaëtan J-R Delcroix et al.
Differentiation; research in biological diversity, 80(4-5), 213-227 (2010-09-04)
Multipotent mesenchymal stromal cells raise great interest for regenerative medicine studies. Some MSC subpopulations have the potential to undergo neural differentiation, including marrow isolated adult multilineage inducible (MIAMI) cells, which differentiate into neuron-like cells in a multi-step neurotrophin 3-dependent manner....
Adeline Orts-Del'Immagine et al.
PloS one, 9(2), e87748-e87748 (2014-02-08)
The mammalian spinal cord and medulla oblongata harbor unique neurons that remain in contact with the cerebrospinal fluid (CSF-cNs). These neurons were shown recently to express a polycystin member of the TRP channels family (PKD2L1) that potentially acts as a...
Mohamed Nemir et al.
Circulation research, 98(12), 1471-1478 (2006-05-13)
Embryonic stem cells represent an attractive source of cardiomyocytes for cell-replacement therapies. However, before embryonic stem cells can be successfully used for the treatment of cardiac diseases, the precise molecular mechanisms that underlie their cardiogenic differentiation must be identified. A...
Sissi Dolci et al.
Frontiers in pharmacology, 8, 703-703 (2017-10-28)
Oligodendrocyte loss can lead to cognitive and motor deficits. Current remyelinating therapeutic strategies imply either modulation of endogenous oligodendrocyte precursors or transplantation of in vitro expanded oligodendrocytes. Cell therapy, however, still lacks identification of an adequate source of oligodendrocyte present...
David Arboleda et al.
Cellular and molecular neurobiology, 31(7), 1113-1122 (2011-06-02)
Adipose-derived stromal cells (ASCs) are an alternative source of stem cells for cell-based therapies of neurological disorders such as spinal cord injury (SCI). In the present study, we predifferentiated ASCs (pASCs) and compared their behavior with naïve ASCs in vitro...
Thanh N Doan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 24(13), 3335-3343 (2004-04-02)
Sensory neurons express hyperpolarization-activated currents (I(H)) that differ in magnitude and kinetics within the populations. We investigated the structural basis for these differences and explored the functional role of the I(H) channels in sensory neurons isolated from rat nodose ganglia....
Neurofilaments and neurological disease
Al-Chalabi A and Miller C C
Bioessays, 25(4), 346-355 (2003)
Yibo Qu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(28), 9392-9401 (2010-07-16)
During hindbrain development, facial branchiomotor neurons (FBM neurons) migrate from medial rhombomere (r) 4 to lateral r6. In zebrafish, mutations in planar cell polarity genes celsr2 and frizzled3a block caudal migration of FBM neurons. Here, we investigated the role of...
E Delmas et al.
Cell death & disease, 7, e2079-e2079 (2016-02-06)
Fibroblast growth factor 1 (FGF1) is a prototypic member of the FGFs family overexpressed in various tumors. Contrarily to most FGFs, FGF1 lacks a secretion peptide signal and acts mainly in an intracellular and nuclear manner. Intracellular FGF1 induces cell...
Chihiro Takasaki et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(19), 4995-5006 (2008-05-09)
Glutamate transporters are involved in neural differentiation, neuronal survival, and synaptic transmission. In the present study, we examined glutamate transporter 1 (GLT1) expression in the neonatal somatosensory cortex of C57BL/6 mice, and pursued its role in somatosensory development by comparing...
Grzegorz Wicher et al.
Journal of neurotrauma, 34(22), 3173-3182 (2017-05-12)
Traumatic brain injury (TBI) is a devastating condition, often leading to life-long consequences for patients. Even though modern neurointensive care has improved functional and cognitive outcomes, efficient pharmacological therapies are still lacking. Targeting peripherally derived, or resident inflammatory, cells that...
Yi-Chin Li et al.
Brain and behavior, 5(8), e00356-e00356 (2015-09-12)
Erythropoietin (EPO) has potent neuroprotective effects. The short-term delivery of high-dose EPO seemed to improve patients' neuromuscular functions; however, excessive EPO resulted in systematically high hematocrit and thrombotic risk. In our study, we established a cellular material for future in vivo...
Deniz Gökbuget et al.
Nature communications, 6, 8584-8584 (2015-10-16)
MicroRNAs (miRNAs) are crucial regulators of myelination in the peripheral nervous system (PNS). However, the miRNAs species involved and the underlying mechanisms are largely unknown. We found that let-7 miRNAs are highly abundant during PNS myelination and that their levels...
Mi Jin Kim et al.
Antioxidants & redox signaling, 28(18), 1587-1602 (2017-05-26)
Glycating stress can occur together with oxidative stress during neurodegeneration and contribute to the pathogenic mechanism. Nerve growth factor (NGF) accumulates in several neurodegenerative diseases. Besides promoting survival, NGF can paradoxically induce cell death by signaling through the p75 neurotrophin...
Thomas Boettger et al.
The EMBO journal, 22(20), 5422-5434 (2003-10-09)
K-Cl co-transporters are encoded by four homologous genes and may have roles in transepithelial transport and in the regulation of cell volume and cytoplasmic chloride. KCC3, an isoform mutated in the human Anderman syndrome, is expressed in brain, epithelia and...
Takahiro Sasaki et al.
Human molecular genetics, 15(6), 943-952 (2006-02-03)
Charcot-Marie-Tooth disease (CMT) is the most common inherited peripheral nerve disorder. The causative gene for axonal type CMT2E has been identified as neurofilament light (NF-L) chain. Using cultured cells and in vitro assays, we analyzed the filament formation ability of...
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