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Guo Nan Yin et al.
The journal of sexual medicine, 18(1), 17-28 (2020-11-28)
Radical prostatectomy for prostate cancer can not only induce cavernous nerve injury (CNI), but also causes cavernous hypoxia and cavernous structural changes, which lead to a poor response to phosphodiesterase 5 inhibitors. To investigate the therapeutic effect of oral administration...
Lilla Reiniger et al.
Acta neuropathologica communications, 1, 8-8 (2013-11-21)
Sporadic, inherited and acquired prion diseases show distinct histological patterns of abnormal prion protein (PrP) deposits. Many of the inherited prion diseases show striking histological patterns, which often associate with specific mutations. Most reports have focused on the pattern of...
Maryam Haji Ghasem Kashani et al.
Cell journal, 15(1), 55-64 (2013-05-24)
There is longstanding experimental and clinical evidence that supports the idea that replacement of dopaminergic (DAergic) neurons can ameliorate functional disabilities of Parkinson's disease (PD). The purpose of the present study is to examine the efficacy of transplantation of rat...
Enrique Gabandé-Rodríguez et al.
The EMBO journal, 38(2) (2018-12-12)
Neuropathic lysosomal storage disorders (LSDs) present with activated pro-inflammatory microglia. However, anti-inflammatory treatment failed to improve disease pathology. We characterise the mechanisms underlying microglia activation in Niemann-Pick disease type A (NPA). We establish that an NPA patient and the acid...
Haktan Altinova et al.
Tissue engineering and regenerative medicine, 13(5), 585-600 (2016-10-20)
The implantation of bioengineered scaffolds into lesion-induced gaps of the spinal cord is a promising strategy for promoting functional tissue repair because it can be combined with other intervention strategies. Our previous investigations showed that functional improvement following the implantation...
Maintenance of adult porcine retina and retinal pigment epithelium in perfusion culture: characterisation of an organotypic in vitro model
Kobuch K, et al.
Experimental Eye Research, 86(4), 661-668 (2008)
Ji-Kan Ryu et al.
The journal of sexual medicine, 11(2), 411-423 (2013-11-21)
Recently, much attention has focused on stem cell therapy; bone marrow-derived stem cells (BMSCs) are one of the most studied mesenchymal stem cells used in the field of erectile dysfunction (ED). However, a major limitation for the clinical application of...
Rose Z Hill et al.
eLife, 7 (2018-03-22)
Somatosensory neurons mediate responses to diverse mechanical stimuli, from innocuous touch to noxious pain. While recent studies have identified distinct populations of A mechanonociceptors (AMs) that are required for mechanical pain, the molecular underpinnings of mechanonociception remain unknown. Here, we...
Jens Ingwersen et al.
Journal of neurochemistry (2018-02-24)
Multiple sclerosis is characterised by inflammatory neurodegeneration, with axonal injury and neuronal cell death occurring in parallel to demyelination. Regarding the molecular mechanisms responsible for demyelination and axonopathy, energy failure, aberrant expression of ion channels and excitotoxicity have been suggested...
Chandrakumar Balaratnasingam et al.
Investigative ophthalmology & visual science, 48(8), 3632-3644 (2007-07-27)
To investigate the axonal cytoskeleton changes occurring in the prelaminar region, lamina cribrosa, and postlaminar region of the porcine optic nerve after an acute increase in intraocular pressure (IOP) and whether this corresponds with axonal transport abnormalities. Six white Landrace...
Andrea Hunyadi et al.
Brain structure & function, 225(1), 321-344 (2019-12-21)
Extracellular matrix (ECM) became an important player over the last few decades when studying the plasticity and regeneration of the central nervous system. In spite of the established role of ECM in these processes throughout the central nervous system (CNS)...
Elisa Greotti et al.
iScience, 16, 340-355 (2019-06-17)
Genetically Encoded Ca2+ Indicators (GECIs) are extensively used to study organelle Ca2+ homeostasis, although some available probes are still plagued by a number of problems, e.g., low fluorescence intensity, partial mistargeting, and pH sensitivity. Furthermore, in the most commonly used...
Salim Megat et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(3), 393-411 (2018-11-22)
Nociceptors, sensory neurons in the DRG that detect damaging or potentially damaging stimuli, are key drivers of neuropathic pain. Injury to these neurons causes activation of translation regulation signaling, including the mechanistic target of rapamycin complex 1 (mTORC1) and mitogen-activated...
Geoffrey Chan et al.
Experimental eye research, 198, 108154-108154 (2020-07-28)
Astrocytes are critical for the maintenance of retinal ganglion cell (RGC) axonal function and viability, and form a key component of the functional neurovascular unit. Recently, we described the quantitative properties of astrocytes in relation to the capillary distributions in...
