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" within Papeles
H Muramatsu et al.
Biochemical and biophysical research communications, 177(2), 652-658 (1991-06-14)
Midkine (MK) is the product of a retinoic acid responsive gene, MK, and is the initial member of a new family of heparin binding factors. Recombinant MK produced by an L-cell clone transfected with an MK cDNA was purified to...
Thomas F Deuel et al.
Archives of biochemistry and biophysics, 397(2), 162-171 (2002-02-14)
Pleiotrophin (PTN the protein, Ptn the gene) is a 136 amino acid secreted heparin-binding cytokine that signals diverse functions, including lineage-specific differentiation of glial progenitor cells, neurite outgrowth, and angiogenesis. Pleiotrophin gene expression is found in cells in early differentiation...
Characterization of the human pleiotrophin gene. Promoter region and chromosomal localization.
Li Y S, et al.
The Journal of Biological Chemistry, 267(36), 26011-26016 (1992)
Jamie A Davies et al.
BMC developmental biology, 14, 35-35 (2014-09-11)
Glandular organs require the development of a correctly patterned epithelial tree. These arise by iterative branching: early branches have a stereotyped anatomy, while subsequent branching is more flexible, branches spacing out to avoid entanglement. Previous studies have suggested different genetic...
Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus.
Gonzalez-Castillo C, et al.
Frontiers in Cellular Neuroscience, 8, 443-443 (2015)
N Zhang et al.
The Journal of biological chemistry, 274(19), 12959-12962 (1999-05-01)
The pleiotrophin (PTN) gene (Ptn) is a potent proto-oncogene that is highly expressed in many primary human tumors and constitutively expressed in cell lines derived from these tumors. The product of the Ptn gene is a secreted 136-amino acid heparin...
Pleiotrophin expression during odontogenesis.
Erlandsen H, et al.
The Journal of Histochemistry and Cytochemistry, 60(5), 366-375 (2012)
B S Hampton et al.
Molecular biology of the cell, 3(1), 85-93 (1992-01-01)
Heparin-binding growth-associated molecule (HB-GAM) was purified from adult bovine brain and chicken heart. The yield of HB-GAM is increased by 5- to 10-fold when 250 mM NaCl is added to the homogenization buffer, indicating that HB-GAM may exist as a...
J Merenmies et al.
The Journal of biological chemistry, 265(28), 16721-16724 (1990-10-05)
An 18-kDa protein (designated herein as the heparin-binding growth-associated molecule, HB-GAM), the expression of which in rat brain correlates to the rapid postnatal developmental phase, was previously isolated and suggested to have a role in the maturation and growth of...
Chun-Xian Du et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 122(10), 905-913 (2014-04-05)
Pleiotrophin (PTN) has been demonstrated to be strongly expressed in many fetal tissues, but seldom in healthy adult tissues. While PTN has been reported to be expressed in many types of tumors as well as at high serum concentrations in...
N Maeda et al.
The Journal of cell biology, 142(1), 203-216 (1998-07-14)
Pleiotrophin/heparin-binding growth-associated molecule (HB-GAM) is a specific ligand of protein tyrosine phosphatase zeta (PTPzeta)/receptor-like protein tyrosine phosphatase beta (RPTPbeta) expressed in the brain as a chondroitin sulfate proteoglycan. Pleiotrophin and PTPzeta isoforms are localized along the radial glial fibers, a...
Growth Factors
Principles of Tissue Engineering (2014)
The effects of pleiotrophin in proliferative vitreoretinopathy.
Ding X, et al.
Graefe'S Archive For Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, 255(5), 873-884 (2017)
Encyclopedia of Cancer (2017)
Heather A Himburg et al.
Nature medicine, 16(4), 475-482 (2010-03-23)
Hematopoietic stem cell (HSC) self-renewal is regulated by both intrinsic and extrinsic signals. Although some of the pathways that regulate HSC self-renewal have been uncovered, it remains largely unknown whether these pathways can be triggered by deliverable growth factors to...