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Antonia Hildebrand et al.
Molecular vision, 20, 1749-1757 (2015-01-06)
Corneal transplantation is the most frequent and successful form of tissue transplantation in adults (<10% rejection). In young children, any corneal opacity should be corrected as early as possible to prevent lifelong visual impairment. However, the corneal graft rejection rate
Elenaz Naderkhani et al.
Journal of pharmaceutical sciences, 103(2), 661-668 (2014-01-08)
The antiviral drug acyclovir (ACV) suffers from poor solubility both in lipophilic and hydrophilic environment, leading to low and highly variable bioavailability. To overcome these limitations, this study aimed at designing mucoadhesive ACV-containing liposomes to improve its permeability. Liposomes were
Vijesh Kumar et al.
Journal of chromatography. A, 1368, 155-162 (2014-12-03)
Aggregates of monoclonal antibody (mAb) therapeutics, due to their perceived impact on immunogenicity, are recognized as a critical quality attribute by the regulatory authorities as well as the industry. Hence, removal of aggregates is a key objective of bioprocessing. At
Kaihao Tang et al.
Applied and environmental microbiology, 81(2), 774-782 (2014-11-16)
Gram-negative bacteria use N-acyl homoserine lactones (AHLs) as quorum sensing (QS) signaling molecules for interspecies communication, and AHL-dependent QS is related with virulence factor production in many bacterial pathogens. Quorum quenching, the enzymatic degradation of the signaling molecule, would attenuate
Edwin L de Vrij et al.
PloS one, 9(4), e93218-e93218 (2014-04-12)
Hibernation is an energy-conserving behavior in winter characterized by two phases: torpor and arousal. During torpor, markedly reduced metabolic activity results in inactivity and decreased body temperature. Arousal periods intersperse the torpor bouts and feature increased metabolism and euthermic body
Anna Miodek et al.
Sensors (Basel, Switzerland), 15(10), 25015-25032 (2015-10-02)
An aptasensor with enhanced anti-fouling properties has been developed. As a case study, the aptasensor was designed with specificity for human thrombin. The sensing platform was developed on screen printed electrodes and is composed of a self-assembled monolayer made from
Fei Huang et al.
PloS one, 9(6), e100993-e100993 (2014-06-28)
The homologous recombination pathway is responsible for the repair of DNA double strand breaks. RAD51, a key homologous recombination protein, promotes the search for homology and DNA strand exchange between homologous DNA molecules. RAD51 is overexpressed in a variety of
Ronald P M Gonçalves et al.
Shock (Augusta, Ga.), 42(5), 415-423 (2014-07-09)
The aim of the present study was to investigate the existence of gender-related differences in the profile of changes that occur in cardiac functionality during endotoxic shock. For this, both male and female Wistar rats received a single injection of
Alban Bujard et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63, 36-44 (2014-07-11)
The parallel artificial membrane permeability assay (PAMPA) is a high-throughput screening (HTS) method that is widely used to predict in vivo passive permeability through biological barriers, such as the skin, the blood brain barrier (BBB) and the gastrointestinal tract (GIT).
D H Currie et al.
Applied and environmental microbiology, 80(16), 5001-5011 (2014-06-08)
Thermoanaerobacterium saccharolyticum, a Gram-positive thermophilic anaerobic bacterium, grows robustly on insoluble hemicellulose, which requires a specialized suite of secreted and transmembrane proteins. We report here the characterization of proteins secreted by this organism. Cultures were grown on hemicellulose, glucose, xylose
Jonny W Dennis et al.
Parasites & vectors, 7, 378-378 (2014-08-21)
Tsetse flies are the biological vectors of African trypanosomes, the causative agents of sleeping sickness in humans and nagana in animals. The tsetse endosymbiont Sodalis glossinidius has been suggested to play a role in tsetse susceptibility to infection. Here we
Gabriel B Akanni et al.
Journal of the science of food and agriculture, 95(5), 1094-1102 (2014-11-06)
The cladodes of Opuntia ficus-indica (prickly pear cactus) have a low protein content; for use as a balanced feed, supplementation with other protein sources is therefore desirable. We investigated protein enrichment by cultivation of the yeasts Candida utilis and Kluyveromyces
Kalinda Watson et al.
The Science of the total environment, 542(Pt A), 672-684 (2015-11-08)
During disinfection, bromide, iodide and natural organic matter (NOM) in source waters can lead to the formation of brominated and/or iodinated disinfection by-products (DBPs), which are often more toxic than their chlorinated analogues. The objective of this study was to
Limei Liu et al.
Antioxidants & redox signaling, 21(11), 1571-1581 (2013-12-18)
Although uncoupling protein 2 (UCP2) negatively regulates intracellular reactive oxygen species (ROS) production and protects vascular function, its participation in vascular benefits of drugs used to treat cardiometabolic diseases is largely unknown. This study investigated whether UCP2 and associated oxidative
Tomaz Mars et al.
The Journal of membrane biology, 248(2), 273-283 (2014-12-24)
Transfection of primary human myoblasts offers the possibility to study mechanisms that are important for muscle regeneration and gene therapy of muscle disease. Cultured human myoblasts were selected here because muscle cells still proliferate at this developmental stage, which might
Dilek Battal et al.
