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Carolien P J Deen et al.
Nutrients, 12(7) (2020-07-16)
It is unclear whether niacin nutritional status is a target for improvement of long-term outcome after renal transplantation. The 24-h urinary excretion of N1-methylnicotinamide (N1-MN), as a biomarker of niacin status, has previously been shown to be negatively associated with
Michelle C Potter et al.
PloS one, 9(9), e102936-e102936 (2014-09-26)
Pyridoxine is used as a supplement for treating conditions such as vitamin deficiency as well as neurological disorders such as depression, epilepsy and autism. A significant neurologic complication of pyridoxine therapy is peripheral neuropathy thought to be a result of
Chang'an Wang et al.
Fish physiology and biochemistry, 46(3), 1011-1018 (2020-01-18)
In this study, the effects of dietary myo-inositol on the skin mucosal immunity and growth of taimen (Hucho taimen) fry were determined. Triplicate groups of 500 fish (initial weight 5.58 ± 0.15 g) were fed different diets containing graded levels of myo-inositol (28.75
Sidney M Gospe
Pediatric neurology, 26(3), 181-185 (2002-04-17)
Pyridoxine-dependent seizures, although a rare clinical entity, have been recognized as an etiology of intractable seizures in neonates and infants for more than 45 years. Recent research has focused on the molecular and neurochemical aspects of this disorder, as well
Yan Zhou et al.
European journal of drug metabolism and pharmacokinetics, 38(1), 5-13 (2012-10-24)
Pyridoxine is always simultaneously administered orally with isoniazid for tuberculosis patients in the clinic to prevent or treat the nervous system side effects induced by isoniazid. So the aim of this research was to investigate the effects of pyridoxine on
Troy J Plumb et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 62(6), 1155-1159 (2013-07-09)
Type 1 primary hyperoxaluria is a genetic disorder caused by deficiency of the liver-specific peroxisomal enzyme alanine-glyoxylate aminotransferase. This enzyme deficiency leads to excess oxalate production and deposition of calcium oxalate salts, resulting in kidney failure and systemic oxalosis. Aside
Vijay P Singh et al.
The Journal of organic chemistry, 78(4), 1478-1487 (2013-01-16)
Vitamin B6 is involved in a variety of enzymatic transformations. Some recent findings also indicate an antioxidant role of the vitamin in biological systems. We set out to turn pyridoxine (1a) into a catalytic chain-breaking and hydroperoxide-decomposing antioxidant by replacing
G Ravi et al.
Journal of immunological methods, 445, 59-66 (2017-03-23)
Riboflavin (vitamin B
Mohamed K Abd El-Rahman et al.
Talanta, 221, 121409-121409 (2020-10-21)
Choline (Ch+), is a vitamin-like essential water-soluble organic micronutrient. The US-FDA requires that infant formula not made from cow's milk must be supplemented with Ch+. Direct determination of Ch+ in milk powders and infant formulas is a challenging task due
Andressa Reis et al.
Scientific reports, 9(1), 8471-8471 (2019-06-13)
Rhodophiala bifida (R. bifida) is a representative of the Amaryllidaceae plant family and is rich in montanine, an alkaloid with high pharmaceutical potential. Despite the interest in these compounds, many steps of the biosynthetic pathway have not been elucidated. In
Agnieszka Wasilewska et al.
Medical science monitor : international medical journal of experimental and clinical research, 9(3), CR147-CR151 (2003-03-18)
There is increasing evidence that plasma homocysteine level is an independent risk factor for atherosclerosis. Low levels of serum folates, cobalamin and pyridoxine are associated with increased risk of cardiovascular disease. Most dietary products contain cholesterol as well as methionine
Iga Rybicka et al.
Journal of nutritional science and vitaminology, 63(2), 125-132 (2017-05-30)
Gluten-free (GF) products are those with a natural absence or acceptable level (<20 mg/kg) of gluten. They should be a part of a diet for people with gluten-related disorders, like celiac disease. Recently the popularity of a gluten-free diet (GFD)
Florian Oswald et al.
Frontiers in microbiology, 9, 1213-1213 (2018-06-29)
Cyanide is a minor constituent of crude syngas whose content depends on the feedstock and gasification procedure. It is a known poison to metal catalysts and inhibits iron-containing enzymes like carbon monoxide dehydrogenase of acetogenic organisms. Therefore, it is considered
Yingying Yu et al.
Marine drugs, 18(4) (2020-04-23)
The present study investigated the effect of dietary astaxanthin (AX) on the growth performance, antioxidant parameters, and repair of hepatopancreas damage in Pacific white shrimp (Litopenaeus vannamei). To evaluate the hepatopancreas protective function of AX in shrimps, we compared the
Robert T Burns et al.
PloS one, 9(11), e109535-e109535 (2014-11-13)
Marine sediments can contain B vitamins, presumably incorporated from settled, decaying phytoplankton and microorganisms associated with decomposition. Because B vitamins may be advantageous for the energetically intensive processes of metamorphosis, post-metamorphic growth, and reproduction, we tested several B vitamins to
Frida Niss et al.
