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Beth L Calder et al.
Journal of food science, 77(10), S342-S347 (2012-09-04)
After-cooking darkening (ACD) is an inherent and undesirable trait that develops in cooked potatoes. The objective of this study was to evaluate the effectiveness of sodium acid sulfate (SAS) dip treatments compared to other antigraying treatments and a control to
Hua-Yan Ren et al.
Oncotarget, 6(6), 4080-4096 (2015-03-05)
Tumor necrosis factor receptor associated factor 4 (TRAF4) is an important adaptor protein that plays a significant role in several signaling pathways. By studying the relationship between TRAF4 and 70 kDa ribosomal protein S6 kinase (p70s6k) in vivo, we demonstrated
Elspeth M Beauchamp et al.
Molecular cancer therapeutics, 14(1), 202-212 (2014-10-26)
Arsenic trioxide (As2O3) exhibits potent antineoplastic effects and is used extensively in clinical oncology for the treatment of a subset of patients with acute myeloid leukemia (AML). Although As2O3 is known to regulate activation of several signaling cascades, the key
Arvind Shakya et al.
Molecular and cellular biology, 35(6), 1014-1025 (2015-01-15)
The mechanisms whereby the crucial pluripotency transcription factor Oct4 regulates target gene expression are incompletely understood. Using an assay system based on partially differentiated embryonic stem cells, we show that Oct4 opposes the accumulation of local H3K9me2 and subsequent Dnmt3a-mediated
Wei Zhao et al.
Huan jing ke xue= Huanjing kexue, 32(8), 2477-2484 (2012-05-25)
Acid birnessite was treated with Na4P2O7 at pH 2, 4, 5 respectively. After the treatments, the species and content of manganese ion in the complex solution, and the variation of average oxidation state (AOS) of Mn in birnessite, and the
Ana A Baburamani et al.
International journal of molecular sciences, 16(9), 22509-22526 (2015-09-24)
Perturbation of mitochondrial function and subsequent induction of cell death pathways are key hallmarks in neonatal hypoxic-ischemic (HI) injury, both in animal models and in term infants. Mitoprotective therapies therefore offer a new avenue for intervention for the babies who
Sanko Nguyen et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 77(1), 75-83 (2010-09-30)
The potential of liposomes as a drug delivery system for use in the oral cavity has been investigated. Specifically targeting for the teeth, the in vitro adsorption of charged liposomal formulations to hydroxyapatite (HA), a common model substance for the
Ivana D'Andrea et al.
EMBO molecular medicine, 7(7), 904-917 (2015-04-18)
Although PI3Kγ has been extensively investigated in inflammatory and cardiovascular diseases, the exploration of its functions in the brain is just at dawning. It is known that PI3Kγ is present in neurons and that the lack of PI3Kγ in mice
Jessica T Y Yue et al.
Nature communications, 6, 5970-5970 (2015-01-13)
The brain emerges as a regulator of hepatic triglyceride-rich very-low-density lipoproteins (VLDL-TG). The neurocircuitry involved as well as the ability of fatty acids to trigger a neuronal network to regulate VLDL-TG remain unknown. Here we demonstrate that infusion of oleic
Xin Li et al.
Chemico-biological interactions, 232, 12-20 (2015-03-17)
Cisplatin is a chemotherapy drug commonly used for the treatment of human cancers, however, drug resistance poses a major challenge to clinical application of cisplatin in cancer therapy. Recent studies have shown that chrysin, a natural flavonoid widely found in
Jenny Calvén et al.
Journal of translational medicine, 13, 281-281 (2015-09-01)
Bronchial smooth muscle cells (BSMCs) from severe asthmatics have been shown to overexpress the Th2-driving and asthma-associated cytokine IL-33. However, little is known regarding factors involved in BSMC production of IL-33. Rhinovirus (RV) infections cause asthma exacerbations, which exhibit features
Jayanta K Das et al.
Microvascular research, 98, 126-138 (2015-02-11)
While significant progress has been made to advance our knowledge of microvascular lesion formation, yet the investigation of how stem-like cells may contribute to the pathogenesis of microvascular diseases is still in its infancy. We assessed whether the inhibitor of
Manabu Seino et al.
Oncology reports, 35(1), 593-601 (2015-11-05)
Ovarian cancer is the most lethal gynecological malignancy, for which platinum- and taxane-based chemotherapy plays a major role. Chemoresistance of ovarian cancer poses a major obstacle to the successful management of this devastating disease; however, effective measures to overcome platinum
Electrochemical exfoliation of graphite for producing graphene using saccharin
MK PK, et al.
Royal Society of Chemistry Advances, 5(66), 53865-53869 (2015)
Annamaria Cimini et al.
Journal of cellular physiology, 230(4), 813-820 (2014-10-08)
Ketoprofen L-lysine salt (KLS), a NSAID, is widely used for its analgesic efficacy and tolerability. L-lysine salification was reported to increase the solubility and the gastric absorption and tolerance of ketoprofen. Since the management of NSAIDs gastrotoxicity still represents a
Israr Ahmad et al.
Molecular and cellular biochemistry, 393(1-2), 209-222 (2014-04-29)
Cytochrome P4502E1 (CYP2E1), glutathione-S-transferase A4-4 (GSTA4-4), and inducible nitric oxide synthase (iNOS) are implicated in maneb- and paraquat-induced toxicity leading to various pathological conditions. The study aimed to investigate the role of CYP2E1 in maneb- and paraquat-induced oxidative stress in
Juliane Hellfritsch et al.
