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P4458

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Itaru Minagawa et al.
The Biochemical journal, 441(1), 265-273 (2011-09-09)
RLF (relaxin-like factor), also known as INSL3 (insulin-like peptide 3), is a novel member of the relaxin/insulin gene family that is expressed in testicular Leydig cells. Despite the implicated role of RLF/INSL3 in testis development, its native conformation remains unknown....
Wnt-modified materials mediate asymmetric stem cell division to direct human osteogenic tissue formation for bone repair.
Okuchi, et al.
Nature Materials, 20, 108-118 (2021)
Seth T Scanlon et al.
The Journal of experimental medicine, 208(10), 2113-2124 (2011-09-21)
Airborne exposure to microbial cell wall lipids such as lipopolysaccharide triggers innate immune responses that regulate susceptibility to allergic airway inflammation. α-Glycosylceramides represent another widespread class of microbial lipids that directly stimulate innate-like, IL-4- and IL-13-producing, CD1d-restricted NKT cells. In...
Byron Deorosan et al.
Stem cells international, 2011, 429187-429187 (2011-05-24)
Mesenchymal stem cells (MSCs) have become a critical addition to all facets of tissue engineering. While most in vitro research has focused on their behavior in two-dimensional culture, relatively little is known about the cells' behavior in three-dimensional culture, especially...
Qiong Fan et al.
Cells, 9(5) (2020-05-18)
The cholesterol-sensing nuclear receptor liver X receptor (LXR) and the glucose-sensing transcription factor carbohydrate responsive element-binding protein (ChREBP) are central players in regulating glucose and lipid metabolism in the liver. More knowledge of their mechanistic interplay is needed to understand...
Rakhi Srivastava et al.
Evidence-based complementary and alternative medicine : eCAM, 2011, 427031-427031 (2011-08-27)
In Indian traditional medicine, Boerhaavia diffusa (punarnava) roots have been widely used for the treatment of dyspepsia, jaundice, enlargement of spleen, abdominal pain and as an anti-stress agent. Pharmacological evaluation of the crude ethanolic extract of B. diffusa roots has...
Catherine J Walsh et al.
Marine drugs, 6(2), 291-307 (2008-08-30)
Harmful algal blooms (HABs) of the toxic dinoflagellate, Karenia brevis, produce red tide toxins, or brevetoxins. Significant health effects associated with red tide toxin exposure have been reported in sea life and in humans, with brevetoxins documented within immune cells...
Manuel Garcia-Moreno et al.
Molecular cell, 74(1), 196-211 (2019-02-26)
The compendium of RNA-binding proteins (RBPs) has been greatly expanded by the development of RNA-interactome capture (RIC). However, it remained unknown if the complement of RBPs changes in response to environmental perturbations and whether these rearrangements are important. To answer these...
Sarina Gouravan et al.
International journal of molecular sciences, 19(4) (2018-03-24)
The BRAFV600E mutation, which in melanoma is targetable with vemurafenib, is also found in sarcomas and we here evaluate the therapeutic potential in sarcoma cell lines. Four sarcoma cell lines harboring the BRAFV600E mutation, representing liposarcomas (SA-4 and SW872), Ewing...
Suneeta Tumati et al.
The Journal of pharmacology and experimental therapeutics, 330(3), 810-817 (2009-06-06)
Studies have shown that long-term (5alpha,6alpha)-7,8-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol (morphine) treatment increases the sensitivity to painful heat stimuli (thermal hyperalgesia). The cellular adaptations contributing to sustained morphine-mediated pain sensitization are not fully understood. It was shown previously (J Neurosci 22:6747-6755, 2002) that sustained...
Marti Cabanes-Creus et al.
Molecular therapy. Methods & clinical development, 17, 1139-1154 (2020-06-04)
Use of the prototypical adeno-associated virus type 2 (AAV2) capsid delivered unexpectedly modest efficacy in an early liver-targeted gene therapy trial for hemophilia B. This result is consistent with subsequent data generated in chimeric mouse-human livers showing that the AAV2...
Anne Kristin Aksaas et al.
Journal of molecular signaling, 6, 10-10 (2011-09-02)
Post-transcriptional processing of pre-mRNA takes place in several steps and requires involvement of a number of RNA-binding proteins. How pre-mRNA processing is regulated is in large enigmatic. The catalytic (C) subunit of protein kinase A (PKA) is a serine/threonine kinase...
Hiroki Kannen et al.
Mass spectrometry (Tokyo, Japan), 9(1), A0091-A0091 (2020-12-11)
Combined therapy using photodynamic therapy (PDT) and chemotherapy has been proposed for anticancer-drug-resistant cancer cells. To evaluate the efficacy of such a combined therapy, the uptakes of an anticancer drug and a photosensitizer in cancer cells must be assessed. Mass...
Sandra Hakim et al.
Human molecular genetics, 25(11), 2295-2313 (2016-10-30)
Polycystic kidney disease (PKD) is a common cause of renal failure with few effective treatments. INPP5E is an inositol polyphosphate 5-phosphatase that dephosphorylates phosphoinositide 3-kinase (PI3K)-generated PI(3,4,5)P
Caroline Bull et al.
PloS one, 10(3), e0119367-e0119367 (2015-03-10)
Chronic psychological stress and nutritional deficiencies are factors that impact negatively on human health and disease risk. Chronic stress has been associated with accelerated leukocyte telomere shortening in numerous cohorts, however, a mechanistic link has proven elusive. This study tested...