Environmental science and pollution research international, 25(12), 12183-12188 (2018-03-12)
The use of in vitro bioassays for studies of toxic activity in environmental water samples is a rapidly expanding field of research. Cell-based bioassays can assess the total toxicity exerted by a water sample, regardless whether the toxicity is caused
Ali M Yehia et al.
Analytica chimica acta, 1104, 95-104 (2020-02-29)
Paper-based microfluidic device was designed with wax-printing to combine potentiometric, fluorimetric and colorimetric detection zones. This newly developed trimodal paper chip has been used for on-site determination of ketamine hydrochloride (KET) as a date rape drug in beverages. The device
Zhichao Liu et al.
PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be translated
Monika A Lesniewska et al.
Drug development and industrial pharmacy, 41(4), 663-669 (2014-03-04)
Acyclovir (ACV) belongs to a class of drugs with low bioavailability. Selected ACV esters including acetyl (Ac-), isobutyryl (iBut-), pivaloyl (Piv-), ethoxycarbonyl (Etc-) and nicotinoyl (Nic-) were synthesized, and their lipophilicity was determined by the high-performance liquid chromatography (HPLC) RP
Thangavelu Kokulnathan et al.
Ultrasonics sonochemistry, 44, 231-239 (2018-04-24)
In the modern world, the contamination of ecosystem by human and veterinary pharmaceutical drugs through the metabolic excretion, improper disposal/industrial waste has been subjected to a hot issue. Therefore, exploitation of exclusive structured material and reliable technique is a necessary
Shilpa Bothra et al.
Analytical and bioanalytical chemistry, 410(1), 201-210 (2017-11-04)
This communication focusses on the synthesis of red fluorescent lysozyme cocooned gold nanoclusters (Lyso-AuNCs) that have been successfully applied for the selective and specific recognition of the vitamin B
Ziyi Yin et al.
Autophagy, 16(5), 900-916 (2019-07-18)
Cells are faced with various stresses during their growth and development, and autophagy is a degradative process in which cells can break down their own components to recycle macromolecules and provide energy under these stresses. For pathogenic fungi that utilize
Yijun Kang et al.
The British journal of nutrition, 118(6), 431-440 (2017-10-06)
Anaemia during pregnancy, characterised by Hb <110 g/l, is a specific risk factor for adverse maternal and perinatal outcomes in developing countries. The objective of this study was to determine the effectiveness of daily antenatal supplementation with multiple micronutrients (MMN)
Anna Maria Gori et al.
Clinical chemistry, 52(7), 1318-1324 (2006-05-13)
Low dietary intake and low serum concentrations of vitamin B6 and/or folate are associated with increased risk of vascular events, possibly because of their association with inflammation, which plays a crucial role in the pathogenesis of cardiovascular diseases. Using data
Xuanyu Tao et al.
Microbiome, 8(1), 84-84 (2020-06-07)
In a warmer world, microbial decomposition of previously frozen organic carbon (C) is one of the most likely positive climate feedbacks of permafrost regions to the atmosphere. However, mechanistic understanding of microbial mediation on chemically recalcitrant C instability is limited;
Clara D M van Karnebeek et al.
American journal of human genetics, 105(3), 534-548 (2019-08-20)
Early-infantile encephalopathies with epilepsy are devastating conditions mandating an accurate diagnosis to guide proper management. Whole-exome sequencing was used to investigate the disease etiology in four children from independent families with intellectual disability and epilepsy, revealing bi-allelic GOT2 mutations. In-depth
Matthias Fellner et al.
Biochemistry, 57(38), 5513-5523 (2018-08-31)
LarE from Lactobacillus plantarum is an ATP-dependent sulfur transferase that sacrifices its Cys176 sulfur atom to form a dehydroalanine (Dha) side chain during biosynthesis of the covalently linked nickel-pincer nucleotide (NPN) cofactor (pyridinium 3-thioamide-5-thiocarboxylic acid mononucleotide) of lactate racemase. Coenzyme
Yu-Jun Wan et al.
Journal of agricultural and food chemistry, 67(3), 895-904 (2019-01-05)
It has been found that probiotic-fermented carrot pulp has a beneficial effect in reducing blood glucose, more so than unfermented pulp. This paper explores the reason for this by looking at fermentation-induced changes in nutritional components and hypoglycemic effects of
Kathleen M Hayden et al.
Alzheimer's & dementia : the journal of the Alzheimer's Association, 13(11), 1187-1196 (2017-05-23)
The Mediterranean and Dietary Approaches to Stop Hypertension diets have been associated with lower dementia risk. We evaluated dietary inflammatory potential in relation to mild cognitive impairment (MCI)/dementia risk. Baseline food frequency questionnaires from n = 7085 women (aged 65-79 years) were
Paulo Rema et al.
Animals : an open access journal from MDPI, 9(4) (2019-04-26)
Insects are emerging as a sustainable alternative to fishmeal and fish oil in aquafeeds. This study assessed the effect of graded incorporation levels of defatted yellow mealworm (Tenebrio molitor) protein meal on juvenile rainbow trout (Oncorhynchus mykiss) growth performance, body
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