Antioxidants & redox signaling, 22(11), 938-950 (2015-02-04)
Mitochondrial thioredoxin reductase (Txnrd2) is a central player in the control of mitochondrial hydrogen peroxide (H2O2) abundance by serving as a direct electron donor to the thioredoxin-peroxiredoxin axis. In this study, we investigated the impact of targeted disruption of Txnrd2
Jiyong Zhang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(5), 1739-1753 (2015-01-23)
Impaired blood-brain barrier function represents an important component of hypoxic-ischemic brain injury in the perinatal period. Proinflammatory cytokines could contribute to ischemia-related blood-brain barrier dysfunction. IL-6 increases vascular endothelial cell monolayer permeability in vitro. However, contributions of IL-6 to blood-brain
Lauren Bourke et al.
PloS one, 10(12), e0143771-e0143771 (2015-12-05)
An increasing number of investigations including human studies demonstrate that pharmacological ischaemic preconditioning is a viable way to protect the heart from myocardial ischaemia/reperfusion (I/R) injury. This study investigated the role of hydroxychloroquine (HCQ) in the heart during I/R injury.
C Blázquez et al.
Cell death and differentiation, 22(10), 1618-1629 (2015-02-24)
The CB1 cannabinoid receptor, the main molecular target of endocannabinoids and cannabis active components, is the most abundant G protein-coupled receptor in the mammalian brain. In particular, the CB1 receptor is highly expressed in the basal ganglia, mostly on terminals
Saurabh Chattopadhyay et al.
EMBO reports, 16(11), 1535-1547 (2015-09-06)
Mammalian Toll-like receptors (TLR) recognize microbial products and elicit transient immune responses that protect the infected host from disease. TLR4--which signals from both plasma and endosomal membranes--is activated by bacterial lipopolysaccharides (LPS) and induces many cytokine genes, the prolonged expression
Bianca C Bernardo et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(12), 5097-5110 (2014-08-26)
Expression of microRNA-652 (miR-652) increases in the diseased heart, decreases in a setting of cardioprotection, and is inversely correlated with heart function. The aim of this study was to assess the therapeutic potential of inhibiting miR-652 in a mouse model
Joanna M Woodcock et al.
Oncotarget, 6(16), 14522-14536 (2015-05-15)
14-3-3 proteins play a pivotal role in controlling cell proliferation and survival, two commonly dysregulated hallmarks of cancers. 14-3-3 protein expression is enhanced in many human cancers and correlates with more aggressive tumors and poor prognosis, suggesting a role for
Jenny Schneiders et al.
Brain, behavior, and immunity, 48, 147-164 (2015-03-31)
The transcription factor nuclear factor interleukin 6 (NF-IL6) plays a pivotal role in neuroinflammation and, as we previously suggested, hypothalamus-pituitary-adrenal-axis-activation. Here, we investigated its contribution to immune-to-brain communication and brain controlled sickness symptoms during lipopolysaccharide (LPS)-induced (50 or 2500 μg/kg
Jie Cheng et al.
Nature communications, 6, 7209-7209 (2015-06-11)
The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that responds to environmental toxicants, is increasingly recognized as a key player in embryogenesis and tumorigenesis. Here we show that a variety of tryptophan derivatives that act as endogenous AhR ligands
Larbi Amazit et al.
The Journal of biological chemistry, 290(36), 21876-21889 (2015-07-24)
Aldosterone regulates sodium homeostasis by activating the mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily. Hyperaldosteronism leads todeleterious effects on the kidney, blood vessels, and heart. Although steroidal antagonists such as spironolactone and eplerenone are clinically useful for
Hiroki Otani et al.
PloS one, 10(6), e0129838-e0129838 (2015-06-20)
TAE226, a bis-anilino pyrimidine compound, has been developed as an inhibitor of focal adhesion kinase (FAK) and insulin-like growth factor-I receptor (IGF-IR). In this study, we investigated the effect of TAE226 on non-small-cell lung cancer (NSCLC), especially focusing on the
Rouzbeh Daylami et al.
Journal of experimental & clinical cancer research : CR, 33, 102-102 (2014-12-17)
Pancreatic ductal adenocarcinoma has proven to be one of the most chemo-resistant among all solid organ malignancies. Several mechanisms of resistance have been described, though few reports of strategies to overcome this chemo-resistance have been successful in restoring sensitivity to
Jesse Hwang et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(52), E5706-E5715 (2014-12-17)
An shRNA-mediated screen of the 48 human nuclear receptor genes identified multiple candidates likely to influence the production of human cytomegalovirus in cultured human fibroblasts, including the estrogen-related receptor α (ERRα), an orphan nuclear receptor. The 50-kDa receptor and a
Liselotte Hardy et al.
PloS one, 10(8), e0136658-e0136658 (2015-08-26)
Bacterial vaginosis (BV), a condition defined by increased vaginal discharge without significant inflammation, is characterized by a change in the bacterial composition of the vagina. Lactobacillus spp., associated with a healthy vaginal microbiome, are outnumbered by BV-associated organisms. These bacteria
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