Therapeutic drug monitoring, 37(6), 805-811 (2015-05-21)
Mescaline, the primary psychoactive chemical in peyote cactus, has been consumed for thousands of years in ancient religious ceremonies. The US military wanted to determine if mescaline intake was a problem for personnel readiness. Twenty thousand seventeen urine specimens negative
Linda Vignozzi et al.
The journal of sexual medicine, 11(7), 1694-1708 (2014-05-23)
In subjects with erectile dysfunction responding poorly to sildenafil, metformin was reported to improve erections. The aim of this study is to investigate metformin's mechanism of action on erectile function, particularly focusing on adenosine (ADO) and nitric oxide (NO) signaling
E A Ustiugova et al.
Prikladnaia biokhimiia i mikrobiologiia, 48(6), 618-625 (2013-01-22)
The Lactococcus lactis subsp. lactis 194-K strain has been established to be able to produce two bacteriocins, one of which was identified as the known lantibiotic nisin A, and the other 194-D bacteriocin represents a polypeptide with a 2589-Da molecular
Ł Sęczyk et al.
Food & function, 6(11), 3560-3566 (2015-08-26)
The study examined the effect of fortification of bean paste with onion skin phenolics. The antioxidant potential and in vitro digestibility of nutrients in the light of phenolic-food matrix interactions were studied. Bean paste was supplemented with onion skin extracts
Ryutaro Ochi-ishi et al.
Molecular pain, 10, 53-53 (2014-08-17)
Paclitaxel is an effective chemotherapeutic agent widely used for the treatment of solid tumors. The major dose-limiting toxicity of paclitaxel is peripheral neuropathy. The mechanisms underlying the development and maintenance of paclitaxel-induced peripheral neuropathy are still unclear, and there are
Valentina Manzo et al.
Talanta, 128, 486-492 (2014-07-26)
In this study, six non-steroidal anti-inflammatory drugs (NSAIDs) were extracted from water samples using the rotating-disk sorptive extraction (RDSE) technique. The extraction disk device contains a central cavity that allows for the incorporation of a powdered sorbent phase (Oasis™ HLB).
Meghan Lee Arnold et al.
Journal of visualized experiments : JoVE, (163) (2020-10-06)
Toxicity of misfolded proteins and mitochondrial dysfunction are pivotal factors that promote age-associated functional neuronal decline and neurodegenerative disease across species. Although these neurotoxic challenges have long been considered to be cell-intrinsic, considerable evidence now supports that misfolded human disease
Mei-Juan Cai et al.
The Journal of biological chemistry, 289(38), 26630-26641 (2014-08-07)
The steroid hormone 20-hydroxyecdysone (20E) initiates insect molting and metamorphosis. By contrast, juvenile hormone (JH) prevents metamorphosis. However, the mechanism by which JH inhibits metamorphosis remains unclear. In this study, we propose that JH induces the phosphorylation of Broad isoform
Laurence Berthod et al.
Water research, 67, 292-298 (2014-10-10)
The partitioning of pharmaceuticals in the environment can be assessed by measuring their adsorption coefficients (Kd) between aqueous and solid phases. Measuring this coefficient in sewage sludge gives an indication of their partitioning behaviour in a wastewater treatment plant and
Pramod K Gupta et al.
Bioconjugate chemistry, 25(6), 1091-1102 (2014-05-21)
We have designed lectin functionalized Lipo-polymerosome bearing Amphotericin B (Lec-AmB-L-Psome) for specific internalization via lectin receptors overexpressed on infected macrophages of mononuclear phagocytic system (MPS) for the effective management of intramacrophage diseases such as visceral leishmaniasis. The lipo-polymerosome composed of
C Cappadone et al.
Biochemical and biophysical research communications, 467(2), 348-353 (2015-10-04)
Osteosarcoma (OS) is the most common primary malignant tumor of bone, occurring most frequently in children and adolescents. The mechanism of formation and development of OS have been studied for a long time. Tumor suppressor pathway governed by p53 gene
Chenglong Ji et al.
Fish & shellfish immunology, 47(1), 79-84 (2015-09-04)
Inorganic arsenic is a known pollutant with two chemical forms, arsenite (As (III)) and arsenate (As (V)), in marine environment. Clam Ruditapes philippinarum is an important fishery species along the Bohai coast. In this study, the biological effects induced by
R Meier et al.
International journal of pharmaceutics, 496(1), 12-23 (2015-05-31)
As different batches of the same excipients will be intermixed during continuous processes, the traceability of batches is complicated. Simplified formulations may help to reduce problems related to batch intermixing and traceability. Twin-screw granulation with subsequent tableting was used to
Do no harm: calcium and phosphate supplementation in kidney transplant recipients.
Neeraj Singh et al.
Transplantation, 96(11), e81-e82 (2013-12-04)
Marwa Ahmed et al.
Chirality, 26(11), 754-763 (2014-03-08)
New affinity monolithic capillary columns of 150 µm internal diameter were prepared in situ fused glass capillary via either immobilization or encapsulation of Candida antarctica lipase B (CALB) on or within polymer monoliths, respectively. The immobilized lipase-based monoliths were prepared
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