David Abasiwani Alagpulinsa et al.
Cancer biology & therapy, 16(6), 976-986 (2015-05-23)
RAD51-mediated recombinational repair is elevated in multiple myeloma (MM) and predicts poor prognosis. RAD51 has been targeted to selectively sensitize and/or kill tumor cells. Here, we employed a peptide nucleic acid (PNA) to inhibit RAD51 expression in MM cells. We...
Yuxia Jiao et al.
Journal of neurochemistry, 105(5), 1746-1760 (2008-02-06)
Densin is a member of the leucine-rich repeat (LRR) and PDZ domain (LAP) protein family that binds several signaling molecules via its C-terminal domains, including calcium/calmodulin-dependent protein kinase II (CaMKII). In this study, we identify several novel mRNA splice variants...
Tuula Klaavuniemi et al.
BMC cell biology, 10, 22-22 (2009-03-31)
The PDZ-LIM proteins are a family of signalling adaptors that interact with the actin cross-linking protein, alpha-actinin, via their PDZ domains or via internal regions between the PDZ and LIM domains. Three of the PDZ-LIM proteins have a conserved 26-residue...
V D Boppana et al.
Parasite immunology, 31(6), 287-295 (2009-06-06)
Mosquitoes represent the most important vector for transmitting pathogens that cause human disease. Central to pathogen transmission is the ability to divert the host immune system away from Th1 and towards Th2 responsiveness. Identification of the mosquito factor(s) critical for...
Bashar M Thejer et al.
BMC molecular and cell biology, 21(1), 24-24 (2020-04-05)
Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in many cancer cells, where it is associated with detrimental patient outcomes. It contains phosphorylated tyrosines which evolutionarily preceded deuterostome gastrulation and tissue differentiation mechanisms. We demonstrate that manipulating PGRMC1 phosphorylation status...
Martin Häring et al.
STAR protocols, 1(1), 100030-100030 (2020-10-29)
Vagal sensory neurons relay viscero- and somatosensory information from within the body and play a key role in maintaining physiological homeostasis. We recently characterized the diversity of vagal sensory neurons in the mouse using a single-cell transcriptomics approach. Here, we...
Mizuho Inai et al.
Photodiagnosis and photodynamic therapy, 20, 238-245 (2017-10-29)
Subcellular localization of a photosensitizer is known to determine the therapeutic efficacy of photodynamic therapy (PDT). Cell membrane is an optimal target that promises an effective treatment outcome. We previously developed a novel photosensitizer named porphyrus envelope (PE) by combining...
Pei-Ching Chang et al.
PloS one, 9(2), e88556-e88556 (2014-02-20)
Prostate cancer (PCa) cells undergoing neuroendocrine differentiation (NED) are clinically relevant to the development of relapsed castration-resistant PCa. Increasing evidences show that autophagy involves in the development of neuroendocrine (NE) tumors, including PCa. To clarify the effect of autophagy on...
Effect of Lactobacillus brevis KB290 on the cell-mediated cytotoxic activity of mouse splenocytes: a DNA microarray analysis
Fukui Y, et al.
The British Journal of Nutrition, 110(9), 1617-1629 (2013)
Marek Piotrowski et al.
Colloids and surfaces. B, Biointerfaces, 135, 8-17 (2015-08-02)
The main objectives of the present study were to investigate the biocompatibility of polyelectrolyte-coated nanocapsules and to evaluate the neuroprotective action of the nanoencapsulated water-insoluble neuroprotective drug-undecylenic acid (UDA), in vitro. Core-shell nanocapsules were synthesized using nanoemulsification and the layer-by-layer...
Christopher M Coleman et al.
The open virology journal, 5, 114-123 (2011-11-03)
Respiratory Syncytial Virus (RSV) causes annual epidemics of respiratory disease particularly affecting infants. The associated airway inflammation is characterized by an intense neutrophilia. This neutrophilic inflammation appears to be responsible for much of the pathology and symptoms. Previous work from...
Kentaro Kato et al.
PLoS biology, 9(8), e1001133-e1001133 (2011-09-14)
Organisms are structurally robust, as cells accommodate changes preserving structural integrity and function. The molecular mechanisms underlying structural robustness and plasticity are poorly understood, but can be investigated by probing how cells respond to injury. Injury to the CNS induces...
Sachiko Ohshima et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 17(1), 73-80 (2008-10-23)
Recombinant adeno-associated virus (rAAV)-mediated gene transfer is an attractive approach to the treatment of Duchenne muscular dystrophy (DMD). We investigated the muscle transduction profiles and immune responses associated with the administration of rAAV2 and rAAV8 in normal and canine X-linked...
David Castro et al.
Toxins, 12(5) (2020-05-14)
Ciguatoxins (CTXs) are a group of neurotoxins responsible for the syndrome ciguatera fish poisoning (CFP) as a result of the consumption of contaminated fish. The presence of these toxins has been detected around the Pacific, Caribbean and Indian coasts. Recent...
Sarah E Conduit et al.
Human molecular genetics, 28(2), 230-244 (2018-09-29)
Polycystic kidney disease (PKD) results from excessive renal epithelial cell proliferation, leading to the formation of large fluid filled cysts which impair renal function and frequently lead to renal failure. Hyperactivation of numerous signaling pathways is hypothesized to promote renal...
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