Lepeng Zeng et al.
Stem cells (Dayton, Ohio), 24(11), 2355-2366 (2006-08-26)
We show that multipotent adult progenitor cells (MAPCs) can be derived from both postnatal and fetal swine bone marrow (BM). Although swine MAPC (swMAPC) cultures are initially mixed, cultures are phenotypically homogenous by 50 population doublings (PDs) and can be...
Yuhki Saito et al.
eLife, 5 (2016-05-26)
The neuron specific RNA-binding proteins NOVA1 and NOVA2 are highly homologous alternative splicing regulators. NOVA proteins regulate at least 700 alternative splicing events in vivo, yet relatively little is known about the biologic consequences of NOVA action and in particular...
Gianfranca Miconi et al.
Journal of cellular biochemistry, 116(5), 864-876 (2015-01-07)
Recently, glioma stem cells have been identified as the main cause of glioma propagation and recurrence and a number of several cell markers have been indicated as putative GSC markers. In the present work, a retrospective study to evaluate the...
Chandrakumar Balaratnasingam et al.
Investigative ophthalmology & visual science, 49(3), 986-999 (2008-03-11)
To study the time-dependent effects of elevated intraocular pressure (IOP) on axonal transport and cytoskeleton proteins in the porcine optic nerve head. Fifteen pigs were used for this study. Rhodamine-beta-isothiocyanate was injected into the vitreous of each eye to study...
Y Yang et al.
Journal of neurochemistry, 73(6), 2286-2298 (1999-12-03)
The transcriptional mechanism underlying amyloid precursor protein (APP) regulation in primary neurons during development was investigated. We observed an approximately threefold elevation of APP mRNA levels in differentiating rat hippocampal neurons between day 1 and day 7 in culture and...
Thomas S Jacques et al.
The EMBO journal, 29(1), 222-235 (2009-11-21)
It has been suggested that intrinsic brain tumours originate from a neural stem/progenitor cell population in the subventricular zone of the post-natal brain. However, the influence of the initial genetic mutation on the phenotype as well as the contribution of...
Neurofilament proteins are synthesized in nerve endings from squid brain
Crispino M, et al.
Journal of Neurochemistry, 61(3), 1144-1146 (1993)
Junting Huang et al.
Cell reports, 33(1), 108233-108233 (2020-10-08)
The innate immune system responds to infections that give rise to pain. How the innate immune system interacts with the sensory nervous system and contributes to pain is poorly understood. Here we report that hyperactivity of innate immunity primes and...
Chandrakumar Balaratnasingam et al.
Investigative ophthalmology & visual science, 50(6), 2824-2838 (2009-01-27)
Cytoskeleton proteins play a critical role in maintaining retinal ganglion cell structure, viability, and function. This study documents the distribution of cytoskeleton protein subunits in the various regions of the normal human optic nerve and identifies important relationships among mitochondria...
Cristiane Neves Alessi Pissulin et al.
Journal of photochemistry and photobiology. B, Biology, 167, 256-263 (2017-01-15)
Local anesthetics are used to relieve pre- and postoperative pain, acting on both sodium channels and nicotinic acetylcholine receptors (nAChR) at the neuromuscular junction (NMJ). Bupivacaine acts as a non-competitive antagonist and has limitations, such as myotoxicity, neurotoxicity, and inflammation....
Prerana Bhan et al.
Traffic (Copenhagen, Denmark), 21(2), 231-249 (2019-10-18)
Model organisms are increasingly used to study and understand how neurofilament (NF)-based neurological diseases develop. However, whether a NF homolog exists in C. elegans remains unclear. We characterize TAG-63 as a NF-like protein with sequence homologies to human NEFH carrying...
Chandrakumar Balaratnasingam et al.
Investigative ophthalmology & visual science, 51(6), 3019-3028 (2010-01-22)
To examine the time-dependent effects of focal axonal ischemia on the retinal ganglion cell (RGC) cytoskeleton. Eight pigs were used. Small retinal arteriolar branches were occluded by argon laser to induce focal ischemic insults that were maintained for a period...
Jon O Cleary et al.
NeuroImage, 56(3), 974-983 (2011-02-12)
Extensive worldwide efforts are underway to produce knockout mice for each of the ~25,000 mouse genes, which may give new insights into the underlying pathophysiology of neurological disease. Microscopic magnetic resonance imaging (μMRI) is a key method for non-invasive morphological...
Sui-Bin Ma et al.
Molecular brain, 13(1), 161-161 (2020-11-25)
Previous studies have shown that CCL2 may cause chronic pain, but the exact mechanism of central sensitization is unclear. In this article, we further explore the presynaptic role of CCL2. Behavioral experiments show that intervertebral foramen injection CCR2 antagonists into...
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